Journal of materials chemistry. B最新文献

{"title":"Dual and sequential drug delivery systems with antimicrobial and bone regenerative therapeutic effects.","authors":"Miguel A Rodrigues, Carla Ferreira, João P Borges, Beatriz G Bernardes, Ana L Oliveira, José D Santos, Maria A Lopes","doi":"10.1039/d5tb00579e","DOIUrl":"https://doi.org/10.1039/d5tb00579e","url":null,"abstract":"<p><p>Bone defect healing is often compromised by infections acquired during surgery, hindering regeneration. An effective solution should first prevent infection and then promote bone repair. Localised drug-delivery systems capable of dual and sequential release of antimicrobial and bone-regenerative agents represent a promising solution; however, precisely controlling this sequential release remains an unmet challenge. To address this issue, this study explores a novel approach by developing delivery systems based on either hollow or non-hollow porous bioceramics with an alginate hydrogel matrix, resulting in cutting-edge systems with a controlled, stage-specific release of antimicrobial and bone regenerative agents that meet the clinical needs. Gentamicin served as the antimicrobial agent, while raloxifene and/or alendronate represented hydrophobic and hydrophilic bone-regenerative agents. The systems were evaluated for release profiles, kinetic modelling, and the effects of lyophilisation and sterilisation (using ethylene oxide or supercritical CO₂) on drug stability and release kinetics. The release followed a precise dual-sequential pattern: gentamicin was released over 2-3 weeks, followed by another 2-3 weeks of bone-regenerative agents. Kinetic model fitting showed that gentamicin release was driven mainly by diffusion (with or without hydrogel swelling), and raloxifene/alendronate release was dominated by a mixture of diffusion and polymeric matrix swelling/erosion. Lyophilisation and sterilisation preserved release profiles, though timeframes shifted slightly, with supercritical CO₂ causing minimal delay. Gentamicin retained strong antimicrobial activity post-processing, confirming the system's potential for infection control and bone repair.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic chemo-photothermal therapy and osteogenic activity using graphene oxide-functionalized composite whitlockite bone particles.","authors":"Abdelrahman I Rezk, Jung-Mi Oh, Abdalla Abdal-Hay, Jun Lee, Sungkun Chun, Beom-Su Kim","doi":"10.1039/d5tb00240k","DOIUrl":"https://doi.org/10.1039/d5tb00240k","url":null,"abstract":"<p><p>The aim of this study is to develop innovative multifunctional bone substitutes by engineering graphene oxide (GO) and doxorubicin (DOX)-conjugated whitlockite (WH) composites (WG@DOX) for enhanced bone regeneration and targeted drug delivery. To assess the physicochemical properties of WG@DOX composites, we performed a series of characterization techniques, including morphological analysis, X-ray diffraction, Fourier-transform infrared spectroscopy, photothermal measurements, drug release studies, and <i>in vitro</i> bioactivity evaluation. Leveraging GO's photothermal properties, WG@DOX exhibited enhanced heat generation under NIR laser irradiation. The bone particles demonstrated sustained, pH-sensitive, and light-triggered drug release. This led to superior biocompatibility and drug delivery, enabling potent synergistic chemo-photothermal therapy. Importantly, the WG@DOX composites exhibited a synergistic therapeutic effect, combining the cytotoxic effects of DOX chemotherapy with the localized hyperthermia induced by GO under NIR laser irradiation, leading to significant eradication of MG63 osteosarcoma cells. Furthermore, the synergistic effects of GO and Mg²⁺ ions within the WH-GO composite particles markedly enhanced osteoblast adhesion, proliferation, and osteogenic differentiation by upregulating key osteogenic proteins.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-fast and multi-responsive anisotropic nanofibrous actuator with remote control.","authors":"Zijun Zhu, Lantao He, Tingxu Guo, Tong Shao, Jianwu Lan, Shaojian Lin, Patrick Theato, Jiaojiao Shang","doi":"10.1039/d5tb01168j","DOIUrl":"https://doi.org/10.1039/d5tb01168j","url":null,"abstract":"<p><p>The development of high-performance soft actuators capable of integrating multimodal responsiveness, ultrafast actuation, and programmable deformation remains a critical challenge in soft robotics, primarily due to inherent limitations in current hydrogel-based and elastomer-based systems. These conventional actuators often suffer from compromised functionality, slow response kinetics, and complex fabrication processes. Herein, we present an anisotropic nanofibrous actuator platform that overcomes these limitations through the synergistic combination of structurally aligned electrospun nanofibers and multi-stimulus responsive polymer composites. Our design uniquely integrates three independent actuation mechanisms-thermoresponsive poly(<i>N</i>-isopropyl acrylamide-<i>co</i>-4-acryloyl benzophenone) (P(NIPAM-<i>co</i>-ABP)), photothermally active gold nanoparticles, and pH-sensitive poly(diethylaminoethyl methacrylate-<i>co</i>-methyl methacrylate-<i>co</i>-4-acryloyl