Xinliang Guo, Wei He, Yufei Wang, Yuhang Wang, Wutong Du, Ryan Tsz Kin Kwok, Hongyan Liu, Ben Zhong Tang, Huajie Zhu
{"title":"Comparison of the optical characteristics of pseudo-resonance and non-pseudo-resonance structures.","authors":"Xinliang Guo, Wei He, Yufei Wang, Yuhang Wang, Wutong Du, Ryan Tsz Kin Kwok, Hongyan Liu, Ben Zhong Tang, Huajie Zhu","doi":"10.1039/d6tb00673f","DOIUrl":"https://doi.org/10.1039/d6tb00673f","url":null,"abstract":"<p><p>Five pairs of pseudo-resonance structures, which have two sets of physical data, such as two sets of NMR spectra in solution, and non-pseudo-resonance structures were synthesized under mild conditions. Among these, two of the pseudo-resonance structures exhibited either stronger aggregation-induced emission (AIE) brightness or distinct emission colors compared to their corresponding non-pseudo-resonance analogues. Furthermore, one AIE pseudo-resonance structure demonstrated lower toxicity and faster cell membrane penetration than its non-pseudo-resonance counterpart and exhibited high efficiency in endoplasmic reticulum (ER) imaging. This new approach may hold potential for further development in biological imaging and molecular diagnostics.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molecular engineering of B/N substituents in asymmetrical salicylaldimine-based boranils for tuning solid-state emission and cellular lipid-droplet imaging.","authors":"Xiaoyan Gao, Mingyue Cao, Jie Huang, Haiyang Yu, Zhiqiang Liu, Xiaoqiang Yu","doi":"10.1039/d6tb00747c","DOIUrl":"https://doi.org/10.1039/d6tb00747c","url":null,"abstract":"<p><p>Boranil derivatives have rapidly emerged as readily synthesized and strongly emissive materials. While their properties can be easily tuned by varying the salicylaldimine precursor, little attention has been paid to the effect of substituents on the boron atom. In this work, a series of asymmetrical BFPh-bridged boranil derivatives were synthesized, and their photophysical properties in solution and solid state were investigated. X-ray crystallographic analysis confirmed that five second-period elements (from B to F) were incorporated into a single molecule within this family of asymmetrical BFPh-bridged compounds. These derivatives not only retain nearly unity quantum yields and show potential for lipid droplet imaging, but also display Stokes shifts that are 20 nm larger than those of the corresponding symmetric BF<sub>2</sub>- and BPh<sub>2</sub>-bridged analogues.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rounak Pokharel, Vasanti Dhakate, Jessica Onyak, Elif Ertugral, Chandrasekhar R Kothapalli, Nic D Leipzig
{"title":"Matrix-bound Tenascin-C directs neuronal differentiation through stiffness-tuned MeHA hydrogels mimicking the spinal cord microenvironment.","authors":"Rounak Pokharel, Vasanti Dhakate, Jessica Onyak, Elif Ertugral, Chandrasekhar R Kothapalli, Nic D Leipzig","doi":"10.1039/d6tb00247a","DOIUrl":"https://doi.org/10.1039/d6tb00247a","url":null,"abstract":"<p><p>Spinal cord injury (SCI) leads to a complex remodeling of the extracellular matrix (ECM), where Tenascin-C (TNC) is strongly upregulated during the early phases of the injury cascade. While TNC is known to influence neural cell behavior, its functional role and mode of presentation in guiding neuronal differentiation remains unclear. In this study, we developed a stiffness-controlled methacrylated hyaluronic acid (MeHA) hydrogel platform that mimics the mechanical properties of the spinal cord and enables defined matrix immobilization of TNC. <i>In vivo</i> analyses showed elevated TNC expression from day 1, with the strongest perilesional signal during the subacute period (1 week-1 month). Using this temporal insight, we investigated the role of matrix-bound <i>versus</i> soluble TNC in directing neuronal differentiation of induced spinal cord progenitor cells <i>in vitro</i>. Immobilized TNC presented with naïve spinal cord stiffness matched MeHA substrates significantly enhanced neuronal and motor neuron differentiation, as evidenced by increased βIII-tubulin and ISL1 expression, compared to soluble TNC or unmodified controls. These effects were strongly dependent on both ligand concentration and matrix stiffness, highlighting a narrow bioactive window for TNC-mediated signaling (effective window: 100-200 nM; reduced responses at ≥300 nM). Furthermore, bulk 3D MeHA hydrogels functionalized with TNC supported cell viability and sustained neuronal differentiation, demonstrating translational relevance for future scaffold-based neural repair. These findings identify TNC as a matrix-bound bioactive cue that interacts with the mechanical environment to regulate neuronal lineage commitment, providing a framework for designing next-generation biomaterials for neural repair.