Journal of materials chemistry. B最新文献

{"title":"Design and characterisation of ZIF-8/alginate composites as drug carrier systems.","authors":"Sarah V Dummert, Sylvia Dörschmidt, Theresa Bloehs, Katia Rodewald, Miriam Caviglia, Claudia Schmidt, Mian Zahid Hussain, Julien Warnan, Roland A Fischer, Angela Casini, Romy Ettlinger","doi":"10.1039/d5tb00614g","DOIUrl":"https://doi.org/10.1039/d5tb00614g","url":null,"abstract":"<p><p>Metal-organic frameworks (MOFs) are promising candidates for drug carrier systems due to their high porosity and tuneable structures, however, their clinical translation is restrained. Integrating MOFs into processable matrices improves mechanical properties, processability, and often drug delivery performance. Hydrogels, as soft, three-dimensional polymer networks with high flexibility and biocompatibility, are particularly favourable candidates for advanced MOF-based drug carriers. However, a lack of fundamental material studies limits full exploitation of the potential and hinders further development of such composites. To address this, this study provides a physicochemical investigation of MOF/alginate hydrogels using ZIF-8 as a benchmark MOF and thioflavin T (ThT) as a model drug. A rapid, <i>in situ</i> encapsulation approach enabled the fabrication of ThT@ZIF-8 (14.2 wt% loading), which was incorporated into an alginate matrix (ThT@ZIF-8@Alg) at 95 wt%, putting MOF carrier functionality in a processable form. Characterisation including X-ray diffraction, infrared and diffuse-reflectance UV/Vis spectroscopy, and electron microscopy enabled a detailed investigation of MOF properties in the composite and confirmed its retained structural integrity. Drug release studies of ThT@ZIF-8@Alg closely mirrored the pure MOF's pH-triggered behaviour. Furthermore, by comparing different methods of incorporating ThT in (ZIF-8@)Alg matrices, we demonstrate the versatility of such composites in achieving customisable release profiles. <i>In vitro</i> preliminary studies of the antiproliferative activity of ThT@ZIF-8@Alg in cancerous and non-tumorigenic cells support the idea of sustained controlled release of ThT over 72 h at pH 7.4. This strategy advances MOF-hydrogel-based drug delivery systems, with potential applications in topical treatments and implant coatings.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidation-responsive PEG-poly(α-lipoic acid) nanoparticles for coenzyme Q₁₀ delivery attenuate hepatic ischemia-reperfusion injury <i>via</i> ROS scavenging and ferroptosis inhibition.","authors":"Yu Guan, Jinyu Liu, Jing Yang, Sufang Chen, Weifeng Yao, Shengyuan Gong, Chunsheng Xiao, Mingqiang Li, Gangjian Luo, Ziqing Hei","doi":"10.1039/d5tb01118c","DOIUrl":"https://doi.org/10.1039/d5tb01118c","url":null,"abstract":"<p><p>Hepatic ischemia-reperfusion injury (IRI) is characterized by an acute surge of reactive oxygen species (ROS) upon reperfusion, leading to oxidative damage and cell death. Ferroptosis, a form of iron-dependent lipid peroxidation-driven cell death, has recently been implicated in hepatic IRI, compounding the injury. Here, we present an oxidation-responsive nanoparticle system designed to mitigate liver IRI by scavenging ROS and inhibiting ferroptosis. We synthesized a PEGylated poly(α-lipoic acid) (PEG-PαLA) copolymer that self-assembles into nanoparticles encapsulating the lipophilic antioxidant coenzyme Q₁₀ (CoQ₁₀). The PEG-PαLA/CoQ₁₀ nanoparticles have an average diameter of ∼100 nm and release CoQ₁₀ preferentially under oxidative conditions. <i>In vitro</i>, the nanoparticles efficiently neutralized free radicals and protected hepatocytes from oxidative injury. In a mouse model of partial hepatic IRI, treatment with PEG-PαLA/CoQ₁₀ nanoparticles significantly reduced liver injury markers, preserved liver histology, and abrogated lipid peroxidation, indicating suppression of ferroptosis. Our results demonstrated that the PEG-PαLA/CoQ₁₀ nanoparticle is a novel antioxidant nanomedicine that synergistically attenuates ROS-mediated damage and ferroptotic cell death in hepatic IRI. These findings highlight a promising strategy for protecting organs from ischemia-reperfusion damage by targeting oxidative stress and ferroptosis with responsive biomaterial carriers.