Journal of materials chemistry. B最新文献

{"title":"A multifunctional theranostic nanoagent for precise NIR-II FL imaging and synergistic chemodynamic/H2/SGB therapy of allergic rhinitis.","authors":"Weiwei Zhang, Lin Chen, Chunmei Jiang, Shutong Wu, Zhigan Lv, Ning Zhang, Wenjing Cui, Qin Liu, Rong Dai, Ziliang Zheng, Ruiping Zhang","doi":"10.1039/d5tb01086a","DOIUrl":"https://doi.org/10.1039/d5tb01086a","url":null,"abstract":"<p><p>Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa mediated by immunoglobulin E (IgE) and characterized by infiltration of inflammatory cells, such as eosinophils, and excessive production of reactive oxygen species (ROS). Alleviating oxidative stress and inflammation at AR sites is an effective approach for improving pathological conditions and modulating the microenvironment. Herein, we have developed novel multifunctional theranostic nanoagents (ACB NGs) to achieve precise and rapid second near-infrared fluorescence (NIR-II FL) imaging and a promising combination treatment of synergistic chemodynamic/gas/stellate ganglion block (SGB) therapy. With suitable size and excellent biocompatibility, ACB NGs passively target AR inflammatory sites to realize effective accumulation. Then, the Ce³⁺/Ce⁴⁺ redox pair can exhibit SOD/CAT-like enzymatic activity to rapidly deplete ROS to alleviate oxidative stress and inflammation. Simultaneously, the controlled release of hydrogen (H₂) in a slightly acidic environment results in precise synergistic antioxidative and anti-inflammatory effects with CeO₂. Moreover, SGB therapy further inhibits the secretion of pro-inflammatory cytokines and reduces oxidative stress, achieving a therapeutic effect by modulating the inflammatory microenvironment in AR. In summary, ACB NGs represent novel biomineralized nanoagents offering efficient combination therapy, which will provide new perspectives for the treatment and monitoring of AR.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145277042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CVD-grown MXene-CNT nanocomposite-assisted electrochemical immunosensors for label-free and ultra-sensitive monitoring of thyroid-stimulating hormone in artificial serum.","authors":"Vijayaraj Kathiresan, Sakda Jampasa, Thirumal Vediyappan, Dharuman Venkataraman, Viwat Vchirawongkwin, Orawon Chailapakul","doi":"10.1039/d5tb01632k","DOIUrl":"10.1039/d5tb01632k","url":null,"abstract":"<p><p>Thyroid-stimulating hormone (TSH) is a critical clinical biomarker for evaluating thyroid function and is essential in diagnosing and monitoring related hormonal disorders. However, the development of point-of-care diagnostic devices for the early detection of TSH-associated diseases remains challenging, particularly due to constraints in measurement methodologies in resource-limited settings. This research describes an effective electrochemical immunosensor developed from a novel seamless three-dimensional (3D) Ti₃C₂T_<i>x</i> (MXene)-carbon nanotube (CNT) nanocomposite, specifically engineered for the ultrasensitive and label-free detection of low TSH concentrations. The MXene-CNT nanocomposite was synthesized using the chemical vapor deposition (CVD) method, and its physical characteristics and electrochemical sensing capabilities were examined. The unique synergetic properties of the MXene-CNT nanocomposite enhance antibody immobilization, expand the sensor's surface area (0.119 cm²), provide additional binding sites, and improve electrical conductivity, leading to superior sensitivity and stability of the biosensor. With a label-free format, the redox mediator signal decreased significantly in response to varying concentrations of TSH, attributable to the insulating immunocomplexes formed between anti-TSH and TSH on the MXene-CNT-modified disposable electrode. The method achieved a dynamic linear range of 0.1-10 000 pg mL^-1, with a detection limit of 0.03 pg mL^-1, showcasing high selectivity against interferents. Importantly, this study presents the first successful electrochemical detection of TSH in artificial serum using the CVD-grown MXene-CNT nanocomposite immunosensor, underscoring its potential for real-sample analysis in complex biological environments. The current study opens new avenues for leveraging the CVD-grown MXene-CNT nanocomposites in designing and developing molecular diagnosis-based electrochemical and related biosensors.