Journal of materials chemistry. B最新文献

Unilateral thermosensitive Janus hemostatic dressing for matching coagulation physiological processes.

Journal of materials chemistry. B Pub Date : 2025-04-09 DOI: 10.1039/d4tb02871f

Chuanjuan Chen, Yicheng Zhang, Siqi Chen, Qinhui Chen

{"title":"Unilateral thermosensitive Janus hemostatic dressing for matching coagulation physiological processes.","authors":"Chuanjuan Chen, Yicheng Zhang, Siqi Chen, Qinhui Chen","doi":"10.1039/d4tb02871f","DOIUrl":"https://doi.org/10.1039/d4tb02871f","url":null,"abstract":"Hemostatic dressings are a simple and effective method for managing bleeding emergencies. Based on the blood coagulation process, hemostatic dressings work optimally by aggregating hemocytes and releasing coagulation factors, sealing blood in a sequential manner. Janus materials, which have different compartmentalized components, have the ability to independently perform multiple functions. In this study, a Janus nonwoven fabric with thermo-sensitivity on one side, is designed to be consistent with the physiological process of coagulation. When utilized for hemostasis, the poly(N-isopropylacrylamide) (PNIPAM) side of the Janus material undergoes a phase transition within 1 minute. Prior to this, it adsorbs blood at the injured site and aggregates hemocytes to form a primary thrombus; afterwards, it helps sealing the site to decrease blood loss. During this process, the bioactive glass (BG) side continuously releases SiO44- and Ca2+ to activate coagulation factors and accelerate the cascade reaction. The phase transition and hydrophilic/hydrophobic transition of the material are triggered by body temperature and are rapidly completed, just like clicking a switch. In a rat femoral artery model, the blood loss using Janus BG-PNIPAM was only 0.15 g, which is 17.4% and 20.0% the blood loss level achieved by CN and QuikClot® gauze, respectively. Furthermore, the biosafety profile of Janus BG-PNIPAM provides assurance for potential clinical applications.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of cysteine-sensitive bimodal probes for in situ monitoring of early-stage pulmonary fibrosis progression and therapeutic effects.

Journal of materials chemistry. B Pub Date : 2025-04-09 DOI: 10.1039/d5tb00183h

Yang Wan, Wenxiu Li, Huayong Zhu, Sixin Ai, Weiying Lin

{"title":"Development of cysteine-sensitive bimodal probes for in situ monitoring of early-stage pulmonary fibrosis progression and therapeutic effects.","authors":"Yang Wan, Wenxiu Li, Huayong Zhu, Sixin Ai, Weiying Lin","doi":"10.1039/d5tb00183h","DOIUrl":"https://doi.org/10.1039/d5tb00183h","url":null,"abstract":"Pulmonary fibrosis (PF) is a chronic interstitial lung disease characterized by excessive extracellular matrix deposition and lung scarring, leading to impaired lung function, severe respiratory distress, and potentially fatal outcomes. Early diagnosis of PF is crucial for optimizing treatment strategies to improve patient prognosis. However, an activated near-infrared fluorescent (NIRF) and photoacoustic (PA) bimodal probe for non-invasive in situ imaging of PF is still lacking. In this study, we developed a novel cysteine-sensitive NIRF/PA dual-modal probe, MR-Cys, for in situ monitoring of early progression and the therapeutic response in a mouse model of PF. The probe MR-Cys selectively detects cysteine (Cys) levels in vivo, thereby activating both NIRF and PA signals. Using NIRF/PA dual-modal imaging technology, MR-Cys successfully tracked fluctuations in Cys levels within the PF mouse model. After treatment with nintedanib (OFEV), a notable decrease in both PA and NIRF signal intensities was observed in the treated mice, indicating that MR-Cys can be used to assess the therapeutic efficacy for PF. Therefore, MR-Cys not only holds great promise for early detection of pulmonary fibrosis progression, but also offers a precise monitoring tool for the optimization of personalized treatment plans.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Making the negative positive - fluorination of indole as an efficient strategy to improve guanidinium-containing gene carriers. 负负得正--吲哚的氟化是改进含胍基因载体的有效策略。

Journal of materials chemistry. B Pub Date : 2025-04-09 DOI: 10.1039/d4tb02529f

Markus Kötzsche, Jan Egger, Andreas Dzierza, Liên Sabrina Reichel, Ivo Nischang, Anja Traeger, Dagmar Fischer, Kalina Peneva

