Journal of materials chemistry. B最新文献

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Synergistic approaches for combating the pathogen Acinetobacter baumannii: dynamic constitutional frameworks and pillararene-based self-assembled drug delivery systems. 对抗病原体鲍曼不动杆菌的协同方法:动态结构框架和基于柱状芳烯的自组装给药系统。
Journal of materials chemistry. B Pub Date : 2025-06-20 DOI: 10.1039/d5tb00453e
Dmytro Strilets, Steven Van Meerbeek, Anke Breine, Charles Van der Henst, Tom Coenye, Stéphane P Vincent
{"title":"Synergistic approaches for combating the pathogen <i>Acinetobacter baumannii</i>: dynamic constitutional frameworks and pillararene-based self-assembled drug delivery systems.","authors":"Dmytro Strilets, Steven Van Meerbeek, Anke Breine, Charles Van der Henst, Tom Coenye, Stéphane P Vincent","doi":"10.1039/d5tb00453e","DOIUrl":"https://doi.org/10.1039/d5tb00453e","url":null,"abstract":"<p><p>In this study, we developed dynamic and supramolecular structures to combat the highly resistant pathogen <i>Acinetobacter baumannii</i>. This Gram-negative ESKAPE pathogen has a strong ability to form biofilms, which raises a key but challenging question: how to discover molecules active on both planktonic bacteria and their biofilms. To achieve this, we introduce two non-covalent ordered systems with antimicrobial and antibiofilm effects based on two distinct types of interactions: dynamic covalent bonding and supramolecular self-assembly. We discovered and optimized potent systems based on a cationic dynamic constitutional framework and a pillararene-antibiotic self-assembled drug delivery system through a synergistic screening process. Our screening methodology is based on searching for the synergistic effect of subcomponents to determine their optimal combinations and optimize their antibacterial potency. Crucially, our synergistic screening approach not only enables the rapid optimization of component combinations but also demonstrates the potential to generate potent bioactivity from individually inactive molecules and transform antibiotics with poor antibiofilm efficacy into highly active supramolecular systems, offering a significant advancement in combating challenging pathogens, such as <i>A. baumannii</i>.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergistic integration of ADSCs and egg white hydrogel microspheres for accelerated wound regeneration. ADSCs与蛋清水凝胶微球协同整合促进伤口再生。
Journal of materials chemistry. B Pub Date : 2025-06-20 DOI: 10.1039/d5tb00007f
Yu He, Ying Zhao, Qiang Chang, Ting Li, Zhaowei Zeng
{"title":"Synergistic integration of ADSCs and egg white hydrogel microspheres for accelerated wound regeneration.","authors":"Yu He, Ying Zhao, Qiang Chang, Ting Li, Zhaowei Zeng","doi":"10.1039/d5tb00007f","DOIUrl":"https://doi.org/10.1039/d5tb00007f","url":null,"abstract":"<p><p>Accelerating wound healing poses a significant challenge in clinical practice, necessitating the exploration of innovative strategies. The development of biomaterials with tissue repair and regenerative properties represents a forefront approach to addressing this challenge; however, the functional characteristics and application methods of these materials remain limited. In this context, a novel bioactive micro carrier (Bio-MC) was developed from egg white hydrogel microspheres (EWMs) which served as a bio-niche incorporating adipose-derived stem cells (ADSCs). This formulation capitalizes on the intrinsic tissue reparative capabilities of stem cells, allowing for the sustained release of multiple growth factors. These factors, <i>via</i> paracrine signaling, promote the proliferation and migration of neighboring cells, thereby creating an environment that supports wound healing. Upon application to wound sites, Bio-MCs exhibited significant effectiveness in enhancing the healing process by promoting tissue regeneration, increasing collagen deposition, and facilitating vascularization. The paracrine signaling mediated by Bio-MCs has the potential to exert lasting beneficial effects on cells in a comprehensive and physiologically relevant manner. In comparison to conventional growth factor treatments, the Bio-MC offers enhanced application versatility and functional attributes, indicating substantial promise in the field of tissue repair and regeneration and representing a noteworthy advancement in the clinical management of wounds.