工作类型对血浆神经营养素水平的影响:航空飞行员、建筑工人和健身教练的初步研究。

Neuro endocrinology letters Pub Date : 2023-10-23
Piercarlo Minoretti, Andrés S Santiago Sáez, Ángel F García Martín, Miryam Riera, Manuel Gómez Serrano, Abdelilah Lahmar, Enzo Emanuele
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引用次数: 0

摘要

背景:神经营养素(NTs)包含一组密切相关的蛋白质,调节神经元生长和存活的各个方面。与工作相关的因素与循环NTs水平之间的潜在关联尚未得到广泛研究。在这项初步调查中,我们评估了来自三个不同专业类别的健康个体的血浆脑源性神经营养因子(BDNF)、神经生长因子(NGF)、神经营养因子-3(NT-3)和神经营养因子-4(NT-4)的浓度,每个专业类别都有独特的工作环境和生活方式因素。方法:这项研究涉及来自三个专业领域的60名男性:航空飞行员、建筑工人和健身教练(每类20名参与者),他们是在常规职业健康预约中招募的。使用市售免疫测定法测量NTs的血浆水平,并在三个专业组中进行比较。结果:在所研究的职业中,健身教练表现出最高浓度的BDNF和NGF,航空公司飞行员排名第二,建筑工人表现出最低水平。与健身教练和建筑工人相比,航空公司飞行员的NT-3水平显著下降,但后两种职业之间没有差异。所有三个职业组的NT-4水平相似。结论:我们的初步结果表明,参与神经元和认知功能各个方面的NT的血浆浓度可能在健康个体中表现出显著差异,这取决于他们的职业。这些观察结果值得进一步研究,以探索对职业医学领域的潜在影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of Job Types on Plasma Neurotrophins Levels: A Preliminary Study in Airline Pilots, Construction Workers, and Fitness Instructors.

Background: Neurotrophins (NTs) encompass a group of closely associated proteins regulating various aspects of neuronal growth and survival. The potential association between work-related factors and the levels of circulating NTs has not been extensively examined. In this preliminary investigation, we evaluated plasma concentrations of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) in a cohort of healthy individuals from three distinct professional categories, each with unique work environments and lifestyle factors.

Methods: The study involved 60 men from three professional fields: airline pilots, construction laborers, and fitness trainers (20 participants per category) recruited during routine occupational health appointments. Plasma levels of NTs were measured using commercially available immunoassays and compared in the three professional groups.

Results: Among the professions studied, fitness instructors displayed the highest concentrations of BDNF and NGF, with airline pilots ranking second, and construction workers showing the lowest levels. Significantly decreased NT-3 levels were observed in airline pilots compared to fitness instructors and construction workers, but no differences were found between the latter two occupations. NT-4 levels were similar across all three occupational groups.

Conclusions: Our pilot results suggest that plasma concentrations of NTs, which are involved in various aspects of neuronal and cognitive functioning, may display significant differences among healthy individuals depending on their occupation. These observations warrant additional research to explore potential implications for the field of occupational medicine.

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