Neuro endocrinology letters最新文献_第9页

Cancer's aftermath: posttraumatic growth as an intermediate step to perceived benefits. 癌症的后果：创伤后成长是实现预期利益的中间步骤。

Neuro endocrinology letters Pub Date : 2023-09-29

Lucia Ráczová, Jana Turzáková, Tomáš Sollár

{"title":"Cancer's aftermath: posttraumatic growth as an intermediate step to perceived benefits.","authors":"Lucia Ráczová, Jana Turzáková, Tomáš Sollár","doi":"","DOIUrl":"","url":null,"abstract":"Background: The need to develop understanding of the posttraumatic growth (PTG) in the population of cancer survivors has increased in recent years. The daily functioning of cancer survivors involves factors that affect the development of PTG and the process by which it arises.Objectives: The main objective was to explore PTG process and its influencing factors in cancer survivors.Methods: Using qualitative research design, the study applied in-depth interviews and the method of life-line drawing with seven female cancer survivors, aged between 49 and 73. Data were analyzed using grounded theory methodology.Results: The main category in the process is persistence in consequences associated with two categories of triggers, external and internal. The various outcomes (PTG, acceptance, uncertainty) depend on perceived possibility of taking control over consequences in cancer survivors. PTG is a result of individual accommodation of illness consequences in which taking control and accommodation lead to self-regulation of pain, self-confidence, and positive self-image.Conclusion: Possibility of taking control over the disease consequences and active approach to acquiring new skills are central explanatory variables modifying the process of persistence in consequences of illness and the reasons of PTG. The PTG model has the potential to be adapted to other cancer-related outcomes that are relevant to the daily lives of cancer survivors.","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"44 6","pages":"391-398"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41163713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Higher concentration in serum of insulin autoantibodies in patients with schizophrenia or related psychosis, compared to in control subjects. 精神分裂症或相关精神病患者血清中胰岛素自身抗体浓度高于对照组。

Neuro endocrinology letters Pub Date : 2023-09-29

Kristina Melkersson, Sophie Bensing

{"title":"Higher concentration in serum of insulin autoantibodies in patients with schizophrenia or related psychosis, compared to in control subjects.","authors":"Kristina Melkersson, Sophie Bensing","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: In a recent study, we found increased antibody reactivity against the insulin receptor-A and insulin-like growth factor 1 receptor and their ligands in patients with schizophrenia or related psychosis, indicating that an autoimmune-mediated process may underlie development of schizophrenia. The aim of this study was to supplement our previous study with analysing additional neuronal- and diabetes-associated autoantibodies of potential interest for schizophrenia in the same patients and controls as in the foregoing study.Material and methods: Analyses of neuronal (NMDAR, VGKC, AMPAR, GABABR, DPPX, GAD)- and voltage-gated calcium channel (VGCC) autoantibodies in cerebrospinal fluid (12 patients, 11 controls) and of diabetes-associated (GAD, IA-2, ZnT8, insulin)- and VGCC autoantibodies in serum (17 patients, 11 controls) were done by standard methods. Additionally, patients (n = 16) were accessed for clinical symptoms with the Positive and Negative Syndrome Scale (PANSS) for schizophrenia.Results: Concentrations in cerebrospinal fluid of NMDAR-, VGKC-, AMPAR-, GABABR-, DPPX-, GAD- and VGCC autoantibodies were below detection limits in all patients and controls. Concentration in serum of insulin autoantibodies was significantly higher in patients than in controls (p = 0.001), whereas no significant differences were found in concentrations in serum of GAD-, IA-2-, ZnT8- or VGCC autoantibodies between patients and controls. Patients' serum concentrations of insulin autoantibodies tended to inversely correlate to their PANSS scores.Conclusion: In this study, we show higher concentration in serum of insulin autoantibodies in patients with schizophrenia. This finding is of importance since autoantibodies against insulin may be implicated in the autoimmune-mediated process underlying development of schizophrenia.","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"44 6","pages":"358-367"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41166148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-stigma in patients with schizophrenia: Impact and management. 精神分裂症患者的自我污名：影响和管理。

Neuro endocrinology letters Pub Date : 2023-09-29

Marie Ociskova, Jan Prasko, Michaela Holubova, Klara Latalova, Tomas Sollar, Marta Zatkova, Milos Slepecky, Jonas Bocek