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Boosting anti-tumor immunity with boron-based nanosheets via photodynamic-elicited pyroptosis and adjuvant delivery. 硼基纳米片通过光动力诱导的焦亡和佐剂递送增强抗肿瘤免疫。
Journal of materials chemistry. B Pub Date : 2025-06-20 DOI: 10.1039/d5tb00801h
Xinran Xie, Shuaiyin Zhang, Ming Liu, Yang Ye, Yongxin Huang, Zhixin Li, Junyan Lin, Jie Liu, Jingchun Zhou, Changyi Xu, Zhaoxu Tu
{"title":"Boosting anti-tumor immunity with boron-based nanosheets <i>via</i> photodynamic-elicited pyroptosis and adjuvant delivery.","authors":"Xinran Xie, Shuaiyin Zhang, Ming Liu, Yang Ye, Yongxin Huang, Zhixin Li, Junyan Lin, Jie Liu, Jingchun Zhou, Changyi Xu, Zhaoxu Tu","doi":"10.1039/d5tb00801h","DOIUrl":"https://doi.org/10.1039/d5tb00801h","url":null,"abstract":"<p><p>Photodynamic therapy (PDT) has emerged as a promising non-invasive therapeutic modality for tumor treatment. Moreover, PDT has the potential to induce immunogenic cell death (ICD), and its combination with immunotherapeutic strategies has become a promising approach for tumor therapy. In this study, we designed a multifunctional nanoplatform, IR@BP-L, which integrates PDT-induced pyroptosis with loxoribine as an immune agonist. On one hand, the effective accumulation of IR@BP-L at the tumor site enables PDT treatment <i>via</i> near-infrared light irradiation, generating a large amount of reactive oxygen species (ROS) to induce pyroptosis and promote local immunity. On the other hand, loxoribine is responsively released under near-infrared light irradiation and within the weakly acidic tumor microenvironment, thereby enhancing immune activation at the tumor site. As a TLR7 agonist, loxoribine effectively stimulates dendritic cell maturation, thereby potentiating T cell-dependent antitumor immunity. This co-delivery system amplifies immune activation by combining PDT-induced pyroptosis with immune agonist, leading to more effective antitumor outcomes. The nanoplatform demonstrated excellent immune activation effects and the ability to reverse the immunosuppressive tumor microenvironment after intravenous administration. Our strategy offered valuable insights for the development of a synergistic strategy for cancer immunotherapy.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
pH-Independent charge-reversal strategy for enhanced tumor penetration based on hyaluronidase-responsive tellurium-containing polycarbonate nanocarriers. 基于透明质酸酶反应的含碲聚碳酸酯纳米载体增强肿瘤穿透的ph无关电荷逆转策略。
Journal of materials chemistry. B Pub Date : 2025-06-20 DOI: 10.1039/d5tb00368g
Jieni Hu, Wang Zhou, Yan Zhou, Haiyan Hu, Shujun Ran, Yan Zhang
{"title":"pH-Independent charge-reversal strategy for enhanced tumor penetration based on hyaluronidase-responsive tellurium-containing polycarbonate nanocarriers.","authors":"Jieni Hu, Wang Zhou, Yan Zhou, Haiyan Hu, Shujun Ran, Yan Zhang","doi":"10.1039/d5tb00368g","DOIUrl":"https://doi.org/10.1039/d5tb00368g","url":null,"abstract":"<p><p>The charge-reversal strategy has been of great significance for enhancing the penetration of nanomedicines in tumors. However, conventional charge reversal has always been confined to pH variation. Herein, we proposed a pH-independent charge-reversal strategy based on