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dual-function hydrogel microspheres coordinate immune regulation and osteogenesis coupling to promote femoral regeneration.","authors":"Lingjun Wang, Zhengxia Ni, Yiyang Huang, Jiannan Mao, Jie Wu, Wei Wang, Xinzhao Jiang, Liang Zhou, Jincheng Tang, Kun Xi, Yong Gu, Liang Chen","doi":"10.1039/d5tb02399h","DOIUrl":"https://doi.org/10.1039/d5tb02399h","url":null,"abstract":"<p><p>The skeletal immune microenvironment plays a critical role in the repair of bone defects; however, current strategies focusing on macrophage M2 polarization and their application in bone regeneration remain limited. To address this, we developed a methacrylated gelatin (GelMA) microsphere system using microfluidic technology, co-loading IL-4 and chitosan-BSA nanoparticles (CNP) encapsulating calcitonin gene-related peptide (CGRP) to achieve temporally controlled release and immuno-osteogenic synergistic regulation. In the early stage, IL-4 secretion promotes macrophage polarization toward the M2 phenotype, improving the inflammatory microenvironment, while the sustained release of CGRP subsequently enhances angiogenesis and osteogenic differentiation, establishing a microenvironment favorable for bone regeneration. In a femoral condyle defect model, these composite microspheres significantly accelerated new bone formation and defect healing, exhibiting an osteogenic pattern centered around the microspheres. This study provides a novel temporally controlled release strategy for promoting bone regeneration through immune microenvironment modulation, offering potential translational value in bone tissue engineering.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dictated cell adhesion and migration using microfluidic-controlled synthetic hydrogels exhibiting programmable viscoelasticities.","authors":"Haochen Yang, Ziyuan Li, Gilad Davidson-Rozenfeld, Meng Li, Yuxing Shang, Linjie Chen, Yingchao Ma, Yifan Ge, Itamar Willner, Junji Zhang","doi":"10.1039/d6tb00438e","DOIUrl":"https://doi.org/10.1039/d6tb00438e","url":null,"abstract":"<p><p>Mechanosensing interactions between the extracellular matrix (ECM) and the intracellular cytoskeleton are fundamental to cellular functions such as motility, proliferation, and adhesion, driven by the dynamic, bidirectional, tension-regulated maturation of focal adhesion (FA) sites. We demonstrate that native mechanosensing interactions and their downstream functions are precisely controlled using synthetic hydrogels. We introduce a microfluidic-assisted synthesis of imine-crosslinked hyaluronic acid-gelatin copolymer hydrogels (HAG), enabling controlled, predefined gradient viscoelasticity. Specifically, three native tissues (muscle, epidermis, and cartilage)-mimicking HAG hydrogels were prepared, matching their effective Young's modulus (Ymod) and stress relaxation time (<i>τ</i><sub>1/2</sub>). Enhanced cell spreading and directional cell migration are observed, with a preference for substrates with tissue-matching viscoelasticity. These mechanosensing reactions are confirmed by traction force microscopy, revealing a tight correlation between native tissue mechano-properties and the hydrogel viscoelastic parameters. We demonstrate that the signaling efficacies of the FAK and associated YAP/TAZ pathways, central regulators of FA formation and cell migration, are tuned by substrate tissue-matching viscoelasticity. We implement these preprogrammed viscoelastic gradient hydrogels as spatiotemporal cell-separation matrices, enabling viscoelasticity-driven migration of binary cell mixtures. This work provides a potent platform for studying cell-material interactions, offering significant potential applications in tissue engineering, immunotherapy, and regenerative medicine.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Innovative design of fluorescent PLGA-1,8-naphthalimide nanoparticles as multifunctional materials for next-generation nanotechnology and biomedicine.","authors":"Yuriev Danil, Tkachenko Sergey, Ermolin Danila, Ivanov Ilya, Melnikov Pavel, Malinovskaya Julia, Ryabova Anastasia, Mishin Alexander, Perfilov Maxim, Ramil Khasbiullin, Medvedev Michael, Skorb Ekaterina, Oshchepkov Maxim, Gelperina Svetlana, Oshchepkov Alexander","doi":"10.1039/d5tb02866c","DOIUrl":"https://doi.org/10.1039/d5tb02866c","url":null,"abstract":"<p><p>Poly(lactic-<i>co</i>-glycolic acid) (PLGA)-based nanoparticles featuring covalently incorporated 1,8-naphthalimide fluorophores were developed through DFT/TD-DFT-guided molecular engineering. Systematic variation of 4-position substituents and carbon spacer lengths established clear structure-property relationships governing spectral-luminescent characteristics and conjugate stability. Computational