Journal of materials chemistry. B最新文献_第8页

Extracellular matrix-inspired natural polymer-based composite hydrogel dressings for infected wound healing. 细胞外基质启发的天然聚合物基复合水凝胶敷料，用于感染伤口愈合。

Journal of materials chemistry. B Pub Date : 2025-06-10 DOI: 10.1039/d5tb00981b

Jun-Hui Yang, Wen-Ling Du, Hao-Jie Tan, Yu-Xin Zong, Qing-Ning Wang, Bai-Song Zhao, Zhi-Guo Wang, Rui Zhang, Jia-Zhuang Xu, Zhong-Ming Li

{"title":"Extracellular matrix-inspired natural polymer-based composite hydrogel dressings for infected wound healing.","authors":"Jun-Hui Yang, Wen-Ling Du, Hao-Jie Tan, Yu-Xin Zong, Qing-Ning Wang, Bai-Song Zhao, Zhi-Guo Wang, Rui Zhang, Jia-Zhuang Xu, Zhong-Ming Li","doi":"10.1039/d5tb00981b","DOIUrl":"https://doi.org/10.1039/d5tb00981b","url":null,"abstract":"Developing an effective hydrogel dressing to protect against bacterial infection and exhibit synchronously integrated mechanical robustness and self-healing properties is highly desirable for infected wound healing in clinical practice. Inspired by the extracellular matrix (ECM), we constructed a dynamic and nondynamic synergy network to prepare a natural polymer-based composite hydrogel dressing for infected wound healing. The aldehyde groups of oxidized hyaluronic acid were bonded with amino groups of carboxymethyl chitosan and polyacrylamide (PAAm) via the Schiff base reaction to form a dynamic crosslinked network, mimicking the dynamically reversible glycosaminoglycan network in the ECM. A nondynamic PAAm network was created via UV-irradiated free radical polymerization, analogous to the covalently crosslinked collagen network in the ECM. The elaborate dynamic and nondynamic synergy network enabled the resultant hydrogel dressing to exhibit high mechanical strength and fatigue resistance, excellent self-healing properties and the remarkable antibacterial activity. An in vivo Staphylococcus aureus-infected full-thickness wound model revealed that our natural polymer-based composite hydrogel dressing significantly reduced inflammation and promoted the formation of granulation tissues and angiogenesis to achieve accelerated infected wound healing. This study offers a valuable reference for designing and fabricating multifunctional hydrogel dressings for treating wound infection.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring PEKK: properties, applications and promise of personalized medicine. 探索PEKK：个性化医疗的特性、应用和前景。

Journal of materials chemistry. B Pub Date : 2025-06-10 DOI: 10.1039/d5tb00596e

Honglin Zhu, Zhize Liu, Ming Lu, Xiao Han, Shuang Zhang

引用次数: 0

Quaternary ammonium-functionalized carbon nanotubes/alginate nanocomposite hydrogels support myoblast growth and differentiation. 季铵功能化碳纳米管/海藻酸盐纳米复合水凝胶支持成肌细胞生长和分化。

Journal of materials chemistry. B Pub Date : 2025-06-10 DOI: 10.1039/d5tb00601e

Ludovica Ceroni, Tianqi Feng, Laura Calvillo, Stefano Casalini, Patrick Van Rijn, Enzo Menna

{"title":"Quaternary ammonium-functionalized carbon nanotubes/alginate nanocomposite hydrogels support myoblast growth and differentiation.","authors":"Ludovica Ceroni, Tianqi Feng, Laura Calvillo, Stefano Casalini, Patrick Van Rijn, Enzo Menna","doi":"10.1039/d5tb00601e","DOIUrl":"https://doi.org/10.1039/d5tb00601e","url":null,"abstract":"Carbon nanotube (CNT) composite hydrogels are promising materials for tissue engineering due to the biocompatibility of the matrix and the electrical conductivity of the filler, which is crucial for promoting the growth and functions in electroactive tissues. While pristine CNTs are insoluble, we synthesized and fully characterized a water-soluble CNT derivative (fCNT) bearing quaternary ammonium groups, and we homogeneously dispersed it within alginate-based hydrogels. Through external and internal gelation we obtained two plain and two fCNT-filled hydrogels (HG1 and HG2 and HG1-fCNT and HG2-fCNT, respectively), and we compared the physical properties of the four different materials. A measurement setup and an approach were specifically designed for the electrical characterization of our hydrogel samples, showing that the addition of a low amount (0.1 mg mL-1) of fCNT enhanced the conductivity of the hydrogel from internal gelation (HG2-fCNT) by more than one order of magnitude, from 5.7 × 10-10 to 2.8 × 10-8 S cm-1. Even more interestingly, HG2-fCNT featured a faster transmission of low frequency signals (with time scales from 1 ms to 100 ms, typical of electroactive biological tissues) than the other samples. Finally, the behavior of the four hydrogels as scaffolds for muscle tissue engineering was compared through studies of myoblast viability, proliferation, and differentiation. A relevant improvement in differentiation (more than doubling the number and area of myotubes and the fusion index) was obtained by adding the fCNT in the case of HG2-fCNT, in line of its superior electrical properties. These outcomes hint at the feasibility of using the fCNT combined with the alginate hydrogel in order to support the myoblast growth and proliferation.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Charge microenvironment and bioactivity of in situ-formed PEG-RGD dual hydrogel dressings promote wound healing. 原位形成的PEG-RGD双水凝胶敷料的电荷微环境和生物活性促进伤口愈合。

