关于日本人积极移情和特质宽容相关基因多态性的探索性研究。

Neuro endocrinology letters Pub Date : 2023-12-12
Masahiro Matsunaga, Yohsuke Ohtsubo, Takahiko Masuda, Yasuki Noguchi, Hidenori Yamasue, Keiko Ishii
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引用次数: 0

摘要

研究目的以往的研究表明,良好的人际关系对人的主观幸福感大有裨益。最近,我们重点研究了发展良好人际关系的两种重要方式:积极移情(关注他人的幸福)和特质宽容(倾向于原谅他人)。我们新颖地开展了一项探索性全基因组关联研究(GWAS),以确定与日本人的积极同理心和特质宽容相关的候选基因多态性:我们基于小样本人群和相对较低的门槛,通过 GWAS 首次发现了与积极移情和特质宽容相关的几个基因多态性。随后,我们利用实时聚合酶链反应系统对这些候选基因中的三个基因多态性进行了验证:结果表明,人类信息素受体(vomeronasal type-1 receptor 1,VN1R1)(rs61744949)的多态性与积极移情相关。此外,与多巴胺和血清素生物合成有关的 5-羟色胺(5-羟色胺)受体 7(HTR7:rs77843021)和酪氨酸 3-单氧化酶/色氨酸 5-单氧化酶激活蛋白,epsilon(YWHAE:rs9908013)的遗传多态性与特质宽容有关:本研究新颖地说明了 VN1R1 基因多态性对积极移情的影响,以及 HTR7 和 YWHAE 基因多态性对特质宽容的影响。该研究发现了以前未报道过的基因多态性与发展良好人际关系的必要能力之间的关系。这将对未来的积极心理学和社会心理学研究产生重大影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exploratory research on genetic polymorphisms associated with positive empathy and trait forgivingness among the Japanese.

Objectives: Previous studies have indicated that good human relationships contribute significantly to subjective well-being. We recently focused on two important ways of developing good interpersonal relationships: positive empathy, which focuses on the happiness of other people, and trait forgivingness, a tendency to forgive others. We novelly conducted an exploratory genome-wide association study (GWAS) to identify candidate gene polymorphisms associated with positive empathy and trait forgivingness among the Japanese.

Material and methods: We for the first time identified several genetic polymorphisms associated with positive empathy and trait forgivingness through the GWAS based on a small sample population and relatively low threshold. We subsequently validated three genetic polymorphisms from these candidate genes using a real-time polymerase chain reaction system.

Results: The results demonstrated that polymorphism in the vomeronasal type-1 receptor 1 (VN1R1) (rs61744949), a putative human pheromone receptor, is associated with positive empathy. In addition, genetic polymorphisms in the 5-hydroxytryptamine (serotonin) receptor 7 (HTR7: rs77843021) and tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon (YWHAE: rs9908013), which are associated with dopamine and serotonin biosynthesis, are associated with trait forgivingness.

Conclusion: This study novelly illustrated the influence of the genetic polymorphism in VN1R1 on positive empathy and that of genetic polymorphisms in HTR7 and YWHAE on trait forgivingness. It identified a relationship between previously unreported genetic polymorphisms and the necessary abilities for developing good human relationships. This will significantly impact future research on positive psychology and social psychology.

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