Journal of materials chemistry. B最新文献

{"title":"Engineered microbial sensors: providing a new paradigm for disease detection.","authors":"Xuan-Ren Shi, Yi-Fan Zhang, Ying Zhou, Zhen-Ping Zou, Bang-Ce Ye","doi":"10.1039/d5tb01468a","DOIUrl":"https://doi.org/10.1039/d5tb01468a","url":null,"abstract":"<p><p>Microorganisms can be programmed into engineered microbial sensors (EMSs) capable of responding to disease biomarkers. Compared to traditional diagnostics, EMSs exhibit superior advantages in cost-effectiveness, environmental adaptability, and non-invasive, <i>in situ</i> diagnostics. These advantages have been further bolstered by recent advances in synthetic biology, which have improved the reliability, accuracy, and safety of EMSs in disease detection, particularly <i>in vivo</i>. In this review, we elucidate the fundamental design principles of EMSs and summarize their research progress across diverse diagnostic scenarios. Furthermore, we evaluate recent advances in EMSs encapsulation strategies, including micro- and macro-encapsulation, and their potential for translation into practical applications. Finally, we outline future perspectives and analyze key challenges in the medical applications of EMSs, including biosafety concerns, signal stability issues, and the absence of standardized clinical evaluation protocols.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L-DNA-based probes for the detection of radiation-induced DNA strand cleavage.","authors":"Ryanne N Ehrman, Wenrui Zhong, Rosemarie Elloisa P Acero, Ziqi Wang, Nancy Tran, Olivia R Brohlin, Laurentiu M Pop, Jonathan T Sczepanski, Jeremiah J Gassensmith","doi":"10.1039/d5tb01491c","DOIUrl":"https://doi.org/10.1039/d5tb01491c","url":null,"abstract":"<p><p>Accurate assessment of DNA strand breaks is essential for evaluating the efficacy of radiation therapy, yet most existing methods rely on indirect detection of reactive oxygen species (ROS), which are unreliable in hypoxic tumor environments and do not consistently correlate with DNA damage. Here, we report a nuclease-resistant, L-DNA-based Förster resonance energy transfer (FRET) probe that directly detects radiation-induced DNA strand cleavage. The probes consist of short single-stranded L-DNA labeled with FAM and TAMRA fluorophores, designed to lose FRET upon strand scission. Both two- and six-thymidine variants (L-T2 and L-T6) were synthesized and shown to resist enzymatic degradation while maintaining fluorescence under irradiation up to 50 Gy. Radiation exposure induces a dose-dependent increase in donor fluorescence, with L-T2 exhibiting greater sensitivity in physiological buffer. The probes are quantitatively responsive, with detectable signal shifts from as little as 1% cleavage and a linear relationship between donor/acceptor emission ratios and DNA breakage. In cells, however, the behavior is more complex. While L-T6 exhibits dose-dependent FRET loss in certain contexts, particularly in radiation-sensitive SKBR3 cells, the extent of cleavage is significantly reduced compared to <i>in vitro</i> conditions. Glutathione depletion failed to enhance intracellular cleavage, suggesting that other mechanisms of protection or sequestration are at play. These findings highlight the challenges of sensing strand scission in the cytoplasm and point to unanticipated barriers to detecting radiation-induced damage in living cells.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating rheumatoid arthritis using fibroblast-activated protein-α-responsive micelles through a cascade control program.","authors":"Yu Li, Pei Xie, Ruixin Gong, Junlong Chen, Yaxue Liu, Zongning Yin","doi":"10.1039/d5tb01441g","DOIUrl":"https://doi.org/10.1039/d5tb01441g","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA), a chronic autoimmune disorder affecting 1% globally, urgently demands advanced therapies to overcome the systemic toxicity and limited efficacy of conventional glucocorticoids like dexamethasone (Dex). In this study, we constructed LMWH-Gly-Pro-ODA/Dex (LGPO/Dex) micelles, which synergistically integrate low molecular weight heparin (LMWH)-mediated active targeting with Gly-Pro-mediated fibroblast-activated protein (FAP)-α-responsive drug release to achieve spatiotemporal precision in RA treatment. The system operates through a three-stage cascade mechanism: (1) targeting the inflamed joints, (2) inflammation-responsive drug release to modulate pathological microenvironments (<i>e.g.</i>, normalizing M1/M2 macrophage polarization), and (3) suppression of monocyte recruitment to prevent disease progression. LGPO/Dex micelles showed excellent RA therapeutic effects in the adjuvant-induced arthritis (AIA) model. Joint swelling, serum TNF-α, and nitric oxide (NO) levels in LGPO/Dex-treated rats showed no significant difference from healthy controls (ns) while exhibiting marked improvement over Dex monotherapy (**, <i>P</i> < 0.01). Notably, it also significantly reduced Dex-associated adverse effects. This study confirmed the feasibility of using FAP-α as a therapeutic target for RA and provided a new idea for RA treatment, offering a blueprint for disease-microenvironment-programmed therapeutics.