Neuro endocrinology letters最新文献

{"title":"Visual analysis of subarachnoid hemorrhage research hotspots based on CiteSpace and VOSviewer: A retrospective study.","authors":"Zhenqiang Hao, Peigang Lu, Bo Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the hotspots and frontiers in the field of subarachnoid hemorrhage using the bibliometrics method and providing references for academic research.</p><p><strong>Methods: </strong>All published studies related to subarachnoid hemorrhage published in the Web of Science core database from 1 January 2016 to 25 September 2021 were retrospectively identified using VOSviewer and CiteSpace software. Visualization VOSviewer and CiteSpace software were used to perform statistical and cluster analyses on authors, countries, institutions, keywords, and co-cited documents. Knowledge graphs were drawn.</p><p><strong>Results: </strong>A total of 7151 research papers related to subarachnoid hemorrhage were included for analysis. The number of papers on subarachnoid hemorrhage research showed an upward trend. The leading countries in subarachnoid hemorrhage research were the United States, China, and Japan. In addition, the Harvard Medical School, the Mayo Clinic, and the Capital Medical University were leading authorities subarachnoid hemorrhage research. The common keywords formed 7 clusters. There were 13 clusters of citations.</p><p><strong>Conclusions: </strong>Research hotspots and directions in subarachnoid hemorrhage research were identified, such as cerebral aneurysm, early brain injury, vasospasm, and prognosis model.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 2","pages":"77-85"},"PeriodicalIF":0.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of nutritional status and swallowing functions of children with neuromuscular disordes.","authors":"Gülen Gul Mert, Didem Biçer, M Özlem Hergüner, Faruk İncecik","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>It is important to raise awareness of the nutritional problems that can be overlooked during the follow-up visits with children who suffer from neuromuscular diseases, as these dietary differences may lead to additional neurological and systemic problems and impair the quality of life of the patient. The aim of this study was to evaluate the nutritional status of children with neuromuscular disorders and to prevent possible complications by recognizing possible nutritional problems in advance.</p><p><strong>Methods: </strong>Patients who applied to the outpatient clinic at Cukurova University, Faculty of Medicine, Department of Pediatric Neurology beginning in April 2022 with a neuromuscular disorder diagnosis were followed up with and were included in the study. Age, gender, weight, height, body mass index (BMI), ambulation status, presence of constipation, and nutritional status of each patient at their last examination were evaluated and recorded in the standard data collection form. The Eating Assessment Tool (EAT-10) scale, which is an objective test, was used to evaluate nutritional problems.</p><p><strong>Results: </strong>A total of 50 patients were included in the study. Of the patients followed, 27 (54%) had Duchenne muscular dystrophy (DMD), 10 (20%) had congenital muscular dystrophy (CMD), and 13 (26%) had limb girdle muscular dystrophy (LGMD). The mean age of the patients was 11 years 5 months. Eight of the patients (16%) were female and 42 (84%) were male. While all of the patients could take food orally 17 patients (34%) had constipation. Of the patients, 16 (32%) were able to walk without support, 12 (24%) were able to walk with support, and 22 (44%) were non-ambulatory. While 19 of the patients' (38%) mealtime duration was <15 minutes, 22 (44%) ate for 15-30 minutes, and 9 (18%) ate for >30 minutes. There were 8 patients (16%) whose daily feeding time exceeded 3 hours. Of these patients, 3 were in the DMD group, 4 were in the CMD group, and only one was in the LGMD group. The mean EAT-10 score of the patients was 4.46, although it varied according to the disease subgroups.</p><p><strong>Conclusion: </strong>Regular monitoring of the nutritional status of children with neuromuscular disorders using objective and practical methods, along with timely and appropriate interventions when necessary, can significantly improve the quality of life and living standards of these patients.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 2","pages":"91-95"},"PeriodicalIF":0.