Journal of materials chemistry. B最新文献_第2页

Bioelectronics: Emerging trends and applications. 生物电子学：新兴趋势和应用。

Journal of materials chemistry. B Pub Date : 2025-06-02 DOI: 10.1039/d5tb90077h

Anna-Maria Pappa, Eleonora Macchia, Hong Liu, George Malliaras

引用次数: 0

Membrane fusogenic liposomes facilitate the production of immunostimulatory extracellular vesicles for enhanced cancer therapy. 膜促聚变脂质体促进免疫刺激细胞外囊泡的产生，以增强癌症治疗。

Journal of materials chemistry. B Pub Date : 2025-06-02 DOI: 10.1039/d4tb02807d

Qi Xie, Yuan Gao, Wei Chen, Haoyu Zhang, Chuansheng Fu, Samira Batur, Yixuan Zhou, Yang Li, Jiao Zhang, Zhiping Zhang, Li Kong

{"title":"Membrane fusogenic liposomes facilitate the production of immunostimulatory extracellular vesicles for enhanced cancer therapy.","authors":"Qi Xie, Yuan Gao, Wei Chen, Haoyu Zhang, Chuansheng Fu, Samira Batur, Yixuan Zhou, Yang Li, Jiao Zhang, Zhiping Zhang, Li Kong","doi":"10.1039/d4tb02807d","DOIUrl":"https://doi.org/10.1039/d4tb02807d","url":null,"abstract":"Cancer therapy based on extracellular vesicles faces several practical challenges, such as low production, inadequate stability, and inefficiency, making it difficult to achieve ideal therapeutic effects. To address these issues, a novel engineering technology of EVs was developed based on the autonomous \"fusion-exocytosis\" process. Specifically, membrane fusogenic liposomes (MFLs) with unique physical and chemical properties were engineered by tailoring the components, which could interact with cells to facilitate mutual fusion of lipid membranes and release fusogenic extracellular vesicles (FEVs). As an inducer of immunogenic cell death (ICD) and enhancer of EV production, monensin (Mon) was incorporated into MFLs. The synergistic action of MFLs and Mon not only increased the production of released FEVs but also significantly enhanced their immunogenicity, effectively promoting maturation of dendritic cells (DCs). Consequently, the obtained FEVs effectively inhibited tumor growth by activating anti-cancer immune responses. This engineering method of generating FEVs could substantially increase production and enhance immunogenicity, which would facilitate their clinical translation for cancer therapy.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymeric nanocarriers for cancer treatment: the promise of sensitive poly(2-(diisopropylamino)ethyl methacrylate). 用于癌症治疗的高分子纳米载体：敏感的聚(2-（二异丙基氨基）甲基丙烯酸乙酯的前景。

Journal of materials chemistry. B Pub Date : 2025-05-30 DOI: 10.1039/d5tb00268k

Joana S Ferreira, João P Vareda, A S Oliveira, Jéssica S Barbosa, Francisca Bastos, Patrícia V Mendonça, A C Fonseca

{"title":"Polymeric nanocarriers for cancer treatment: the promise of sensitive poly(2-(diisopropylamino)ethyl methacrylate).","authors":"Joana S Ferreira, João P Vareda, A S Oliveira, Jéssica S Barbosa, Francisca Bastos, Patrícia V Mendonça, A C Fonseca","doi":"10.1039/d5tb00268k","DOIUrl":"https://doi.org/10.1039/d5tb00268k","url":null,"abstract":"Polymeric nanoparticles are extremely valuable carriers for drug/gene delivery to treat cancer, as they can protect different therapeutic agents during blood circulation while being able to deliver them at desired locations. Owing to the versatility of polymers, it is possible to fine-tune the performance of nanocarriers by changing different properties, such as chemical structure, architecture, composition and molecular weight or even by functionalising the polymers with targeting molecules. The use of pH-sensitive polymers is a very popular strategy to prepare smart carriers, taking advantage of the acidic intratumoural environment to induce hydrophobic/hydrophilic transitions that allow fast and efficient release of small drugs or genetic material. This review summarizes the contributions of the use of promising pH-sensitive poly(2-(diisopropylamino)ethyl methacrylate) (PDPA), with pKa around 6.2, in the preparation of nanocarriers for the treatment of different types of cancer through gene therapy, drug delivery or photodynamic therapy. Interest in PDPA-based copolymers for biomedical applications is increasing, as different studies have reported successful encapsulation and delivery of different therapeutic molecules with PDPA-based smart nanocarriers. In vivo studies have shown that tumour growth can be suppressed, revealing the potential of new cancer therapies.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and study of amorphous calcium phosphate dual-targeted drug-carrying platforms. 无定形磷酸钙双靶向载药平台的合成与研究。

