Journal of materials chemistry. B最新文献_第3页

Correction: Construction and evaluation of platelet concentrate/mesoporous bioactive glass composite scaffolds for bone repair: injectable platelet-rich fibrin (i-PRF) vs. concentrated growth factors (CGF). 校正：用于骨修复的血小板浓缩物/介孔生物活性玻璃复合材料支架的构建和评价：可注射的富血小板纤维蛋白（i-PRF）与浓缩生长因子（CGF）。

Journal of materials chemistry. B Pub Date : 2025-07-10 DOI: 10.1039/d5tb90110c

Yuanyuan Guo, Zhizheng Li, Mengran Ma, Lingqiang Meng, Dan Lin

引用次数: 0

Nanozymes: new strategy for the management drug-induced acute liver injury. 纳米酶：治疗药物性急性肝损伤的新策略。

Journal of materials chemistry. B Pub Date : 2025-07-10 DOI: 10.1039/d5tb00448a

Minrui Kan, Yanan Wang, Nan Cheng, Kunlun Huang, Xiaoyun He

{"title":"Nanozymes: new strategy for the management drug-induced acute liver injury.","authors":"Minrui Kan, Yanan Wang, Nan Cheng, Kunlun Huang, Xiaoyun He","doi":"10.1039/d5tb00448a","DOIUrl":"https://doi.org/10.1039/d5tb00448a","url":null,"abstract":"Nanozymes, characterized by their multiple enzymatic activities, have emerged as powerful tools for scavenging free radicals, offering robust antioxidant and anti-inflammatory properties. Their straightforward synthesis, high stability, and versatile applications have made them increasingly prominent in biomedical research. Drug-induced acute liver injury (DIALI) has become a significant contributor to acute liver injury, primarily driven by the excessive release of reactive oxygen species (ROS), the generation of inflammatory factors, and the induction of macrophage polarization, ultimately leading to hepatocyte death. Nanozymes, with their unique ability to scavenge ROS and mitigate inflammation, present a promising therapeutic strategy for DIALI. In this review, we provide an in-depth exploration of the mechanisms underlying DIALI and a comprehensive summary of nanozyme-based therapeutic approaches. This includes nanozymes composed of various metallic and non-metallic elements, targeted delivery systems, and surface modification strategies. Furthermore, we discuss the current challenges and future prospects of nanozymes in the treatment of DIALI, highlighting their potential to revolutionize the management of this condition.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A synthetic biomolecular condensate from plant proteins with controlled colloidal properties. 一种由植物蛋白合成的生物分子凝聚物，具有可控的胶体特性。

Journal of materials chemistry. B Pub Date : 2025-07-10 DOI: 10.1039/d5tb00137d

Pratyusha Ghosh, Nataliia Buhaichuk, Jenna Carr, Sakurako Tani, Raj Shankar Hazra, Sijo Mathew, Yongki Choi, Mohiuddin Quadir

{"title":"A synthetic biomolecular condensate from plant proteins with controlled colloidal properties.","authors":"Pratyusha Ghosh, Nataliia Buhaichuk, Jenna Carr, Sakurako Tani, Raj Shankar Hazra, Sijo Mathew, Yongki Choi, Mohiuddin Quadir","doi":"10.1039/d5tb00137d","DOIUrl":"https://doi.org/10.1039/d5tb00137d","url":null,"abstract":"A synthetic biomolecular condensate (sBC) consisting of a prolamin-rich, plant protein, zein, has been engineered. These artificial condensates were prepared from the liquid-liquid phase (LLP) separation of a protein-rich liquid phase in water. To ensure the colloidal stability of the separated condensate, the protein was chemically modified either via quaternization with glycidyl trimethyl ammonium chloride (GTMAC) or covalently connecting poly(ethylene glycol) by reductive amination, respectively. The modified protein condensates, termed QZs and PZs (for quaternized and PEG-conjugated zein, respectively) exhibited hydrodynamic diameters (DH) ranging from 100-300 nm and surface charge or ζ-potential of +35 to -19 mV, which ensured condensate stability via inter-particle repulsion. The size, charge, stability, and morphology of the condensate particles can be optimized by mixing both types of modified proteins (QZs and PZs) at a pre-determined stoichiometry. Such stoichiometric interactions of proteins electrostatically and thermodynamically stabilized the sBCs. These sBCs can be enriched with small molecules, which can be exchanged with their bulk environment, showcasing their potential to compartmentalize chemical species. In vitro studies indicated cellular internalization and accumulation of sBCs depending on their surface properties. Inspired by the condensation of proteins occurring in cells via LLP, this work provides a robust, scalable strategy to design stable, functional condensates that can be used as a platform to understand the structure and function of natural condensates.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molten stringing 3D printed microfibrous net-integrated mineralized hydrogels with tunable micromechanical and cell-responsive properties. 熔融线3D打印微纤维网集成矿化水凝胶具有可调的微机械和细胞响应特性。