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperprolactinemia-associated erectile dysfunction: retrospective cohort evaluating the effect of prolactin normalization on IIEF-5.","authors":"Marek Broul, Aneta Hujová, Lucie Radovnická, Alberto Malucelli, Eva Jozífková, Michaela Liegertová","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>In addition to hypogonadism, other endocrine disorders-particularly hyperprolactinemia-can significantly influence erectile dysfunction (ED) in men. The aim of our study was to evaluate the effect of normalizing prolactin (PRL) levels on erectile function in men diagnosed with ED and hyperprolactinemia. The primary outcome was improvement in IIEF-5.</p><p><strong>Methods: </strong>We retrospectively analyzed a three group of patients (N = 20) diagnosed with hyperprolactinemia who simultaneously presented with ED, confirmed by clinical criteria and results of the International Index of Erectile Function-5 (IIEF-5) questionnaire. Group Conservative did not receive hyperprolactinemia treatment. Treatment of hyperprolactinemia consisted of pharmacotherapy with dopaminergic agonists (group Dostinex) and/or neurosurgical intervention, depending on individual findings (group Surgery). For ED therapy, each patient received one of the phosphodiesterase 5 inhibitors (PDE5I)-specifically sildenafil, tadalafil, vardenafil, or avanafil.</p><p><strong>Results: </strong>After successful hyperprolactinemia therapy, all treated patients achieved normalized PRL levels. At the same time, each patient showed an improvement in IIEF-5 scores, indicating a significant enhancement in erectile function. Groups Conservative showed tendency to improve. Groups Dostinex and Surgery reached significant enhancement in erectile function.</p><p><strong>Conclusion: </strong>Our results confirmed the positive impact of resolving the primary endocrine cause on overall sexual health. These findings underscore the importance of comprehensive hormonal assessment in the management of male sexual dysfunction, including measurement of PRL levels. While hyperprolactinemia is a relatively uncommon cause of ED, its treatment-whether pharmacological or surgical-can lead to PRL normalization and a marked improvement in erectile function. The combined use of PDE5I and hyperprolactinemia treatment represents an effective therapeutic approach that should be considered in the care of men with ED.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 2","pages":"107-114"},"PeriodicalIF":0.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian Rhythm Disruption and Sleep Disorders in Alzheimer's Disease: Mechanistic Insights and Therapeutic Potentials.","authors":"Kechen Liu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Alzheimer's Disease (AD) is the leading cause of dementia worldwide, with significant cognitive and behavioural impairments that devastate individuals and their families. Cohort-level findings, demonstrate the broader population-level implications of Sleep and Circadian Rhythm Disruption (SCRD) in AD and underscore the need for early interventions, emphasizing the importance of timely action. However, the mechanism remains unclear. SCRD impairs the glymphatic system, which is responsible for the clearance of neurotoxic proteins such as amyloid-β and tau during slow-wave sleep, accelerating neurodegeneration. Moreover, SCRD exacerbates neuroinflammation by disrupting the circadian regulation of immune responses, mainly through the dysregulation of microglial activity and pro-inflammatory cytokine release, which further promotes neuronal damage. This review summarizes the current understanding of SCRD in AD, outlining the mechanistic links, evidence from animal models, and emerging treatments targeting SCRD in AD, as well as promising new drug targets emerging from preclinical studies. Circadian modulation may represent a novel therapeutic avenue for AD.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 2","pages":"59-69"},"PeriodicalIF":0.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transgenerational trauma and schema therapy: Imagery rescripting and chairwork in practice.","authors":"Jan Prasko, Jakub Vanek, Frantisek Hodny, Ilona Krone, Julius Burkauskas, Julija Gecaite-Stonciene, Marija Abeltina, Alicja Juskiene, Marta Zatkova, Ieva Bite, Milos Slepecky, Jan Pasztor, Pavel Doubek, Marie Ociskova","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Transgerational transmitted trauma is the transmission of psychological injuries between generations. This article uses two case vignettes to explore selected schema therapy approaches that help clients process transgenerationally transmitted trauma from their ancestors. Specific methods of imagery rescripting and chair work enable clients to transform maladaptive patterns of experiencing into healthier coping strategies, support better stress management, improve emotional regulation and communication in relationships, and encourage more profound relationships with themselves and others.