Journal of materials chemistry. B最新文献_第2页

Development of a dextrin-vitamin D3 micelle nanocarrier for the antimicrobial peptide LLKKK18 as a potential therapeutic agent for bone infections. 开发抗菌肽 LLKKK18 的糊精-维生素 D3 胶束纳米载体，作为骨感染的潜在治疗剂。

Journal of materials chemistry. B Pub Date : 2024-11-13 DOI: 10.1039/d4tb00903g

Alexandra Machado, Miguel Gama, José Alberto Martins

{"title":"Development of a dextrin-vitamin D3 micelle nanocarrier for the antimicrobial peptide LLKKK18 as a potential therapeutic agent for bone infections.","authors":"Alexandra Machado, Miguel Gama, José Alberto Martins","doi":"10.1039/d4tb00903g","DOIUrl":"10.1039/d4tb00903g","url":null,"abstract":"In this work, an expedite synthesis was developed for a self-assembled micelle carrier for the antimicrobial peptide LL18. Covalent one-pot functionalization of dextrin with succinylated vitamin D3 and succinic anhydride produced an amphiphilic material that undergoes self-assembly into micelles in aqueous medium. Succinylated dextrin-vitamin D3 micelles were efficiently loaded with LL18 by electrostatic and hydrophobic interactions. Remarkably, the LL18-loaded micelle formulation dramatically improves the antibacterial activity of free LL18 against S. aureus, completely abrogates its severe hemolytic activity, redirects the internalization of LL18 from the perinuclear region of osteoblasts to the lysosomes and reduces cellular toxicity towards osteoblasts and macrophages. Overall, this work demonstrates that self-assembled micelle formulations based on dextrin, vitamin D3 and antimicrobial peptides, are promising platforms to develop multifunctional antibiotic-independent antimicrobial agents, not prone to the development of bacterial resistance, to treat bone infections.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and characterization of β-tricalcium phosphate-based self-passivating coatings on magnesium alloys. 基于β-磷酸三钙的镁合金自钝化涂层的设计与表征

Journal of materials chemistry. B Pub Date : 2024-11-13 DOI: 10.1039/d4tb01214c

Erdem Şahin, Roberta Ruggiero, Marco Tatullo, Francesco Paduano, Meltem Alp, Ahmed Şeref

{"title":"Design and characterization of β-tricalcium phosphate-based self-passivating coatings on magnesium alloys.","authors":"Erdem Şahin, Roberta Ruggiero, Marco Tatullo, Francesco Paduano, Meltem Alp, Ahmed Şeref","doi":"10.1039/d4tb01214c","DOIUrl":"10.1039/d4tb01214c","url":null,"abstract":"Background: Magnesium alloys degrade rapidly in salt solutions, which limits their use without passivating treatments. AZ31 alloy is particularly promising for implant applications owing to its biodegradability and mechanical properties, necessitating effective corrosion-resistant coatings. Aim: In this study, a self-passivating reactive coating was designed and evaluated for AZ31 magnesium alloy plates using β-tricalcium phosphate (TCP) to enhance corrosion resistance and biocompatibility. Methods: Solutions of TCP, trisodium citrate, magnesium nitrate, hydroxyethyl cellulose (HEC), and sodium chloride were used to dip-coat AZ31 plates. The coated samples were immersed in 3.5 wt% NaCl solution. Phase evolution was analysed using gravimetry, X-ray diffraction (XRD), energy-dispersive X-ray (EDX) spectroscopy, and scanning electron microscopy (SEM). The biological response of the coated samples was evaluated through MTT and resazurin assays. Results: The coating formed a stable TCP/HEC layer that gradually dissolved over two weeks, converting the surface to magnesium hydroxide, magnesium oxychloride, and magnesium phosphate phases. The formation of brucite, responsible for passivation in the long term, was observed. The coating effectively prevented excessive magnesium oxychloride formation and stabilised magnesium hydroxide after one week. Biological characterization indicated that the coating on AZ31 is safe on the Saos-2 and L929 cell lines. Conclusion: The TCP-based coating enhances the corrosion resistance of AZ31 alloy in salt solutions, promoting passivating phases and limiting corrosive products, thereby ameliorating biocompatibility issues. This coating demonstrates substantial potential for extending the longevity and functionality of magnesium alloy implants.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconfiguring the endogenous electric field of a wound through a conductive hydrogel for effective exudate management to enhance skin wound healing. 通过导电水凝胶重新配置伤口的内生电场，有效管理渗出物，促进皮肤伤口愈合。