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constructing near-infrared dyes with D-A-D-type Stokes shifts based on asymmetric electron-donating properties and their applications.","authors":"Ying-Kun Liu, Mao-Hua Wang, Li-Rui Huo, Jian-Yong Wang","doi":"10.1039/d4tb01939c","DOIUrl":"https://doi.org/10.1039/d4tb01939c","url":null,"abstract":"<p><p>An excessive amount of sulfur dioxide (SO₂) poses a threat to the microenvironment of living organisms and, in severe cases, can cause inflammation, cardiovascular diseases, and respiratory damage. As one of the important atmospheric pollutants, SO₂ and its derivatives are widely used in the production of additives and chemicals, and are important factors affecting physiological activities. To achieve the goal of detection, we developed a new near-infrared (NIR) fluorescent probe, Cou-Oxo, which can be used to obtain a ratiometric response to SO₂ derivatives in cells, zebrafish, and plant rhizomes. This novel NIR dye with a large π-system was created by combining two small π-dyes. Its structural features led to a markedly expanded Stokes shift of 321 nm. The NIR ratiometric fluorescence properties of the probe were achieved through the addition reaction of SO₂ derivatives (HSO₃^-) to the CC double bond on the Cou-Oxo probe, which possesses a detection limit of 0.942 μM, a short response time (within 30 s), satisfactory biocompatibility, excellent anti-interference, and pH stability. The probe was successfully used to detect changes in exogenous and endogenous SO₂ levels in cancer cells and living zebrafish. More interestingly, we successfully visualized SO₂ in normal and SO₂ poisoned tobacco seedlings as a model.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> and <i>in vivo</i> characterization of novel magnesium alloy implants enhanced by hydrothermal and sol-gel treatments for bone regeneration.","authors":"Daniele Bellavia, Francesco Paduano, Silvia Brogini, Roberta Ruggiero, Rosa Maria Marano, Angela Cusanno, Pasquale Guglielmi, Antonio Piccininni, Matteo Pavarini, Agnese D'Agostino, Alessandro Gambardella, Chiara Peres, Gianfranco Palumbo, Roberto Chiesa, Gianluca Zappini, Marco Tatullo, Gianluca Giavaresi","doi":"10.1039/d5tb01282a","DOIUrl":"https://doi.org/10.1039/d5tb01282a","url":null,"abstract":"<p><p>Magnesium alloys are emerging as promising materials for biodegradable orthopedic implants due to their mechanical strength and biocompatibility. However, their clinical use is hindered by rapid degradation and hydrogen gas evolution, which can compromise implant stability and bone healing. This study investigates the biocompatibility, genotoxicity, and osteointegration of magnesium implants (AZ31) produced <i>via</i> Superplastic Forming and enhanced through Hydrothermal and Sol-Gel surface treatments. Both techniques produced uniform Mg(OH)₂-based coatings, but only alloy with hydrothermal treatment exhibited a markedly slower <i>in vitro</i> degradation. Cytotoxicity and Ames mutagenicity assays confirmed the biocompatibility and non-mutagenic nature of all implant types. <i>In vivo</i> evaluation in a rat femoral defect model revealed successful bone formation around all implant types, with comparable trabecular bone area. However, surface-treated implants showed a significantly lower bone-to-implant contact compared to the control AZ31 alloy, with solgel-treated alloys exhibiting an accelerated degradation rate and higher hydrogen release, which may influence tissue integration. These results highlight the role of surface modification in tuning degradation behavior and bone interface characteristics, with solgel-treated alloys resorbing faster. The combination of superplastic forming processing with strategic surface treatments offers a promising approach to achieving controlled biodegradation, although further optimization is needed to improve bone-implant integration. This work supports the further development of surface-engineered Mg implants for safe and functional orthopedic applications.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartphone-integrated colorimetric and fluorometric sensor based on copper-doped carbon dots for visual and rapid detection of thiram.","authors":"Tingting Lei, Yating Xu, Yuanyu Tang, Siyi Tan, Jiafu Xiao, Shaojing Zhao, Minhuan Lan","doi":"10.1039/d5tb01611h","DOIUrl":"https://doi.org/10.1039/d5tb01611h","url":null,"abstract":"<p><p>Achieving highly selective visual detection of thiram is essential for ensuring food safety and environmental protection. Here, we developed a smartphone-integrated colorimetric and fluorometric dual-mode sensor based on copper-doped carbon dots (Cu-CDs). The Cu-CDs were synthesized <i>via</i> hydrothermal treatment of L-tryptophan and CuCl₂·2H₂O. These Cu-CDs exhibited two fluorescence emission peaks at 350 nm and 450 nm, with a