Journal of materials chemistry. B Pub Date : 2025-07-10 DOI: 10.1039/d5tb00449g

Dongxuan Li, Fengxiong Luo, Yu Yang, Ziqi Zhao, Ruiqi Mao, Yawen Huang, Yafang Chen, Kefeng Wang, Yujiang Fan, Xingdong Zhang

{"title":"Molten stringing 3D printed microfibrous net-integrated mineralized hydrogels with tunable micromechanical and cell-responsive properties.","authors":"Dongxuan Li, Fengxiong Luo, Yu Yang, Ziqi Zhao, Ruiqi Mao, Yawen Huang, Yafang Chen, Kefeng Wang, Yujiang Fan, Xingdong Zhang","doi":"10.1039/d5tb00449g","DOIUrl":"https://doi.org/10.1039/d5tb00449g","url":null,"abstract":"Micro/nanofibrous materials play an increasingly important role in tissue regeneration due to their ECM-mimicking properties and mechanical regulation capabilities. This study developed a microfiber fabrication method based on molten stringing of fused deposition modeling (FDM), successfully creating an ordered microfiber network with spatial structures. It surpasses the size limits of FDM filaments, enabling the precise fabrication of microfibers with diameters of 15-150 μm. The customizable PLA microfiberous-net was then encapsulated in GelMA hydrogel and mineralized in situ, effectively producing biomimetic bone repair materials with customization of surface microstructures and control of micromechanics, which in turn influences and regulates cell behavior. By adjusting the structure and density of the microfiber network, it is possible to control the compressive modulus, viscoelasticity, and tensile strength to match the micromechanical environment for cell spreading and proliferation. Additionally, the network structure can guide cell alignment and aggregation, influencing cell morphology and enabling controlled guidance of cellular behavior. Our simple and convenient microfibrous printing method holds great potential for the preparation of various fibrous materials for tissue regeneration.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Near infrared light driven nanocatalyst with hole-mediated GSH-depletion for augmented memory therapy. 近红外光驱动的孔介导gsh耗竭纳米催化剂用于增强记忆疗法。

Journal of materials chemistry. B Pub Date : 2025-07-10 DOI: 10.1039/d5tb00892a

Zhiming Deng, Jialian Li, Chunqian Hu, Yiyu Tang, Jun Zhong, Hanlin Wei, Jiayou Tao, Qi Zheng

引用次数: 0

Dual-function supramolecular system of α-hydroxy acid-based ionic liquids and peptides for enhanced anti-aging transdermal delivery. α-羟基酸离子液体和多肽双功能超分子体系增强抗衰老透皮给药。

Journal of materials chemistry. B Pub Date : 2025-07-08 DOI: 10.1039/d5tb00580a

Zhenyuan Wang, Lu Zhang, Biao Wang, Mi Wang, Jiaheng Zhang

{"title":"Dual-function supramolecular system of α-hydroxy acid-based ionic liquids and peptides for enhanced anti-aging transdermal delivery.","authors":"Zhenyuan Wang, Lu Zhang, Biao Wang, Mi Wang, Jiaheng Zhang","doi":"10.1039/d5tb00580a","DOIUrl":"https://doi.org/10.1039/d5tb00580a","url":null,"abstract":"This work developed a dual-function supramolecular co-assembly system based on malic acid-derived ionic liquid (BMa) and acetyl hexapeptide-8 (AHP-8) for enhanced anti-aging transdermal delivery. The system alleviates dynamic wrinkles by inhibiting neurotransmitter release and repairs static wrinkles by promoting collagen production. In vitro transdermal studies showed that the 24-h cumulative permeation of AHP-8 in BMa/AHP-8 was 3.10 times that of free AHP-8. Molecular dynamics simulations revealed that BMa reduces the free energy barrier for AHP-8 permeation mainly due to the interactions between cations and the lipid matrix. Cellular assays demonstrated that BMa/AHP-8 significantly increased collagen I production by regulating the TGF-β pathway and inhibited acetylcholine release more effectively than AHP-8 alone. Clinical trials indicated that the subjects using the BMa/AHP-8 facial cream experienced a greater reduction in wrinkle number, length, and area after 28 days than those using AHP-8 monotherapy. This research provides a novel transdermal delivery approach for developing non-invasive, highly effective anti-aging cosmetic formulations.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phosphorothioated DNA engineered fusion liposomes for ultrasound-responsive targeted intracellular protein delivery. 磷酸化DNA工程融合脂质体用于超声响应靶向细胞内蛋白递送。

