Journal of materials chemistry. B最新文献

{"title":"Polymeric nanocarriers for cancer treatment: the promise of sensitive poly(2-(diisopropylamino)ethyl methacrylate).","authors":"Joana S Ferreira, João P Vareda, A S Oliveira, Jéssica S Barbosa, Francisca Bastos, Patrícia V Mendonça, A C Fonseca","doi":"10.1039/d5tb00268k","DOIUrl":"https://doi.org/10.1039/d5tb00268k","url":null,"abstract":"<p><p>Polymeric nanoparticles are extremely valuable carriers for drug/gene delivery to treat cancer, as they can protect different therapeutic agents during blood circulation while being able to deliver them at desired locations. Owing to the versatility of polymers, it is possible to fine-tune the performance of nanocarriers by changing different properties, such as chemical structure, architecture, composition and molecular weight or even by functionalising the polymers with targeting molecules. The use of pH-sensitive polymers is a very popular strategy to prepare smart carriers, taking advantage of the acidic intratumoural environment to induce hydrophobic/hydrophilic transitions that allow fast and efficient release of small drugs or genetic material. This review summarizes the contributions of the use of promising pH-sensitive poly(2-(diisopropylamino)ethyl methacrylate) (PDPA), with p<i>K</i>_a around 6.2, in the preparation of nanocarriers for the treatment of different types of cancer through gene therapy, drug delivery or photodynamic therapy. Interest in PDPA-based copolymers for biomedical applications is increasing, as different studies have reported successful encapsulation and delivery of different therapeutic molecules with PDPA-based smart nanocarriers. <i>In vivo</i> studies have shown that tumour growth can be suppressed, revealing the potential of new cancer therapies.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and study of amorphous calcium phosphate dual-targeted drug-carrying platforms.","authors":"Huan Hong, Wentao Ma, Yushuang Jiao, Bo Cheng, Jing Yang, Binbin Li, Xinyu Wang","doi":"10.1039/d5tb00525f","DOIUrl":"https://doi.org/10.1039/d5tb00525f","url":null,"abstract":"<p><p>Atherosclerosis (AS) has emerged as a significant worldwide health challenge, necessitating the development of a drug-loading platform to achieve precise delivery of anti-AS therapeutics to lesion sites, thereby mitigating its impact. Given the mildly acidic microenvironment and the abundance of activated macrophages overexpressing scavenger receptor class A (SR-A) at AS lesions, we fabricated a pH-responsive, SR-A-targeting multifunctional drug-loading platform (dextran sulfate-heparin/amorphous calcium phosphate, DS-HEP/ACP) <i>via</i> the coprecipitation method. This design enables efficient delivery of the platform to AS plaques with minimal drug loss during systemic circulation. In this study, we characterized the fundamental properties and biological performance of the synthesized DS-HEP/ACP platform and evaluated the anti-AS efficacy of the atorvastatin calcium (AT)-loaded DS-HEP/ACP@AT system <i>in vitro</i>. <i>In vitro</i> drug release results demonstrated that the platform exhibited superior controlled drug release properties, prolonged drug circulation under physiological conditions, while releasing the drug in the weakly acidic microenvironment of AS. Cellular uptake experiments revealed that the modification of the carrier with DS enabled the drug-loading platform to demonstrate efficient uptake through SR-A receptor-specific mechanisms in stimulated macrophages, achieved <i>via</i> specific receptor-mediated targeting strategies. In anti-AS evaluations, the DS-HEP/ACP@AT system demonstrated anti-inflammatory and lipid-lowering effects <i>in vitro</i>, outperforming monotherapy by combining AT-driven lipid reduction with the platform's intrinsic ability to block phagocytosis of oxidized low-density lipoprotein (Ox-LDL) by macrophages. This dual-targeting AS drug-loading platform achieved precise drug delivery, controlled drug release, and enhanced anti-AS efficacy. In summary, our study validates the DS-HEP/ACP@AT system as a promising candidate for AS therapy.