Journal of materials chemistry. B Pub Date : 2025-05-30 DOI: 10.1039/d5tb00525f

Huan Hong, Wentao Ma, Yushuang Jiao, Bo Cheng, Jing Yang, Binbin Li, Xinyu Wang

{"title":"Synthesis and study of amorphous calcium phosphate dual-targeted drug-carrying platforms.","authors":"Huan Hong, Wentao Ma, Yushuang Jiao, Bo Cheng, Jing Yang, Binbin Li, Xinyu Wang","doi":"10.1039/d5tb00525f","DOIUrl":"https://doi.org/10.1039/d5tb00525f","url":null,"abstract":"Atherosclerosis (AS) has emerged as a significant worldwide health challenge, necessitating the development of a drug-loading platform to achieve precise delivery of anti-AS therapeutics to lesion sites, thereby mitigating its impact. Given the mildly acidic microenvironment and the abundance of activated macrophages overexpressing scavenger receptor class A (SR-A) at AS lesions, we fabricated a pH-responsive, SR-A-targeting multifunctional drug-loading platform (dextran sulfate-heparin/amorphous calcium phosphate, DS-HEP/ACP) via the coprecipitation method. This design enables efficient delivery of the platform to AS plaques with minimal drug loss during systemic circulation. In this study, we characterized the fundamental properties and biological performance of the synthesized DS-HEP/ACP platform and evaluated the anti-AS efficacy of the atorvastatin calcium (AT)-loaded DS-HEP/ACP@AT system in vitro. In vitro drug release results demonstrated that the platform exhibited superior controlled drug release properties, prolonged drug circulation under physiological conditions, while releasing the drug in the weakly acidic microenvironment of AS. Cellular uptake experiments revealed that the modification of the carrier with DS enabled the drug-loading platform to demonstrate efficient uptake through SR-A receptor-specific mechanisms in stimulated macrophages, achieved via specific receptor-mediated targeting strategies. In anti-AS evaluations, the DS-HEP/ACP@AT system demonstrated anti-inflammatory and lipid-lowering effects in vitro, outperforming monotherapy by combining AT-driven lipid reduction with the platform's intrinsic ability to block phagocytosis of oxidized low-density lipoprotein (Ox-LDL) by macrophages. This dual-targeting AS drug-loading platform achieved precise drug delivery, controlled drug release, and enhanced anti-AS efficacy. In summary, our study validates the DS-HEP/ACP@AT system as a promising candidate for AS therapy.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collagen/fibronectin-based lung carcinoma culture platform: development and characterization of a new tumor model for vascular mimicry study. 基于胶原/纤维连接蛋白的肺癌培养平台：血管模拟研究的新肿瘤模型的开发和表征。

Journal of materials chemistry. B Pub Date : 2025-05-30 DOI: 10.1039/d5tb00673b

Qun Huang, Xinrui Xu, Zulala Halbiyat, Xuebo Wei, Lei Wang, Junjie Ren, Ke Xu, Tingjuan Huang, Qizhi Shuai

