Journal of materials chemistry. B最新文献

{"title":"Non-Ti MXenes: new biocompatible and biodegradable candidates for biomedical applications.","authors":"Vijayakumar G Gayathri, Bartholomew Richard, Jithin Thomas Chacko, Jagadeesh Bayry, P Abdul Rasheed","doi":"10.1039/d4tb01904k","DOIUrl":"https://doi.org/10.1039/d4tb01904k","url":null,"abstract":"<p><p>MXenes are a class of two-dimensional nanomaterials with the general formula M_<i>n</i>+1X_<i>n</i>T_<i>x</i>, where M denotes a transition metal, X denotes either carbon or nitrogen and T_<i>x</i> refers to surface terminations, such as -OH, -O, -F or -Cl. The unique properties of MXenes, including their tunable surface chemistry and high surface area-to-volume ratio, make them promising candidates for various biomedical applications, such as targeted drug delivery, photothermal therapy and so on. Among the family of MXenes, titanium (Ti)-based MXenes, especially Ti₃C₂T_<i>x</i>, have been extensively explored for biomedical applications. However, despite their potential, Ti-based MXenes have shown some limitations, such as low biocompatibility. Recent studies have also indicated that Ti MXenes may disrupt spermatogenesis and accumulate in the uterus. Non-Ti MXenes are emerging as promising alternatives to Ti-based MXenes due to their superior biodegradability and enhanced biocompatibility. Recently, non-Ti MXenes have been explored for a range of biomedical applications, including drug delivery, photothermal therapy, chemodynamic therapy and sonodynamic therapy. In addition, some non-Ti MXenes exhibit enzyme-mimicking activity, such as superoxide dismutase and peroxidase-like functions, which play a major role in scavenging reactive oxygen species (ROS). This review discusses the properties of non-Ti MXenes, such as biocompatibility, biodegradability, antibacterial activity, and neuroprotective effects, highlighting their potential in various biomedical applications. These properties can be leveraged to mitigate oxidative stress and develop safe and innovative strategies for managing chronic diseases. This review provides a comprehensive analysis of the various biomedical applications of non-Ti MXenes, including their use in drug delivery and combinatorial therapies and as nanozymes for sensing and therapeutic purposes. The theranostic applications of non-Ti MXenes are also discussed. Finally, the antibacterial properties of non-Ti MXenes and the proposed mechanisms are discussed. The review concludes with a summary of the key findings and future perspectives. In short, this review provides a thorough analysis of the biomedical applications of non-Ti MXenes, emphasizing their unique properties, potential opportunities and challenges in the field.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional hydroxyquinoline-derived turn-on fluorescent probe for Alzheimer's disease detection and therapy.","authors":"Priyam Ghosh, Sayantani Mukhopadhyay, Thirukumaran Kandasamy, Subrata Mondal, Siddhartha Sankar Ghosh, Parameswar Krishnan Iyer","doi":"10.1039/d4tb01740d","DOIUrl":"https://doi.org/10.1039/d4tb01740d","url":null,"abstract":"<p><p>Understanding molecular motifs that can interfere with amyloid fibrillation through non-covalent interactions is essential for addressing abnormal protein aggregation and associated human diseases. The pursuit of efficient diagnostic and treatment approaches for Alzheimer's disease (AD) has resulted in the development of M8HQ, a multifaceted small molecule turn-on probe derived from 8-hydroxyquinoline with versatile capabilities. M8HQ shows a strong affinity for amyloid beta (Aβ) fibrils, and its ability to target lysosomes enhances therapeutic precision by localizing within these organelles. This localization is essential for restoring cellular balance and maintaining LAMP1 expression, both of which are crucial for addressing AD. It also displays the ability to disaggregate Aβ fibrils and inhibit their formation, thus addressing therapeutic processes in AD progression. M8HQ further blocks reactive oxygen species (ROS)-mediated apoptosis, providing neuroprotective effects. Additionally, it chelates metal ions like Cu(II) and Fe(III), mitigating metal-induced aggregation and oxidative stress. Molecular docking and simulation studies have elucidated the interactions between M8HQ and Aβ, confirming its binding efficacy and stability. These combined properties highlight M8HQ's potential as a comprehensive diagnostic and therapeutic tool for AD.