{"title":"Self-stigma in patients with schizophrenia: Impact and management.","authors":"Marie Ociskova, Jan Prasko, Michaela Holubova, Klara Latalova, Tomas Sollar, Marta Zatkova, Milos Slepecky, Jonas Bocek","doi":"","DOIUrl":"","url":null,"abstract":"Background: Prejudices against individuals with schizophrenia can interfere with diagnostic and treatment processes, particularly with the patient's further adaptation and reintegration. Self-stigma could have significant detrimental consequences for patients suffering from psychotic disorders, including schizophrenia.Method: This paper reviews findings about self-stigma connected to schizophrenia. The PubMed database used the keywords to find the papers published from January 1997 to March 2023, and 189 articles were included in the review process.Results: The schizophrenia-related stigma decreases patients' self-confidence, worsens their social functioning, and impedes daily functioning. Feelings of embarrassment are prominent in many patients with schizophrenia. Self-stigma predicts many unfavourable outcomes - more severe social anxiety and depressive symptoms, lower self-confidence, hopelessness, worse social functioning, lower quality of life, worse treatment cooperation, and lower adherence to medication adherence. Addressing self-stigma in psychoeducation or psychotherapy may increase the patient's stigma resistance and well-being. Self-help groups present an underutilised but potentially effective strategy.Conclusion: Stigma presents a common issue in patients with schizophrenia. Targeting the issue in clinical management or psychotherapy may be beneficial. Still, more high-quality intervention studies are needed.","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"44 6","pages":"368-383"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41168380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between cognitive impairment and the disability in people with multiple sclerosis. 多发性硬化症患者认知障碍与残疾的关系。

Neuro endocrinology letters Pub Date : 2023-07-28

Bianka Suchá, Pavel Šiarnik, Stanislava Klobucká, Peter Turčáni, Branislav Kollár

{"title":"Association between cognitive impairment and the disability in people with multiple sclerosis.","authors":"Bianka Suchá, Pavel Šiarnik, Stanislava Klobucká, Peter Turčáni, Branislav Kollár","doi":"","DOIUrl":"","url":null,"abstract":"Background: Cognitive impairment (CI) may be present in people with multiple sclerosis (PwMS) in different stages of the disease, as well as in PwMS with various degrees of disability. This study aimed to investigate cognitive decline over a period of 12 months and to examine an association between cognition and the disability in PwMS, also over a period of 12 months.Methods: The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) battery was used, containing the Symbol Digit Modalities Test (SDMT), the Categorical Verbal Learning Test (CVLT), and the Brief Visuospatial Memory Test-Revised (BVMT-R). The Expanded Disability Status Scale (EDSS), Timed 25-Foot Walk (T25FW), and 9-Hole Peg Test (9-HPT) were used to assess the degree of disability. For the analysis of cognitive decline over the period of 12 months, Wilcoxon signed-rank test (paired sample t-test) was used. For the correlation between cognition and disability, Spearman's correlation test was used.Results: We observed statistically meaningful difference only in one measure of cognition (CVLT), not the other two (SDMT and BVMT-R). SDMT significantly correlated with methods assessing the degree of disability in both time points. In the second examination, we observed a correlation between BICAMS and 9-HPT. Similarly, SDMT and BVMT-R also correlated with EDSS.Conclusion: To investigate the cognitive decline in PwMS, a longer period of time probably should have been chosen. EDSS is commonly used to monitor disease progression, but it does not include the evaluation of various parameters, such as cognition or upper limb function. Its use with the 9-HPT and cognitive tests may represent a more reliable and comprehensive assessment of a patient's clinical condition.","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"44 5","pages":"283-289"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41170721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Black & white relations: Intimate relationships of patients with borderline personality disorder. 黑白关系：边缘型人格障碍患者的亲密关系。

Neuro endocrinology letters Pub Date : 2023-07-28

Marie Ociskova, Jan Prasko, Frantisek Hodny, Michaela Holubova, Jakub Vanek, Kamila Minarikova, Vlastimil Nesnidal, Tomas Sollar, Milos Slepecky, Krystof Kantor

