Journal of materials chemistry. B最新文献_第6页

PEGylated W_4.6N₄/WO₃ nanoparticles as a near-infrared photothermal agent for effective cancer therapy. 聚乙二醇化W4.6N4/WO3纳米颗粒作为近红外光热剂用于有效的癌症治疗。

Journal of materials chemistry. B Pub Date : 2025-06-30 DOI: 10.1039/d5tb00665a

Rui Yang, Jianping Li, Hao Song, Cong Wang, Na Xu

引用次数: 0

Wearable microfluidic immunosensors for point-of-care detection of bio-analytes: a critical review. 用于即时检测生物分析物的可穿戴微流控免疫传感器：综述。

Journal of materials chemistry. B Pub Date : 2025-06-27 DOI: 10.1039/d5tb00682a

Emadoddin Amin Sadrabadi, Foad Soleimani, Neda Naseri, Mohsen Ghiasi Tarzi, Kobra Omidfar

{"title":"Wearable microfluidic immunosensors for point-of-care detection of bio-analytes: a critical review.","authors":"Emadoddin Amin Sadrabadi, Foad Soleimani, Neda Naseri, Mohsen Ghiasi Tarzi, Kobra Omidfar","doi":"10.1039/d5tb00682a","DOIUrl":"https://doi.org/10.1039/d5tb00682a","url":null,"abstract":"Early and timely disease diagnosis is crucial for effective treatment and improved clinical outcomes. Antibodies and their fragments are among the most widely used affinity reagents in point-of-care (POC) assays because of their target specificity and affinity. Traditional immunosensors, the analytical devices utilizing antibodies as the biorecognition elements, are time-consuming and require advanced lab settings, limiting their use in POC testing. Recent research focuses on developing specific, portable, and cost-effective miniaturized diagnostic tests for various applications. Wearable immunosensors offer rapid, specific, and affordable solutions, especially in remote settings. However, they fall short in manipulating low-volume samples and multiplex detection of bioanalytes. Integrating these assays with micro/nanofabrication technologies would be beneficial to patient care because the various laboratory assays can be miniaturized and incorporated into a lab-on-a-body. This review aims to outline recent progress in developing wearable immunosensors and highlight the utility of these assays in detecting bio-analytes. Furthermore, prospects, opportunities, and remaining challenges within this research area are presented to facilitate their translation into clinical settings.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A buoyant plasmonic microbubble-based SERS sensing platform for amyloid-beta protein detection in Alzheimer's disease. 基于浮力等离子体微泡的阿尔茨海默病淀粉样蛋白检测SERS传感平台。

Journal of materials chemistry. B Pub Date : 2025-06-27 DOI: 10.1039/d5tb00632e

Willis Kwun Hei Ho, Qin Zhang, Fariza Zhorabe, Jiaxiang Yan, Yutian Gu, Shujun Wang, Changqing Yi, Yu Zhang, Mo Yang

{"title":"A buoyant plasmonic microbubble-based SERS sensing platform for amyloid-beta protein detection in Alzheimer's disease.","authors":"Willis Kwun Hei Ho, Qin Zhang, Fariza Zhorabe, Jiaxiang Yan, Yutian Gu, Shujun Wang, Changqing Yi, Yu Zhang, Mo Yang","doi":"10.1039/d5tb00632e","DOIUrl":"https://doi.org/10.1039/d5tb00632e","url":null,"abstract":"Amyloid-β (Aβ) plaques are a key pathological hallmark of Alzheimer's disease (AD), highlighting the need for highly sensitive bioassays for Aβ detection to enable AD diagnosis. Here, we synthesized a buoyant plasmonic substrate composed of polyvinyl alcohol microbubbles (MBs) decorated with in situ-reduced gold nanoparticles (Au NPs). Benefiting from its inherent buoyancy and near-infrared plasmonic properties, the Au/MB substrate serves as an ideal platform for biomolecular sensing via the surface-enhanced Raman spectroscopy (SERS) technique. Compared to conventional flat SERS substrates, the three-dimensional (3D) curved surface of the Au/MB substrate significantly increases the effective sensing area, while its inherent buoyancy facilitates the efficient removal of unbound targets, thereby enhancing detection specificity. By functionalizing Au/MB substrates with copper ions (Cu2+) and 4-mercaptobenzoic acid (4-MBA), we achieved sensitive detection of AD-related Aβ proteins. In the presence of the target analyte, the interaction between Aβ proteins and Cu2+ induces molecular deformation and orientation changes in 4-MBA, leading to distinct spectral changes in the SERS signals. The results demonstrate that the developed Au/MB-based SERS sensor enables sensitive detection of Aβ1-40 oligomers with a sensitivity as low as 10-9 M. Therefore, this work not only establishes a foundational framework for designing buoyant plasmonic substrate-based SERS sensing platform but also paves the way for the quantitative detection of disease-associated protein biomarkers, contributing to advancements in AD diagnostics.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasonic activation of polymer-drug conjugates for targeted and combinational pancreatic cancer therapy. 靶向和联合治疗胰腺癌的聚合物药物偶联物的超声活化。