benzophenone) (P(DEAEMA-<i>co</i>-MMA-<i>co</i>-ABP))-within an oriented nanofibrous architecture. Precise control of fiber alignment through electrospinning techniques enables programmable directional bending responses, while the bilayer configuration facilitates asymmetric deformation through differential swelling behavior. The highly porous nanofibrous network architecture provides rapid mass transport pathways, yielding exceptional actuation speeds (<0.3 s, 360°) that surpass conventional hydrogel-based systems. Furthermore, the actuator still maintains its rapid responsiveness in the air (4 s, 35°). Additionally, the aligned nanofiber morphology contributes to remarkable mechanical robustness, supporting loads up to 178 times its own mass. This work establishes a versatile materials platform that addresses critical challenges in soft robotics by combining multimodal environmental responsiveness, ultrafast actuation kinetics, and programmable deformation control through a scalable fabrication approach. The design principles demonstrated here provide new opportunities for developing advanced soft robotic systems with biomimetic functionality and enhanced performance characteristics.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailored surface topographical scaffolds: a breakthrough in osteoarthritic cartilage and subchondral bone defect repair.","authors":"Bowen Zheng, Jiawei Xing, Xuehan Tang, Ze He, Qingran Tang, Shibo Liu, Yin Xiao, Jiazhuang Xu, En Luo, Yao Liu","doi":"10.1039/d5tb00943j","DOIUrl":"https://doi.org/10.1039/d5tb00943j","url":null,"abstract":"<p><p>Osteoarthritis, a common degenerative joint disorder, has consistently increased in incidence in recent years. Bioactive scaffolds with specific surface topographies have demonstrated significant therapeutic potential for addressing the complex structures of articular cartilage and subchondral bone. Key signaling pathways, notably Wnt/β-catenin and NF-κB, are critical mediators in tissue repair processes. Developing osteochondral tissue engineering requires a thorough evaluation of parameters such as biocompatibility, biodegradability, and mechanical properties. Advanced manufacturing technologies allow precise manipulation of micro- and nano-scale topological structures, providing essential mechanical support, establishing optimal cellular microenvironments, and enabling controlled delivery of therapeutic agents and growth factors. In this review, we systematically summarized the design principles of cell scaffolds in osteochondral repair, outlined the preparation methods for topological structures, and focused on the signaling pathways related to micro- and nano-scale topological structures and how they affect key biological processes of cells, such as cell adhesion, proliferation, migration, and differentiation. Furthermore, we discussed the future development of biomaterial scaffolds with unique micro- and nano-scale topological structures to guide future treatment of osteoarthritis.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart biosensors with self-healing materials.","authors":"Mohammad Ali Farzin, Seyed Morteza Naghib, Navid Rabiee","doi":"10.1039/d5tb01139f","DOIUrl":"https://doi.org/10.1039/d5tb01139f","url":null,"abstract":"<p><p>Real-time, <i>in situ</i>, and continuous biosensors face considerable challenges related to durability, as prolonged operation often leads to mechanical or functional degradation. In this context, materials with self-healing properties offer a transformative advantage. By enabling automatic recovery from physical damage, these materials significantly extend sensor lifespan, reduce maintenance costs, and minimize environmental waste. The emergence of self-healing systems has already driven major advancements in fields such as electronic skins (E-skins), smart textiles, and soft robotics, with even greater potential in the realms of implantable and underwater biosensors. Furthermore, self-healing materials are poised to accelerate the development of resilient wireless sensor networks, facilitating their integration into the Internet of Things (IoT) and human-machine interfaces. In response to these promising opportunities, significant research efforts have been directed toward embedding self-repairing capabilities into biosensor platforms. This review presents the latest innovations in self-healing biosensors, covering a range of designs including E-skins, eutectogel-based devices, textile-integrated sensors, implantable systems, electrochemical and fire sensors, as well as underwater applications. To provide a comprehensive understanding, the discussion begins with fundamental design strategies for engineering self-healing materials and progresses to their implementation in biosensing technologies. The review concludes by outlining future research directions and emerging applications that underscore the pivotal role of self-healing materials in shaping the next generation of robust, intelligent biosensors.