Journal of materials chemistry. B Pub Date : 2025-06-10 DOI: 10.1039/d5tb00683j

Chuanjie He, Yulin Wang, Xinyu Fang, Wenkai Jiang, Sihan Liu, Xiaoli Yi, Kai Zhang, Hai Lin, Qin Zeng, Xiangdong Zhu, Ya Li, Xu Song, Xingdong Zhang

{"title":"Charge microenvironment and bioactivity of in situ-formed PEG-RGD dual hydrogel dressings promote wound healing.","authors":"Chuanjie He, Yulin Wang, Xinyu Fang, Wenkai Jiang, Sihan Liu, Xiaoli Yi, Kai Zhang, Hai Lin, Qin Zeng, Xiangdong Zhu, Ya Li, Xu Song, Xingdong Zhang","doi":"10.1039/d5tb00683j","DOIUrl":"https://doi.org/10.1039/d5tb00683j","url":null,"abstract":"Healing of large skin wounds involves a complex biological process with overlapping phases, facing challenges from fibroblast proliferation, immune response, and extracellular matrix (ECM) remolding. Hydrogel dressings serve as temporary barriers protecting injured tissue from exogenous infections while providing an advantageous microenvironment for cellular regeneration. However, traditionally molded hydrogels through catalyzed or triggered crosslinking into fixed size and strength prior to treatment struggle to integrate tightly with irregular wound surfaces, leading to dressing detachment and wound exposure in areas with high curvature and mobility. Here, we designed CGRGDGC peptide enantiomers, incorporating with 4 arm-PEG-maleimide, to in situ form functional and morphologically matching dual-phasic hydrogel dressing. In situ elastic hydrogel dressing forms within 10 min after applying, with a storage modulus of 1300 Pa and internal porous networks. The peptide incorporation increased the surface potential to ∼370 mV, twice that of PEG hydrogels. The bioactive L-peptide hydrogel exhibited strongest immunomodulation and skin regeneration enhancement, while the non-bioactive D-peptide hydrogel also showed significant promotion compared to the PEG hydrogel. We demonstrated that both the charge microenvironment and bioactivity of hydrogel dressing regulate the immune response and promote wound healing after skin injury. This research provides novel insights and strategies showing that non-ligand peptide sequences achieve biological functions by modulating molecular potential and that adjusting the charge microenvironment and incorporating bioactive peptides through peptide phase introduction enhance skin regeneration.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable biodegradable polysaccharide-based hydrogels for stem cell delivery and cartilage regeneration. 可注射的可生物降解多糖类水凝胶，用于干细胞输送和软骨再生。

Journal of materials chemistry. B Pub Date : 2025-06-09 DOI: 10.1039/d5tb00287g

Xiaojie Lin, Ruofan Liu, Yang Zhou, Jacob Beitzel, Aya Noguchi, Masayuki Kyomoto, Miqin Zhang

