Journal of materials chemistry. B最新文献

{"title":"Sprayed antibacterial layer on titanium implants to eradicate biofilms by photoelectrons under near-infrared light.","authors":"Junyu Dong, Shuqi Feng, Kai Wang, Yufei Tang, Keyi Yao, Sze Wing Cheung, Lin Xiang, Xuemei Zhou","doi":"10.1039/d5tb01187f","DOIUrl":"https://doi.org/10.1039/d5tb01187f","url":null,"abstract":"<p><p>Infection induced by bacteria through biofilms can lead to implantation failure. Antibacterial implants against biofilms are being investigated, but the preparation conditions are sometimes challenging, especially when reactions occur on the implant surface. In this work, a pre-synthesized nanoparticle suspension is prepared that consists of rare earth compounds and Au nanoparticles (RE NPs/Au NPs), which are active under near-infrared light (NIR). The seed-assisted growth method allows intimate contact between Au NPs and RE NPs, which maximizes energy transfer from NIR by the upconversion effect. The suspension is deposited on titanium implants by a sonication-assisted spray that includes commercial SLA Ti and anodic Ti (with TiO₂ nanotubes on the surface) with controlled density of particles. The biofilm can be removed using the sprayed implants with NIR treatment both <i>in vitro</i> and <i>in vivo</i> through extracellular photoelectron therapy (PET) mechanism, and the implants exhibit high biocompatibility and physical stability for implantation. The antibacterial efficiency of anodic Ti implants surpasses that of SLA Ti, possibly due to the immobilization of RE NPs/Au NPs and improved charge transfer kinetics at the interface. Such a methodology could be applicable for a wide range of uses of biomaterial surfaces.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Staying one step ahead of chronic wounds by designing symbiotic, responsive functionality into dynamic nanohydrogels.","authors":"Ayushi Priyam, Lilith M Caballero Aguilar, Negar Mahmoudi, Colin J Barrow, David R Nisbet, Richard J Williams","doi":"10.1039/d5tb01558h","DOIUrl":"https://doi.org/10.1039/d5tb01558h","url":null,"abstract":"<p><p>The dynamic environment of chronic wounds makes them an on-going clinical challenge. Conventional treatments often fail to respond to the pharmacological complexities of the system effectively, which compounded by ineffective pharmacokinetics, means a new multifactorial paradigm is required. Simple hydrogels have long been proposed to be effective wound dressings, as they can provide a highly hydrated and regenerative microenvironment; however, their colloidal instability and inefficient loading parameters may cause burst release of therapeutics and require multiple reapplications, which is both pharmacologically and economically unfavourable. Nanomaterials, on the other hand, facilitate sustained therapeutic release and are generally regarded as stable; however, to avoid off target effects, they need to be spatially defined in a controlled fashion. Here, we discuss the progress made towards engineering the activity of these nanohydrogels through developments in multicomponent materials. The goal is to meet both the wound and clinically relevant demands <i>via</i> the inclusion of symbiotic features across multiple length scales. We introduce critical developments enabled by this approach and discuss their potential application as therapeutic delivery agents to treat various common chronic wounds. We propose future directions to further develop nanohydrogels as function-at-demand topical wound dressings to contain chronic wounds.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An AI-assisted multiplex fluorescence sensing platform for grading diagnosis of Alzheimer's disease.","authors":"Yibiao Liu, Zhongzeng Zhou, Xingyun Liu, Jian Zeng, Qiong Liu, Tailin Xu","doi":"10.1039/d5tb01103e","DOIUrl":"https://doi.org/10.1039/d5tb01103e","url":null,"abstract":"<p><p>Blood-based biomarkers have become increasingly important for Alzheimer's disease (AD) diagnosis. However, due to individual variations, diagnostic accuracy using a single blood biomarker remains low, making it challenging to implement in large-scale AD screening efforts. Herein, we developed a multiplex fluorescent sensing platform for simultaneously measuring Aβ40, Aβ42, and P-tau181 in the blood, and constructed an artificial intelligence (AI) model. These three biomarkers were analyzed in 60 clinical samples: 15 healthy control, 15 subjective cognitive decline, 15 mild cognitive impairment, and 15 AD samples. The AI model based on these three biomarkers exhibited high predictive accuracy (91%), high positive predictive value (PPV) and low false rate (8.8%). The diagnostic accuracy and PPV of the AI model exceeded 90% for AD grading diagnosis in clinical samples. This study introduces a promising strategy for disease diagnosis and grading based on multi-biomarker analysis.