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent analysis of six NSAIDs in human plasma using polyurethane/B-N-S-co-doped rGO nanofiber-modified glassy carbon electrode followed by EA-SPME.","authors":"Fatemeh Nejabati, Homeira Ebrahimzadeh","doi":"10.1039/d5tb00847f","DOIUrl":"https://doi.org/10.1039/d5tb00847f","url":null,"abstract":"<p><p>Herein, a novel voltammetric biosensor was designed and constructed for the simultaneous measurement of six nonsteroidal anti-inflammatory drugs (NSAIDs), including celecoxib, mefenamic acid, acetaminophen, naproxen, ibuprofen, and caffeine. In this biosensor, the glassy carbon electrode (GCE) was used as an unmodified working electrode. For modification, the water based-polyurethane-(B-N-S)-co doped-rGO electrospun nanofibers (WB-PU-(B-N-S)-rGO NFs) were first collected on the conductive surface of GCE. Subsequently, the biosensor was used to analyze the presence of six NSAIDs in human plasma samples. Prior to this analysis, the plasma samples were prepared using electrospun nanofibers made of polyvinyl alcohol/casein/tannic acid/polyaniline/titanium dioxide nanoparticles (PVA/CAS/TA/PANI/TiO₂ NPs) in electrically assisted solid phase microextraction (EA-SPME) on a pewter rod. The WB-PU-(B-N-S)-rGO NFs were characterized with Fourier transform-infrared (FT-IR), field emission-scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy with elemental mapping analysis (EDS-Mapping), and X-ray diffraction (XRD), which confirmed the synthesis of this nanocomposite. According to optimum conditions, the wide linear range was 30-900 μM with <i>R</i>² ≥ 0.9585, and low detection limits ranged from 8.6 to 47.5 μM based on S/N = 3. The intra-day and inter-day RSDs% were obtained within 4.17-4.90% and 4.92-5.49%, respectively. Finally, the efficiency of the electrochemical biosensor was evaluated to determine these six NSAIDs in human plasma samples with good recoveries (91.0-102.8%).</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A self-gelling hemostatic powder driven by hydrogen bonding and electrostatic interactions with antibacterial and antioxidant properties.","authors":"Cheng Cao, Qi Yang, Liming Chen, Xiuqiang Li, Jiazhuo Gong, Lei Liang, Chaojie Yu, Bingyan Guo, Xueyu Wang, Zhongming Zhao, Yuwei Qiu, Fanglian Yao, Junjie Li, Hong Zhang","doi":"10.1039/d5tb00032g","DOIUrl":"https://doi.org/10.1039/d5tb00032g","url":null,"abstract":"<p><p>Self-gelling powders present distinctive advantages for managing incompressible wounds with elusive bleeding points. In this study, a self-gelling powder composed of polyacrylic acid/arginine-modified polylysine/tannic acid (PAA/PLG/TA) is developed. The system's formation is primarily driven by hydrogen bonding and electrostatic interactions. To enhance the self-gelling behavior, the guanidinium group from arginine is integrated into the polylysine chain to form PLG, thereby improving electrostatic interactions with the carboxyl groups on PAA. Upon contact with blood at the wound site, the PAA/PLG/TA powder rapidly absorbs water, forming a self-gel and establishing robust adhesion with the tissue. The mechanical properties of the self-gelling powder can be modulated by adjusting the PAA/PLG ratio. In the presence of PAA, the amino groups are protonated and positively charged, yielding a potent antibacterial effect, alleviating oxidative stress, and facilitating the repair of traumatized tissue. The incorporation of TA increases the cross-linking degree within the self-gel, enhances tissue adhesion properties, and provides binding sites for red blood cells and platelets. <i>In vitro</i> and <i>in vivo</i> hemostasis results show that the PAA/PLG/TA self-gelling hemostatic powder significantly reduces hemostasis time and bleeding volume compared to commercial chitosan hemostatic powder. Consequently, the PAA/PLG/TA self-gelling hemostatic powder holds promising potential for future rapid hemostasis applications.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conductive nano nickel oxide/hydroxide paper electrochemical sensor for serotonin detection in genetically engineered <i>Drosophila</i>.","authors":"Sharmila Prashanth, Manvitha Kadandelu, Shamprasad Varija Raghu, K Sudhakara Prasad, Airody Vasudeva Adhikari","doi":"10.1039/d5tb01216c","DOIUrl":"https://doi.org/10.1039/d5tb01216c","url":null,"abstract":"<p><p>Serotonin is considered an integral part in neuropsychiatric diseases, such as major depressive disorder, schizophrenia, post-traumatic stress disorder, obsessive-compulsive disorder, anxiety disorder, and substance use disorder. Understanding the levels of serotonin under different disease conditions is important. Herein, we explored the development of an efficient electrochemical sensor utilizing sustainable paper electrode integrated with nanocomposites through a simultaneous electrochemical deposition strategy. The as-developed sensor is further investigated with surface and electrochemical studies to understand the robust fabrication of the sensor as well as the electrochemical characteristics to show the improved electron transfer kinetics and detection capabilities even in the presence of common interfering biomolecules. The sensor demonstrated a broad linear range from 0.007 nM to 500 μM, with an impressive limit of detection of 0.024 nM for the low concentration range (0.007-0.48 nM) and 383.7 nM for the high concentration range both falling well within the clinically relevant detection levels of serotonin. To evaluate the practical performance, the developed sensor was tested on brain homogenates obtained from genetically modified <i>Drosophila melanogaster</i> models with different serotonin levels. The sensor effectively detected the <i>in vivo</i> changes in serotonin level, and the results were validated against gold-standard HPLC analysis and immunohistochemical staining experiments. The sensors' notable stability, selectivity, and sensitivity towards serotonin make them a valuable tool for neurochemical research and clinical applications, particularly in studying serotonin-related neurological conditions and advancing personalized treatments.