{"title":"Making the negative positive - fluorination of indole as an efficient strategy to improve guanidinium-containing gene carriers.","authors":"Markus Kötzsche, Jan Egger, Andreas Dzierza, Liên Sabrina Reichel, Ivo Nischang, Anja Traeger, Dagmar Fischer, Kalina Peneva","doi":"10.1039/d4tb02529f","DOIUrl":"https://doi.org/10.1039/d4tb02529f","url":null,"abstract":"The balance between hydrophilic and hydrophobic components plays an important role in polymeric delivery of nucleic acids. Besides using hydrophobic moieties in the polymer design, fluorination is a promising method to increase the hydrophobicity of polymers. To systematically investigate this effect, N-(2-(1H-indol-3-yl)ethyl)methacrylamide and three fluorinated analogues have been synthesized and copolymerized with 3-guanidinopropyl methacrylamide and 2-hydroxypropyl methacrylamide via an aqueous reversible addition-fragmentation chain transfer (aRAFT) polymerization. A library of eight terpolymers with 5 to 23 mol% of an indole analogue and molar mass about 20 kg mol-1 showed comparably strong DNA binding starting at N/P 2 and formed polyplexes with hydrodynamic diameters around 100 nm. Additionally, no negative impact on biocompatibility was observed. Heparin release studies showed increased DNA binding strength with higher amounts of hydrophobic moieties, while fluorination exhibited similar effects as increasing the indole content. This was also important for pDNA transfection efficiency, where an optimum for DNA binding strength was unveiled. The rapid release and the excessive binding of DNA were identified as factors that negatively impacted transfection efficiency, both influenced by the amount of indole moieties and fluorination. On the other hand, the right degree of hydrophobicity was able to increase the transfection efficiency of the modified polymer by more than threefold. These findings highlight the role of hydrophobic moieties in nucleic acid delivery and provide valuable insights for future polymer design, suggesting that the strategic incorporation of fluorinated monomers can effectively fine-tune DNA interactions.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vegetable oil-derived functional polymers in biomedical applications: hurdles and possibilities.

Journal of materials chemistry. B Pub Date : 2025-04-09 DOI: 10.1039/d4tb02648a

Shrinjay Ghosh, Santanu Ghosh

{"title":"Vegetable oil-derived functional polymers in biomedical applications: hurdles and possibilities.","authors":"Shrinjay Ghosh, Santanu Ghosh","doi":"10.1039/d4tb02648a","DOIUrl":"https://doi.org/10.1039/d4tb02648a","url":null,"abstract":"Over the past several years, renewable resource-based polymers have consistently attracted research attention from academia and industry as an alternative to petroleum-based polymers. Depletion of fuel reserves, the rising cost of petroleum products, and strict government regulations drive the search for alternative resources. Vegetable oils have been considered as one of the sustainable feedstocks considering their natural abundance, low cost, and ecological acceptance. Vegetable oils are used to generate various biobased functional polymers like polyester, polyamide, poly(ester amide)s, polyurethane, and photocurable resins. These polymers have demonstrated a wide range of applications, including coating materials, fire retardants, and adhesives, and have also been explored in biomedical research. This review provides a comprehensive discussion on developing various polymers derived from vegetable oils, which show promise in biomedical applications such as tissue engineering, drug delivery, antimicrobial, tissue adhesives, and biosensor applications. Additionally, the review highlights the challenges and future opportunities associated with these sustainably sourced biobased polymers.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-strength bone polyurethane adhesive with rapid curing for bone tissue injury repair. 高强度骨聚氨酯粘合剂，可快速固化，用于骨组织损伤修复。