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual antibacterial and antibiofilm strategy based on an injectable NO-releasing supramolecular hydrogel for periodontitis treatment.","authors":"Lili Wang, Hong Chen, Dongna Xie, Jiale Wan, Weinan Ren, Dong Ma, Guowei Li, Wu Zhang","doi":"10.1039/d5tb01062d","DOIUrl":"https://doi.org/10.1039/d5tb01062d","url":null,"abstract":"<p><p>Periodontitis, a microbially-driven chronic inflammatory disease intricately linked to systemic disorders, is conventionally managed through mechanical debridement supplemented with adjunctive antibiotic therapy. However, the anatomical complexity of deep periodontal pockets often impedes complete biofilm eradication, while the transient retention of therapeutics within these pockets and emerging antibiotic resistance undermine treatment efficacy. To address these challenges, we developed an injectable supramolecular hydrogel (Gel) incorporating PEHA/NONOate as a nitric oxide (NO) donor. This system leverages the hydrogel's shear-thinning properties for minimally invasive delivery into deep periodontal pockets, enabling sustained and controlled NO release. PEHA, as a polyamine-based NO donor, overcomes the inherent instability of gaseous NO through high-capacity storage and gradual liberation, thereby exerting potent antibacterial and biofilm-disrupting effects without inducing cytotoxicity. Our findings demonstrate that this innovative platform not only provides an effective solution for deep-tissue antimicrobial therapy but also has translational potential for managing other refractory infections.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inducing ferroptosis in breast cancer with nanoparticles: a promising and challenging therapeutic strategy.","authors":"Zhiyu Wang, Peiyao Xiao, Yuxuan Guo, Zhuomeng Zheng, Xinyu Wang, Chunming Yang, Jun Long, Jie Wang, Guangchun He, Chanjuan Zheng, Shujun Fu, Yian Wang, Xiyun Deng","doi":"10.1039/d5tb00768b","DOIUrl":"https://doi.org/10.1039/d5tb00768b","url":null,"abstract":"<p><p>Breast cancer, marked by its high global incidence and mortality rates, presents significant clinical challenges. Conventional treatments such as surgery, radiotherapy, chemotherapy, immunotherapy, and targeted therapy often fail to achieve the expected therapeutic efficacy. Ferroptosis, a unique form of regulated cell death driven by iron-dependent lipid peroxidation, has been found to confer higher sensitivity to drug-resistant and highly metastatic breast cancer cells. However, breast cancer therapy based on ferroptosis induction has encountered bottleneck issues such as low stability and poor targeting. Recently, ferroptosis induction <i>via</i> nanoparticles has been explored as a promising strategy and has shown great potential in breast cancer therapy. These nanoparticles, with specific surface modifications, can interfere with iron metabolism, glutathione metabolism, and lipid metabolism through photothermal therapy, photodynamic therapy, or by delivering therapeutic cargo (<i>e.g.</i>, drugs, DNA, RNA), ultimately inducing ferroptosis in cancer cells. This review summarizes the characteristics and synthesis methods of nanoparticles designed to induce ferroptosis in breast cancer. We also discuss the mechanisms and clinical potential of different nanoparticle types, as well as future directions in their synthesis, targeting specificity, and biological safety, emphasizing their potential to revolutionize breast cancer treatment.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-inspired rational design of multiscale topographical interfaces: pansy petal replicas as high-fidelity SERS platforms for single-cell analysis.","authors":"M Barshutina, Z Bochkova, I Zavidovskiy, S Barshutin, D Yakubovsky, V Solovei, A Baizhumanov, G Maksimov, A Arsenin, V Volkov, N Brazhe, S Novikov","doi":"10.1039/d5tb01784j","DOIUrl":"https://doi.org/10.1039/d5tb01784j","url":null,"abstract":"<p><p>Engineering biointerfaces that provide both robust cell capture and optimal signal enhancement is a central challenge in the development of materials for cellular diagnostics. Conventional top-down fabrication methods are often complex and costly, limiting their widespread application. Here, we introduce a bio-inspired rational design strategy for creating