{"title":"Black & white relations: Intimate relationships of patients with borderline personality disorder.","authors":"Marie Ociskova, Jan Prasko, Frantisek Hodny, Michaela Holubova, Jakub Vanek, Kamila Minarikova, Vlastimil Nesnidal, Tomas Sollar, Milos Slepecky, Krystof Kantor","doi":"","DOIUrl":"","url":null,"abstract":"Background: Individuals with borderline personality disorder (BPD) suffer from an excessive fear of abandonment, leading to tense moments in their intimate relationships. These struggles translate into lower marital satisfaction perceived by both intimate partners. However, this connection is bidirectional, since conflicts with a romantic partner are the most common precipitating factors of decompensation in BPD patients.Method: This narrative review was performed using PubMed, Web of Science, and Scopus databases with keywords \"borderline personality disorder\", \"partnership\", marital problems\", and \"marital conflicts\". Articles, books, and book chapters published within January 1980 - December 2020 were extracted and analysed. Additional sources were found while reviewing references of relevant articles. The total of 131 papers met the inclusion criteria.Results: Patients with BPD struggle with reaching marital satisfaction. They often find themselves in disharmonic and unfulfilling relationships. The association between the relationship issues and BPD may partly come from misunderstanding one or both partners' behaviour. Individuals with BPD tend to misinterpret their partner's behaviour, struggle with communication, and sometimes be verbally and physically aggressive. They often do not recognize that their intrapersonal processes influence their interpersonal struggles. Understanding the role of the maladaptive personality traits in the relationship and their management could be beneficial for both partners.Conclusion: Individuals with BPD often report dysfunctional romantic relationships characterized by insecure attachment, maladaptive communication, and lower relationship satisfaction. Future studies should focus on finding effective strategies of couples´ therapy working with this population.","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"44 5","pages":"321-331"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41127331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First-onset type 1 diabetes in an elderly woman with multiple islet-associated autoantibodies, and a literature review. 一例老年妇女首次发病的1型糖尿病伴多种胰岛相关自身抗体及文献综述。

Neuro endocrinology letters Pub Date : 2023-07-28

Shinichi Tanaka, Hajime Tanaka, Hideaki Kurata, Takeshi Katsuki, Toshihide Kawai

{"title":"First-onset type 1 diabetes in an elderly woman with multiple islet-associated autoantibodies, and a literature review.","authors":"Shinichi Tanaka, Hajime Tanaka, Hideaki Kurata, Takeshi Katsuki, Toshihide Kawai","doi":"","DOIUrl":"","url":null,"abstract":"An 80-year-old Japanese woman had shown no indication of diabetes but regularly saw a primary-care physician for health management. Six months before her referral to our hospital, her HbA1c was 6.0%. She was referred to us for diabetic ketosis because she was urine ketone body-positive with a blood glucose level of 397 mg/dL and HbA1c of 14.6%. She was diagnosed with type 1 diabetes mellitus (T1DM) with glutamic acid decarboxylase (GAD) antibodies >2,000 U/mL (by ELISA) and IA-2 antibodies >30 U/mL. Insulin injections were introduced, and she was discharged. Laboratory tests during her hospitalization were negative for thyroid antibodies (TgAb, TPOAb). Elderly individuals with first-onset T1DM who are positive for IA-2 antibody are rare, and multiple-positive cases of pancreatic islet-associated autoantibodies are particularly rare. IA-2 antibodies have an approx. 60% positive rate in acute-onset T1DM, but they are more likely to be positive in children and adolescents and are known to turn negative earlier than anti-GAD antibodies. Although a large amount of insulin is needed in general in such cases, our patient was successfully treated with a small amount of insulin. IA-2 antibody has been reported to be positive even in GAD antibody-negative individuals. In some cases, IA-2 antibody and other antibodies are positive even in elderly-onset diabetes, and this contributes to the diagnosis of T1DM.","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"44 5","pages":"336-339"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41166718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioelectrical impedance analysis to assess hydration in critically ill patients: A practical guide demonstrating its use on artificially ventilated COVID patients. 评估危重患者水合作用的生物电阻抗分析：一份实用指南，证明其在人工通气的新冠肺炎患者中的应用。