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of halloysite nanotube-based nanomaterials for theranostic applications: fluorescent probes and chemodynamic activity.","authors":"Marina Massaro, Federica Leone, Françisco M Raymo, Raquel de Melo Barbosa, Rita Sánchez-Espejo, César Viseras, Renato Noto, Serena Riela","doi":"10.1039/d5tb00510h","DOIUrl":"10.1039/d5tb00510h","url":null,"abstract":"<p><p>The development of theranostic systems is of fundamental importance for the treatment of diseases. These systems should combine the features of fluorescent molecules that can act as diagnostic systems and species with therapeutic potential. Herein, we report the synthesis of a multifunctional halloysite nanotube (HNT)-based nanomaterial <i>via</i> the covalent modification of the external surface of the clay with a halochromic probe and the immobilization of Fe₃O₄ nanoparticles (HNTs-1@Fe₃O₄) with chemodynamic activity. The covalent modification of HNTs was performed using two different synthetic approaches, and the best strategy was evaluated by estimating the degree of functionalization of the clay <i>via</i> thermogravimetric analysis. The synthesized nanomaterial was thoroughly characterized, and its photoluminescence properties under different conditions, <i>i.e.</i> different solvents, pH conditions and temperatures, were studied. The HNTs-1@Fe₃O₄ nanomaterial was found to exhibit good peroxidase-like activity, as shown by testing its performance in the catalytic oxidation of the colorless enzyme substrate 3,3',5,5'-tetramethylbenzidine (TMB) to blue TMB oxide (ox-TMB) in the presence of H₂O₂. This study highlights the usefulness of the covalent approach for modifying halloysite surfaces to generate nanomaterials for potential tissue imaging under different stimuli. In addition, the combination with Fe₃O₄NPs led to the synthesis of multifunctional materials with potential use as theranostic systems for the treatment of diseases.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Titanium dioxide/graphene oxide blending into polyethersulfone hollow fiber membranes improves biocompatibility and middle molecular weight separation for bioartificial kidney and hemodialysis applications.","authors":"Nidhi Pandey, Jayesh Bellare","doi":"10.1039/d5tb00229j","DOIUrl":"https://doi.org/10.1039/d5tb00229j","url":null,"abstract":"<p><p>Hollow fiber membranes (HFMs) are critical components in hemodialysis and bioartificial kidney (BAK) applications, with ongoing research focused on optimizing biomaterials for improved performance. In this study, polyethersulfone (PES) HFMs were modified by incorporating titanium dioxide (TiO₂) and graphene oxide (GO) during the spinning process. This approach leverages the non-toxicity, hydrophilicity, and dispersion stability of TiO₂ alongside the large surface area of GO to enhance membrane properties. Characterization and performance evaluations demonstrated that TiO₂/GO-doped PES HFMs exhibit superior biocompatibility and hemocompatibility compared to plain PES, TiO₂/PES, and GO/PES membranes. Confocal microscopy revealed improved HEK293 cell attachment and proliferation, corroborated by MTT assays showing higher cell viability and flow cytometry indicating no cytotoxic effects. Hemocompatibility tests confirmed negligible hemolysis and anti-inflammatory properties, making the membranes suitable for blood-contacting applications. Furthermore, separation performance analyses highlighted TG(0.5/1.5) as the optimal composition, offering a balance of enhanced toxin removal and cell compatibility. These findings establish TiO₂/GO-doped PES HFMs as promising candidates for BAK and hemodialysis, combining excellent biocompatibility, hemocompatibility, and separation efficiency.