{"title":"Collagen/fibronectin-based lung carcinoma culture platform: development and characterization of a new tumor model for vascular mimicry study.","authors":"Qun Huang, Xinrui Xu, Zulala Halbiyat, Xuebo Wei, Lei Wang, Junjie Ren, Ke Xu, Tingjuan Huang, Qizhi Shuai","doi":"10.1039/d5tb00673b","DOIUrl":"https://doi.org/10.1039/d5tb00673b","url":null,"abstract":"Lung cancer is a prevalent and deadly malignancy worldwide. Traditional angiogenesis has been augmented by the discovery of vascular mimicry (VM), an alternative mechanism where tumor cells form vascular-like structures that contribute to tumor aggressiveness independent of endothelial vessels. The study of VM has been constrained by limitations in existing in vitro models, particularly conventional tissue culture-treated plates, which fail to fully replicate the complex tumor microenvironment. Existing biomimetic models are yet to effectively reproduce VM signatures specific to non-small cell lung cancer (NSCLC), hindering further research and therapeutic development. In this context, our research aimed to address these challenges by exploring collagen/fibronectin biological macromolecules as novel biomimetic environments to study VM in NSCLC. Here, we created a collagen/fibronectin-based engineered tumor model both in vivo and in vitro to explore how these matrices affect cellular behaviors, including proliferation, colony formation, migration, stemness, and VM formation. Using extensive gene expression profiling, we characterized NSCLC cells grown in these matrices to identify key genes influencing VM formation. Furthermore, we selected two reported anti-tumor drugs and their potential VM inhibitory effects and verified the practical application of this model by developing a VM-rich tumor model in vivo. Our findings underscore the pivotal role of ECM components, particularly collagen and fibronectin, in modulating critical biological processes in cancer and VM formation. In addition, the two antitumor agents we selected have the potential to inhibit VM occurrence. By simulating the ECM environment conducive to VM, we developed a VM-rich tumor model, and our study provided insights into potential mechanisms underlying VM formation and its regulation in NSCLC.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromogenic ecdysis of Au@Ag nanorods assembled in a hydrogel for selective detection of ammonia vapors in food. 水凝胶中组装的Au@Ag纳米棒的显色电泳选择性检测食品中的氨蒸汽。

Journal of materials chemistry. B Pub Date : 2025-05-29 DOI: 10.1039/d5tb00636h

Mahima Chandel, Prem Singh, Kamaljit Kaur, Lalitya Chadalawada, T S Abhijith, Keshav Bhardwaj, Amit Jaiswal, Vijayakumar Shanmugam

引用次数: 0

Key challenges and coping strategies for the detection of bacteria at ultralow concentrations. 超低浓度细菌检测的主要挑战和应对策略。

Journal of materials chemistry. B Pub Date : 2025-05-29 DOI: 10.1039/d5tb00176e

Zhentan Lu, Siwei Zhang, Qiue Yin, Weihong Chen, Le Zhou, Shan Liu, Dong Wang

引用次数: 0

Ultrasensitive detection of arsenic in water using laser-scribed graphene-based electrodes. 利用激光刻写石墨烯基电极对水中砷的超灵敏检测。

Journal of materials chemistry. B Pub Date : 2025-05-29 DOI: 10.1039/d5tb00041f

Abhinandan Mohanty, Shubham Upadhye, Gopal K Pradhan, Pranati Nayak

引用次数: 0

Impact of protein corona and light modulation on the antibacterial activity of light-activated silver nanoparticles. 蛋白电晕和光调制对光活化银纳米粒子抑菌活性的影响。