Journal of materials chemistry. B Pub Date : 2025-06-27 DOI: 10.1039/d5tb01250c

Dimitra Toumpa, Athina Angelopoulou, Konstantinos Avgoustakis, George Pasparakis

引用次数: 0

Improving extracellular matrix penetration with biocatalytic metal-organic framework nanoswimmers. 生物催化金属-有机骨架纳米游泳剂改善细胞外基质渗透。

Journal of materials chemistry. B Pub Date : 2025-06-27 DOI: 10.1039/d5tb00509d

Qianfan Chen, Si Liu, Peijun Qin, Jueyi Xue, Peiji Deng, Ziping Li, John Whitelock, Tianruo Guo, Kang Liang

{"title":"Improving extracellular matrix penetration with biocatalytic metal-organic framework nanoswimmers.","authors":"Qianfan Chen, Si Liu, Peijun Qin, Jueyi Xue, Peiji Deng, Ziping Li, John Whitelock, Tianruo Guo, Kang Liang","doi":"10.1039/d5tb00509d","DOIUrl":"https://doi.org/10.1039/d5tb00509d","url":null,"abstract":"The development of self-propelled nanomotors offers a promising strategy to enhance targeted drug delivery efficiency in cancer therapy. Active motion is believed to aid nanomotors in overcoming the physical barriers of the tumor microenvironment, allowing for deep tissue penetration; however, this crucial concept lacks detailed mechanistic understanding. In this study, we report catalase and collagenase dual-enzyme functionalized zeolitic imidazolate framework-90 (ZIF-90) nanomotors. Catalase enables the nanomotors with self-propulsion in the presence of low amount of hydrogen peroxide, while collagenase enables catalytic decomposition of collagen, a major component of the extracellular matrix (ECM), thereby enhancing motility and facilitating deeper penetration into the ECM. Experimental and computational studies elucidated the detailed mechanisms governing ECM penetration kinetics. Using a three-dimensional tumor spheroid model, the nanomotors demonstrated enhanced tissue penetration, leading to improved drug delivery and a significant reduction in cell viability. These findings underscore the potential of self-propelled nanomotors to improve drug delivery efficiency in solid tumors by leveraging both biocatalytic activity and active motion to navigate biological barriers.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Embedding oxygen heterocycles into BODIPY to enhance intersystem crossing for photodynamic therapy. 在BODIPY中嵌入氧杂环，增强系统间的交叉，用于光动力治疗。

Journal of materials chemistry. B Pub Date : 2025-06-26 DOI: 10.1039/d5tb00427f

Yu Zhang, Zhiqiang Cui, Jakub Širůček, Denis Jacquemin, Boris Le Guennic, Xiaohong Sun, Xin-Dong Jiang, Gaowu Qin

引用次数: 0

Wire arc additively manufactured nitinol with excellent superelasticity for biomedical applications. 丝弧增材制造的镍钛诺具有优异的超弹性，用于生物医学应用。

Journal of materials chemistry. B Pub Date : 2025-06-26 DOI: 10.1039/d5tb00336a

Muralidhar Yadav, Ajit Kumar, Deepak Kumar, Sagar Nilawar, Murugaiyan Amirthalingam, Satyam Suwas, Kaushik Chatterjee