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A carbazole-naphthoyl hydrazone conjugate and its Zn(II)-complex as stimuli-responsive smart materials: detection of VOCs and Cu²⁺, AIE insights and bioimaging applications.","authors":"Himani Sharma, Akansha Yadav, Akhilendra K Maurya, Rampal Pandey","doi":"10.1039/d5tb00462d","DOIUrl":"https://doi.org/10.1039/d5tb00462d","url":null,"abstract":"<p><p>A readily accessible hydrazone ((<i>E</i>)-<i>N</i>'-((9-ethyl-9<i>H</i>-carbazol-3-yl)methylene)-3-hydroxy-2-naphthohydrazide ligand (HL) and its luminescent Zn(II)-complex (1) have been synthesized and thoroughly characterized using several spectro-analytical techniques. The photophysical properties of HL and 1 have been explored in both solid and solution states. Interestingly, HL displayed reversible mechanochromism under ambient light and reversible mechanofluorochromism under 365 nm UV irradiation. Complex 1 comprising HL does not show any sharp visual color changes under ambient light; however, it exhibits noteworthy reversible mechanofluorochromism under 365 nm UV light (bright yellow to golden yellow). Besides solid-state UV-vis and photoluminescence spectroscopy, the underlying mechanism of phase transformation has further been explored by SEM, PXRD, and TGA/DSC analyses. As anticipated, 1 demonstrated remarkable J-type AIE characteristics in a THF/H₂O mixture and H-type AIE in DMSO/H₂O, which correlated well with the UV-vis, luminescence, and nanoparticle tracking analysis (NTA) results. Furthermore, when comparing HL and 1, only Zn(II)-complex 1 effectively and selectively detects Cu²⁺ in aqueous DMSO medium, and the limit of detection was determined to be 9.1 × 10^-7 M. Moreover, both HL and 1 were investigated for their biological applications and the MTT assay revealed that 1 is less cytotoxic than HL toward the MCF-7 breast cancer cell line. Furthermore, 1 showed strong fluorescence in the cytosol of the cells compared to HL, and thus it can be used as a cell staining agent. Overall, the present research findings offer a straightforward mutual comparison between HL and 1 and their multifunctional behavior for a wide range of applications in environmental sensing, data storage devices, and bioimaging studies.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"pH-Responsive bimetallic MOF nanoparticles enable triple-synergistic radiosensitization for enhanced radiotherapy.","authors":"Qijun Du, Guohua Wu, Ao Xie, Di Wu, Wenqi Hu, Qinrui Lu, Jie Liu, Jiashu Wang, Youlong Yang, Bangchuan Hu, Haijie Hu, Shuqi Wang","doi":"10.1039/d5tb00926j","DOIUrl":"https://doi.org/10.1039/d5tb00926j","url":null,"abstract":"<p><p>Radiotherapy (RT) faces hypoxia-induced radioresistance, as oxygen-deficient tumor regions limit reactive oxygen species (ROS) generation. Current hypoxia-targeting strategies (<i>e.g.</i>, prodrugs, nanocarriers) struggle with inefficient delivery, off-target effects, and clinical translation barriers, necessitating advanced oxygenation or hypoxia-specific radiosensitization approaches. Herein, we developed pH-responsive BM-DOX@BSA nanoparticles (NPs) using a solvothermal method. Bi(NO₃)₃, MnCl₂, and TCPP were used as precursors, with DOX loaded for chemotherapy. BSA was added to enhance biocompatibility. <i>In vitro</i> and <i>in vivo</i> experiments assessed ROS generation, drug release, cytotoxicity, and tumor suppression efficacy under X-ray irradiation. BM-DOX@BSA NPs exhibited pH-responsive degradation, releasing DOX more rapidly in acidic conditions. They markedly increased the generation of ROS under X-ray irradiation, resulting in enhanced apoptosis of tumor cells and DNA damage. This effectively improved the efficacy of radiation dynamic therapy (RDT). <i>In vivo</i>, the NPs combined with RT achieved 100% tumor suppression in HepG2 tumor-bearing mice, demonstrating excellent biocompatibility and therapeutic efficacy.