Journal of materials chemistry. B Pub Date : 2025-07-08 DOI: 10.1039/d5tb00643k

Danchu Gong, Dajiang Du, Di Li

{"title":"Phosphorothioated DNA engineered fusion liposomes for ultrasound-responsive targeted intracellular protein delivery.","authors":"Danchu Gong, Dajiang Du, Di Li","doi":"10.1039/d5tb00643k","DOIUrl":"https://doi.org/10.1039/d5tb00643k","url":null,"abstract":"Ultrasound-mediated drug delivery, despite its benefits of deep-tissue penetration and minimal side effects, faces significant challenges in terms of targeting specificity and cargo preservation, especially for protein therapeutics. In this study, we introduce a novel liposomal delivery platform that synergizes targeted delivery with spatially controlled ultrasound activation. This system employs aptamer-mediated tumor targeting and ultrasound-induced membrane fusion capabilities, allowing for the precise spatial control of protein cargo release directly into the cytoplasm of target cells. We use Cytochrome C as a model therapeutic protein to demonstrate the efficiency of this fusion liposome system in maintaining protein integrity while achieving efficient intracellular delivery. In vivo studies show significant therapeutic efficacy in tumor models via spatially-resolved ultrasound stimulation. This platform overcomes key limitations of traditional ultrasound-responsive delivery systems by enabling specific targeting and broadening the range of viable therapeutic cargo types. This versatile approach signifies a substantial advancement in controlled deep-tissue protein delivery, presenting wide-ranging potential for various therapeutic applications. The fusion liposome system offers a promising strategy for targeted protein therapeutics, particularly in scenarios requiring spatial precision and deep tissue penetration.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Fenton-like biocatalysis of CuPd bimetallic nanozymes by alkylamine ligand self-assembled monolayers. 烷基胺配体自组装单层增强CuPd双金属纳米酶的fenton类生物催化作用。

Journal of materials chemistry. B Pub Date : 2025-07-08 DOI: 10.1039/d5tb00443h

Fangming Zhang, Jingxia Xu, Zhuyuan Peng, Guofeng Li, Lingyun Zhao, Wensheng Xie, Xing Wang

{"title":"Enhancing Fenton-like biocatalysis of CuPd bimetallic nanozymes by alkylamine ligand self-assembled monolayers.","authors":"Fangming Zhang, Jingxia Xu, Zhuyuan Peng, Guofeng Li, Lingyun Zhao, Wensheng Xie, Xing Wang","doi":"10.1039/d5tb00443h","DOIUrl":"https://doi.org/10.1039/d5tb00443h","url":null,"abstract":"The synergistic effect of copper and palladium makes CuPd bimetallic nanozymes potential candidates for tumor biocatalysis. However, their practical catalytic activity is closely related to their surface modification and structure. In this study, CuPd nanozymes were prepared by a one-step reduction method using various surface ligands (decamethylamine (DA), dodecamethylamine (DDA), hexadecamethylamine (HDA), and octadecamethylamine (ODA)) with different alkylamine lengths in order to study the effects of surface self-assembled monolayers (SAMs) formed by ligands. TEM, XPS, and XRD results showed that all four nanozymes were similar in their structures, sizes, and compositions. However, the as-synthesized CuPd@DA and CuPd@HDA presented higher Fenton-like activity due to the lower steric hindrance caused by ordered and thinner SAMs. In contrast, both CuPd@DDA and CuPd@ODA exhibited weak biocatalytic activity for the thicker and stacked SAMs because of the long length of alkylamine ligands. In vitro anti-tumor cytotoxicity evaluation showed lower IC50 values for CuPd@DA (104.6 μg mL-1) and CuPd@HDA (118.6 μg mL-1), and higher values for CuPd@DA and CuPd@HDA, demonstrating the biocatalytic differences caused by surface SAMs. This study provides unique insights for optimizing the biocatalytic effect of bimetallic nanozymes in the perspective of surface SAMs.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CMCS/PEGDA-based photoresponsive hydrogel with high efficiency for gingival retraction and rapid hemostasis. 基于CMCS/ pegda的光反应水凝胶，用于牙龈收缩和快速止血。