modeling accurately predicted experimental absorption/emission features. The optimized PLGA-fluorophore conjugates yielded nanoparticles with high aqueous fluorescence, excellent colloidal stability, and approximately two-fold higher photostability than PLGA-Cy5 under the tested imaging conditions. Live-cell confocal microscopy (405 nm excitation) demonstrated strong emission and homogeneous distribution in 4T1/HeLa cells, confirming suitability for <i>in vitro</i> cellular imaging with high cell viability. This covalent PLGA labeling platform establishes a quantifiable foundation for advanced fluorescent nanomaterials in cellular imaging applications. While these results establish a robust platform for cellular imaging applications, extended <i>in vivo</i> validation remains a goal for future work.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacob A Lewis, Ronit Freeman, Tristan D Clemons, Jacqueline M Godbe, Nicholas Stephanopoulos, Samuel I Stupp
{"title":"Nonionic peptide amphiphiles and their supramolecular co-assemblies tune charge density and bioactivity.","authors":"Jacob A Lewis, Ronit Freeman, Tristan D Clemons, Jacqueline M Godbe, Nicholas Stephanopoulos, Samuel I Stupp","doi":"10.1039/d6tb00293e","DOIUrl":"10.1039/d6tb00293e","url":null,"abstract":"<p><p>Supramolecular peptide assemblies generally rely on ionic groups for solubility in aqueous media but charge may sometimes affect their biological functions. Cationic residues in these assemblies are often associated with cell toxicity, and charged amino acids lead to supramolecular structures that are dependent on both pH and ionic strength. We report here on the synthesis of a nonionic peptide amphiphile (PA) containing a decaethylene glycol segment and its supramolecular co-assembly with ionic PA monomers as a strategy to produce uncharged assemblies and to fine tune charge density. We show that while morphology and internal structure depend on counterion screening and on pH for charged PA assemblies, these nonionic molecules self-assemble to form high-aspect ratio filaments containing β-sheets stable with or without ion screening and at acidic, neutral, and basic pH. By co-assembling nonionic PA molecules with charged PA molecules, we could produce supramolecular copolymers with tunable surface charge density, yet with stronger internal order than either fully charged or fully uncharged assemblies. Using an <i>in vitro</i> model for osteogenic differentiation of mesenchymal stem cells, we found that supramolecular assemblies containing nonionic molecules or co-assemblies of both nonionic and ionic PA molecules exhibit greater bioactivity than assemblies containing only charged molecules. We hypothesize that the enhanced bioactivity originates in the synergy between protein binding by PA molecules and increased supramolecular dynamics introduced by the nonionic ethylene glycol segments. Thus, nonionic PAs and their co-assemblies can be used to investigate how charge density and other factors affect bioactivity of water-soluble supramolecular nanostructures.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Perfluoroalkylated amphiphilic porphyrin nanomicelles for improved photodynamic therapy: anti-tumour efficacy through stability enhancement and O<sub>2</sub> enrichment.","authors":"Dan-Wei Zhang, Danying Ma, Congying Guo, Zhuo Lei, Yajie Zhu, Rui Gao, Hui Wang, Jia Tian, Wei Zhou, Zhan-Ting Li","doi":"10.1039/d6tb00359a","DOIUrl":"https://doi.org/10.1039/d6tb00359a","url":null,"abstract":"<p><p>Amphiphilic porphyrin nanomicelles have been established as new single-molecule photodynamic agents (PDAs) for cancer treatment. Further improvement of the photodynamic performance will increase the potential of this class of PDAs for practical application. Here, we prepare four new porphyrin compounds F-TSCnP (<i>n</i> = 5-8) that bear a <i>n</i>-C<sub>5</sub>F<sub>11</sub>, <i>n</i>-C<sub>6</sub>F<sub>13</sub>, <i>n</i>-C<sub>7</sub>F<sub>15</sub>, and <i>n</i>-C<sub>8</sub>F<sub>17</sub> chain, respectively. We demonstrate that, compared with the analogues that bear a shorter perfluoroalkyl or <i>n</i>-C<sub>8</sub>H<sub>17</sub> chain, <i>n</i>-C<sub>8</sub>F<sub>17</sub>-bearing compound F-TSC8P can self-assemble into nanomicelles that possess increased stability and uniformity as well as improved intracellular self-delivering capacity. We further illustrate that nanomicelles formed by F-TSC8P form a unique fluorocarbon microphase, which can enrich and deliver O<sub>2</sub> to achieve remarkably enhanced photosensitizing activity for <sup>1</sup>O<sub>2</sub> generation. <i>In vivo</i> assay using a mouse model reveals that, compared with the fluorine-free counterpart, F-TSC8P, which has a therapeutic index of 10, exhibits a 150% increase in photodynamic activity for tumour growth inhibition.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aleksandra Domke, Mariusz Jancelewicz, Tomasz Szymański, Marcin Jarek, Jakub Rybka, Szymon Mania, Adrianna Banach-Kopeć, Zuzanna Buchwald, Mariusz Sandomierski, Maria Ratajczak, Marcel Jakubowski, Marta Woźniak-Budych, Katarzyna Staszak