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Collagen/fibronectin-based lung carcinoma culture platform: development and characterization of a new tumor model for vascular mimicry study.","authors":"Qun Huang, Xinrui Xu, Zulala Halbiyat, Xuebo Wei, Lei Wang, Junjie Ren, Ke Xu, Tingjuan Huang, Qizhi Shuai","doi":"10.1039/d5tb00673b","DOIUrl":"https://doi.org/10.1039/d5tb00673b","url":null,"abstract":"<p><p>Lung cancer is a prevalent and deadly malignancy worldwide. Traditional angiogenesis has been augmented by the discovery of vascular mimicry (VM), an alternative mechanism where tumor cells form vascular-like structures that contribute to tumor aggressiveness independent of endothelial vessels. The study of VM has been constrained by limitations in existing <i>in vitro</i> models, particularly conventional tissue culture-treated plates, which fail to fully replicate the complex tumor microenvironment. Existing biomimetic models are yet to effectively reproduce VM signatures specific to non-small cell lung cancer (NSCLC), hindering further research and therapeutic development. In this context, our research aimed to address these challenges by exploring collagen/fibronectin biological macromolecules as novel biomimetic environments to study VM in NSCLC. Here, we created a collagen/fibronectin-based engineered tumor model both <i>in vivo</i> and <i>in vitro</i> to explore how these matrices affect cellular behaviors, including proliferation, colony formation, migration, stemness, and VM formation. Using extensive gene expression profiling, we characterized NSCLC cells grown in these matrices to identify key genes influencing VM formation. Furthermore, we selected two reported anti-tumor drugs and their potential VM inhibitory effects and verified the practical application of this model by developing a VM-rich tumor model <i>in vivo</i>. Our findings underscore the pivotal role of ECM components, particularly collagen and fibronectin, in modulating critical biological processes in cancer and VM formation. In addition, the two antitumor agents we selected have the potential to inhibit VM occurrence. By simulating the ECM environment conducive to VM, we developed a VM-rich tumor model, and our study provided insights into potential mechanisms underlying VM formation and its regulation in NSCLC.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chromogenic ecdysis of Au@Ag nanorods assembled in a hydrogel for selective detection of ammonia vapors in food.","authors":"Mahima Chandel, Prem Singh, Kamaljit Kaur, Lalitya Chadalawada, T S Abhijith, Keshav Bhardwaj, Amit Jaiswal, Vijayakumar Shanmugam","doi":"10.1039/d5tb00636h","DOIUrl":"https://doi.org/10.1039/d5tb00636h","url":null,"abstract":"<p><p>Chromogenic sensors are highly appreciated, but the color change must be significant to clearly indicate the change. We proposed a hydrogel sensor containing Au-bead@Ag nanorods for the detection of ammonia to ascertain the shelflife of meat. Polymers with different water-holding capacity were tested. Agarose gel had the required amount of water to capture ammonia to show a significant visible color change as a function of different ammonia concentrations. Microscopy and X-ray photoemission spectroscopy (XPS) showed the captured ammonia tuned the pH to dissolve Ag in Au-bead@Ag nanorods into ions/clusters/alloys for the color change. The color changed from orange to blue-green in the gel after 3 h of exposure to an ammonia-spiked meat sample.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Key challenges and coping strategies for the detection of bacteria at ultralow concentrations.","authors":"Zhentan Lu, Siwei Zhang, Qiue Yin, Weihong Chen, Le Zhou, Shan Liu, Dong Wang","doi":"10.1039/d5tb00176e","DOIUrl":"https://doi.org/10.1039/d5tb00176e","url":null,"abstract":"<p><p>Bacterial contamination is often characterized by high infectivity, even at very low doses. Developing rapid, cheap, and simple methods to detect bacteria at ultralow-concentrations is essential for improving public health. Most of the published reviews are about particular detection principles, such as optical and electrochemical biosensors. To date, there are no reviews that discuss how to design materials for detecting bacteria at ultralow concentrations. First, the importance of detecting bacteria with ultralow concentrations is explained in the review. Additionally, research advances in PCR, electrochemistry, immunohistochemistry-based methods (ELISA and LFIA), colorimetric detection and surface-enhanced Raman scattering are discussed for ultralow-concentration bacterial detection. Finally, the challenges and future possibilities for detecting ultralow concentrations of bacteria are also presented.