右侧和左侧局灶性癫痫患者的 HPA 轴功能。

Neuro endocrinology letters Pub Date : 2024-04-07
Aysenur Avarisli, Asuman Orhan Varoglu, Havva Keskin, Hayriye Erman
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引用次数: 0

摘要

目的:癫痫与下丘脑-垂体-肾上腺(HPA)轴之间存在复杂的相互联系。本研究旨在评估 HPA 轴在局灶性癫痫患者(包括右侧或左侧大脑半球偏侧性癫痫患者)中的作用:研究对象包括 60 名局灶性癫痫患者,年龄在 18 至 85 岁之间,癫痫发作来自单侧大脑半球,头颅磁共振成像无破坏性病变,以及 32 名健康人。患者组和对照组分别在 8 点和 23 点抽血检测血清皮质醇水平和血清褪黑激素水平。对患者组和对照组进行匹兹堡睡眠质量指数和埃普沃思嗜睡量表测试:结果:患者的褪黑激素水平下降(p < 0.001),睡眠质量较差(p = 0.035)。患者的皮质醇水平低于健康人的皮质醇水平,但差异无统计学意义(p = 0.107)。皮质醇和褪黑激素水平在来自右半球或左半球的癫痫患者之间没有明显差异。左半球癫痫发作患者的癫痫病程更长(p = 0.013),发作频率更高(p = 0.013),首次发作年龄更小(p = 0.038),接受多种治疗的比例更高(p = 0.05):结论:局灶性癫痫患者皮质醇和褪黑激素水平低可能是 HPA 轴紊乱的一个指标。结论:局灶性癫痫患者皮质醇和褪黑激素水平偏低可能是 HPA 轴功能紊乱的指标,不同癫痫半球的局灶性癫痫患者在 HPA 轴功能方面没有明显差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
HPA axis function in patients with right and left focal lateralized epilepsy.

Objectives: There is a complex, reciprocal link between epilepsy and the hypothalami pituitary-adrenal (HPA) axis. This study aimed to evaluate the role of the HPA axis in individuals with focal epilepsy, including those with right- or left-hemispheric lateralized epilepsy.

Material and methods: The study comprised 60 individuals with focal epilepsy, ages 18 to 85, with seizures coming from a single hemisphere, no destructive lesions on cranial magnetic resonance imaging, and 32 healthy persons. Blood was drawn from the patient and control groups at 8.00 for serum cortisol level and at 23.00 for serum melatonin level. The Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale were administered to both the patient and control groups.

Results: Patients showed decreased melatonin levels (p < 0.001) and poorer sleep quality (p = 0.035). The cortisol level of the patients was found to be lower than the cortisol level of healthy individuals, although it was not statistically significant (p = 0.107). Cortisol and melatonin levels did not significantly differ between patients with seizures coming from the right or left hemisphere. The patients with seizures originating from the left hemisphere had a longer duration of epilepsy disease (p = 0.013), higher seizure frequency (p = 0.013), lower age of first seizure onset (p = 0.038), and a higher rate of polytherapy (p = 0.05).

Conclusion: Low cortisol and melatonin levels in patients with focal epilepsy may be an indicator of disruption in the HPA axis. There is no significant difference in the HPA axis function between patients with focal epilepsy according to the epileptic hemisphere.

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