Journal of materials chemistry. B Pub Date : 2024-11-13 DOI: 10.1039/d4tb01349b

Yukun Yan, Yuanyuan Chen, Hanqing Dai, Wanlu Zhang, Ruiqian Guo

{"title":"Reconfiguring the endogenous electric field of a wound through a conductive hydrogel for effective exudate management to enhance skin wound healing.","authors":"Yukun Yan, Yuanyuan Chen, Hanqing Dai, Wanlu Zhang, Ruiqian Guo","doi":"10.1039/d4tb01349b","DOIUrl":"10.1039/d4tb01349b","url":null,"abstract":"The ionic environment has a strong influence on the bioelectricity of skin, which is also present in the wound healing process. Inspired by this, we proposed a mechanism for hydrogel-based dressings to respond to endogenous electric fields through exudate absorption and conducted a verification study using a typical hydrogel, namely, polyacrylamide and sodium alginate (PAM-SA) hydrogels, as an example. Theoretical calculations showed that the PAM-SA hydrogels could absorb and orient the various electrolytes of exudate in the hydrogel at the wound site, contributing to the reconstruction of the electric field at the wound site. During the treatment process, this effect significantly accelerated the healing process of the rat epidermis, which exceeded the conventional dressing in terms of healing speed and efficacy, and the wounds on the complete layer of rat skin (wound area: 1.13 cm2) could be rapidly repaired within 10 days. Revealing the electrophysiological behavior of PAM-SA dressings during wound healing can help further improve the design model, the optimization concept, and development paths for the bioelectrical structures of modern dressings and bioelectrical stimulation in wound healing.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on porous coral scaffolds containing a hydroxyapatite layer doped with selenium and their properties. 含掺硒羟基磷灰石层的多孔珊瑚支架及其性能研究

Journal of materials chemistry. B Pub Date : 2024-11-13 DOI: 10.1039/d4tb01112k

Tianjing Bao, Jian Ren, Yiyuan Wu, Yang Cao, Haobo Pan, Chunlin Deng

引用次数: 0

A smart adaptable metal sequestering peptide conjugate to modulate Aβ fibrillar aggregation. 一种可调节 Aβ 纤维聚集的智能型金属螯合肽共轭物。

Journal of materials chemistry. B Pub Date : 2024-11-13 DOI: 10.1039/d4tb01093k

Tanmay Mondal, Sujan Kalita, Rinku Dutta, Bhubaneswar Mandal

{"title":"A smart adaptable metal sequestering peptide conjugate to modulate Aβ fibrillar aggregation.","authors":"Tanmay Mondal, Sujan Kalita, Rinku Dutta, Bhubaneswar Mandal","doi":"10.1039/d4tb01093k","DOIUrl":"10.1039/d4tb01093k","url":null,"abstract":"The aggregation of amyloid β peptide (Aβ) in the presence of elevated levels of transition-metal ions, e.g., Fe3+, Cu2+, Zn2+, is accountable for enhanced cellular toxicity in Alzheimer's disease. Many strategies are reported to inhibit either Cu2+, Zn2+, or Fe3+-induced Aβ fibrillation, focused on one metal. Herein, a taurine-containing adaptable metal sequestering peptide (AMSP) has been developed as the modulator of any of the cited metal-induced Aβ-aggregation in vitro. We designed the peptide conjugate comprising VFFA as a recognition motif and a taurine moiety coupled with a pendant chain of glutamic acid such that the -SO3H groups of taurine lie nearby 13His and 14His of Aβ, and sequester such metal ions that construct the salt bridge preponderantly via13His-metal-14His composition as well as bridges with 6His of Aβ. We checked the modulation of fibrillar aggregates of Aβ in the presence of metal ions by monitoring the fibril accumulation using several biophysical methods. The results established that non-aggregating AMSP sequesters Zn2+ preferably, along with Fe3+ and Cu2+ ions from the metal-Aβ complex at the physiological condition, efficiently inhibiting Aβ aggregation. While such adaptable metal binders that can chelate various metals are new, AMSP inhibits aggregation through selective recognition and metal scavenging.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photocaging of amino acids and short peptides by arylidenethiazoles: mechanism, photochemical characteristics and biological behaviour. 芳基亚噻唑对氨基酸和短肽的光致变色：机理、光化学特性和生物学行为。