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasensitive detection of arsenic in water using laser-scribed graphene-based electrodes.","authors":"Abhinandan Mohanty, Shubham Upadhye, Gopal K Pradhan, Pranati Nayak","doi":"10.1039/d5tb00041f","DOIUrl":"https://doi.org/10.1039/d5tb00041f","url":null,"abstract":"<p><p>Arsenic contamination in water poses a serious health risk due to its high toxicity, even at ppb levels. In this work, we report a cost-effective graphene-based sensor with ultralow detection capabilities for arsenic. This is achieved by enhancing the catalytic efficiency of graphene electrodes through sunlight-assisted photothermal oxidation of a metal salt into metal oxide nanoparticles. The sensor demonstrated high sensitivity (34.81 ± 1.74 μA cm^-2 ppb^-1) and an ultralow detection limit (LOD 0.0636 ppb). Field tests on water samples from arsenic-contaminated zones in West Bengal, India, showed results consistent with the state-of-the-art ICP-OES analysis, highlighting the sensor's potential for practical, on-site arsenic monitoring.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of protein corona and light modulation on the antibacterial activity of light-activated silver nanoparticles.","authors":"Varsha Godakhindi, Anjumana Jannati Nur, Mariya Munir, Juan L Vivero-Escoto","doi":"10.1039/d5tb00081e","DOIUrl":"10.1039/d5tb00081e","url":null,"abstract":"<p><p>Silver nanoparticles (AgNPs) as antimicrobial agents have gained extensive popularity due to their broad-spectrum action. Recently, AgNPs have been combined with photosensitizers (PS) to develop a synergistic antimicrobial effect. This synergy is associated with the light-activated increase in the release of Ag⁺, which drives the antibacterial mechanism against antibiotic-resistant bacteria (ARB). A factor typically not considered in the performance of AgNPs is the environmental conditions, such as salt and protein content, that significantly impact their bactericidal effect. In this work, we used protoporphyrin IX (PpIX) as a PS to synthesize PpIX-AgNPs. We elucidated the critical role of environmental conditions on the colloidal stability of PpIX-AgNPs in different bacterial culture media. We also determined the impact of the culture media on the light-activated release kinetics of Ag⁺. We found that cell media with lower protein and higher salt content drive the colloidal stability and release kinetics of Ag⁺ from AgNPs. Furthermore, we have shown that the multiple-irradiation approach of this light-controlled platform maximizes the release of Ag⁺ and promotes effective antibacterial action. We successfully tested this multiple-irradiation strategy in methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) demonstrating ∼7-log-unit reduction at 1.5 μg mL^-1 of PpIX-AgNP. A 6-log-unit MRSA inhibition was achieved in the nutrient broth (NB) media under the same irradiation strategy. We envision that this light-activated PpIX-AgNPs system can overcome major issues with the elimination of ARB and reduce side effects.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supramolecular hydrogels derived from 2 : 1-[α/aza]-pseudopeptides: design, structural analysis and self-assembly in solution, solid, and gel states.","authors":"Mohamed I A Ibrahim, Jacques Bodiguel, Guillaume Pickaert, Loïc Stefan, Koichi Matsuo, Marie-Christine Averlant-Petit","doi":"10.1039/d4tb02288b","DOIUrl":"https://doi.org/10.1039/d4tb02288b","url":null,"abstract":"<p><p>Synthesis of innovating supramolecular hydrogels based on low molecular weight gelators (LMWGs < 2000 Da) has gained significant interest within the scientific research community due to their wide-ranging potential applications. Most supramolecular hydrogels, induced by a self-assembly process, are stabilized <i>via</i> non-covalent interactions. Recently, our research group has investigated the gelation properties of new low molecular weight hydrogelators (LWMHGs) based on Fmoc-functionalized 2 : 1-[α/aza]-azapeptides. This study presents the synthesis and characterization of two Fmoc-N-functionalized 2 : 1-[α/aza]-trimers: Fmoc-FazaFA (1) and Fmoc-D-FazaFA (2). Both molecules have demonstrated their capability to form hydrogels at pH 7.0 and 10.0, and the analysis of their monomeric states in solution using spectroscopic techniques (including NMR and FTIR) and in the crystal state (using X-ray diffraction) revealed a β-turn conformation. Molecular dynamics simulations were used for 3D model determination. Additionally, the structure of both molecules in the gel state was examined by circular dichroism (CD) experiments. The findings have confirmed that intermolecular hydrogen bonding and π-stacking between the aromatic moieties are the primary driving forces behind the self-assembly and hydrogelation phenomena. Rheology measurements validated the solid-like behavior of both hydrogels (<i>G</i>' > <i>G</i>'' within the studied frequency range). Finally, the self-assembly is emphasized through the fibrous structure observed by SEM imaging.