fluorescence quantum yield of 20.8%. Cu²⁺ on the surface of the Cu-CDs could selectively bind to thiram to form a Cu²⁺-thiram complex, which quenched the fluorescence at 450 nm of the Cu-CDs <i>via</i> the inner filter effect and dynamic quenching effect. In contrast, the fluorescence at 350 nm was changed slightly. The color of the solution was changed from colorless to yellow. These changes allowed for a fluorometric and colorimetric dual-mode optical response. The proposed sensor possessed high sensitivity and selectivity and demonstrated reliable performance in real water samples. Its integration with a smartphone further enabled convenient, on-site detection. This work presented a robust and cost-effective strategy for monitoring thiram in applications related to food safety and environmental protection.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional Ag-PDA@PCM composite eutectogel based electronic skin for personal thermal management and a machine learning assisted wearable sensor.","authors":"Junjie Gong, Yi Chen, Dandan Liu, Huawei Cai, Lisha Jiang, Haibo Wang","doi":"10.1039/d5tb01479d","DOIUrl":"https://doi.org/10.1039/d5tb01479d","url":null,"abstract":"<p><p>Inspired by the perception and temperature regulation functionalities of human skin, multifunctional electronic skin (E-skin) for human motion detection and personal thermal management has attracted great attention. Here, we design an E-skin with strain sensing and personal thermal management capabilities based on a PAA-AgPPCM-<i>x</i> eutectogel, which was fabricated by introducing silver nanoparticle-deposited polydopamine-coated phase change microcapsules into an eutectogel matrix. The prepared eutectogel-based E-skin exhibits photothermal conversion, thermal energy storage and temperature regulation capabilities, and can effectively use solar energy for thermal management of the human body. Meanwhile, due the excellent mechanical properties and high conductivity of eutectogels, the eutectogel-based E-skin has the characteristics of a wide working range (0-400% strain), high sensitivity (highest gauge factor value is 5.13), fast response (239 ms) and recovery (337 ms), and excellent fatigue resistance (1000 cycles), and has successfully realized human motion detection, facial micro-expression recognition, and voice recognition. In addition, the eutectogel-based E-skin can be combined with machine learning algorithms to accurately classify 10 types of different complex gesture signals with high precision (97.0%). This multifunctional photothermal phase change microcapsule composite eutectogel-based E-skin shows great potential for application in intelligent wearable devices and personalized healthcare.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon dots meet artificial intelligence: applications in biomedical engineering.","authors":"Yalei Guo, Yige Liu, Jiajin Yang, Yulu Wu, Haosen Lian, Xiufa Tang, Chunjie Li, Weitong Cui, Zhiyong Guo","doi":"10.1039/d5tb00593k","DOIUrl":"https://doi.org/10.1039/d5tb00593k","url":null,"abstract":"<p><p>Carbon dots (CDs) are fluorescent carbon nanomaterials typically less than 10 nm in size with excellent water solubility, low toxicity, high biocompatibility, favorable optical properties, and modifiable surface. CDs have great promise in various fields, including bioimaging, sensing, and drug delivery. With the emergence of artificial intelligence (AI) technologies, particularly machine learning (ML) and deep learning (DL) algorithms, new avenues for synthesis optimization, performance improvement, and accurate detection and diagnosis using CDs in biomedical engineering have been opened up. This article aims to present a comprehensive review of the applications of AI in CD research, from material design and performance optimization to material characterization and data analysis. It also addresses the possible areas of application for AI-assisted CDs in biomedical engineering, highlighting the importance and future directions of this interdisciplinary area of research. In addition, the potential role of CDs in advancing AI technologies such as optoelectronic storage devices and neuromorphic computing is explored, as well as the lasting impact of the convergence of CDs and AI on the future course of technological advancement.