Journal of materials chemistry. B Pub Date : 2025-05-29 DOI: 10.1039/d5tb00081e

Varsha Godakhindi, Anjumana Jannati Nur, Mariya Munir, Juan L Vivero-Escoto

{"title":"Impact of protein corona and light modulation on the antibacterial activity of light-activated silver nanoparticles.","authors":"Varsha Godakhindi, Anjumana Jannati Nur, Mariya Munir, Juan L Vivero-Escoto","doi":"10.1039/d5tb00081e","DOIUrl":"10.1039/d5tb00081e","url":null,"abstract":"Silver nanoparticles (AgNPs) as antimicrobial agents have gained extensive popularity due to their broad-spectrum action. Recently, AgNPs have been combined with photosensitizers (PS) to develop a synergistic antimicrobial effect. This synergy is associated with the light-activated increase in the release of Ag+, which drives the antibacterial mechanism against antibiotic-resistant bacteria (ARB). A factor typically not considered in the performance of AgNPs is the environmental conditions, such as salt and protein content, that significantly impact their bactericidal effect. In this work, we used protoporphyrin IX (PpIX) as a PS to synthesize PpIX-AgNPs. We elucidated the critical role of environmental conditions on the colloidal stability of PpIX-AgNPs in different bacterial culture media. We also determined the impact of the culture media on the light-activated release kinetics of Ag+. We found that cell media with lower protein and higher salt content drive the colloidal stability and release kinetics of Ag+ from AgNPs. Furthermore, we have shown that the multiple-irradiation approach of this light-controlled platform maximizes the release of Ag+ and promotes effective antibacterial action. We successfully tested this multiple-irradiation strategy in methicillin-resistant Staphylococcus aureus (MRSA) demonstrating ∼7-log-unit reduction at 1.5 μg mL-1 of PpIX-AgNP. A 6-log-unit MRSA inhibition was achieved in the nutrient broth (NB) media under the same irradiation strategy. We envision that this light-activated PpIX-AgNPs system can overcome major issues with the elimination of ARB and reduce side effects.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supramolecular hydrogels derived from 2 : 1-[α/aza]-pseudopeptides: design, structural analysis and self-assembly in solution, solid, and gel states. 由2:1 -[α/aza]-假多肽衍生的超分子水凝胶：溶液、固体和凝胶态的设计、结构分析和自组装。

Journal of materials chemistry. B Pub Date : 2025-05-29 DOI: 10.1039/d4tb02288b

Mohamed I A Ibrahim, Jacques Bodiguel, Guillaume Pickaert, Loïc Stefan, Koichi Matsuo, Marie-Christine Averlant-Petit

{"title":"Supramolecular hydrogels derived from 2 : 1-[α/aza]-pseudopeptides: design, structural analysis and self-assembly in solution, solid, and gel states.","authors":"Mohamed I A Ibrahim, Jacques Bodiguel, Guillaume Pickaert, Loïc Stefan, Koichi Matsuo, Marie-Christine Averlant-Petit","doi":"10.1039/d4tb02288b","DOIUrl":"https://doi.org/10.1039/d4tb02288b","url":null,"abstract":"Synthesis of innovating supramolecular hydrogels based on low molecular weight gelators (LMWGs < 2000 Da) has gained significant interest within the scientific research community due to their wide-ranging potential applications. Most supramolecular hydrogels, induced by a self-assembly process, are stabilized via non-covalent interactions. Recently, our research group has investigated the gelation properties of new low molecular weight hydrogelators (LWMHGs) based on Fmoc-functionalized 2 : 1-[α/aza]-azapeptides. This study presents the synthesis and characterization of two Fmoc-N-functionalized 2 : 1-[α/aza]-trimers: Fmoc-FazaFA (1) and Fmoc-D-FazaFA (2). Both molecules have demonstrated their capability to form hydrogels at pH 7.0 and 10.0, and the analysis of their monomeric states in solution using spectroscopic techniques (including NMR and FTIR) and in the crystal state (using X-ray diffraction) revealed a β-turn conformation. Molecular dynamics simulations were used for 3D model determination. Additionally, the structure of both molecules in the gel state was examined by circular dichroism (CD) experiments. The findings have confirmed that intermolecular hydrogen bonding and π-stacking between the aromatic moieties are the primary driving forces behind the self-assembly and hydrogelation phenomena. Rheology measurements validated the solid-like behavior of both hydrogels (G' > G'' within the studied frequency range). Finally, the self-assembly is emphasized through the fibrous structure observed by SEM imaging.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0