Journal of materials chemistry. B最新文献

{"title":"A state-of-the-art review of multi-cross-linked hydrophobic associated hydrogels for soft electronic, biomedical, and environmental applications.","authors":"Pooria Rahmani, Akbar Shojaei, Mohammadreza Sahabi, Mohammad Akbarizadeh, Mani Mahmoodi, Aref Zarghanishiraz","doi":"10.1039/d5tb00506j","DOIUrl":"https://doi.org/10.1039/d5tb00506j","url":null,"abstract":"<p><p>Thanks to their considerable toughness, self-recoverability, high swelling degree and stimuli-responsiveness, hydrophobic association (HA) hydrogels are promising in wearable electronics, biomedical applications and the water treatment industry. Multiple (physical and/or chemical) cross-links can also promote the above-mentioned properties, broadening the applications of the gels. Previous reviews on the HA hydrogels focused only on their mechanical and self-healing properties for biomedical applications. Herein, we aim to introduce HA hydrogels having multiple crosslinks (multi-cross-linked HA (MCHA) gels), discuss their various properties, and then present their (potential) practical applications. To explain, this review first describes the synthesis of MCHA gels. Then, the mechanical, rheological, self-healing, injectability, swelling, and stimuli-responsive properties of MCHA hydrogels are discussed. In the meantime, we suggest useful approaches to address the current challenges for the sake of improving these properties. Finally, based on the properties of MCHA gels, we introduce their (potential) applications in the fields of soft electronics, biomedicine, the environment, and superabsorbents, followed by evaluation of the performance of the developed devices in some cases. Taken together, this review can provide helpful perspectives for developing high-performance MCHA hydrogels.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boosting PDT with DPA-NI-Bu: high photocytotoxicity through redox homeostasis perturbation.","authors":"Jingwen Tu, Zhiyuan Wang, Mengzhao Zhang, Suntao Shi, Miao Zhong, Zhengyu Ma, Haijuan Zhang, Jiang Wu, Zhongtian Bai, Baoxin Zhang","doi":"10.1039/d5tb00693g","DOIUrl":"https://doi.org/10.1039/d5tb00693g","url":null,"abstract":"<p><p>Photodynamic therapy (PDT) is a promising cancer treatment that relies on reactive oxygen species (ROS) to disrupt cellular redox homeostasis, ultimately leading to cell death. The thioredoxin (Trx) system is a pivotal regulatory system for antioxidant defence, which plays a key role in immune response and cell death. Thus, perturbating the Trx system could enhance the efficacy of PDT. Naphthalimide skeletons are research hotspots in photosensitizers due to their tunable photophysical properties and high ROS yield. A series of novel photosensitizers based on naphthalimide skeletons were designed and synthesized here. Photocytotoxicity assays demonstrated that most compounds possessed considerable photosensitive effects, and DPA-NI-Bu exhibited the highest photocytotoxicity (phototoxicity index > 66.23) with IC₅₀ values of 1.51 ± 0.32 μM upon light activation. Mechanistic studies revealed that DPA-NI-Bu significantly disrupts intracellular redox homeostasis by disrupting the Trx system and glutathione (GSH) system, thereby promoting apoptosis. Furthermore, clone formation assays showed that DPA-NI-Bu exerted a potent photodynamic effect, inhibiting tumor cell proliferation by 94.9 ± 2.8%. These findings highlight the significant improvement in photosensitizing properties through structural modification and offer valuable insights for designing more effective photosensitizers for PDT applications.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144628353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autologous extracellular vesicles derived from conjunctival squamous cell carcinoma deliver therapeutic microRNAs to induce apoptosis in originating cancer.","authors":"Suresh Thangudu, Sourabh Mehta, Hala Shakib Dhowre, Sanja Bojic, Golnaz Haghverdi, Albert Y Wu, Tarik F Massoud, Ramasamy Paulmurugan","doi":"10.1039/d5tb00587f","DOIUrl":"10.1039/d5tb00587f","url":null,"abstract":"<p><p>There are significant challenges in treating advanced and recurrent conjunctival squamous cell carcinoma (cSCC). Therapeutic miRNAs directed at cSCC may have anticancer potential, but questions remain regarding efficiency of their targeted delivery. In this study, we address limitations of miRNA delivery by engineering autologous extracellular vesicles (EVs) of ∼130 nm sizes derived from cSCC UMSCC9 cells and tumors (cSCC-EVs) using a microfluidic based reconstruction system. We ICG-labelled these cSCC-EVs to enable subsequent tracking of miRNA delivery to tumors <i>in vivo</i>, and loaded them with Cy5-labelled antimiR-10b to monitor delivery efficiency of miRNA-ICG-EVs <i>in vitro</i> and <i>in vivo</i> using optical imaging. We characterized miRNA-ICG-EVs and confirmed their successful internalization into UMSCC9 cells in culture using confocal microscopy and FACS analysis. In an orthotopic subconjunctival implantation mouse model of cSCC, fluorescence signals in miRNA-ICG-EV-treated mice remained strong at tumor locations even 96 h after <i>in vivo</i> administration. We found in mice treated with miRNA-ICG-EVs that there were significantly higher levels of both intracellular Cy5-antimiR-10b on <i>ex vivo</i> tumor histological analysis, and antimiR-10b-induced apoptotic cells in tumors on TUNEL assay, as well as a significant reduction in tumor growth on <i>in vivo</i> optical coherence tomography and <i>ex vivo</i> H&E staining. Taken together, we show that targeted delivery of therapeutic miRNAs encapsulated within autologously-derived EVs may have substantial potential in future adjunctive clinical treatment for cSCC. This novel approach may provide a minimally invasive and personalized strategy that could be combined with topical chemotherapy in future clinical applications.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical immunosensor for antibody recognition against SARS-CoV-2 B-cell epitope: impact of RBD mutations on antigen-antibody binding.","authors":"Freddy A Nunez, Vivian L de Oliveira, Cesar Remuzgo, Marcos R de A Silva, Isabela Daher, Jamille R Oliveira, Tamires L Silva, Edecio Cunha-Neto, Jorge Kalil, Keity S Santos, Quinn A Besford, Wendel A Alves","doi":"10.1039/d5tb00630a","DOIUrl":"https://doi.org/10.1039/d5tb00630a","url":null,"abstract":"<p><p>During the SARS-CoV-2 pandemic, the receptor-binding domain (RBD) of the spike protein emerged as a critical target for neutralizing antibodies. While immunoinformatics predicts binding sites, <i>in vitro</i> confirmation of epitope-antibody interactions remains a challenge. Here, we present a modular and highly sensitive square wave voltammetry immunosensor platform based on zinc oxide nanorods (ZnONRs) for detecting antibody responses to SARS-CoV-2 variant epitopes. The device leverages three distinct B-cell peptides (P44; spike415-429) corresponding to the wild-type (WT), gamma, and omicron variants, differing by a single amino acid at the K417 mutation hotspot. This modular design enables rapid adaptation to emerging variants by simply exchanging the peptide recognition element. The immunosensor exhibited detection limits of 0.14 ng mL^-1 (WT), 0.19 ng mL^-1 (gamma), and 0.35 ng mL^-1 (omicron) using the monoclonal neutralizing antibody B38. Clinical validation with human serum samples demonstrated that: (1) WT-infected individuals showed markedly reduced antibody binding to the P44 omicron peptide; (2) BNT162b2-vaccinated individuals displayed strong responses to the WT and gamma peptides but not omicron; and (3) single amino acid mutations at position 417 significantly impacted antibody detection. Importantly, biosensor results showed a strong positive correlation with neutralizing antibody titers measured by pseudovirus assays (<i>r</i> = 0.79). Our results confirm that the modular ZnONRs-peptide biosensor platform is not only sensitive and specific but also versatile, scalable, and rapidly adaptable to future SARS-CoV-2 variants or other emerging pathogens. This approach provides a clinically relevant, point-of-care alternative for serological assessment and monitoring of variant-specific immune responses.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in platelet-rich plasma therapy for osteoarthritis: mechanisms and clinical efficacy.","authors":"Liang Cai, Jiali Chen, Qiong Yuan, Weihua Zhuang, Gang Wang, Xuemei Xu, Yongchao Yao, Wenchuang Walter Hu","doi":"10.1039/d5tb00394f","DOIUrl":"https://doi.org/10.1039/d5tb00394f","url":null,"abstract":"<p><p>Osteoarthritis (OA) is a progressive and highly prevalent joint disorder that affects millions of people worldwide, particularly among older adults. Platelet-rich plasma (PRP), an autologous blood-derived product rich in growth factors and cytokines, has emerged as a promising therapeutic option for OA owing to its potential to reduce symptoms