hyaluronidase-responsive polycarbonate nanocarriers bearing quaternary ammonium groups. We developed multifunctional polycarbonate-based nanocarriers using tellurium/quaternary ammonium-containing carbonate copolymers. The encapsulation of cisplatin was achieved through coordination complexation with tellurium atoms. The positive charge was shielded from the circulation <i>in vivo</i> by the modification of hyaluronic acid and then exposed in HAase. <i>In vitro</i> cell experiments confirmed the selective killing effect of the drug carriers on pancreatic tumor cells and revealed a mitochondria-targeted pro-apoptotic mechanism. <i>In vivo</i> animal experiments verified the anti-tumor ability and significant tumor tissue penetration ability of the drug carriers. Therefore, the proposed pH-independent deep-tumor-penetration nanocarriers provide a potential nanoplatform for the stable clinical treatment of dense solid tumors.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compiling modules of photosensitizers and quaternary phosphonium blocks into material networks via a co-polymerization strategy: an effective way to fabricate antimicrobial agents against drug resistance. 通过共聚合策略将光敏剂和季磷块模块编译成材料网络:一种制备抗耐药性抗菌剂的有效方法。
Journal of materials chemistry. B Pub Date : 2025-06-20 DOI: 10.1039/d5tb00083a
Jiawei Lv, Cheng Zeng, Richao Shen, Shuangyu Dong, Yong Li, Sanbao Wang, Hongting Fan, Haowen Huang, Zhiwang Yang, Ziqiang Lei, Hengchang Ma
{"title":"Compiling modules of photosensitizers and quaternary phosphonium blocks into material networks <i>via</i> a co-polymerization strategy: an effective way to fabricate antimicrobial agents against drug resistance.","authors":"Jiawei Lv, Cheng Zeng, Richao Shen, Shuangyu Dong, Yong Li, Sanbao Wang, Hongting Fan, Haowen Huang, Zhiwang Yang, Ziqiang Lei, Hengchang Ma","doi":"10.1039/d5tb00083a","DOIUrl":"https://doi.org/10.1039/d5tb00083a","url":null,"abstract":"<p><p>Quaternary ammonium and phosphonium compounds have been widely used as two important classes of antimicrobial agents worldwide. However, over-reliance and misuse of the limited antimicrobial agents have driven the development and spread of resistance of bacteria to these materials. Thus, overcoming the growing bacterial drug resistance is a challenging work in ensuring public health. In this work, we compiled two modules comprising photosensitizers and quaternary phosphonium blocks integrated into material networks <i>via</i> a co-polymerization method, resulting in desired antimicrobial materials with the capability to generate reactive oxygen species (ROS) and exhibiting high affinity towards negatively charged bacterial membranes. This synergistic effect enabled ROS to destroy bacterial membranes within an effective migration distance. As a result, poly(TPAs-2&P<sup>+</sup>-4) was optimized as a promising antibacterial agent, which demonstrated superior bacteria killing and imaging abilities against four bacteria lines, namely, <i>E. coli</i>, methicillin-resistant <i>S. aureus</i>, <i>E. faecalis</i> and <i>P. aeruginosa.</i> The minimum inhibitory concentration (MIC) was determined as 75 μg mL<sup>-1</sup> for <i>E. coli</i> and methicillin-resistant <i>S. aureus</i> and 150 and 350 μg mL<sup>-1</sup> for <i>E. faecalis</i> and <i>P. aeruginosa</i>, respectively.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design of halloysite nanotube-based nanomaterials for theranostic applications: fluorescent probes and chemodynamic activity. 用于治疗应用的高岭土纳米管纳米材料的设计:荧光探针和化学动力学活性。
Journal of materials chemistry. B Pub Date : 2025-06-20 DOI: 10.1039/d5tb00510h
Marina Massaro, Federica Leone, Françisco M Raymo, Raquel de Melo Barbosa, Rita Sánchez-Espejo, César Viseras, Renato Noto, Serena Riela