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rationally designed protein A surface molecularly imprinted magnetic nanoparticles for the capture and detection of <i>Staphylococcus aureus</i>.","authors":"Kritika Narula, Soumya Rajpal, Snehasis Bhakta, Senthilguru Kulanthaivel, Prashant Mishra","doi":"10.1039/d4tb00392f","DOIUrl":"10.1039/d4tb00392f","url":null,"abstract":"<p><p><i>Staphylococcus aureus</i> (<i>S. aureus</i>), a commensal organism found on the human skin, is commonly associated with nosocomial infections and exhibits virulence mediated by toxins and resistance to antibiotics. The global threat of antibiotic resistance has necessitated antimicrobial stewardship to improve the safe and appropriate use of antimicrobials; hence, there is an urgent demand for the advanced, cost-effective, and rapid detection of specific bacteria. In this regard, we aimed to selectively detect <i>S. aureus</i> using surface molecularly imprinted magnetic nanoparticles templated with a well-known biomarker protein A, specific to <i>S. aureus</i>. Herein, a highly selective surface molecularly imprinted polymeric thin layer was created on ∼250 nm magnetic nanoparticles (MNPs) through the immobilization of protein A to aldehyde functionalized MNPs, followed by monomer polymerization and template washing. This study employs the rational selection of monomers based on their computationally predicted binding affinity to protein A at multiple surface residues. The resulting MIPs from rationally selected monomer combinations demonstrated an imprinting factor as high as ∼5. Selectivity studies revealed MIPs with four-fold higher binding capacity (BC) to protein A than other non-target proteins, such as lysozyme and serum albumin. In addition, it showed significant binding to <i>S. aureus</i>, whereas negligible binding to other non-specific Gram-negative, <i>i.e. Escherichia coli</i> (<i>E. coli</i>), <i>Pseudomonas aeruginosa</i> (<i>P. aeruginosa</i>), and Gram-positive, <i>i.e. Bacillus subtilis</i> (<i>B. subtilis</i>), bacteria. This MIP was employed for the capture and specific detection of fluorescently labeled <i>S. aureus.</i> Quantitative detection was performed using a conventional plate counting technique in a linear detection range of 10¹-10⁷ bacterial cells. Remarkably, the MIPs also exhibited approximately 100% cell recovery from milk samples spiked with <i>S. aureus</i> (10⁶ CFU mL^-1), underscoring its potential as a robust tool for sensitive and accurate bacterial detection in dairy products. The developed MIP exhibiting high affinity and selective binding to protein A finds its potential applications in the magnetic capture and selective detection of protein A as well as <i>S. aureus</i> infections and contaminations.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":"5699-5710"},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Looking back, moving forward: protein corona of lipid nanoparticles.","authors":"Yue Gao, Yeqi Huang, Chuanyu Ren, Peiwen Chou, Chuanbin Wu, Xin Pan, Guilan Quan, Zhengwei Huang","doi":"10.1039/d4tb00186a","DOIUrl":"10.1039/d4tb00186a","url":null,"abstract":"<p><p>Lipid nanoparticles (LNPs) are commonly employed for drug delivery owing to their considerable drug-loading capacity, low toxicity, and excellent biocompatibility. Nevertheless, the formation of protein corona (PC) on their surfaces significantly influences the drug's <i>in vivo</i> fate (such as absorption, distribution, metabolism, and elimination) upon administration. PC denotes the phenomenon wherein one or multiple strata of proteins adhere to the external interface of nanoparticles (NPs) or microparticles within the biological milieu, encompassing <i>ex vivo</i> fluids (<i>e.g.