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporally modulated polyphenol-protein coating for accelerated healing of chronic wounds.","authors":"Linhua Li, Qingyin Li, Chunle Zhang, Zhengjiang Cao, Chang Liu, Rifang Luo, Yunbing Wang, Xiaoxi Zeng, Ping Fu","doi":"10.1039/d5tb01078k","DOIUrl":"https://doi.org/10.1039/d5tb01078k","url":null,"abstract":"<p><p>Chronic wounds are a common and serious complication. Abnormal microenvironments such as excessive oxidative stress, chronic inflammation, bacterial infection, and cellular dysfunction severely inhibit the wound healing process, leading to increased rates of amputation and mortality in diabetic patients. In this study, a novel polyphenol-activated protein coating (PDA/HK@LZM) was successfully constructed <i>via</i> the adsorption of lysozyme on the surface of a polyphenol nanocomposite comprising dopamine and honokiol. The coating effectively maintains the integrity of secondary and tertiary protein structures and preserves up to 91% of the lysozyme activity. Moreover, the PDA/HK@LZM coating achieves the spatiotemporal regulation of the chronic wound microenvironment. In the initial stage, lysozyme dominates the immune response by enhancing macrophage phagocytosis and modulating inflammatory factors, while honokiol synergizes with free radical scavenging and antimicrobial activity; all three synergistically enhance the wound self-cleaning function. In the repair stage, exposed honokiol regulates inflammation, polarizing macrophages from the pro-inflammatory M1-type to the anti-inflammatory M2-type and accelerating wound repair. Moreover, the release of honokiol into the microenvironment prevents the formation of vascular microthrombi, facilitating the delivery of nutrients and oxygen. Full-thickness skin wound experiments confirmed the effectiveness of the PDA/HK@LZM coating dressing in promoting rapid healing of chronic wounds. This study introduces a novel strategy for constructing polyphenol-activated protein coatings with spatiotemporal modulation wound microenvironment, opening new possibilities for the efficient treatment of chronic wounds.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and characterisation of ZIF-8/alginate composites as drug carrier systems.","authors":"Sarah V Dummert, Sylvia Dörschmidt, Theresa Bloehs, Katia Rodewald, Miriam Caviglia, Claudia Schmidt, Mian Zahid Hussain, Julien Warnan, Roland A Fischer, Angela Casini, Romy Ettlinger","doi":"10.1039/d5tb00614g","DOIUrl":"https://doi.org/10.1039/d5tb00614g","url":null,"abstract":"<p><p>Metal-organic frameworks (MOFs) are promising candidates for drug carrier systems due to their high porosity and tuneable structures, however, their clinical translation is restrained. Integrating MOFs into processable matrices improves mechanical properties, processability, and often drug delivery performance. Hydrogels, as soft, three-dimensional polymer networks with high flexibility and biocompatibility, are particularly favourable candidates for advanced MOF-based drug carriers. However, a lack of fundamental material studies limits full exploitation of the potential and hinders further development of such composites. To address this, this study provides a physicochemical investigation of MOF/alginate hydrogels using ZIF-8 as a benchmark MOF and thioflavin T (ThT) as a model drug. A rapid, <i>in situ</i> encapsulation approach enabled the fabrication of ThT@ZIF-8 (14.2 wt% loading), which was incorporated into an alginate matrix (ThT@ZIF-8@Alg) at 95 wt%, putting MOF carrier functionality in a processable form. Characterisation including X-ray diffraction, infrared and diffuse-reflectance UV/Vis spectroscopy, and electron microscopy enabled a detailed investigation of MOF properties in the composite and confirmed its retained structural integrity. Drug release studies of ThT@ZIF-8@Alg closely mirrored the pure MOF's pH-triggered behaviour. Furthermore, by comparing different methods of incorporating ThT in (ZIF-8@)Alg matrices, we demonstrate the versatility of such composites in achieving customisable release profiles. <i>In vitro</i> preliminary studies of the antiproliferative activity of ThT@ZIF-8@Alg in cancerous and non-tumorigenic cells support the idea of sustained controlled release of ThT over 72 h at pH 7.4. This strategy advances MOF-hydrogel-based drug delivery systems, with potential applications in topical treatments and implant coatings.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}