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasmall metal nanoclusters as efficient luminescent probes for bioimaging.","authors":"Xinyue Dou, Sariah Saalah, Chel-Ken Chiam, Jianping Xie, Coswald Stephen Sipaut","doi":"10.1039/d4tb02207f","DOIUrl":"https://doi.org/10.1039/d4tb02207f","url":null,"abstract":"<p><p>Ultrasmall metal nanoclusters (NCs, <2 nm) have emerged as a novel class of luminescent probes due to their atomically precise size and tailored physicochemical properties. The rapid advancements in the design and utilization of metal NC-based luminescent probes are facilitated by the atomic-level manipulation of metal NCs. This review article explores (i) the engineering of metal NCs' functions for bioimaging applications, and (ii) the diverse uses of metal NCs in bioimaging. We begin by presenting an overview of the engineering functions of metal NCs as luminescent probes for bioimaging applications, highlighting key strategies for enhancing NCs' luminescence, biocompatibility and targeting capabilities towards biological specimens. Our discussion then centers on the bioimaging applications of metal NCs in subcellular organelles, individual cells, tissues, and entire organs. Finally, we offer a perspective on the challenges and potential developments in the future use of metal NCs for bioimaging applications.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in Chinese medicine monomers and their nanoformulations on myocardial ischemia/reperfusion injury.","authors":"Yanrong Zhou, Li Wang, Lina Sun, Rui Tan, Zheng Wang, Renjun Pei","doi":"10.1039/d4tb02091j","DOIUrl":"https://doi.org/10.1039/d4tb02091j","url":null,"abstract":"<p><p>Myocardial ischemia/reperfusion injury (MIRI) is the entire process of myocardial injury resulting from ischemia and hypoxia following acute myocardial infarction, which involves complicated pathogenesis including energy metabolism disorders, calcium overload, oxidative stress and mitochondrial dysfunction. Traditional Chinese medicine (TCM) has attracted intensive attention in the treatment of MIRI owing to its multitarget therapeutic effects and low systemic toxicity. Increasing evidence indicates the promising application of TCM on the protection of cardiomyocytes, improvement of endothelial cell functions and regulation of energy metabolism and inflammatory response. Although the efficacy of TCM has been well-proven, the underlying mechanisms remain unclear. Additionally, the clinical application of much TCM had been hampered due to its low aqueous solubility, poor gastrointestinal absorption, and decreased bioavailability. In this review, we examined the pathological mechanism of MIRI and highlighted recent research studies on the therapeutic effects and molecular mechanisms of monomer compounds derived from TCM. We also summarized the latest studies in nanoformulation-based strategies for improving the targeting and stability of TCM monomers and exerting synergistic effects. The aim of this study was to provide a scientific basis for the treatment of MIRI with TCM monomers combined with nanomaterials, revealing their clinical significance and development prospects.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 vaccine based on ferritin complexes with screened immunogenic sequences from the Fv-antibody library.","authors":"Jaeyong Jung, Tae-Hun Kim, Jae-Yeon Park, Soonil Kwon, Jeong Soo Sung, Min-Jung Kang, Joachim Jose, Misu Lee, Hyun-Jin Shin, Jae-Chul Pyun","doi":"10.1039/d4tb01595a","DOIUrl":"https://doi.org/10.1039/d4tb01595a","url":null,"abstract":"<p><p>In this study, the vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was developed using ferritin complexes with the immunogenic sequences screened against the SARS-CoV-2 spike protein (SP) from the Fv-antibody library. The Fv-antibody library was prepared on the outer membrane of <i>E. coli</i> by the expression of the V_H region of immunoglobulin G (IgG) with a randomized complementarity-determining region 3 (CDR3). Four Fv-antibodies to the receptor-binding domain (RBD) were screened from the Fv-antibody library, which had a comparable binding constant (<i>K</i>_D) between SARS-CoV-2 SP and the angiotensin-converting enzyme 2 (ACE2) receptor. The binding sites of screened Fv-antibodies on the RBD were analyzed using a docking analysis, and these binding sites were used as immunogenic sequences for the vaccine. The four immunogenic sequences were modified and co-expressed as a part of ferritin which was assembled into a ferritin complex. After the vaccination of ferritin complexes to mice, the anti-sera were analyzed to have a high enough titer. Additionally, the immune responses were found to be activated by vaccination, such as the expression of IgG subclasses and the increased level of cytokines. The neutralizing activity of the anti-sera was estimated using a cell-based infection assay based on pseudo-virus expressing the SP of SARS-CoV-2 variants.