Neuro endocrinology letters Pub Date : 2023-07-28

Marcela Káňová, Karin Petřeková, Nadezhda Borzenko, Klára Rusková, Ivana Nytra, Pavla Dzurňáková

{"title":"Bioelectrical impedance analysis to assess hydration in critically ill patients: A practical guide demonstrating its use on artificially ventilated COVID patients.","authors":"Marcela Káňová, Karin Petřeková, Nadezhda Borzenko, Klára Rusková, Ivana Nytra, Pavla Dzurňáková","doi":"","DOIUrl":"","url":null,"abstract":"Determining body contents such as body water volume and body cell mass have significant uses in health and disease. Accumulation of extracellular water is particularly difficult to monitor using classical methods. Bioelectrical impedance analysis (BIA) is a simple, rapid, and noninvasive method, based on the principle that the flow of altering electrical current through a particular tissue differs depending on the content of water and electrolytes. It is thus able to measure body composition, including total body and extracellular water. Although bioimpedance holds up quite well compared to the gold standard that is dual-energy X-ray, it has certain limitations in critically ill patients. Specifically, it cannot distinguish between intravascular and interstitial volume in the extracellular compartment, and as it employs equations based on population measurement, compositions can diverge significantly with severe overhydration or in the morbidly obese. Bioelectrical vector analysis (BIVA) does not use the calculations and is part of the measurements in newer multifrequency bioimpedance devices. There is growing evidence of the adverse effect of overhydration in critically ill patients and bioimpedance can be used to monitor hydration, but there is no information on how to use this method for bedside monitoring in practice. In this review we present a practical approach to Phase angle and BIA/BIVA interpretations for monitoring hydration status and rapid loss of skeletal muscle mass and their clinical use, on a cohort of critical COVID patients under artificial lung ventilation.","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"44 5","pages":"271-282"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41180803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pupillography in contemporary sleep medicine - A narrative review. 当代睡眠医学中的瞳孔描记术——叙述性综述。

Neuro endocrinology letters Pub Date : 2023-07-28

Jan Mizera, Milan Sova, Samuel Genzor, Tomas Krejci, Jaromir Vachutka, Jakub Vanek, Pavol Pobeha, Jan Prasko

{"title":"Pupillography in contemporary sleep medicine - A narrative review.","authors":"Jan Mizera, Milan Sova, Samuel Genzor, Tomas Krejci, Jaromir Vachutka, Jakub Vanek, Pavol Pobeha, Jan Prasko","doi":"","DOIUrl":"","url":null,"abstract":"Excessive daytime sleepiness (EDS) is a common symptom of sleep disorders such as narcolepsy, obstructive sleep apnea, and hypersomnia. The most common tools for assessing EDS are various specialized questionnaires such as Epworth Sleepiness Scale (ESS) and Stanford Sleepiness Scale (SSS). However, the scores obtained from self-rating questionnaires do not seem to measure physiological sleepiness but rather a more complex phenomenon of subjective sleepiness modulated by other factors such as motivation, expectation, and capability of self-perception. The golden standard for measuring physiological sleepiness and assessing EDS is the Multiple Sleep Latency Test (MSLT). However, MSLT is very time consuming and requires trained personnel and expensive equipment. Different method modifications are employed in various medical and industrial fields for different purposes. The infrared pupillography in darkness has the potential to measure objective physiological sleepiness, especially the Pupillographic Sleepiness Test (PST), which is the method of choice for pupillographic measurement of daytime sleepiness. The method has also been employed in several specific sleep disorders, outlining possible future usage. This narrative review summarizes the current state of knowledge on the relevance and usefulness of pupillography in sleep medicine.","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"44 5","pages":"297-308"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41173568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Widened retinal arteriolar and venular diameters are not an endophenotype of schizophrenia: A one-time cross-sectional study. 视网膜小动脉和小静脉直径变宽不是精神分裂症的内在表型：一项一次性横断面研究。

Neuro endocrinology letters Pub Date : 2023-07-28

Ladislav Hosak, Evgenii Sadykov, Jana Zapletalova, Jirina Hosakova, Alexandr Stepanov, Klara Latalova, Jiri Masopust, Omar Sery, Jan Studnicka