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging bismuth vanadate-based biosensor platforms for diagnostic, imaging, therapeutic and antibacterial applications.","authors":"Akshay Sidhi Poovethamkandiyil, Karthika K Palliyalil, Karthik Sujith, Anjali Paravannoor, Priyanka Ganguly, Baiju Kizhakkekilikoodayil Vijayan","doi":"10.1039/d5tb01332a","DOIUrl":"https://doi.org/10.1039/d5tb01332a","url":null,"abstract":"<p><p>BiVO₄ nanostructures are n-type semiconductor photocatalysts with a narrow band gap that is sensitive to visible light. This photocatalytic property, along with unique electrochemical properties, remarkable biocompatibility, tunable surface chemistry, ease of synthesis and facile morphology tuning, has made them attractive candidates in the field of biosensor platforms. These biosensors offer highly sensitive, point-of-care, non-invasive diagnostic and therapeutic applications for various conditions like neurological disorders, multiple tumours and some pathological conditions. Additionally, these materials have gained attraction in imaging-guided therapeutic and diagnostic imaging platforms, such as up- and down-conversion imaging, CT, MRI, photoacoustic and multimodal imaging platforms. Along with that, visible light-driven reactive oxygen species (ROS) generation by these materials has been applied for photocatalytic disinfection by ROS-mediated killing of bacteria. These applications are crucial for removing dangerous strains of bacteria and antibiotic-resistant bacteria. This review article highlights the recent advancements in BiVO₄-integrated biosensor platforms in diagnostic, therapeutic, imaging and bactericidal applications. The modification and engineering strategies adopted for better suiting BiVO₄ for particular applications are discussed in detail. The challenges in addressing their material stability, biocompatibility and clinical translation are discussed with more emphasis on the potential of BiVO₄ in integrated diagnostic, imaging and therapeutic applications.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial outer membrane vesicles in immune modulation: from mechanisms to applications.","authors":"Yueqing Wang, Runhan Yang, Jun Luo, Jianshu Li, Bo Huang, Jiaojiao Yang","doi":"10.1039/d5tb01708d","DOIUrl":"https://doi.org/10.1039/d5tb01708d","url":null,"abstract":"<p><p>Outer membrane vesicles (OMVs), naturally secreted by Gram-negative bacteria, have emerged as versatile tools for immune modulation due to their intrinsic immunogenicity and engineerable properties. This review explores how OMVs activate and regulate both innate and adaptive immunity. They stimulate innate defenses by engaging immune receptors like Toll-like receptors (TLRs), triggering inflammatory pathways, while also shaping adaptive responses through antigen delivery to dendritic cells, promoting T-cell activation and antibody production. We further discuss engineered applications: OMVs serve as customizable vaccine platforms, efficiently delivering antigens and adjuvants, and as targeted drug carriers modified to reduce toxicity. By integrating recent findings on their roles in breaking tumor immunosuppression and enhancing vaccine efficacy, this work underscores OMVs' dual utility as natural immunostimulants and engineered therapeutics. Our synthesis aims to clarify OMV-driven immune mechanisms and accelerate their translation into clinical strategies for cancer treatment and infection prevention, bridging foundational research with practical innovations in immune engineering.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photo-regulated supramolecular artificial proton channels induce cancer cell apoptosis.","authors":"Tianlong Zhang, Yueyue Lu, Canhong Zhu, Yicong Zhang, Yanting Wu, Xiangkun Xing, Jiayun Xu, Shuangjiang Yu, Tengfei Yan, Junqiu Liu","doi":"10.1039/d5tb01835h","DOIUrl":"https://doi.org/10.1039/d5tb01835h","url":null,"abstract":"<p><p>Natural channel proteins can effectively and selectively transport substances across membranes and control the opening and closing of channels under specific stimulation conditions, but achieving the same functions in artificial systems is difficult. Herein, we design a series of PEG-based artificial proton channels with ON/OFF switchable transport behaviors, which can be controlled through light irradiation and the regulation of host-guest interactions. In addition, the results indicated that the molecular length, intramolecular forces and molecular hydrophilicity were closely related to the ion transport properties. Artificial proton channels also exhibit desirable anticancer potential by damaging mitochondria and elevating the lysosomal pH, resulting in the apoptosis of cancer cells. This work not only designs a type of supramolecular artificial proton channel with adjustable transport activity but also provides a method for treating cancer.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}