</p><p><strong>Methods: </strong>Two case studies illustrate imagery rescripting and chair work, in which the client takes the role of their traumatised ancestor. The first case shows a schema therapy of a young woman struggling with repressed emotions related to her family history and the suicide of her grandfather. The second case demonstrates therapeutic work with a client struggling with emotional outbursts and self-harm that are a reflection of transgenerational traumatisation passed down from her mother and grandparents.</p><p><strong>Results: </strong>Both clients experienced a significant reduction in borderline symptoms during the therapeutic work. At the same time, these clients progressed in understanding the inherited transgenerational family patterns and improved their behaviour towards themselves and others.</p><p><strong>Discussion: </strong>Two case examples have shown that experiential interventions such as imagery rescripting and chairwork can help clients process transferred patterns of traumatic experience and behaviour and bring adaptive changes into their lives. Imagery rescripting as a therapeutic tool can bridge the emotional and physical aspects of transferred learned experiences and help clients integrate a new perspective on themselves and others.</p><p><strong>Conclusion: </strong>Imagery rescripting and chairwork can be effective therapeutic tools for addressing transgenerational trauma.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 2","pages":"96-106"},"PeriodicalIF":0.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case: Composite Paraganglioma-Ganglioneuroma in a Neurofibromatosis 1 Patient and Literature Review.","authors":"Ying Du, Li Lin, Sheng Chen, Defei Hong, Xuehong Dong, Aihua Huang, Yongdong Wang, Danjun Dong","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Pheochromocytomas and paragangliomas (PPGLs) are rare catecholamine-secreting neuroendocrine tumors originating from the embryonic neural crest. Approximately 30% of PPGLs are hereditary and are frequently associated with genetic syndromes, including neurofibromatosis type 1 (NF1). Composite PPGLs, which include components of both PPGLs and related tumors such as ganglioneuromas, are extremely rare in NF1 patients.</p><p><strong>Case presentation: </strong>A 40-year-old woman with NF1, identified by multiple neurofibromas, café-au-lait spots, axillary freckling, and Lisch nodules, presented with an incidental mass adjacent to the right adrenal gland. Computed tomography and magnetic resonance imaging revealed a possible PPGL, with additional small nodules suspected to be gastrointestinal stromal tumors or neuroendocrine tumors. Genetic testing revealed a heterozygous NF1 gene mutation, c.2786T>C. The patient underwent successful robotic-assisted laparotomy to remove a 5 cm retroperitoneal tumor. Pathological examination revealed a composite paraganglioma-ganglioneuroma. The patient recovered well postoperatively and was recommended for long-term follow-up.</p><p><strong>Conclusion: </strong>This report describes the first Chinese case of composite extra-adrenal paraganglioma-ganglioneuroma in an NF1 patient, highlighting the importance of a multidisciplinary approach, including genetic analysis, for the accurate diagnosis and management of composite PGLs in NF1 patients. This unique case underscores the clinical significance of recognizing rare composite tumors in diverse populations to improve diagnosis and personalized treatment strategies. Further research into the genetic and clinical implications of these tumors is important.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 2","pages":"70-76"},"PeriodicalIF":0.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key factors underpinning neuroimmune-metabolic-oxidative (NIMETOX) major depression in outpatients: paraoxonase 1 activity, reverse cholesterol transport, increased atherogenicity, protein oxidation, and differently expressed cytokine networks.","authors":"Michael Maes, Ketsupar Jirakran, Laura de Oliveira Semeão, Ana Paula Michelin, Andressa K Matsumoto, Francis F Brinholi, Decio S Barbosa, Chavit Tivirachaisakul, Abbas F Almulla, Drozdstoj Stoyanov, Yingqian Zhang","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Major depressive disorder (MDD) is associated with neuro-immune - metabolic - oxidative (NIMETOX) pathways.