and promote joint repair. The standardization of PRP preparation techniques, including optimized centrifugation protocols and controlled leukocyte content, has significantly improved the consistency and therapeutic effectiveness of PRP. The therapeutic mechanisms of PRP are multifaceted, involving the modulation of inflammatory pathways through key mediators, such as platelet-derived growth factor and transforming growth factor-beta (TGF-β); promotion of cartilage regeneration; extracellular matrix remodeling; and enhancement of angiogenesis and synovial tissue repair. Clinical studies have consistently shown that PRP outperforms hyaluronic acid and corticosteroid injections in terms of pain relief and functional improvement, particularly in patients with mild-to-moderate OA. However, treatment outcomes vary depending on the composition of PRP, preparation methods, injection protocols, and patient characteristics. Emerging trends, such as the combination of PRP with other therapies and innovative delivery systems, offer promising avenues for enhancing therapeutic efficacy and personalizing treatment strategies. This comprehensive review provides an in-depth analysis of recent advances in PRP therapy for OA, with a focus on its preparation protocols, mechanisms of action, and clinical efficacy. This analysis aims to establish a scientific foundation for PRP applications in OA treatment while guiding future research and clinical practices. Future research should prioritize standardizing PRP protocols, exploring long-term outcomes, and optimizing combination therapies to fully realize the potential of PRP in OA management.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of dual acid-visible light-degradable core-crosslinked nanogels with extended conjugate aromatic imines for enhanced drug delivery.","authors":"Kadambari Bairagi, Mehdi Shamekhi, Ioanna Tountas, Natasha Letourneau, Gilles H Peslherbe, Alisa Piekny, Jung Kwon Oh","doi":"10.1039/d5tb00734h","DOIUrl":"https://doi.org/10.1039/d5tb00734h","url":null,"abstract":"<p><p>The development of stimuli-responsive amphiphilic block copolymers and their nanoassemblies/nanogels integrated with degradable covalent chemistry undergoing chemical transitions has been extensively explored as a promising platform for tumor-targeting controlled/enhanced drug delivery. The conjugate aromatic imine bond is unique in responding to acidic pH through acid-catalyzed hydrolysis and visible light through photo-induced <i>E</i>/<i>Z</i> isomerization, thus allowing for a dual acid-light response <i>via</i> a single conjugate aromatic imine bond. Herein, we report a robust strategy for fabricating well-defined core-crosslinked nanogels bearing extended conjugate aromatic imine linkages that exhibit controlled degradation in response to acidic pH and visible light. This approach utilizes the pre-crosslinking of a poly(ethylene glycol)-based block copolymer bearing reactive imidazole pendants with a diol crosslinker bearing an extended conjugate aromatic imine, followed by the mechanical dispersion of the formed crosslinked polymers in an aqueous solution. The fabricated core-crosslinked nanogels with a hydrodynamic diameter of 119 nm are non-cytotoxic, colloidally stable, and capable of encapsulating cancer drug curcumin. They exhibit controlled/enhanced release of encapsulated curcumin at pH = 5 (acidic) or upon irradiation with visible light (<i>λ</i> = 420 nm) as well as exhibit promisingly accelerated and synergistic release under the combination of the above conditions. Furthermore, curcumin-loaded nanogels reduce cell viability in a controlled manner, unlike free drugs. This simplified yet efficient synthetic approach paves the way for the development of smart nanocarriers with potential applications in controlled drug release and cancer therapy.