{"title":"Design of halloysite nanotube-based nanomaterials for theranostic applications: fluorescent probes and chemodynamic activity.","authors":"Marina Massaro, Federica Leone, Françisco M Raymo, Raquel de Melo Barbosa, Rita Sánchez-Espejo, César Viseras, Renato Noto, Serena Riela","doi":"10.1039/d5tb00510h","DOIUrl":"https://doi.org/10.1039/d5tb00510h","url":null,"abstract":"<p><p>The development of theranostic systems is of fundamental importance for the treatment of diseases. These systems should combine the features of fluorescent molecules that can act as diagnostic systems and species with therapeutic potential. Herein, we report the synthesis of a multifunctional halloysite nanotube (HNT)-based nanomaterial <i>via</i> the covalent modification of the external surface of the clay with a halochromic probe and the immobilization of Fe<sub>3</sub>O<sub>4</sub> nanoparticles (HNTs-1@Fe<sub>3</sub>O<sub>4</sub>) with chemodynamic activity. The covalent modification of HNTs was performed using two different synthetic approaches, and the best strategy was evaluated by estimating the degree of functionalization of the clay <i>via</i> thermogravimetric analysis. The synthesized nanomaterial was thoroughly characterized, and its photoluminescence properties under different conditions, <i>i.e.</i> different solvents, pH conditions and temperatures, were studied. The HNTs-1@Fe<sub>3</sub>O<sub>4</sub> nanomaterial was found to exhibit good peroxidase-like activity, as shown by testing its performance in the catalytic oxidation of the colorless enzyme substrate 3,3',5,5'-tetramethylbenzidine (TMB) to blue TMB oxide (ox-TMB) in the presence of H<sub>2</sub>O<sub>2</sub>. This study highlights the usefulness of the covalent approach for modifying halloysite surfaces to generate nanomaterials for potential tissue imaging under different stimuli. In addition, the combination with Fe<sub>3</sub>O<sub>4</sub>NPs led to the synthesis of multifunctional materials with potential use as theranostic systems for the treatment of diseases.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Titanium dioxide/graphene oxide blending into polyethersulfone hollow fiber membranes improves biocompatibility and middle molecular weight separation for bioartificial kidney and hemodialysis applications. 二氧化钛/氧化石墨烯混合到聚醚砜中空纤维膜中,改善了生物相容性和中间分子量分离,用于生物人工肾和血液透析应用。
Journal of materials chemistry. B Pub Date : 2025-06-19 DOI: 10.1039/d5tb00229j
Nidhi Pandey, Jayesh Bellare
{"title":"Titanium dioxide/graphene oxide blending into polyethersulfone hollow fiber membranes improves biocompatibility and middle molecular weight separation for bioartificial kidney and hemodialysis applications.","authors":"Nidhi Pandey, Jayesh Bellare","doi":"10.1039/d5tb00229j","DOIUrl":"https://doi.org/10.1039/d5tb00229j","url":null,"abstract":"<p><p>Hollow fiber membranes (HFMs) are critical components in hemodialysis and bioartificial kidney (BAK) applications, with ongoing research focused on optimizing biomaterials for improved performance. In this study, polyethersulfone (PES) HFMs were modified by incorporating titanium dioxide (TiO<sub>2</sub>) and graphene oxide (GO) during the spinning process. This approach leverages the non-toxicity, hydrophilicity, and dispersion stability of TiO<sub>2</sub> alongside the large surface area of GO to enhance membrane properties. Characterization and performance evaluations demonstrated that TiO<sub>2</sub>/GO-doped PES HFMs exhibit superior biocompatibility and hemocompatibility compared to plain PES, TiO<sub>2</sub>/PES, and GO/PES membranes. Confocal microscopy revealed improved HEK293 cell attachment and proliferation, corroborated by MTT assays showing higher cell viability and flow cytometry indicating no cytotoxic effects. Hemocompatibility tests confirmed negligible hemolysis and anti-inflammatory properties, making the membranes suitable for blood-contacting applications. Furthermore, separation performance analyses highlighted TG(0.5/1.5) as the optimal composition, offering a balance of enhanced toxin removal and cell compatibility. These findings establish TiO<sub>2</sub>/GO-doped PES HFMs as promising candidates for BAK and hemodialysis, combining excellent biocompatibility, hemocompatibility, and separation efficiency.