</p><p><strong>Aims: </strong>To examine the connections among NIMETOX pathways in outpatient MDD (OMDD) with and without metabolic syndrome (MetS); and to determine the prevalence of NIMETOX aberrations in a cohort of OMDD patients.</p><p><strong>Methods: </strong>We included 67 healthy controls and 66 OMDD patients and we assessed various NIMETOX pathways.</p><p><strong>Results: </strong>We successfully identified a subgroup of individuals with aberrations in NIMETOX pathways, including diminished lecithin-cholesterol acyltransferase (LCAT), paraoxonase 1 (PON1) activity, and reverse cholesterol transport (RCT) activities, and elevated atherogenicity, differentially expressed immune networks, and advanced oxidation protein products (AOPP). A large part of the variance (around 44%) in atherogenicity indices was associated with AOPP, fasting blood glucose (FBG), PON1 activity, and immune activation. LCAT activity was positively correlated with PON1 activity and negatively with FBG, AOPP and immune activation. RCT was positively related with the PON1 R/R 192 genotype and negatively with FBG and immune activation. A larger part of the variance in the overall severity of OMDD (50.4%), suicidal behaviors (27.7%), and neuroticism (42.1%) was positively associated with adverse childhood experiences and NIMETOX pathways, including AOPP, immune-related neurotoxicity, FBG, insulin, and atherogenicity, and inversely with immune-related neuroprotection.</p><p><strong>Conclusions: </strong>Many OMDD patients (78.8%) show aberrations in NIMETOX pathways. The features of OMDD, including severity of illness, neuroticism, and suicidal behaviors, are caused by intertwined NIMETOX pathways that may exert additional effects depending on whether MetS is present or not.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 2","pages":"115-125"},"PeriodicalIF":0.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocrinological Differences Between Partial and Complete Primary Empty Sella: A Comparative Analysis.","authors":"Can Akcura, Sedat Can Guney, Samet Alkan, Gulgun Yilmaz Ovali, Zeliha Hekimsoy, Nilufer Ozdemir","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>Empty sella is the herniation of the subarachnoid space into the sella turcica; either secondary to identifiable causes (e.g., surgery or radiotherapy); or spontaneously, which is termed primary empty sella (PES). The amount of cerebrospinal fluid (CSF) in the sella on imaging classifies PES as partial (<50% filling, pituitary >2 mm) or complete (≥50% filling, pituitary <2 mm). Few investigations have compared hormonal abnormalities in partial and complete PES.</p><p><strong>Design: </strong>This study aims to determine whether partial and complete PES differ endocrinologically.</p><p><strong>Material and methods: </strong>Fifty-eight PES patients underwent hormonal evaluation: morning corticotropin (ACTH), cortisol, thyrotropin (TSH), free thyroxine (fT4), follicle‑stimulating hormone (FSH), luteinizing hormone (LH), estradiol (females), total testosterone (males), prolactin (PRL), growth hormone (GH) and insulin‑like growth factor‑1 (IGF‑1). Patients were divided into partial and complete PES groups and endocrinologically assessed.</p><p><strong>Results: </strong>The proportion of secondary adrenal insufficiency and secondary hypogonadism was significantly higher in the complete PES group (p = 0.021 and p = 0.041, respectively). The proportion of cases with two or more affected axes was higher in complete PES (p = 0.010). Secondary hypothyroidism was significantly more common among males (p = 0.001).</p><p><strong>Conclusion: </strong>After a diagnosis of complete PES, clinicians should be cautious about secondary adrenal insufficiency and hypogonadism. It is advisable to perform hormonal testing for all PES patients, regardless of type, because affected‑axis rates often exceed 10% and may reach 50%. Prospective multicenter trials are necessary.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 2","pages":"86-90"},"PeriodicalIF":0.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145035088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed peripheral nerve rehabilitation in aquaporin-3 deficiency in mouse models of sciatic nerve contusion.","authors":"Jie Wang, Sixuan Li, Hong Huang, Yixuan Wang, Miao Li","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Aquaporin-3 (AQP3) water channels are belonging to the aquaporin water channel family, permeable not only to water but also to some small solutes such as glycerol and lactate. The purpose of this study is to investigate the possible functions of AQP3 in peripheral nerve rehabilitation based on AQP3-deficient mice.