Journal of materials chemistry. B Pub Date : 2025-04-09 DOI: 10.1039/d4tb02390k

Xuehua Zhao, Jinju Ding, Chengkai Xuan, Jianing Liao, Xuetao Shi

{"title":"High-strength bone polyurethane adhesive with rapid curing for bone tissue injury repair.","authors":"Xuehua Zhao, Jinju Ding, Chengkai Xuan, Jianing Liao, Xuetao Shi","doi":"10.1039/d4tb02390k","DOIUrl":"https://doi.org/10.1039/d4tb02390k","url":null,"abstract":"Bone tissue adhesives have advantages such as preventing stress shielding and secondary surgical infections, fixing small bone fragments, easing operations, and enhancing wound adaptability. These methods can be applied for the traumatic repair of comminuted fractures. Currently, commercial tissue adhesives fail to meet the biological safety and mechanical strength requirements of bone tissue adhesives. To address this situation, we developed and screened a rapidly cured high-strength polyurethane bone adhesive. Research has shown that polyurethane bone adhesives have shorter curing times (236 s to 273 s), higher tensile moduli (425.88 MPa to 666.38 MPa), compressive moduli (214.67 MPa to 450.66 MPa), and adhesive strengths (0.92 MPa to 5.86 MPa). It can withstand cyclic stresses ranging from 0.01 MPa to 1 MPa for 1000 cycles. Polyurethane bone adhesive surpasses the inadequate adhesive performance and in vivo repair functionality of existing commercial bone cements, achieving effective repair of bone tissue injuries. Furthermore, we developed an unsaturated ester-modified secondary amine curing agent based on the Michael addition reaction, enabling rapid and safe curing of bone polyurethane adhesives and thereby providing a novel and effective repair solution for bone tissue injuries.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macro/nano topological modification of a silk fibroin mesh with mimicked extracellular matrix structure and excellent biocompatibility.

Journal of materials chemistry. B Pub Date : 2025-04-08 DOI: 10.1039/d5tb00344j

Pei Cai, Ying Mao, Xinmei Liu, Zhiwei Li, Jinfeng Wang, Hongshi Zhao, Wenxing Chen, Wangyang Lu

{"title":"Macro/nano topological modification of a silk fibroin mesh with mimicked extracellular matrix structure and excellent biocompatibility.","authors":"Pei Cai, Ying Mao, Xinmei Liu, Zhiwei Li, Jinfeng Wang, Hongshi Zhao, Wenxing Chen, Wangyang Lu","doi":"10.1039/d5tb00344j","DOIUrl":"https://doi.org/10.1039/d5tb00344j","url":null,"abstract":"Synthetic surgical meshes have been widely used for repairing hernias, but their performance, such as nonabsorbability and insufficient mechanical strength, requires further improvement due to postsurgical complications, including chronic pain and inflammation. In this work, naturally derived and bioresorbable silk fibroin meshes (SFM) with three knit patterns were optimized and modified by a combination of regenerated silk fibroin (RSF) and polydopamine (PDA), to endow SFM with a mimicked extracellular matrix (ECM) structure and excellent biocompatibility. Our study confirmed that the modified meshes (SFM@PDA-RSF) exhibited ECM-like structure and good structural stability. Tensile testing results revealed that the SFM substrate played a dominant role in mechanical properties, and SFM@PDA-RSF showed high tensile strength (49.58 N cm-1 transversely, 68.42 N cm-1 longitudinally), which could afford sufficient mechanical support for abdominal wall hernia (AWH) repair (16 N cm-1). Moreover, SFM@PDA-RSF was found to be significantly antioxidant, non-hemolytic, and favorable for cell adhesion and growth, showing great potential for effective hernia repair.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143805218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-engineering bone: pathogenesis, diagnosis and emerging therapies for osteoporosis.

Journal of materials chemistry. B Pub Date : 2025-04-07 DOI: 10.1039/d4tb02628d

Xinyi Dong, Hao Liu, Dian Yuan, Karan Gulati, Yan Liu

{"title":"Re-engineering bone: pathogenesis, diagnosis and emerging therapies for osteoporosis.","authors":"Xinyi Dong, Hao Liu, Dian Yuan, Karan Gulati, Yan Liu","doi":"10.1039/d4tb02628d","DOIUrl":"https://doi.org/10.1039/d4tb02628d","url":null,"abstract":"Osteoporosis, a multifaceted metabolic bone disease, is becoming increasingly prevalent and poses a significant burden on global healthcare systems. Given the limitations of traditional treatments such as pharmacotherapy, tissue engineering has emerged as a promising alternative for osteoporosis management. This review begins by exploring the pathogenesis of osteoporosis, with a focus on the abnormal metabolic, cellular, and molecular signalling microenvironments that drive the disease. We also examine commonly used clinical diagnostic techniques, discussing their strengths and limitations. Notably, this review evaluates various advanced tissue engineering strategies for osteoporosis treatment. Delivery systems, including injectable hydrogels and nanomaterials, are detailed alongside bone tissue engineering materials such as bioactive ceramics, bone cements, and polymers. Additionally, biologically active substances, including exosomes and cytokines, and emerging therapies that leverage small-molecule drugs are explored. Through a comprehensive analysis of the advantages and limitations of current biomaterials and therapeutic approaches, this review provides insights into future directions for tissue engineering-based solutions. By synthesizing current advancements, it aims to inspire innovative perspectives for the clinical management of osteoporosis.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A self-adaptive adhesive, mechanically enhanced, and antibacterial non-woven fabric wound dressing functionalized by a semi-interpenetrating network hydrogel for promoting infected wound healing.