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ROS-responsive conjugated polymer nanoparticles triggered by ultrasound for camptothecin release in breast cancer combination therapy. 超声触发ros响应共轭聚合物纳米颗粒释放喜树碱在乳腺癌联合治疗中的作用。
Journal of materials chemistry. B Pub Date : 2025-06-19 DOI: 10.1039/d5tb00674k
Yipiao Zhang, Tian Tian, Zhaokui Zeng, Chuanpin Chen, Rongrong Wang, Suhong Chen, Hongliang Zheng
{"title":"ROS-responsive conjugated polymer nanoparticles triggered by ultrasound for camptothecin release in breast cancer combination therapy.","authors":"Yipiao Zhang, Tian Tian, Zhaokui Zeng, Chuanpin Chen, Rongrong Wang, Suhong Chen, Hongliang Zheng","doi":"10.1039/d5tb00674k","DOIUrl":"https://doi.org/10.1039/d5tb00674k","url":null,"abstract":"<p><p>The treatment of breast cancer (BC) remains a major challenge. Although chemotherapy is currently the most common treatment, it is limited by high side effects. Responsive drug delivery systems (DDS) enable the controlled release of drugs, which can decrease the side effects of chemotherapy and improve efficacy. However, achieving precise delivery and targeted release of drugs is a major challenge. Here, we present ultrasound-triggered reactive oxygen species (ROS)-responsive conjugated polymer nanoparticles for combination therapy of BC. The conjugated polymer nanoparticles are candidates for the development of potential acoustic sensitizers due to their structural properties with good stability and biocompatible acoustic activation properties. In this study, sono-sensitive polymer nanoparticles (SPN) were used for spatiotemporally controlled sonodynamic therapy (SDT) and ROS-responsive chemotherapy. It was demonstrated that the SPN possessed potent acoustic-dynamic properties and could be activated by ultrasound to generate high levels of ROS, which cleaved ROS-responsive junctions, thereby facilitating the release of camptothecin. Furthermore, the SPN exhibited good long circulation properties and biocompatibility <i>in vivo</i>. The SPN combined with ultrasound treatment showed significant therapeutic effects in both BC cell lines and hormonal mouse models, with tumor suppression rates as high as 76.98 ± 9.09%, and no cardiotoxicity or other side effects were observed. Therefore, the present study provides a feasible strategy for designing novel controlled-release drug systems to improve the therapeutic efficacy of BC.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parallel comparative studies on composition-dependent peroxidase-like catalytic activity of ultrasmall ferrite nanoparticles. 超小铁氧体纳米颗粒组成依赖性过氧化物酶催化活性的平行比较研究。
Journal of materials chemistry. B Pub Date : 2025-06-18 DOI: 10.1039/d5tb00626k
Chunchao Xia, Huan Zhang, Mengmeng Xie, Jiaying Che, Quanqing Feng, Yihan Zhang, Guohang Ma, Minrui Liu, Sixian Hu, Yuan He, Xiaoli Liu, Zhenlin Li, Haiming Fan