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feedback-induced phase separation of hollow condensates to create biomimetic membraneless compartments.","authors":"Jianmian Fu, Bin Wang, Weiping Zhu, Yufang Xu, Xuhong Qian, Yangyang Yang","doi":"10.1039/d4tb01670j","DOIUrl":"https://doi.org/10.1039/d4tb01670j","url":null,"abstract":"<p><p>Intracellular macromolecules have the ability to form membraneless compartments, such as vacuoles and hollow condensates, through liquid-liquid phase separation (LLPS) in order to adapt to changes in their environment. The development of artificial non-homogeneous compartments, such as multiphase hollow or multicavity condensates, has gained significant attention due to their potential to uncover the mechanisms underlying the formation of artificial condensates and biomolecular condensates. However, the complexity of design and construction has hindered progress, particularly in creating dynamic non-homogeneous compartments. In this study, we present a dynamic membraneless compartment using peptide-oligonucleotide conjugates derived from short elastin-like polypeptides (sELP-ONs), which undergo pH-mediated phase transition. Below pH 8.8, the microcompartment exists as microdroplets that transform into non-homogeneous hollow condensates above pH 8.8. Notably, these hollow condensates retain liquid properties and high molecular ordering, and effectively sequester guest molecules with a hollow condensed layer. Furthermore, our sELP-ON microcompartments exhibit a feedback-induced phase transition in response to environmental pH fluctuations generated by complex enzymatic reactions mimicking cellular metabolism, providing a novel dynamic model for creating biomimetic membraneless compartments.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitrogen doped carbon quantum dots: a multifaceted carbon nanomaterial that interferes in an amyloid-forming trajectory.","authors":"Sherin M ElMorsy, Denisse A Gutierrez, Salvador Valdez, Jyotish Kumar, Renato J Aguilera, Mohamed Noufal, Sampath Chinnam, Hemen Sarma, Mahesh Narayan","doi":"10.1039/d4tb02104e","DOIUrl":"https://doi.org/10.1039/d4tb02104e","url":null,"abstract":"<p><p>Carbon quantum dots (CQDs) are a versatile class of carbon-based nanomaterial frameworks that have previously been used as a diagnostic device, in sensing for environmental applications, in bioimaging, and for drug delivery systems. Their versatility stems from their ability to be chemically tailored <i>via</i> functionalization to optimize properties for specific applications. In this study, we have synthesized lactic acid-derived nitrogen doped carbon quantum dots (LAdN-CQDs) and examined their ability to intervene in the conversion of soluble, monomeric hen egg-white lysozyme (HEWL) into mature fibrils. Our data indicate that LAdN-CQDs inhibit HEWL fibril formation in a dose-dependent manner (achieving up to 50% inhibition at 2.5 mg mL^-1). Furthermore, in a neuroblastoma-derived cell line, LAdN-CQDs were found not to disrupt mitochondrial membrane potential or trigger apoptosis at the same concentration range, suggesting that they are biocompatible. LAdN-CQDs effectively neutralized reactive oxygen species (ROS), with a 50% decrease in ROS levels at just 100 μg mL^-1 when challenged with an established free radical generator and protected the cell line from rotenone-induced apoptosis. The ability of LadN-CQDs to inhibit the soluble-to-toxic transformation of HEWL, the tolerance of SHSY-5Y cells to LAdN-CQDs, and their ability to restitute cells from rotenone-induced apoptosis, combined with the biocompatibility findings, suggest that LAdN-CQDs are potentially neuroprotective. The findings indicate that LAdN-CQDs represent a versatile, carbon-based, sustainable nanoplatform that bridges nanotechnology and neuroprotection, promoting the development of green chemistry-based healthcare solutions.