Journal of materials chemistry. B Pub Date : 2025-04-07 DOI: 10.1039/d4tb02851a

Linna Zhang, Guofei Yu, Rui Dai, Shuang Wang, Min Yang, Haibo Wang

{"title":"A self-adaptive adhesive, mechanically enhanced, and antibacterial non-woven fabric wound dressing functionalized by a semi-interpenetrating network hydrogel for promoting infected wound healing.","authors":"Linna Zhang, Guofei Yu, Rui Dai, Shuang Wang, Min Yang, Haibo Wang","doi":"10.1039/d4tb02851a","DOIUrl":"https://doi.org/10.1039/d4tb02851a","url":null,"abstract":"Bacterial infection poses a primary challenge in wound management. However, the commercial non-woven dressings are incapable of treating infected wounds, limiting their clinical applications. Herein, we developed a novel composite dressing, featuring non-woven fabric (NF) decorated with a Zn2+ enhanced semi-interpenetrating network hydrogel (PNGZn@NF), which was achieved by cross-linking graft copolymers composed of acrylic acid and N-hydroxysuccinimide with Zn2+, followed by a coating-heat curing method to securely bond the hydrogel with the NF. The resultant PNGZn@NF exhibited high strength, self-adaptability, adhesion and antibacterial properties, and biocompatibility. In particular, the bacterial killing ratio was up to 99.99% for E. coli and S. aureus. In the in vivo experiments of Staphylococcus aureus (S. aureus) infection, PNGZn@NF showed enhanced infected wound healing ability by eliminating bacteria and reducing inflammation. Given these positive findings, this versatile wound dressing holds great potential in clinical treatment of infected wounds.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategic use of nanomaterials as double-edged therapeutics to control carcinogenesis via regulation of dysbiosis and bacterial infection: current status and future prospects.

Journal of materials chemistry. B Pub Date : 2025-04-07 DOI: 10.1039/d4tb02409e

Mohini Verma, Shiwani Randhawa, Manik Bathla, Nandini Teji, Amitabha Acharya

{"title":"Strategic use of nanomaterials as double-edged therapeutics to control carcinogenesis via regulation of dysbiosis and bacterial infection: current status and future prospects.","authors":"Mohini Verma, Shiwani Randhawa, Manik Bathla, Nandini Teji, Amitabha Acharya","doi":"10.1039/d4tb02409e","DOIUrl":"https://doi.org/10.1039/d4tb02409e","url":null,"abstract":"The human microbiome plays a crucial role in modulating health and disease susceptibility through a complex network of interactions with the host. When the delicate balance of this microbial ecosystem is disrupted, it often correlates with the onset of systemic diseases. An over-abundance of pathogenic microorganisms within the microbiome has been implicated as a driving factor in the development of disease conditions such as diabetes, obesity, and chronic infections. It has been observed that microbiome dysbiosis perturbs metabolic, inflammatory, and immunological pathways, potentially facilitating carcinogenesis. Furthermore, the metabolites associated with microbial dysbiosis exert multifaceted effects, including metabolic interference, host DNA damage, and tumor promotion, further underscoring the microbiome's significance in several of the cancers. This new exploration of microbiome involvement in carcinogenesis needs additional patient sample analysis, which could provide new insights into cancer diagnosis and treatment. However, treating these diseases using drugs, traditional methods, etc. has resulted in multi-drug resistance, and this has eventually made the situation worrisome. This review highlights the importance of nanotechnology, which may tackle these pathogenic conditions simultaneously by targeting common receptors present in bacteria and cancer. Herein, we have explained how nanotechnology may come to the forefront for these treatments. It explores the potential of non-antibiotic disinfectants, i.e., nanoparticles (NPs) with dual targeting capabilities against microbes and cancer cells, using mechanisms such as ROS generation and DNA damage while minimizing the chances of drug resistance.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flavin-based probe for real-time monitoring of hypochlorous acid dynamics in live cells. 基于黄素的探针，用于实时监测活细胞中次氯酸的动态变化。

Journal of materials chemistry. B Pub Date : 2025-04-04 DOI: 10.1039/d4tb02727b

Harsha Gopal Agrawal, Pravin Shankar Giri, Tanima Sahoo, Subha Narayan Rath, Ashutosh Kumar Mishra

引用次数: 0