high-performance SERS platforms for single-cell analysis. By developing a quantitative image analysis methodology, we define a surface complexity coefficient, <i>α</i>, which serves as a predictive metric for the cell-adhesion capacity of a given topography. We demonstrate that pansy petal replicas, identified through this strategy, possess a unique multiscale architecture ideal for erythrocyte analysis. These interfaces exhibit a synergistic interplay between high submicron complexity (<i>α</i> > 20) for robust cell immobilization and cell-conformable micron-scale semi-cavities (8-10 μm) that maximize the interaction area with plasmonic Au nanoparticles (∼30 nm). This optimized topography results in a 2- to 7-fold enhancement of SERS signals from individual erythrocytes compared to other floral-templated substrates. This work not only provides a scalable and cost-effective manufacturing route for advanced SERS materials but also establishes a quantitative framework for designing next-generation biointerfaces for a host of diagnostic and biomedical applications.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a magnetically driven microrobot covered with a time-dependent film for colon drug delivery.","authors":"Xiaoyu Li, Weibin Rong, Lefeng Wang, Hui Xie, Lining Sun","doi":"10.1039/d5tb00721f","DOIUrl":"https://doi.org/10.1039/d5tb00721f","url":null,"abstract":"<p><p>Oral administration is an ideal method for drug delivery, but achieving targeted drug delivery to the colon remains a challenge. In this study, a magnetic microrobot incorporating a colon-specific method was developed, featuring both time-dependent and magnetically driven functions. With the help of commercially available enteric-coated capsules, this microrobot functioned like a pH- and time-dependent sequential trigger system in an <i>in vitro</i> gastrointestinal (GI) simulation environment, a common approach for colon-targeted drug delivery. This design also endowed the microrobot with the ability to achieve <i>in vitro</i> targeted drug delivery without the need for external control. However, in some cases, the complexity and variability of the GI tract may lead to ineffectiveness in colon-specific methods. With internally sealed neodymium-iron-boron (NdFeB) N52 magnets, the microrobot tumbled on the intestinal surface <i>in vitro</i>, demonstrating good controllability and speed. This means that the microrobot can be controlled by a rotating magnetic field when the colon-specific method fails, offering the possibility of <i>in vitro</i> intervention. The <i>in vitro</i> results indicated that this magnetic microrobot, which incorporates a colon-specific method, holds promise as a drug-delivery platform with reduced control costs and enhanced targeting capabilities.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multifunctional curcumin-Fe₃O₄@ZIF-8 nanoformulation as a <i>T</i>₂ MRI contrast agent and pH-responsive theranostic platform for targeted ROS generation, radiosensitization, and triple-negative breast cancer treatment.","authors":"Ali Rahmani, Aziz Maleki, Rahim Jafari, Hamed Rezaeejam, Samad Nadri","doi":"10.1039/d5tb00789e","DOIUrl":"https://doi.org/10.1039/d5tb00789e","url":null,"abstract":"<p><p>Triple-negative breast cancer (TNBC) is one of the most aggressive and treatment-resistant malignancies, necessitating the development of innovative therapeutic approaches. Here, we report a multifunctional theranostic nanoformulation (curcumin-Fe₃O₄@ZIF-8) integrating MRI-guided imaging, pH-responsive drug release, radiosensitization, and reactive oxygen species (ROS)-induced apoptosis into a single platform. Fe₃O₄@ZIF-8 nanoparticles (NPs) served as a T₂-weighted MRI contrast agent, achieving <i>r</i>₂ relaxivity values of 25.14 mM^-1 s^-1 at pH 5.5 and 14.65 mM^-1 s^-1 at pH 7.4, demonstrating pH-responsive contrast enhancement for improved tumor imaging. The ZIF-8 shell enabled tumor-specific curcumin release, with ∼75% drug release at pH 5.5 (tumor microenvironment) <i>versus</i> only ∼45% at pH 7.4 within 48 h, ensuring minimal systemic toxicity. Cellular uptake studies in MDA-MB-231 cells confirmed dose-dependent internalization, with 84.3% nanoparticle uptake at 100 μg mL^-1. Importantly, ROS generation increased by 28.6% at pH 5.5, thereby amplifying oxidative stress and inducing apoptosis. <i>In vitro</i> cytotoxicity assays revealed that Cur-Fe₃O₄@ZIF-8 reduced MDA-MB-231 cell viability by 72.4% at 48 h, with an IC₅₀ of 98.86 μg mL^-1, compared to 293.8 μg mL^-1 for Fe₃O₄@ZIF-8, thus demonstrating an ∼3-fold enhancement in