Journal of materials chemistry. B Pub Date : 2025-07-08 DOI: 10.1039/d5tb00755k

Jiaxin Wu, Yi Liang, Ruyi Li, Mingxin Qiao, Xibo Pei, Xue Yuan, Qianbing Wan, Jian Wang

{"title":"CMCS/PEGDA-based photoresponsive hydrogel with high efficiency for gingival retraction and rapid hemostasis.","authors":"Jiaxin Wu, Yi Liang, Ruyi Li, Mingxin Qiao, Xibo Pei, Xue Yuan, Qianbing Wan, Jian Wang","doi":"10.1039/d5tb00755k","DOIUrl":"https://doi.org/10.1039/d5tb00755k","url":null,"abstract":"Prosthodontics is a dental specialty with a long history of providing patients with prostheses to restore or replace damaged or missing teeth and dentition. Gingival retraction is a vital step after tooth preparation to obtain aesthetic and functional restorations. Gingival retraction materials have been used in clinics and are among the most prospective alternatives to gingival retraction cords. However, gingival bleeding, increased tension of the gingiva, and saliva flushing after tooth preparation might cause difficulties in gingival retraction. The previous materials generally have inadequate mechanical strength, poor hemostasis, and irritating effects. To achieve effective and rapid gingival retraction and hemostasis is a key clinical challenge. This article has described a novel photoresponsive hydrogel based on carboxymethyl chitosan/polyethylene glycol diacrylate (CMCS/PEGDA). CMCS/PEGDA hydrogel injected into the gingival sulcus can rapidly solidify and expand to push away the gingiva under blue light illumination. It possesses excellent rheological properties and mechanical strength, and shows great gingival retraction in the rabbit gingival sulcus. Additionally, CMCS/PEGDA hydrogel can promote clotting, which was verified in the rat tail amputation model. Compared with the control group, the blood loss of CP hydrogel decreased by 59.2%. The hemostatic mechanism of hydrogel is attributed to the concentration of coagulation factors, aggregation of red blood cells, and the activation of the coagulation pathway. The novel composite hydrogel developed in this study has distinguished biocompatibility, splendid mechanical properties, and wonderful hemostasis ability, demonstrating the potential for application in the field of gingival retraction.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lanthanum-loaded ZIF nanomaterials for caries prevention. 用于防龋的载镧ZIF纳米材料。

Journal of materials chemistry. B Pub Date : 2025-07-08 DOI: 10.1039/d5tb01114k

Han Xiao, Yuping Qian, Lijun Zhao, Yiman Tang, Yuan Pan, Yunzi Long, Shihan Li, Yukun Chen, Jiale Sun, Chao Yuan, Ludan Zhang, Wenshu Ge

{"title":"Lanthanum-loaded ZIF nanomaterials for caries prevention.","authors":"Han Xiao, Yuping Qian, Lijun Zhao, Yiman Tang, Yuan Pan, Yunzi Long, Shihan Li, Yukun Chen, Jiale Sun, Chao Yuan, Ludan Zhang, Wenshu Ge","doi":"10.1039/d5tb01114k","DOIUrl":"https://doi.org/10.1039/d5tb01114k","url":null,"abstract":"Dental caries represents one of the most widespread oral health challenges worldwide, impacting people of every age demographic. Traditional anticaries strategies primarily rely on fluoride, yet its chronic overuse may lead to health issues such as dental fluorosis. Lanthanum (La), a rare earth element, has emerged as a promising fluoride alternative due to its low toxicity and strong anticaries activity. However, studies have shown that the direct use of free lanthanum under physiological conditions may cause cellular structural damage, dose-dependent hemolytic reactions, and even liver and kidney fibrosis, highlighting the urgent need to optimize its delivery method. In this study, zeolitic imidazolate framework nanoparticles (La@ZIF) were used to encapsulate lanthanum, enabling its controlled and sustained release, thereby proposing a novel fluoride-free anticaries strategy. Three La@ZIF nanoparticles with varying La incorporation levels (20%, 40%, and 60%) were synthesized via a one-pot method and systematically characterized. Results demonstrated their excellent degradation performance and acid-neutralizing capacity under acidic conditions. In vitro experiments confirmed the favorable biocompatibility of La@ZIF and its ability to effectively promote enamel remineralization and restore surface hardness, achieving comparable efficacy to traditional fluoride treatments. In vivo studies further validated the remineralization potential of La@ZIF in a rat model, with no adverse effects observed on major organs. La@ZIF nanoparticles exhibit remarkable anticaries performance and biosafety, offering a new direction for developing fluoride-free anticaries materials.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0