Journal of materials chemistry. B Pub Date : 2024-11-13 DOI: 10.1039/d4tb01441c

Aleksey A Gagarin, Artem S Minin, Vadim A Shevyrin, Enrico Benassi, Nataliya P Belskaya

{"title":"Photocaging of amino acids and short peptides by arylidenethiazoles: mechanism, photochemical characteristics and biological behaviour.","authors":"Aleksey A Gagarin, Artem S Minin, Vadim A Shevyrin, Enrico Benassi, Nataliya P Belskaya","doi":"10.1039/d4tb01441c","DOIUrl":"10.1039/d4tb01441c","url":null,"abstract":"A series of fluorophores based on the (5-methyl-4-phenylthiazol-2-yl)-3-phenylacrylonitrile (MPTA) core were designed and synthesised for photocaging of amino acids and peptides. The photophysical characteristics of these compounds and their hybrids with biomolecules were thoroughly investigated through a joint experimental, spectral and computational approach. The photorelease ability of the obtained amino acids-MPTA and peptides-MPTA hybrids was studied under various conditions, including different UV irradiation wavelength and power, and solvents. The main reaction products were identified using high-performance liquid chromatography combined with high-resolution mass spectrometry. Photo uncaging kinetics was quantitatively studied using absorption spectroscopy. The mechanism of photorelease of amino acids and peptides was elucidated through quantum mechanical calculations, which were also used for the exploration of photophysical properties of the excited states, and photodissociation energetics quantification. Relationships between the structure of fluorophores and photodissociation characteristics were estimated, and fluorophores with the good uncaging characteristics (biomolecule photoreleasing yield, uncaging rate, and effectiveness) were identified. Cell viability assays using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide or MTT showed a low cytotoxicity of the hybrids. Confocal microscopy revealed the easy penetration of the hybrids into living cells and their selective accumulation in the endoplasmic reticulum, lipid droplets and mitochondria, depending on their chemical structure.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of concern: Surface modification engineering of two-dimensional titanium carbide for efficient synergistic multitherapy of breast cancer. 表达关切：二维碳化钛的表面修饰工程，用于乳腺癌的高效协同综合治疗。

Journal of materials chemistry. B Pub Date : 2024-11-13 DOI: 10.1039/d4tb90175d

Lei Bai, Wenhui Yi, Taiyang Sun, Yilong Tian, Ping Zhang, Jinhai Si, Xun Hou, Jin Hou

引用次数: 0

ATP-responsive copper(II)-doped ZIF-nanoparticles for synergistic cancer therapy: combining cuproptosis and chemo/chemodynamic therapy. 用于癌症协同治疗的 ATP 响应型掺杂铜（II）的 ZIF 纳米粒子：结合杯突疗法和化疗/化学动力学疗法。

Journal of materials chemistry. B Pub Date : 2024-11-13 DOI: 10.1039/d4tb01574f

Wei-Qun Deng, Jun-Tao Chen, Si-Si Chen, Zhi-Qing Wang, Guo-Jiang Mao, Liufang Hu, Juan Ouyang, Chun-Yan Li

{"title":"ATP-responsive copper(II)-doped ZIF-nanoparticles for synergistic cancer therapy: combining cuproptosis and chemo/chemodynamic therapy.","authors":"Wei-Qun Deng, Jun-Tao Chen, Si-Si Chen, Zhi-Qing Wang, Guo-Jiang Mao, Liufang Hu, Juan Ouyang, Chun-Yan Li","doi":"10.1039/d4tb01574f","DOIUrl":"10.1039/d4tb01574f","url":null,"abstract":"Cancer, a pressing global health challenge, is characterized by its rapid onset and high mortality rates. Conventional treatment methods prove insufficient in achieving the desired therapeutic outcomes, underscoring the critical need to identify an effective and safe approach for cancer treatment. In this study, a copper-doped nanoparticle known as Cu2+-DOX@ZIF-90 is designed by incorporating copper(II) (Cu(II)) and encapsulating doxorubicin (DOX) within ZIF-90. Leveraging the elevated ATP levels in cancer cells relative to normal cells, Cu2+-DOX@ZIF-90 undergoes intracellular degradation, leading to the release of DOX and Cu(II). DOX, a traditional chemotherapy drug for clinical use, induces apoptosis in cancer cells. Cu(II) interacts with glutathione (GSH) to generate Cu(I), catalyzing H2O2 to produce ˙OH, thereby prompting apoptosis in cancer cells. Concurrently, the reduction of GSH enhances the therapeutic effect of chemodynamic therapy (CDT). Furthermore, Cu(II) triggers the aggregation of lipoylated mitochondrial proteins, leading to the formation of DLAT oligomers and ultimately promoting cuproptosis in cancer cells. In vivo experimental findings demonstrate that Cu2+-DOX@ZIF-90 does not cause damage to normal tissues and organs in tumor-bearing mice, with a notable tumor inhibition rate of 86.18%. This synergistic approach, combining chemotherapy, CDT, and cuproptosis, holds significant promise for the effective and safe treatment of cancer.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cyano positional isomerism strategy for constructing mitochondria-targeted AIEgens with type I reactive oxygen species generation capability. 利用氰基位置异构策略构建具有 I 型活性氧生成能力的线粒体靶向 AIEgens。

