Recurrent Cushing's Disease Caused by a TPIT-Lineage Densely Granulated Corticotroph Pituitary Neuroendocrine Tumor: A Case Report.

Neuro endocrinology letters Pub Date : 2024-01-31
Weiming Wu, Xiaoying Fu, Wenlong Guo, Hongmei Chen
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Abstract

Introduction: Recurrent Cushing's disease (recurrent CD) is an uncommon and intricate clinical form of Cushing's syndrome. However, the connection between the pathological types of ACTH-secreting PitNETs and the clinical signs of recurrent CD remains uncertain.

Case description: A 64-year-old woman, previously diagnosed with renal carcinoma, was admitted to our hospital due to recent weight gain. Previous endocrine tests indicated fluctuating hypercortisolemia and a recurrent pituitary tumor over the past six years. She underwent two transsphenoidal hypophysectomies, and histopathological analysis of the tumor revealed it as a densely granulated corticotroph tumor (DGCT), a subtype of TPIT-lineage PitNET, accompanied by tumor apoplexy.

Conclusion: This case highlights the connection between recurrent CD and the pathological subtypes of TPIT-lineage DGCT-PitNETs.

由 TPIT 线状致密颗粒垂体皮质营养神经内分泌瘤引起的复发性库欣病:病例报告。
简介复发性库欣病(复发性 CD)是库欣综合征的一种不常见且错综复杂的临床形式。然而,分泌促肾上腺皮质激素的PitNET的病理类型与复发性库欣病的临床表现之间的联系仍不确定:一名曾被诊断为肾癌的 64 岁女性因近期体重增加而入住我院。既往的内分泌检查显示,在过去六年中,她曾出现波动性高皮质醇血症和复发性垂体瘤。她接受了两次经蝶垂体下叶切除术,肿瘤的组织病理学分析表明这是一种致密颗粒皮质营养瘤(DGCT),是TPIT系PitNET的一种亚型,并伴有肿瘤中风:本病例强调了复发性CD与TPIT系DGCT-PitNET病理亚型之间的联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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