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPMA nanomedicine: targeting cancer with precision.","authors":"Sarita Rani, Vinay Kumar, Sofiya Tarannum, Umesh Gupta","doi":"10.1039/d4tb02341b","DOIUrl":"https://doi.org/10.1039/d4tb02341b","url":null,"abstract":"<p><p>Polymer nanotherapeutics have gained prominent attention in drug delivery systems. Polymers are widely explored tools to improve the solubility, stability, bioavailability, and prolonged circulation of therapeutic agents. Abraxane, Myocet, DaunoXome, and Doxil are some examples of successful polymeric nanocarriers approved for cancer treatment. Medicinal chemists have access to a vast array of nanomaterials that include polymeric nanoparticles (PNPs), polymeric micelles (PMCs), prodrugs, liposomes, and dendrimers. Polyethylene glycol (PEG), pHPMA (poly-<i>N</i>-2 hydroxypropyl methacrylamide), polyethylene, polystyrene, and other compounds have been extensively used for drug delivery. This review highlights the importance of pHPMA in nanodrug delivery. First, we review the chemical properties, pharmacology, and pharmacokinetics of pHPMA, followed by its synthetic routes of preparation. Second, we discuss pHPMA-based nanocarriers and their therapeutic efficacy in cancer. In addition, we present the clinical status and future prospects of pHPMA in combination with immunotherapy. We aim to provide comprehensive insights into the current pHPMA nanotherapeutics to facilitate future development.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>N</i>-Methyl-D-aspartate receptors as novel M1 macrophage-specific biomedical imaging nanoplatform agents: feasibility of targeted imaging in an inflammatory mice model.","authors":"Sang Bong Lee, Hui-Jeon Jeon, Dinesh Kumar, Hoon Hyun, Yong Hyun Jeon","doi":"10.1039/d5tb00882d","DOIUrl":"https://doi.org/10.1039/d5tb00882d","url":null,"abstract":"<p><p><i>N</i>-Methyl-D-aspartate receptor (NMDAR)-antibody-labeled mesoporous silica nanoparticles (NMDAR-PEG-DID@MSNs) were developed as a fluorescence imaging tool for M1 macrophage-associated inflammatory diseases. The nanoparticles were synthesized by conjugating NMDAR antibodies, polyethylene glycol (PEG), and the fluorescent dye DID onto mesoporous silica nanoparticles. Their imaging capability was evaluated in chronic (turpentine induced) and acute (lipopolysaccharide and carrageenan-induced) inflammation models, as well as for monitoring the anti-inflammatory effects of dexamethasone. NMDAR-PEG-DID@MSNs enabled the early detection of inflamed lesions, with fluorescence signals persisting for up to 24 hours, and successfully demonstrated the therapeutic efficacy of dexamethasone. These results highlight the potential of this nanoplatform for inflammation diagnosis and therapeutic monitoring.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Construction and evaluation of platelet concentrate/mesoporous bioactive glass composite scaffolds for bone repair: injectable platelet-rich fibrin (i-PRF) <i>vs.</i> concentrated growth factors (CGF).","authors":"Yuanyuan Guo, Zhizheng Li, Mengran Ma, Lingqiang Meng, Dan Lin","doi":"10.1039/d5tb90110c","DOIUrl":"https://doi.org/10.1039/d5tb90110c","url":null,"abstract":"<p><p>Correction for 'Construction and evaluation of platelet concentrate/mesoporous bioactive glass composite scaffolds for bone repair: injectable platelet-rich fibrin (i-PRF) <i>vs.</i> concentrated growth factors (CGF)' by Yuanyuan Guo <i>et al.</i>, <i>J. Mater. Chem. B</i>, 2025, https://doi.org/10.1039/D5TB00413F.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanozymes: new strategy for the management drug-induced acute liver injury.","authors":"Minrui Kan, Yanan Wang, Nan Cheng, Kunlun Huang, Xiaoyun He","doi":"10.1039/d5tb00448a","DOIUrl":"https://doi.org/10.1039/d5tb00448a","url":null,"abstract":"<p><p>Nanozymes, characterized by their multiple enzymatic activities, have emerged as powerful tools for scavenging free radicals, offering robust antioxidant and anti-inflammatory properties. Their straightforward synthesis, high stability, and versatile applications have made them increasingly prominent in biomedical research. Drug-induced acute liver injury (DIALI) has become a significant contributor to acute liver injury, primarily driven by the excessive release of reactive oxygen species (ROS), the generation of inflammatory factors, and the induction of macrophage polarization, ultimately leading to hepatocyte death. Nanozymes, with their unique ability to scavenge ROS and mitigate inflammation, present a promising therapeutic strategy for DIALI. In this review, we provide an in-depth exploration of the mechanisms underlying DIALI and a comprehensive summary of nanozyme-based therapeutic approaches. This includes nanozymes composed of various metallic and non-metallic elements, targeted delivery systems, and surface modification strategies. Furthermore, we discuss the current challenges and future prospects of nanozymes in the treatment of DIALI, highlighting their potential to revolutionize the management of this condition.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}