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming \"cold\" tumors into \"hot\" ones <i>via</i> immunogenic cell death by bufadienolides for reverse immunosuppressive TME in HCC.","authors":"Xin Qiao, Penglong Ma, Jueshuo Guo, YongFu Sun, Li Peng, Na Yu, Wenbao Zuo, Jianhong Yang","doi":"10.1039/d5tb00305a","DOIUrl":"https://doi.org/10.1039/d5tb00305a","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death worldwide. Unfortunately, the inherently immunosuppressive tumor microenvironment (TME) severely limits the anti-tumor efficacy of conventional therapies. Immunogenic cell death (ICD) is a rare immunostimulatory form of cell death and can activate adaptive immune responses as a way to remodel the immunosuppressive tumor microenvironment. In this study, we found that bufadienolide-based nanocrystalline formulations (HBE NCs) can reshape the tumor microenvironment by inducing an ICD, thereby achieving superior anti-tumor efficacy. HBE NCs could effectively induce Hepa1-6 cells to release damage-associated molecular patterns, such as CRT as an \"eat me\" signal, HMGB1 as a \"danger\" signal and ATP as a \"find me\" signal to an active immune system. HBE NCs improved the maturation of dendritic cells, enhanced the infiltration of CD4⁺T and CD8⁺T cells, depleted the number of immunosuppressive MDSCs and Treg cells, and successfully reconstructed immunosuppressed \"cold\" tumors into immune-activated \"hot\" tumors in HCC mice. Notably, dying Hepa1-6 cells treated with HBE NCs can be used as an <i>in vivo</i> \"inactivated vaccine\" to effectively enhance the ability of mice to resist the challenge of a live tumor. Our study demonstrates a promising strategy for remodeling the immunosuppressive TME of liver cancer.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting the signal reliability of non-invasive biosensors <i>via</i> a N-doped graphene quantum dot modified Prussian blue analogue protective layer for glucose monitoring.","authors":"Yi-Hao Chiu, Mia Rinawati, Ling-Yu Chang, Sofiannisa Aulia, Chieh Li, Ping-Chen Shi, Kuan-Jung Chen, Wei-Hsiang Huang, Hitoshi Mizuguchi, Min-Hsin Yeh","doi":"10.1039/d5tb00497g","DOIUrl":"https://doi.org/10.1039/d5tb00497g","url":null,"abstract":"<p><p>Precise and reliable wearable biosensors are essential for diabetes tracking, enhancing result accuracy for patients. Prussian blue (PB) has been the subject of numerous studies in biosensor development due to its high efficiency in hydrogen peroxide reduction. However, PB's limited stability, especially in neutral pH environments, constrains its practical application. A promising approach is to combine PB with its analogues (PBA), offering a protective layer over PB, though at the cost of reduced sensitivity due to blocked active sites. In a pioneering way, this study incorporates N-doped graphene quantum dots (NGQDs) into the protective layer of PBA to address these issues, in conjunction with a PB sensing layer, to develop a wearable biosensor that possesses exceptional stability and accuracy in detection. The NGQDs facilitated the surface reconstruction of PBA driven by a strong electrostatic interaction mechanism, which can notably increase its hydrophilicity for enabling improved H₂O₂ transport. Through these sequential methods, the surface properties of PBA were successfully improved, resulting in a substantial rise in the overall sensor sensitivity of 221.29 ± 1.77 μA mM^-1 cm^-2 for H₂O₂ detection, close to the pristine PB one (247.87 ± 5.35 μA mM^-1 cm^-2). Furthermore, the glucose detection sensitivity was significantly enhanced by the immobilization of glucose oxidase (GOx) on the electrode (90.49 ± 1.08 μA mM^-1 cm^-2). In a sequence, this nanomaterial demonstrated outstanding stability with a current density retention rate of 87.37% over long-term operation at a specific concentration, and the sensitivity remained at 88.17% under repeated use. Therefore, our NGQDs/PBA/PB nanocomposite offers a durable, high-performance solution for non-invasive glucose monitoring in human sweat, advancing the development of next-generation wearable biosensors for continuous diabetes management.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}