Journal of materials chemistry. B最新文献

{"title":"Amphiphilic Janus nanoparticles for image-guided cancer treatment: cell internalization mechanism, molecular action, challenges, and outlook.","authors":"Ahmed Madni, Muhammad Zubair Iqbal, Romana Schirhagl, Waheed S Khan, Sadia Z Bajwa","doi":"10.1039/d5tb01548k","DOIUrl":"https://doi.org/10.1039/d5tb01548k","url":null,"abstract":"<p><p>Cancer is recognized as one of the most fatal diseases across the globe. It accounts for approximately 10 million deaths in 2022, while these statistics are even more alarming for low-income countries due to restricted medical facilities for diagnosis and treatment. The application of conventional treatments, including chemotherapy, radiation therapy, and surgery, causes adverse side effects by damaging healthy cells and inducing drug resistance. Therefore, these treatments are increasingly approached with caution by medical practitioners and clinicians, who are actively seeking safer and more effective alternatives. The advent of nanotechnology has opened new opportunities where multifunctional nanoscale components can be integrated to fabricate hybrid nanostructures. Structures such as Janus nanoparticles (JNPs) hold significant promise in cancer imaging and drug delivery applications. JNPs provide novel opportunities for the formation of multidrug nanosystems or combinations of tracking and therapeutic moieties for cancer treatment. This review discusses the latest studies on amphiphilic JNPs and further describes the mechanisms that are followed to internalize and exert their function against cancer. Various challenges in the synthesis and use of JNPs are also highlighted in addition to the prospects, indicating options for cancer treatment in pre-clinical and clinical applications.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Self-assembling peptide nanomaterials co-engineered with linoleic acid and catechol motifs for synergistic ferroptosis-photothermal therapy-chemotherapy.","authors":"Binbin Gao, Xin Tian, Xinming Li","doi":"10.1039/d5tb90170g","DOIUrl":"https://doi.org/10.1039/d5tb90170g","url":null,"abstract":"<p><p>Correction for 'Self-assembling peptide nanomaterials co-engineered with linoleic acid and catechol motifs for synergistic ferroptosis-photothermal therapy-chemotherapy' by Binbin Gao <i>et al.</i>, <i>J. Mater. Chem. B</i>, 2025, <b>13</b>, 8808-8818, https://doi.org/10.1039/D5TB00700C.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D bioprinting of biomimetic self-assembling peptides and neural stem cells for nervous tissue engineering.","authors":"Hugues Mondésert, Chiara Malloggi, Andrea Lazzaro, Giulia Sala, Valentina Corvaglia, Mahdi Forouharshad, Fabrizio Gelain","doi":"10.1039/d5tb00279f","DOIUrl":"https://doi.org/10.1039/d5tb00279f","url":null,"abstract":"<p><p>Tissue engineering involves the creation of biological constructs using scaffolds, cells, and therapeutic factors. 3D bioprinting, using hydrogels as bioinks, allows precise deposition of cells and materials to develop 3D scaffolds with tunable shapes and porosity. Self-assembling peptide (SAP) hydrogels are gaining attention due to their nanofibrillar structure, biomimetic properties, biocompatibility, and ready tailoring for specific tissues. This study focuses on the development of 3D printed scaffolds using a SAP-based bioink, composed of a linear SAP and a blend of linear, branched, and functionalized SAPs, which promotes cell adhesion and differentiation, for nervous tissue engineering applications. A microfluidic RX1 bioprinter equipped with a coaxial printhead allowed precise control over cell deposition while minimising shear stress during printing. The printing process was optimised by testing different parameters and investigating rheological properties of the bioink, resulting in the successful printing of up to 10-mm-diameter ring-shaped and self-standing scaffolds. Scanning electron microscopy analyses revealed a highly porous nanofiber structure. Encapsulation of murine neural stem cells was achieved through two strategies: Strategy 1, in which SAP and cells were loaded separately, and Strategy 2, in which SAP and cells were mixed before printing. Although cell viability was slightly lower in the bioprinted constructs compared to the control, it increased over time with both strategies. Within 7 days, cells adhered well, sprouted, and differentiated into the main neural phenotypes (neurons, astrocytes, and oligodendrocytes). The present results confirm the potential of SAPs as bioinks for nervous tissue engineering applications.