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontiers in fluorescence imaging: tools for the <i>in situ</i> sensing of disease biomarkers.","authors":"Lei Yang, Hongwei Hou, Jinghong Li","doi":"10.1039/d4tb01867b","DOIUrl":"https://doi.org/10.1039/d4tb01867b","url":null,"abstract":"<p><p>Fluorescence imaging has been recognized as a powerful tool for the real-time detection and specific imaging of biomarkers within living systems, which is crucial for early diagnosis and treatment evaluation of major diseases. Over the years, significant advancements in this field have been achieved, particularly with the development of novel fluorescent probes and advanced imaging technologies such as NIR-II imaging, super-resolution imaging, and 3D imaging. These technologies have enabled deeper tissue penetration, higher image contrast, and more accurate detection of disease-related biomarkers. Despite these advancements, challenges such as improving probe specificity, enhancing imaging depth and resolution, and optimizing signal-to-noise ratios still remain. The emergence of artificial intelligence (AI) has injected new vitality into the designs and performances of fluorescent probes, offering new tools for more precise disease diagnosis. This review will not only discuss chemical modifications of classic fluorophores and <i>in situ</i> visualization of various biomarkers including metal ions, reactive species, and enzymes, but also share some breakthroughs in AI-driven fluorescence imaging, aiming to provide a comprehensive understanding of these advancements. Future prospects of fluorescence imaging for biomarkers including the potential impact of AI in this rapidly evolving field are also highlighted.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From experimental studies to computational approaches: recent trends in designing novel therapeutics for amyloidogenesis.","authors":"Pooja Ghosh, Agnibin Kundu, Debabani Ganguly","doi":"10.1039/d4tb01890g","DOIUrl":"https://doi.org/10.1039/d4tb01890g","url":null,"abstract":"<p><p>Amyloidosis is a condition marked by misfolded proteins that build up in tissues and eventually destroy organs. It has been connected to a number of fatal illnesses, including non-neuropathic and neurodegenerative conditions, which in turn have a significant influence on the worldwide health sector. The inability to identify the underlying etiology of amyloidosis has hampered efforts to find a treatment for the condition. Despite the identification of a multitude of putative pathogenic variables that may operate independently or in combination, the molecular mechanisms responsible for the development and progression of the disease remain unclear. A thorough investigation into protein aggregation and the impacts of toxic aggregated species will help to clarify the cytotoxicity of aggregation-mediated cellular apoptosis and lay the groundwork for future studies aimed at creating effective treatments and medications. This review article provides a thorough summary of the combination of various experimental and computational approaches to modulate amyloid aggregation. Further, an overview of the latest developments of novel therapeutic agents is given, along with a discussion of the possible obstacles and viewpoints on this developing field. We believe that the information provided by this review will help scientists create innovative treatment strategies that affect the way proteins aggregate.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bright \"D-A-D\" semiconducting small molecule aggregates for NIR-II fluorescence bioimaging guiding photothermal therapy.","authors":"Qian Xie, Wansu Zhang, Xiaofeng Yang, Chunyu Zhou, Liang Zhang, Tao Sun, Mingfu Gong, Dong Zhang","doi":"10.1039/d4tb02333a","DOIUrl":"https://doi.org/10.1039/d4tb02333a","url":null,"abstract":"<p><p>Donor-acceptor-donor (D-A-D) semiconducting small molecule nanoparticles have emerged as high-performance NIR-II fluorophores for real-time bioimaging. However, due to their intrinsic defects in aggregation-caused quenching (ACQ) and \"energy gap law\", D-A-D semiconducting small molecule nanoparticles typically exhibit low NIR-II fluorescence quantum yields (QYs). Herein, both the strategies of aggregation induced emission (AIE) and intermolecular charge transfer (CT) have been incorporated into the design of new D-A-D semiconducting small molecules. AIE enhances the NIR-II fluorescence intensity of NIR-II fluorophore aggregates in nanoparticles, while intermolecular CT increases both NIR absorption and NIR-II emission, thereby further improving their NIR-II fluorescence QYs. Four D-A-D semiconducting small molecules (TD, TT, TC, and TCD) were designed. Due to the combination of intermolecular CT and AIE of TCD aggregates, the NIR absorption and NIR-II fluorescence signals of TCD NPs were stronger than those of TD NPs and TT NPs with a single AIE property or TC NPs with strong intermolecular CT. Furthermore, TCD NPs demonstrated excellent performance in <i>in vivo</i> NIR-II fluorescence bioimaging guiding photothermal therapy.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}