{"title":"Parallel comparative studies on composition-dependent peroxidase-like catalytic activity of ultrasmall ferrite nanoparticles.","authors":"Chunchao Xia, Huan Zhang, Mengmeng Xie, Jiaying Che, Quanqing Feng, Yihan Zhang, Guohang Ma, Minrui Liu, Sixian Hu, Yuan He, Xiaoli Liu, Zhenlin Li, Haiming Fan","doi":"10.1039/d5tb00626k","DOIUrl":"https://doi.org/10.1039/d5tb00626k","url":null,"abstract":"<p><p>Ferrite nanoparticles, known for their enzyme-like catalytic activity, have gained significant attention as innovative nanozymes for various catalysis medicine applications. However, the relationship between catalytic activity and ultrasmall ferrite nanoparticle composition remains unclear, which hinders the development of ferrite-based nanozymes with high catalytic performance. Here, we have synthesized a series of ultrasmall ferrite nanozymes for studying their composition dependent peroxidase (POD)-like activity. Initially, their size and surface charge were regulated to assess their impact on POD-like activity. The results indicate that smaller ferrite nanozymes with a negative charge exhibited superior activity when using TMB as the substrate. Subsequently, we examined the ultrasmall ferrite nanozymes with the same size and surface charge but different compositions (CoFe<sub>2</sub>O<sub>4</sub>, MnFe<sub>2</sub>O<sub>4</sub>, and γ-Fe<sub>2</sub>O<sub>3</sub>), and comprehensively investigated the effect of composition on POD-like activity. The results show that the POD-like activity is closely related to the composition of the ultrasmall ferrite nanozymes and the activity order towards TMB is found to be CoFe<sub>2</sub>O<sub>4</sub> > MnFe<sub>2</sub>O<sub>4</sub> > γ-Fe<sub>2</sub>O<sub>3</sub>. By comparing the catalytic performance of nanoparticles with different compositions, the influence of composition on their activity is elucidated. Furthermore, we determined that the optimal pH and temperature for the POD-like catalytic activity of ultrasmall CoFe<sub>2</sub>O<sub>4</sub> nanozyme were pH = 4-4.5 and 30 °C. Under these optimal catalytic conditions, the ultrasmall CoFe<sub>2</sub>O<sub>4</sub> nanozymes exhibited a higher POD-like activity, resulting in increased tumor cell staining intensity. This suggests that ultrasmall CoFe<sub>2</sub>O<sub>4</sub> nanozymes may serve as a viable alternative to horseradish peroxidase for immunohistochemical staining applications. This work provides experimental evidence for designing efficient ultrasmall ferrite catalysts for nanozyme catalysis medicine applications.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing dendritic cells as immunological bridges to potentiate mRNA cancer vaccines. 利用树突状细胞作为免疫桥梁增强mRNA癌症疫苗。
Journal of materials chemistry. B Pub Date : 2025-06-18 DOI: 10.1039/d5tb00995b
Ruiying Wu, Huixin Li, Ziqin Li, Kai Hao, Huayu Tian
{"title":"Harnessing dendritic cells as immunological bridges to potentiate mRNA cancer vaccines.","authors":"Ruiying Wu, Huixin Li, Ziqin Li, Kai Hao, Huayu Tian","doi":"10.1039/d5tb00995b","DOIUrl":"https://doi.org/10.1039/d5tb00995b","url":null,"abstract":"<p><p>mRNA-based cancer vaccines have emerged as a transformative immunotherapy, with dendritic cells (DCs) serving as pivotal orchestrators of innate and adaptive antitumor immunity. This review explores how DCs function as immunological bridges to enhance mRNA vaccine efficacy by integrating antigen presentation with coordinated immune cell crosstalk. We first outline the functional diversity of DC subsets, emphasizing their maturation dynamics and intrinsic potential in mRNA vaccines. Next, we discuss key advancements in mRNA vaccine development, including optimized <i>in vitro</i>-transcribed (IVT) mRNA constructs and delivery platforms <i>in vivo</i>. A central focus is the DC-mediated immune response, detailing mechanisms by which DCs prime cytotoxic CD8<sup>+</sup> T cells, engage CD4<sup>+</sup> T helper cells, activate B cells for humoral responses, and recruit natural killer (NK) cells for innate killing. This review highlights the current understanding of the role of DCs in enhancing mRNA cancer vaccines and provides perspectives on future research directions, aiming to improve cancer immunotherapy outcomes.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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