</p><p><strong>Methods: </strong>Mature 8-week-old female AQP3-deficient (AQP3-/-) mice and C57BL/6 (WT) mice initially weighing 25~30 g were used in this study. Schwann cells were isolated from sciatic nerves of WT and AQP3-/- mice respectively. AQP3 mRNA and protein expression in sciatic nerve tissues and Schwann cells were detected by RT-PCR, immunoblot analysis, and immunofluorescence staining. Sciatic nerve cross sections from the WT and AQP3-/- mice were stained by toluidine-blue agent to identify the potential influence of AQP3 deficiency to the morphology nerve fibers. The proliferation and migration ability of AQP3-/- and WT Schwann cells were observed in primary cell cultures. To explore the possible role of AQP3 in nerve repair processes, sciatic nerve contusion models were established and walking track analysis was performed on both WT and AQP3-/- mice.</p><p><strong>Results: </strong>AQP3 was localized in the membrane of Schwann cells. AQP3-deficiency did not alter the morphology of fibers in the sciatic nerve. There was an increase of AQP3 protein expression in the sciatic nerve of wild-type mice after injury. Primary culture of Schwann cells and in vitro wound healing model revealed that AQP3-deficient Schwann cells exhibited the same morphology, while showing lower proliferation and migration ability compared with wild-type Schwann cells. There was obvious delay in motor function rehabilitation in AQP3-deficient mice compared with that of wild-type mice.</p><p><strong>Conclusion: </strong>Our study suggested that AQP3 localized in the membrane of Schwann cells and facilitated Schwann cells' proliferation and migration. AQP3 deficiency impaired nerve rehabilitation in wound healing model both in vitro and in vivo. The study support our hypothesis that AQP3 participates in myelin damnification and repair course and the mechanisms underlying the AQP3 in the field of myelin repair and regeneration in peripheral nerves deserves further investigation and exploration in detail.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 1","pages":"49-57"},"PeriodicalIF":0.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autophagy-mediated regulation of psoriasis biomarkers by Dead Sea and magnetized saline waters: An in vitro study.","authors":"Piercarlo Minoretti, Enzo Emanuele, Celia García-Chico, Kayvan Khoramipour, Alejandro Santos-Lozano, Eugenia V Di Brizzi, Simone Lista","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Dysregulated autophagy is linked to abnormal keratinocyte differentiation and persistent psoriatic inflammation. Smart fluids, such as Dead Sea Water (DSW) and saline magnetized water (MW), have emerged as potential non-pharmacological autophagy activators. This study evaluates their effects on psoriasis-like keratinocytes, focusing on calcitonin gene-related peptide (CGRP), a neuropeptide involved in pruritus and inflammation, and secreted frizzled-related protein 4 (SFRP4), whose reduced expression contributes to epidermal hyperplasia. The role of autophagy in mediating these effects was also investigated.</p><p><strong>Methods: </strong>Polycytokine-stimulated HaCaT keratinocytes were treated with DSW or saline MW. CGRP and SFRP4 expression levels were assessed alongside autophagy markers beclin-1 and LC3B. The involvement of autophagy was confirmed using wortmannin, an autophagy inhibitor.</p><p><strong>Results: </strong>Both DSW (4.7 ± 1.9 a.u.) and saline MW (3.6 ± 1.6 a.u.) significantly reduced CGRP expression compared to controls (non-magnetized saline: 7.5 ± 2.3 a.u.; distilled water: 7.6 ± 2.5 a.u.; all p< 0.001). While both fluids enhanced SFRP4 expression equally (p = 0.78), saline MW showed superior CGRP inhibition (p< 0.001). Both fluids mitigated polycytokine-induced reductions in beclin-1 and LC3B levels (all p< 0.001), with saline MW showing more pronounced effects (p< 0.05). Wortmannin impaired the effects of both fluids on CGRP and SFRP4, indicating autophagy mediation.</p><p><strong>Conclusions: </strong>DSW and saline MW show promise as sustainable active ingredients for topical formulations targeting psoriatic inflammation via autophagy activation.</p>","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"46 1","pages":"27-32"},"PeriodicalIF":0.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}