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Component design and functionalization of absorbable bone wax: from bench to bedside.","authors":"Ziyi Li, Sefei Yang, Jinglong Yan, Xuefeng Kang, Dechang Jia, Yu Zhou, Baoqiang Li","doi":"10.1039/d5tb01328c","DOIUrl":"https://doi.org/10.1039/d5tb01328c","url":null,"abstract":"<p><p>The development of safe and efficient absorbable bone wax is urgently required by orthopedic surgeons. Bone wax lacks absorbability and multifunctional properties in clinical practice. The most critical factors determining the successful clinical outcome of absorbable bone wax are absorbability and functionalization, which largely depend on component design. This comprehensive review demonstrates the development of the component design and functionalization of absorbable bone wax from bench to bedside. First, absorbable bone wax is classified into alkylene oxide copolymer-based, polyester-based, and bioceramic cement-based categories, and the component-correlated absorbability is analyzed. Second, the relationship between components and functional outcomes (hemostasis, osteogenesis, and antibacterial activity) is also elucidated. Finally, this review summarizes the clinical advantages and limitations of commercial absorbable bone wax. We look forward to the trends of absorbable bone wax, including controllable degradation, multifunctional integration and standardized evaluation frameworks to bridge translational gaps, which are beneficial to accelerate the transformation of absorbable bone wax from a passive hemostatic agent into an intelligent, tissue-regenerative platform for precision orthopedics.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carrier-free single-molecule hypoxia-activated nanoprodrug of SN38 with ultrahigh drug loading for pancreatic cancer treatment.","authors":"Amrit Regmi, Mouhmad Elayyan, Safiya Nisar, Binglin Sui","doi":"10.1039/d5tb01434d","DOIUrl":"https://doi.org/10.1039/d5tb01434d","url":null,"abstract":"<p><p>Pancreatic cancer remains one of the most lethal malignancies for human health. The anticancer drug SN38 has been proven effective against pancreatic cancer cells; however, its clinical application is limited by its poor aqueous solubility and restricted bioavailability <i>in vivo</i>. In this work, we developed a novel carrier-free single-molecule hypoxia-responsive nanoprodrug of SN38 for the treatment of pancreatic tumors. The nanoprodrug has an ultrahigh drug-loading content of ∼80 wt% and a nanoscale size of ∼50 nm. The drug molecules are masked by a hypoxia-sensitive aromatic azo group in the nanoprodrug, thereby shielding the therapeutic effects and toxicities of SN38 under normoxic conditions. Thus, the toxicity of the new regimen toward healthy cells and tissues is alleviated. In response to the upregulated level of azoreductase enzymes in the hypoxic tumor microenvironment, SN38 molecules are released <i>in situ</i> with their intact structures, exerting a powerful suppressive effect on tumor cells.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanocarbon dots enhancing photothermal therapy for cancer: mechanisms, synergistic strategies, and frontier advances.","authors":"Youan Ji, Suyao Yan, Wenshi Xu, Mengyao Yang, Aibing Chen, Senlin Hou, Juan Du","doi":"10.1039/d5tb01971k","DOIUrl":"https://doi.org/10.1039/d5tb01971k","url":null,"abstract":"<p><p>Cancer, a significant global public health challenge, continues to have high incidence and mortality rates. Photothermal therapy (PTT), as a novel non-invasive treatment, uses photothermal agents to convert light energy into heat energy to precisely kill cancer cells. Nanocarbon dots (CDs) have attracted increasing attention as photothermal agents for cancer therapy due to their good biocompatibility, tunable optical properties, and facile synthesis. This review summarizes the recent progress in CDs for PTT, with a focus on structure-property relationships and performance optimization. We first present the main synthesis strategies of CDs, including top-down and bottom-up approaches, and discuss how precursors, doping, and surface modification influence their photothermal conversion efficiency. The structural characteristics of various CDs reported in the literature are illustrated to highlight the correlation between composition and photothermal behavior. Subsequently, the application of CDs in PTT is reviewed, covering their use in combination with chemotherapy, immunotherapy, and other modalities. We also discuss current challenges, including long-term biosafety, standardized evaluation criteria, and clinical translation. By systematically outlining the design, synthesis, and therapeutic application of photothermal CDs, this review provides a comprehensive theoretical basis and practical guidance for the clinical application of CDs in cancer therapy.