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive wet adhesive materials for oral health: strategies and applications.","authors":"Geyuan Wang, Yuting Zhou, Xinyi He, Xuemei Tang, Zibo Lin, Xiaoxiao Wang, Yuxin Zhang, Xuefeng Hu, Kunneng Liang, Jieyu Zhang, Yunbing Wang","doi":"10.1039/d5tb01661d","DOIUrl":"https://doi.org/10.1039/d5tb01661d","url":null,"abstract":"<p><p>The oral cavity represents a unique and complex anatomical environment characterized by its moist and dynamic nature. This environment is crucial for numerous physiological functions, including digestion, respiration, and phonation, while also serving as a critical interface between the host and various microbial communities. The interplay among resident microbiota, host immune responses, and environmental factors contributes to oral health maintenance. However, this balance can be disrupted, leading to susceptibility to microbial invasion and inflammatory disorders. Conventional oral healthcare materials often fall short in providing sustained therapeutic benefits locally. To address this challenge, researchers combine various bioactive materials with polymer networks designed for wet-adhesion, tailored to the unique conditions of the oral cavity. This review outlines key design strategies for achieving stable wet adhesion, including eliminating interfacial water, establishing robust interfacial linkages, and enhancing material cohesion. Building on interfacial stability, this review further discusses the three dominant strategies for integrating bioactivities, such as antimicrobial, anti-inflammatory, and osteogenic activities, emphasizing the synergistic interplay of bioactivity and wet adhesive performance. Furthermore, this review presents the prospects for bioactive wet adhesive materials in promoting oral health, providing insights into existing challenges and potential avenues for development.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D printable hydrogel inks with metal-organic frameworks for sustained small drug delivery in wound healing.","authors":"Youbin Park, Subin Jin, Se-Na Kim, Chun Gwon Park, Mikyung Shin","doi":"10.1039/d5tb01433f","DOIUrl":"https://doi.org/10.1039/d5tb01433f","url":null,"abstract":"<p><p>Wound healing is a complex and dynamic biological process, and impaired healing can lead to prolonged recovery and increased healthcare costs. Recent advancements in wound healing therapeutics include hydrogel-based biomaterials, nanocarrier-mediated drug delivery systems, and tissue-engineered scaffolds that aim to modulate the wound microenvironment and accelerate tissue regeneration. However, wound healing remains a clinical challenge, particularly when sustained delivery of therapeutic agents and conformal wound coverage are required. Herein, we develop a multifunctional hydrogel system composed of hyaluronic acid modified with methacrylate and a zirconium-based metal-organic framework (MOF), enabling enhanced structural control and drug retention. The resulting hydrogel exhibits tunable photo-crosslinking kinetics, allowing precise gelation behavior and extrusion-based 3D printing without the need for a support bath. Moreover, the integration of hydrophobic and rigid MOF particles significantly suppresses water uptake, imparting anti-swelling properties that facilitate the sustained release of hydrophobic drugs such as quercetin. When applied to a wound healing model, the proposed platform promotes fibroblast migration and tissue regeneration over an extended period, highlighting the therapeutic potential of controlled drug release. Thus, this hydrogel offers a structurally robust, printable, and drug-releasing biomaterial platform for next-generation wound dressings.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering fluorescent probes for tracking lysosomal pH in β-amyloid-induced microglial activation and phagocytosis.","authors":"Subrata Munan, Abir Mondal, Shraddha Tiwari, Rashmi Yadav, Niharika Pareek, Animesh Samanta","doi":"10.1039/d5tb00968e","DOIUrl":"https://doi.org/10.1039/d5tb00968e","url":null,"abstract":"<p><p>Alzheimer's disease (AD) is primarily associated with the aggregation of amyloid-β (Aβ) due to insufficient clearance of Aβ peptides. This leads to deposition of fibrillar Aβ (fAβ), contributing to AD progression. Microglia, the brain's resident immune cells, are central to the phagocytotic-fusion of fAβ. Notably, fAβ itself can activate microglia <i>via</i> toll-like receptor signaling, triggering a phagocytic response. Previous studies have shown that activated microglia exhibit efficient phagocytotic-fusion of fAβ, primarily through lysosomal acidification compared to resting microglia. Therefore, distinguishing microglial activation states is