Journal of materials chemistry. B Pub Date : 2024-11-13 DOI: 10.1039/d4tb01847h

Jiabao Zhuang, Quan Pan, Chunli Zhou, Ziying Cai, Nan Li, Na Zhao

{"title":"The cyano positional isomerism strategy for constructing mitochondria-targeted AIEgens with type I reactive oxygen species generation capability.","authors":"Jiabao Zhuang, Quan Pan, Chunli Zhou, Ziying Cai, Nan Li, Na Zhao","doi":"10.1039/d4tb01847h","DOIUrl":"10.1039/d4tb01847h","url":null,"abstract":"In this work, a series of cationic luminogens (designated as PSMP isomers) were developed based on the cyano positional isomerism strategy. The isomerism of the cyano substituent on the molecular skeleton can finely regulate the optical behaviour, the type of photoinduced reactive oxygen species (ROS), and mitochondria-targeted capability of isomers. Interestingly, PSMP-4, with the cyano group installed at an appropriate location, exhibits a special aggregation-induced emission effect and potent O2˙- generation efficacy through the type I photochemistry pathway. Notably, PSMP-4 can accumulate in mitochondria with high specificity. Taking advantage of its excellent photostability, PSMP-4 realizes in situ mitochondria imaging in a washing-free manner and sensitive response to the change of mitochondrial membrane potential. The integration of comprehensive photophysical properties and mitochondrial specificity enable PSMP-4 to successfully trigger the death of cancer cells through an efficient type I photodynamic therapy process both in vitro and in multicellular tumor spheroid models.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive glass-polymer nanocomposites: a comprehensive review on unveiling their biomedical applications. 生物活性玻璃聚合物纳米复合材料：揭示其生物医学应用的全面综述。

Journal of materials chemistry. B Pub Date : 2024-11-13 DOI: 10.1039/d4tb01525h

Radhakrishnan Sreena, Gurusamy Raman, Geetha Manivasagam, A Joseph Nathanael

{"title":"Bioactive glass-polymer nanocomposites: a comprehensive review on unveiling their biomedical applications.","authors":"Radhakrishnan Sreena, Gurusamy Raman, Geetha Manivasagam, A Joseph Nathanael","doi":"10.1039/d4tb01525h","DOIUrl":"10.1039/d4tb01525h","url":null,"abstract":"Most natural and synthetic polymers are promising materials for biomedical applications because of their biocompatibility, abundant availability, and biodegradability. Their properties can be tailored according to the intended application by fabricating composites with other polymers or ceramics. The incorporation of ceramic nanoparticles such as bioactive glass (BG) and hydroxyapatite aids in the improvement of mechanical and biological characteristics and alters the degradation kinetics of polymers. BG can be used in the form of nanoparticles, nanofibers, scaffolds, pastes, hydrogels, or coatings and is significantly employed in different applications. This biomaterial is highly preferred because of its excellent biocompatibility, bone-stimulating activity, and favourable mechanical and degradation characteristics. Different compositions of nano BG are incorporated into the polymer system and studied for positive results such as enhanced bioactivity, better cell adherence, and proliferation rate. This review summarizes the fabrication and the progress of natural/synthetic polymer-nano BG systems for biomedical applications such as drug delivery, wound healing, and tissue engineering. The challenges and the future perspectives of the composite system are also addressed.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0