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An oxidized dextran and thiolated chitosan-based hydrogel driven biomimetic triple negative breast cancer 3D <i>in vitro</i> model for cancer progression and therapeutic studies.","authors":"Unnati Modi, Pooja Makwana, Bindiya Dhimmar, Soundharya Ramu, Mohit Kumar Jolly, Rajesh Vasita","doi":"10.1039/d5tb00812c","DOIUrl":"https://doi.org/10.1039/d5tb00812c","url":null,"abstract":"<p><p>In the advancing field of <i>in vitro</i> cancer modeling, three-dimensional (3D) culture systems are increasingly recognized for their ability to recapitulate critical tumor-specific characteristics. Given the aggressive nature and high mortality associated with triple-negative breast cancer (TNBC), there is a pressing need to develop physiologically relevant 3D <i>in vitro</i> models that effectively simulate key tumor promoting factors (TPFs). This study presents a modified dextran-chitosan (MDC) hydrogel with engineered non-fouling properties that supports the formation of MDA-MB-231-derived 3D tumoroids. The hydrogel facilitated upregulated expression of extracellular matrix markers, including COL1A1 (2.29-fold↑) and FN1 (0.84-fold↑). Cell proliferation within 3D cultures was significantly reduced on days 2 (<i>p</i> < 0.001), 4 (<i>p</i> < 0.0001), and 6 (<i>p</i> < 0.001) compared to 2D cultures. Enhanced hypoxic conditions (based on EF5 adducts' fluorescence; <i>p</i> < 0.0001), epithelial-to-mesenchymal transition (EMT) traits, and stemness marker expression [<i>e.g.</i>, NANOG (3.33-fold↑)] were observed in 3D tumoroids. Additionally, the 3D tumor microenvironment showed elevated activity of key TPFs, including IL6, IL10, TNFA, FGF2, BMP2, and active TGFB (<i>p</i> < 0.0001). The MDC hydrogel, with stiffness mimicking breast tissue (∼11 kPa), also promoted mechanotransducive signalling, evidenced by increased YAP1 expression (2.4-fold↑) and a significantly elevated nuclear-to-cytoplasmic YAP1 ratio (<i>p</i> < 0.0001) relative to 2D cultures on TCPS (∼3 GPa). Whole transcriptome sequencing and gene set enrichment analyses further validated the enhanced tumorigenic phenotype of the 3D model. Moreover, the 3D tumoroids exhibited significant resistance (<i>p</i> < 0.001) to combined doxorubicin-paclitaxel treatment. Thus, the MDC hydrogel-based 3D TNBC model emerges as a robust and scalable platform for anticancer drug screening, evaluating precision medicine and investigating cancer biology.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial S-layer protein inspired multifunctional peptide for dentin restoration <i>via</i> intrafibrillar mineralization facilitating.","authors":"Ziqian Lu, Yili Guo, Qian Ren, Die Hu, Wei Yin, Yubing Zhang, Manxuan Liu, Zhongcheng Li, Linglin Zhang","doi":"10.1039/d5tb01789k","DOIUrl":"https://doi.org/10.1039/d5tb01789k","url":null,"abstract":"<p><p>Intrafibrillar mineralization, essential for dentin restoration, necessitates precise coordination of microenvironmental factors. Current research on peptide-mediated collagen mineralization often lacks a comprehensive exploration of multifunctionality, focusing instead on isolated aspects such as self-assembly, nucleation ability, or collagen binding. Bacterial S-layer proteins, with their intrinsic self-assembly, collagen-binding features, and ion-capturing functions, offer a blueprint for integrating multifunctionality. Building on these features, we engineer a multifunctional self-assembly peptide (SlpB-21) that integrates essential capabilities to promote collagen mineralization. This innovative peptide synergistically enhances interactions with Ca²⁺ and type I collagen, driving the biomimetic process of intrafibrillar mineralization, which is critical for dentin restoration. Functioning as an \"intermediate gripper\", SlpB-21 efficiently assembles onto demineralized dentin collagen fibrils and directs ordered mineral deposition. Utilizing molecular dynamics simulations and stochastic optical reconstruction microscopy, the research systematically investigates the peptide's self-assembly, its mechanisms of interaction with collagen fibrils and Ca²⁺, and its role in mediating intrafibrillar mineralization. <i>In vitro</i> and <i>in vivo</i> experiments demonstrate the potential of SlpB-21 for biomimetic dentin repair. This study highlights SlpB-21 as a pioneering material for dentin restoration, introducing a novel strategy for biomimetic repair and offering promising avenues for treating early dentin caries.