{"title":"Wire arc additively manufactured nitinol with excellent superelasticity for biomedical applications.","authors":"Muralidhar Yadav, Ajit Kumar, Deepak Kumar, Sagar Nilawar, Murugaiyan Amirthalingam, Satyam Suwas, Kaushik Chatterjee","doi":"10.1039/d5tb00336a","DOIUrl":"https://doi.org/10.1039/d5tb00336a","url":null,"abstract":"Despite some recent successes in the additive manufacturing of nitinol alloys, these parts exhibit poor superelasticity compared to wrought parts, limiting their applications in biomedical devices. In this work, wire arc additive manufacturing (WAAM) was used for processing superelastic biomedical grade nitinol wire as the feedstock material on a Ti-6Al-4V substrate. Nitinol prepared by WAAM was subjected to different controlled heat treatments to improve the superelasticity. Optical microscopy and scanning electron microscopy revealed microstructural anisotropy with columnar to equiaxed grains from the bottom to the top layer of the as-fabricated alloy, which did not alter with heat treatment. X-ray diffraction and transmission electron microscopy confirmed the presence of B2 austenite as the major phase along with NiTi2, Ni3Ti, and Ni4Ti3 precipitates. Af temperatures lie between 20 and 30 °C and are favorable for biomedical applications. Due to 〈001〉 oriented grains revealed by electron backscatter diffraction, nitinol prepared by WAAM, when subjected to an optimized heat treatment schedule, demonstrated excellent superelastic recovery of 98%, which is remarkably higher than reported earlier and similar to wrought alloy. Additionally, the results of cell studies indicated that the nitinol surface better supported cell attachment following heat treatment and was comparable to that of as-cast nitinol. These findings have important implications in establishing WAAM as a viable fabrication route to prepare biomedical implants, wherein additively manufactured parts can be subjected to post-fabrication heat treatments to alleviate limitations of additive manufacturing and prepare implants of desired biomechanical performance.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iodine-containing materials for biomedical applications. 生物医学用含碘材料。

Journal of materials chemistry. B Pub Date : 2025-06-26 DOI: 10.1039/d5tb00534e

Jun-Jie Zeng, Zi-Xi Wang, Fu-Gen Wu

引用次数: 0

Decellularized small intestinal hydrogel-encapsulated BMSCs attenuate dextran sulfate sodium-induced colitis in mice via immunomodulation and tissue repair. 脱细胞小肠水凝胶包封的骨髓间充质干细胞通过免疫调节和组织修复减轻硫酸葡聚糖钠诱导的小鼠结肠炎。

Journal of materials chemistry. B Pub Date : 2025-06-26 DOI: 10.1039/d5tb00706b

Qiaoting Zeng, Huimin Xiao, Yuan Chen, Zhihua Xiao, Yuhong Ren, Qin Liu

{"title":"Decellularized small intestinal hydrogel-encapsulated BMSCs attenuate dextran sulfate sodium-induced colitis in mice via immunomodulation and tissue repair.","authors":"Qiaoting Zeng, Huimin Xiao, Yuan Chen, Zhihua Xiao, Yuhong Ren, Qin Liu","doi":"10.1039/d5tb00706b","DOIUrl":"https://doi.org/10.1039/d5tb00706b","url":null,"abstract":"The treatment of inflammatory bowel disease (IBD) urgently requires effective and safe strategies, and mesenchymal stem cell (MSC)-based therapy has emerged as a research focus due to its immunomodulatory and tissue-repairing capabilities. To enhance the therapeutic efficacy of MSCs, this study developed a decellularized small intestinal (dSI) hydrogel delivery system to encapsulate rat bone marrow-derived MSCs (rBMSCs) for targeted rectal administration to colitis lesions in mice. Results demonstrated that the dSI hydrogel significantly improved the in vivo survival rate of rBMSCs and effectively alleviated dextran sulfate sodium (DSS)-induced colitis symptoms. The dSI hydrogel significantly improved rBMSCs survival in vivo and ameliorated DSS-induced colitis by: suppression of pro-inflammatory cytokines and myeloperoxidase (MPO) expression; restoration of intestinal barrier function and promotion of mucosal regeneration. The dSI hydrogel outperformed conventional PLGA-PEG-PLGA hydrogels in tissue repair due to its superior bioactivity, biocompatibility, biodegradability, and mechanical properties, while its low immunogenicity ensured therapeutic safety. The combined treatment mitigated inflammation, oxidative stress, and tissue damage through multi-target synergistic effects, offering a novel therapeutic approach for IBD. Future studies should further investigate the interaction mechanisms between dSI hydrogel and rBMSCs, optimize dosing regimens, and employ single-cell RNA sequencing to elucidate MSC-mediated immunomodulation in the gut microenvironment. This study provides experimental evidence for the clinical translation of dSI hydrogel-based MSC therapy, highlighting its potential as a promising strategy for IBD treatment.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanically active biomaterials for tissue repair and regeneration. 用于组织修复和再生的机械活性生物材料。

Journal of materials chemistry. B Pub Date : 2025-06-26 DOI: 10.1039/d5tb01180a

Wenzhen Gao, Lian Wang, Qing Zhao, Chenchen Zhou, Bo Huang, Guiting Liu

引用次数: 0