{"title":"<i>In situ</i> engineered selenium nanoparticles enable multifunctional PLA mixed matrix membranes with potential for hemodialysis.","authors":"Aleksandra Domke, Mariusz Jancelewicz, Tomasz Szymański, Marcin Jarek, Jakub Rybka, Szymon Mania, Adrianna Banach-Kopeć, Zuzanna Buchwald, Mariusz Sandomierski, Maria Ratajczak, Marcel Jakubowski, Marta Woźniak-Budych, Katarzyna Staszak","doi":"10.1039/d6tb00354k","DOIUrl":"https://doi.org/10.1039/d6tb00354k","url":null,"abstract":"<p><p>The development of advanced membrane materials capable of combining high filtration efficiency, fouling resistance, antibacterial activity and blood compatibility remains a key challenge in the design of next-generation hemodialysis systems. In this study, polylactic acid (PLA)/PEG mixed-matrix membranes incorporating selenium nanoparticles (Se-NPs), synthesised <i>in situ</i> using ascorbic acid, were fabricated and evaluated as potential candidates for hemodialysis applications. Comprehensive physicochemical characterisation (SEM, TEM, FT-IR, AFM) confirmed the effective formation and uniform distribution of Se-NPs within the polymer matrix, as well as their influence on membrane morphology, hydrophilicity, and nanomechanical properties. The incorporation of Se-NPs significantly improved antifouling performance by reducing BSA adsorption and increasing hydrophilicity, with the 30Se membrane showing the most favourable behaviour. Filtration studies revealed a promising balance between permeability and selectivity, including high pure water flux, efficient creatinine clearance (>90%), and reduced BSA loss, highlighting their relevance for dialysis-like separation processes. Additionally, Se-NP loading imparted antibacterial activity, particularly against <i>E. coli</i>, which may help mitigate infection risks associated with extracorporeal blood purification. Biocompatibility assessments including cytotoxicity, hemolysis, plasma recalcification time, and platelet adhesion demonstrated that the materials maintain excellent compatibility with blood components. Overall, the incorporation of Se-NPs into PLA-based membranes yields multifunctional materials with strong potential for future hemodialysis applications, warranting further optimisation and in-depth biological evaluation.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Subhankar Maity, Arup Sarkar, Arindam Patra, Joy Mitra, Jayanta Haldar
{"title":"Bioinspired antimicrobial glass coatings for clear and infection-resistant surfaces.","authors":"Subhankar Maity, Arup Sarkar, Arindam Patra, Joy Mitra, Jayanta Haldar","doi":"10.1039/d6tb00465b","DOIUrl":"https://doi.org/10.1039/d6tb00465b","url":null,"abstract":"<p><p>Optically transparent glass surfaces that simultaneously prevent fogging, resist contamination, and eliminate microbial growth are highly desirable for medical optics, protective equipment, and advanced architectural applications. In applications where sustained visual clarity and resistance to microbial colonization are critical for diagnostic accuracy and patient safety, as well as in self-cleaning glass panels that reduce water consumption and reliance on chemical surfactants, multifunctional surface coatings are highly desirable. Here, we report a mussel-inspired, single-step dip-coating strategy for covalent immobilization of a dopamine-conjugated quaternary antimicrobial polymer (DQP<sub>Pr</sub>) onto glass substrates, providing a robust, scalable route to multifunctional surface engineering. Atomic force microscopy (AFM) reveals uniform nanoscale coatings, with superhydrophilicity in the Wenzel wetting regime. The modified surfaces exhibit pronounced superhydrophilicity (contact angle of ∼3-4°) while maintaining high visible transparency, enabling effective antifogging performance. The coatings further demonstrate self-cleaning behaviour by efficiently removing hydrophobic particulates upon simple water rinsing. Importantly, above a threshold coating concentration, the surfaces display potent antimicrobial activity against Gram-positive and Gram-negative bacteria as well as drug-resistant fungal strains. The coatings retain structural integrity and functional performance after repeated washing cycles and across varying temperature conditions, underscoring their durability and strong potential for practical biomedical and protective applications.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}