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular matrix-mimicking cryogels in tissue engineering and cancer therapy: from structural design to translational applications abstract.","authors":"Yilong Liu, Canhong Li, Taifu Zhu, Ruiqi Li, Mu Zhang, Xiaoling Li, Dingjun Cai, Zhifei Dai, Lei Wan, Haibin Lu","doi":"10.1039/d5tb01412c","DOIUrl":"https://doi.org/10.1039/d5tb01412c","url":null,"abstract":"<p><p>Cryogels are a class of macroporous hydrogels fabricated through a cryogelation process at sub-zero temperatures, resulting in a highly interconnected pore structure. This review focuses on cryogels that mimic the natural extracellular matrix (ECM) in composition and molecular architecture. These cryogels not only exhibit the high mechanical strength and elasticity characteristic of traditional cryogels but also possess unique structural features and excellent biocompatibility, providing a supportive microenvironment for cellular vitality and metabolic activity. The interconnected pores of cryogels facilitate the establishment of controllable mass transport and oxygen gradients, making them particularly advantageous for applications such as hypoxic tumor modeling where precise microenvironment control is essential. They also show great promise in vaccine development, drug delivery and screening, and combination chemotherapies. These features position cryogels as an ideal platform for cancer research. This review summarizes the principles, processes, and preparation methods of cryogelation for developing ECM-mimicking cryogels. Furthermore, it discusses the effects of polymer composition, crosslinking agents, freezing conditions, and other factors on the physical, chemical, and biological properties of cryogels. Finally, the biomedical applications of ECM-mimicking cryogels are explored, illustrating their potential roles in tissue engineering, cancer research, and therapeutic interventions.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multifunctional theranostic nanoagent for precise NIR-II FL imaging and synergistic chemodynamic/H2/SGB therapy of allergic rhinitis.","authors":"Weiwei Zhang, Lin Chen, Chunmei Jiang, Shutong Wu, Zhigan Lv, Ning Zhang, Wenjing Cui, Qin Liu, Rong Dai, Ziliang Zheng, Ruiping Zhang","doi":"10.1039/d5tb01086a","DOIUrl":"https://doi.org/10.1039/d5tb01086a","url":null,"abstract":"<p><p>Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa mediated by immunoglobulin E (IgE) and characterized by infiltration of inflammatory cells, such as eosinophils, and excessive production of reactive oxygen species (ROS). Alleviating oxidative stress and inflammation at AR sites is an effective approach for improving pathological conditions and modulating the microenvironment. Herein, we have developed novel multifunctional theranostic nanoagents (ACB NGs) to achieve precise and rapid second near-infrared fluorescence (NIR-II FL) imaging and a promising combination treatment of synergistic chemodynamic/gas/stellate ganglion block (SGB) therapy. With suitable size and excellent biocompatibility, ACB NGs passively target AR inflammatory sites to realize effective accumulation. Then, the Ce³⁺/Ce⁴⁺ redox pair can exhibit SOD/CAT-like enzymatic activity to rapidly deplete ROS to alleviate oxidative stress and inflammation. Simultaneously, the controlled release of hydrogen (H₂) in a slightly acidic environment results in precise synergistic antioxidative and anti-inflammatory effects with CeO₂. Moreover, SGB therapy further inhibits the secretion of pro-inflammatory cytokines and reduces oxidative stress, achieving a therapeutic effect by modulating the inflammatory microenvironment in AR. In summary, ACB NGs represent novel biomineralized nanoagents offering efficient combination therapy, which will provide new perspectives for the treatment and monitoring of AR.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145277042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}