</i>, serum-containing culture media) and <i>in vivo</i> fluids (such as blood and tissue fluids). Hence, it is essential to claim the PC formation behaviors and mechanisms on the surface of LNPs. This overview provided a comprehensive examination of crucial aspects related to such issues, encompassing time evolution, controllability, and their subsequent impacts on LNPs. Classical studies of PC generation on the surface of LNPs were additionally integrated, and its decisive role in shaping the <i>in vivo</i> fate of LNPs was explored. The mechanisms underlying PC formation, including the adsorption theory and alteration theory, were introduced to delve into the formation process. Subsequently, the existing experimental outcomes were synthesized to offer insights into the research and application facets of PC, and it was concluded that the manipulation of PC held substantial promise in the realm of targeted delivery.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":"5573-5588"},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liquid exfoliation of molybdenum metallenes for non-inflammatory photothermal therapy of tumors.","authors":"Chenxin Lu, Xiang Huang, Zhaoying Jin, Junwei Deng, Zhengbao Zha, Zhaohua Miao","doi":"10.1039/d4tb00525b","DOIUrl":"10.1039/d4tb00525b","url":null,"abstract":"<p><p>Tissue damage and cell death occurring during photothermal therapy (PTT) for tumors can induce an inflammatory response that is detrimental to tumor therapy. Herein, ultrathin Mo metallene nanosheets with a thickness of <5 nm prepared by liquid phase exfoliation were explored as functional hyperthermia agents for non-inflammatory ablation of tumors. The obtained Mo metallene nanosheets exhibited good photothermal conversion properties and significant reactive oxygen species (ROS) scavenging ability, thus achieving superior cancer cell ablation and anti-inflammatory effects <i>in vitro</i>. For <i>in vivo</i> experiments, 4T1 tumors were ablated while the inflammation-related cytokine levels did not obviously increase, demonstrating that the inflammatory response induced by PTT was inhibited by the anti-inflammatory properties of Mo metallene nanosheets. Moreover, Mo metallene nanosheets depicted good dispersibility and biocompatibility, beneficial for biomedical applications. This work introduces Mo metallenes as promising hyperthermia agents for non-inflammatory PTT of tumors.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":"5690-5698"},"PeriodicalIF":0.0,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term antifouling surfaces for urinary catheters.","authors":"Mustafa Tüfekçi, Sena Hamarat, Tuğba Demir Çalışkan, Hatice Ferda Özgüzar, Ahmet Ersin Meydan, Julide Sedef Göçmen, Ebru Evren, Mehmet İlker Gökçe, Hilal Goktas","doi":"10.1039/d4tb00311j","DOIUrl":"https://doi.org/10.1039/d4tb00311j","url":null,"abstract":"<p><p>The presence of a variety of bacteria is an inevitable/indispensable part of human life. In particular, for patients, the existence and spreading of bacteria lead to prolonged treatment period with many more complications. The widespread use of urinary catheters is one of the main causes for the prevalence of infections. The necessity of long-term use of indwelling catheters is unavoidable in terms of the development of bacteriuria and blockage. As is known, since a permanent solution to this problem has not yet been found, research and development activities continue actively. Herein, polyethylene glycol (PEG)-like thin films were synthesized by a custom designed plasma enhanced chemical vapor deposition (PE-CVD) method and the long-term effect of antifouling properties of PEG-like coated catheters was investigated against <i>Escherichia coli</i> and <i>Proteus mirabilis</i>. The contact angle measurements have revealed the increase of wettability with the increase of plasma exposure time. The antifouling activity of surface-coated catheters was analyzed against the Gram-negative/positive bacteria over a long-term period (up to 30 days). The results revealed that PE-CVD coated PEG-like thin films are highly capable of eliminating bacterial attachment on surfaces with relatively reduced protein attachment without having any toxic effect. Previous statements were supported with SEM, XPS, FTIR spectroscopy, and contact angle analysis.</p>","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}