vital for understanding and potentially modulating Aβ clearance mechanisms in AD. Herein, we systematically modified the structure to develop fluorescent probes (FPs), PS-Mor and PM-DMor based on morpholine-conjugated pyrylium and pyridinium derivatives of indigenous \"IndiFluors\". These probes exhibit strong fluorescence enhancement in lysosomal pH windows by modulating photoinduced electron transfer (PET). The turn-on behavior of the probes was further supported by TD-DFT/PCM theoretical calculations. Confocal imaging revealed that PM-DMor selectively localizes to lysosomes, while PS-Mor targets mitochondria in activated human microglia. PM-DMor effectively monitors intracellular pH changes (ΔpHi) during drug-induced apoptosis and discriminates activated from resting microglial using both fluorescence microscopy and flow cytometry. Importantly, PM-DMor also tracks Aβ-induced microglial activation and subsequent phagocytosis of Aβ. Overall, PM-DMor offers a valuable tool for probing lysosomal dynamics in microglia and holds promise for early-stage therapeutic strategies targeting Aβ clearance in Alzheimer's disease.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive glasses and polyphenols: towards synergistic biological effects for tissue regeneration.","authors":"Zakaria Tabia, Allal Barroug, Hicham Ben Youcef, Hassan Noukrati","doi":"10.1039/d5tb01421b","DOIUrl":"https://doi.org/10.1039/d5tb01421b","url":null,"abstract":"<p><p>Since the discovery of bioactive glasses (BAGs), extensive research has been performed to refine their biological properties and enhance their regenerative potential. Progress in this field has not only focused on tailoring BAGs compositions and creating new synthesis methods but also addressed their association with other therapeutic agents. These associative strategies aim to provide multifunctional biomaterials and elicit synergistic/complementary biological effects that accelerate tissue repair and address a wide range of complex regenerative microenvironments (infection, oxidative stress, <i>etc</i>.). Among these approaches, the combination of ion-doped BAGs with natural polyphenols (PPhs) has shown significant potential in bone regeneration, wound healing, and cancer treatment. This review provides a comprehensive analysis of the BAGs-PPhs hybrid systems, detailing the various methods used for their association and the underlying mechanisms and factors governing BAGs and PPhs interactions. In addition, particular attention is given to how these interactions affect the release and prolong the bioavailability and reactivity of natural PPhs. This review discusses the effect of BAGs-PPhs coupling on BAGs' apatite forming ability and PPhs' antioxidant properties, and highlights key <i>in vitro</i> cellular findings on the osteogenic, angiogenic, immunomodulatory and cancer suppressive properties of BAGs-PPhs constructs, which are supported with <i>in vivo</i> evidence on therapeutic potential of these biomaterials. By offering an overview of the current advancements in this field, this review not only underscores the biomedical relevance of BAGs and PPhs coupling but also outlines existing challenges and identifies research perspectives for accelerating the translation of these biomaterials into clinical applications.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative hyaluronan/gellan gum/hydroxypropyl methyl cellulose membrane for prevention of adhesion in postoperative achilles tendon.","authors":"Shan-Wei Yang, Mu-Ting Li, Chun-Shien Wu, Joseph Yang, Daniel Yang, Shyh-Ming Kuo","doi":"10.1039/d5tb01703c","DOIUrl":"https://doi.org/10.1039/d5tb01703c","url":null,"abstract":"<p><p>A novel anti-adhesion barrier membrane composed of FDA-approved hyaluronan (HA), gellan gum (GG), and hydroxypropyl methylcellulose (HPMC) was developed to prevent postoperative tendon adhesion in our study. Seprafilm, a commercial hydrogel barrier membrane comprising HA and carboxymethyl cellulose (CMC), is effective in abdominal surgeries to reduce postoperative adhesions between the abdominal wall and underlying tissues. However, it is fragile, difficult to handle, and degrades rapidly, limiting its barrier function. Our HA/GG/HPMC (HGH) membrane overcame these drawbacks, exhibiting superior resilience, hydrophilicity, water content, swelling ratio, and stress-strain properties compared to the HG (HA/GG) and Seprafilm membranes. The HGH membrane was highly hydrophilic and reached hydration equilibrium within 3 min, enabling it to wrap tendons snugly without sticking or tearing. It degraded more slowly (60% mass remaining after 12 days <i>in vitro</i>, <i>vs.