therapeutic potency. Furthermore, X-ray radiotherapy (2 Gy) in combination with Cur-Fe₃O₄@ZIF-8 further reduced the IC₅₀ to 80.37 μg mL^-1, underscoring its radiosensitization capabilities. Cell cycle analysis revealed G2/M-phase arrest, contributing to impaired cancer cell proliferation. Apoptosis assays confirmed a significant increase in early and late apoptotic populations, while real-time PCR analysis showed significant downregulation of anti-apoptotic BCL-xL and cyclin D1 genes with considerable upregulation of pro-apoptotic BAX, thus reinforcing the mechanism of tumor suppression. This triple-action theranostic system surpasses conventional chemotherapy and standalone MRI contrast agents by combining precision imaging with targeted therapy, offering transformative advancement in TNBC treatment.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrolytic degradation of PEG-based thiol-norbornene hydrogels enables multi-modal controlled release.","authors":"Nathan H Dimmitt, Chien-Chi Lin","doi":"10.1039/d5tb01524c","DOIUrl":"10.1039/d5tb01524c","url":null,"abstract":"<p><p>Poly(ethylene glycol) (PEG) hydrogels crosslinked by orthogonal thiol-norbornene click chemistry have emerged as an ideal platform for tissue engineering and drug delivery applications due to their rapid crosslinking kinetics and excellent biocompatibility. Norbornene-functionalized PEG (PEGNB) is routinely synthesized through the Steglich esterification of 5-norbornene-2-carboxylic acid with hydroxyl-terminated PEG. When crosslinked with thiol-bearing macromers, PEGNB hydrogels undergo slow hydrolytic degradation due to hydrolysis of ester bonds connecting a PEG backbone and a NB moiety. In prior work, we replaced the pungent and nauseous 5-norbornene-2-carboxylic acid with odorless carbic anhydride (CA) for synthesizing PEG-norbornene-carboxylate (PEGNB_CA), a new macromer that could be readily photo-crosslinked into thiol-norbornene hydrogels with faster hydrolytic degradation than the PEGNB counterparts. In this contribution, we employed a modular approach to tune the hydrolytic degradation of PEGNB_CA hydrogels over days to months. We first demonstrated the diverse crosslinking of PEGNB_CA hydrogels using either photopolymerization or enzymatic crosslinking. We characterized the hydrolytic degradation of these hydrogels under different solution pH values and temperatures. <i>Via</i> adjusting crosslinker functionality and the ratio of fast-degrading PEGNB_CA to slow-degrading PEGNB, tunable hydrolytic degradation of PEGNB_CA hydrogels was achieved from under 2 days to over 3 months. Finally, we designed the highly tunable PEGNB_CA hydrogels with varying mesh sizes, degradation rates, and covalent tethering of degradable linkers to afford long-term controlled release of model drugs.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12498566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An octupolar donor-acceptor dye exploiting aggregation-induced intersystem crossing for efficient ROS generation.","authors":"Dayoung Kang, Yongyang Luo, Tae-Il Kim, Juwon Oh, Jeehyeon Bae, Youngmi Kim","doi":"10.1039/d5tb01914a","DOIUrl":"https://doi.org/10.1039/d5tb01914a","url":null,"abstract":"<p><p>Photodynamic therapy (PDT) requires photosensitizers (PSs) that efficiently generate reactive oxygen species (ROS) or otherwise induce cell damage, even under the hypoxic conditions typical of solid tumor environments. Here, we report a heavy-atom-free octupolar donor-acceptor dye, 3CN, designed with a triphenylamine core and three cyanovinyl-benzothiazole acceptors. This dye harnesses aggregation-induced intersystem crossing (AI-ISC) to promote efficient triplet state population. In aqueous solutions, 3CN spontaneously self-assembles into stable nanoaggregates (3CNAgg) that exhibit excellent colloidal stability and prolonged triplet-state lifetimes. These aggregates demonstrate superior Type I photosensitization capabilities, generating the superoxide anion radical (O₂˙^-) with significantly greater efficiency under white light irradiation than the reference PS, rose bengal. In encapsulated formulation, 3CNEn, exhibits remarkable therapeutic efficacy with IC₅₀ values of 8.6 μM against triple-negative human breast cancer cells (MDA-MB-231), while maintaining potent photocytotoxicity even under severely hypoxic conditions (1% O₂). <i>In vivo</i> studies using mouse models bearing MDA-MB-231 tumors demonstrate 100% inhibition of tumor growth with minimal dark cytotoxicity and inherent tumor-targeting properties.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}