{"title":"Widened retinal arteriolar and venular diameters are not an endophenotype of schizophrenia: A one-time cross-sectional study.","authors":"Ladislav Hosak, Evgenii Sadykov, Jana Zapletalova, Jirina Hosakova, Alexandr Stepanov, Klara Latalova, Jiri Masopust, Omar Sery, Jan Studnicka","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: Studies of schizophrenia endophenotypes may help clinicians better understand the etiopathogenesis and treatment of this mental disorder. The aim of the study was to determine if retinal arteriolar or venular abnormalities are an endophenotype of schizophrenia.Design: We performed a one-time cross-sectional study.Materials and methods: We enlisted schizophrenic patients (n = 53) hospitalized in the Department of Psychiatry, University Hospital Hradec Kralove; their mentally healthy first-degree relatives (n = 53); and unrelated, age- and sex-matched mentally healthy controls (n = 49). We recorded all participants´ sociodemographic and, if relevant, clinical variables. Retinal imaging was carried out using a digital fundus camera (FF450 + IR). Outcomes included retinal vessel calibers measured using the software application VAMPIRE.Results: The study enrolled fifty-three schizophrenic patients (average age 32.1 years; males n = 38), an equal number of healthy relatives (average age 47.3 years; males n = 18), and forty-nine unrelated healthy controls (average age 32.2 years; males n = 35). Patients with schizophrenia had significantly increased retinal arteriolar diameters when compared to unrelated healthy controls (left eye p = 0.003; right eye p = 0.011) but not when compared to healthy relatives. The sizes of the retinal venules were not significantly different among the study groups.Conclusions: Our cross-sectional findings do not support the notion that retinal microvascular anomalies are an endophenotype in schizophrenia. Longitudinal studies of this subject should be included in further research.","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"44 5","pages":"290-296"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41161209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small-cell neuroendocrine carcinoma of the cervix associated with adenocarcinoma in situ: A case report with analysis of molecular abnormalities. 宫颈小细胞神经内分泌癌伴原位腺癌：一例分子异常分析报告。

Neuro endocrinology letters Pub Date : 2023-07-28

Vedran Madžarac, Diana Culej, Darija Mužinić, Gojko Zovko, Vanja Fenzl, Željko Duić

{"title":"Small-cell neuroendocrine carcinoma of the cervix associated with adenocarcinoma in situ: A case report with analysis of molecular abnormalities.","authors":"Vedran Madžarac, Diana Culej, Darija Mužinić, Gojko Zovko, Vanja Fenzl, Željko Duić","doi":"","DOIUrl":"","url":null,"abstract":"Objective: We report a case of small-cell neuroendocrine carcinoma (SNEC) of uterine cervix associated with adenocarcinoma in situ (AIS), and we discuss prognosis, treatment benefit and goals of care.Case report: A 36-year-old pluriparous woman presented with vaginal bleeding. Bimanual pelvic examination revealed a exophytic mass arising from the posterior lip of the cervix. A transvaginal ultrasound revealed endometrium thickness of 7mm and exophytic 39x19mm mass arising from the posterior lip of the cervix. Histopathological analysis of the tumorous lesion revealed a small-cell neuroendocrine carcinoma admixed with adenocarcinoma in situ. Differential immunohistochemistry of the small-cell neuroendocrine carcinoma component was CKAE1/AE3, CD 56, TTF -1 positive with diffuse expression of chromogranin and synaptophysin. HPV type 18 has been detected through PCR sequencing analysis. The next generation sequencing based on a 324-gene panel showed that tumor was microsatellite stable (MSS) with low mutational burden (TMB). Only missense mutations of FGF10, HSD3B1, NBN, PBRM1, RICTOR, SDHA were detected. Radical surgery was performed and the patient received adjuvant chemotherapy consisting of cisplatin/etoposide for six cycles. During 12 months of follow up the patient is free of disease.Conclusion: Neuroendocrine tumour of uterine cervix is an extremely rare and aggressive cancer. Because of its low incidence there is still no standardized treatment approach based on controlled trials. Radical surgery and adjuvant or neoadjuvant chemotherapy is the mainstay of treatment.","PeriodicalId":94154,"journal":{"name":"Neuro endocrinology letters","volume":"44 5","pages":"332-335"},"PeriodicalIF":0.0,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41144224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0