</i> 15% for Seprafilm after 4 days), providing an extended protective presence during the tendon's healing period. In a rat Achilles tendon repair model, the HGH membrane significantly reduced peritendinous adhesions and facilitated better healing histologically. The repaired tendon breaking strength after 3 weeks was significantly higher in the HGH group (37.5 N) than in the untreated (6.5 N), HGC (16 N), or Seprafilm (15.5 N) groups. Haematoxylin and eosin staining indicated that the HGH membrane resulted in significantly less tendon-tissue adhesion and superior healing. In summary, the HGH membrane degraded more slowly, was less fragile, more resilient, and more hydrophilic, making it easier to handle during surgery and thus an effective candidate for preventing adhesions in tendon surgery.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QCM-based ammonia gas sensors with electrospun polymer-based nanofibers for liver and kidney disease detection: a mini-review.","authors":"Rizky Aflaha, Egadwinanda Nabila Suhandhia Putri, Chlara Naren Maharani, Laila Katriani, Ahmad Hasan As'ari, Aditya Rianjanu, Witha Berlian Kesuma Putri, Kuwat Triyana, Ruchi Gupta, Roto Roto","doi":"10.1039/d5tb00842e","DOIUrl":"https://doi.org/10.1039/d5tb00842e","url":null,"abstract":"<p><p>The advanced development of ammonia gas sensors using various sensing platforms has been widely researched, including quartz crystal microbalance (QCM)-based sensors. This review highlights recent research on ammonia gas sensors based on QCM with an electrospun polymer-based nanofiber active layer. The discussion starts with the principle of QCM as a base sensor, and then follows with the effect of electrospinning parameters on the fabricated nanofiber. Then, the discussion focuses on the potential of fabricated QCM-based sensors in directly detecting ammonia as a biomarker of liver and kidney diseases. The key performance parameters of QCM-based ammonia gas sensors, such as sensitivity, detection range, detection limit, and response/recovery time, are comprehensively discussed in this review. Finally, the potential, current challenges, and future perspectives on the application of QCM-based ammonia gas sensors for direct detection of liver and kidney diseases, such as improving selectivity, humidity resistance, and clinical translation, followed by the potential usage of QCM-based sensor arrays, are considered, offering insight into the future direction of QCM-based sensors in probing human diseases.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Savinase-functionalised oxidative drug-loaded nanocarriers enhance the treatment of solid colorectal tumours in a 3D cell culture model.","authors":"Anel G Mun, Nuriya Nurlankyzy, Saule Kalmagambetova, Aidos Baumuratov, Dos Sarbassov, Vesselin N Paunov, Agata N Burska","doi":"10.1039/d5tb01882j","DOIUrl":"https://doi.org/10.1039/d5tb01882j","url":null,"abstract":"<p><p>Colorectal cancer (CRC) mutations drive resistance and poor prognosis, underscoring the need for more effective therapies. The oxidative drug therapy combining arsenic trioxide (ATO) and D-vitamin C (D-VC) has demonstrated promising efficacy by targeting mitochondrial functions and depleting antioxidant defences to induce apoptosis in CRC cells. ATO and D-VC create a hostile environment for cancer cells by simultaneously targeting mitochondrial metabolism and redox homeostasis, reducing their ability to adapt and survive. This study evaluated the cytotoxic effects of ATO/D-VC in 2D cell cultures and 3D cell models, known as clusteroids, generated from CRC cell lines HCT116 and SW620. In the 2D cultures, the ATO/D-VC combination significantly reduced cell proliferation to 40-60% and viability to below 30% of control levels. In contrast, clusteroids showed a more limited response, with proliferation reduced to 60-80% and viability to 80-90%, highlighting the impact of the extracellular matrix (ECM) and cell-cell interactions in limiting drug diffusion within structured tumour microenvironments. To overcome these drug diffusion barriers, ATO and D-VC were individually encapsulated in poloxamer-stabilized shellac-based nanoparticles (NPs) surface functionalized with Savinase, a protease known to degrade ECM components. The cell viability and cell proliferation assays demonstrated that nanoparticle-mediated delivery significantly enhanced treatment efficacy in clusteroids. Dual treatment of Savinase-coated ATO and D-VC loaded NPs caused pronounced disruption of clusteroid morphology and substantially reduced both viability and proliferation to approximately 30-40% of untreated control levels. Compared to the free drug and uncoated nanoparticle formulations, the Savinase-functionalized nanoparticle formulation achieved nearly twice the reduction in viability and proliferation, indicating a marked improvement in therapeutic effect. Unloaded Savinase-coated nanoparticles showed minimal impact, underscoring their biocompatibility. This approach demonstrates the potential of protease-functionalized nanoparticles to enhance the oxidative drug delivery and efficacy in CRC tumours and could potentially allow targeting the therapeutic resistance in other solid tumours with dense ECM barriers.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}