{"title":"Injectable biodegradable polysaccharide-based hydrogels for stem cell delivery and cartilage regeneration.","authors":"Xiaojie Lin, Ruofan Liu, Yang Zhou, Jacob Beitzel, Aya Noguchi, Masayuki Kyomoto, Miqin Zhang","doi":"10.1039/d5tb00287g","DOIUrl":"https://doi.org/10.1039/d5tb00287g","url":null,"abstract":"Current knee osteoarthritis (KOA) treatments mainly provide symptom relief rather than cartilage repair. While regenerative medicine using stem cell therapy holds promise for tissue regeneration and joint function restoration, a significant challenge lies in the efficient and minimally invasive delivery of stem cells to target sites and ensuring high regenerative efficacy. This challenge stems from issues such as cell leakage and reduced cellular activity post-transplantation. In this study, we report the development of an injectable polysaccharide hydrogel (termed Ald-HA/Suc-CS), which is compatible with cells and tissues, and will be suitable to support the proliferation of human adipose-derived stem cells (hADSCs) for cartilage regeneration. The hydrogel is formed on-site at the defect site of articular cartilage by mixing two injectable polymer solutions at physiological temperature post-injection. During the gelation process, hADSCs contained in one of the polymer solutions are encapsulated in the hydrogel. The hydrogel is tailored to create a desired microenvironment with mechanical properties, pore size, and degradation rate suitable for supporting hADSC viability and function. We demonstrated that nearly all of the encapsulated hADSCs remained viable 14 days post-injection and exhibited increased expression of chondrogenic differentiation genes compared to those cultured on 2D surfaces. This hydrogel holds great promise to improve the efficacy of KOA treatment and is potentially applicable to other cell-based therapies.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanozyme-mediated high-entropy-driven photothermally enhanced tumor catalytic therapy. 纳米酶介导的高熵驱动光热增强肿瘤催化治疗。

Journal of materials chemistry. B Pub Date : 2025-06-09 DOI: 10.1039/d5tb00578g

Yixin Xing, Chenlu Yin, Yuying Yin, Jingqiang Xue, Yutong Liu, Jinzhan Li, Liqun Chi, Wei Gu

{"title":"Nanozyme-mediated high-entropy-driven photothermally enhanced tumor catalytic therapy.","authors":"Yixin Xing, Chenlu Yin, Yuying Yin, Jingqiang Xue, Yutong Liu, Jinzhan Li, Liqun Chi, Wei Gu","doi":"10.1039/d5tb00578g","DOIUrl":"https://doi.org/10.1039/d5tb00578g","url":null,"abstract":"Nanozyme-mediated catalytic therapy has emerged as a promising strategy for antitumor treatment, but it is imperative to further improve the catalytic efficiency of nanozymes to achieve potentiated antitumor efficacy. Single-phase high-entropy (HE) nanozymes with desirable enzyme-like catalytic activity and photothermal properties are appealing for enhancing the efficacy of catalytic therapy but have remained synthetically challenging. As a proof-of-concept demonstration, we herein prepared a single-phase HE Prussian blue analogue (HEPBA) using a conventional coprecipitation method. The HE mixing state enabled an exceptionally high photothermal conversion efficiency of 95.3% and a notable photothermally enhanced peroxidase-like catalytic activity. Therefore, the HEPBA-mediated photothermally enhanced catalytic therapy led to potentiated antitumor efficacy in both 4T1 and CT26 tumor-bearing mouse models. Thus, this work provides a rational and flexible platform for convenient and green preparation of biocompatible HE nanozymes and offers new perspectives on the use of HE nanozymes to improve the efficacy of catalytic therapy.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanozymes in Parkinson's disease: strategic approaches, clinical considerations, and challenges. 纳米酶治疗帕金森病：策略方法、临床考虑和挑战。

Journal of materials chemistry. B Pub Date : 2025-06-09 DOI: 10.1039/d5tb00295h

Wanli Huang, Xiaofang Ye, Zhengping Huang, Mimi Li, Binbin Yu, Lichao Ye, Shaobin He, Chunnuan Chen

引用次数: 0

A MMP9-responsive nanozyme hydrogel to promote diabetic wound healing by reconstructing the balance of pro-inflammation and anti-inflammation. 一种响应mmp9的纳米酶水凝胶通过重建促炎和抗炎平衡来促进糖尿病伤口愈合。

Journal of materials chemistry. B Pub Date : 2025-06-09 DOI: 10.1039/d4tb02857k

Jinze Wang, Haiqi Zhang, Sentao Hu, Lie Ma

{"title":"A MMP9-responsive nanozyme hydrogel to promote diabetic wound healing by reconstructing the balance of pro-inflammation and anti-inflammation.","authors":"Jinze Wang, Haiqi Zhang, Sentao Hu, Lie Ma","doi":"10.1039/d4tb02857k","DOIUrl":"https://doi.org/10.1039/d4tb02857k","url":null,"abstract":"Excessive reactive oxygen species (ROS) lead to persistent inflammation in diabetic wounds inducing excessive inflammatory factors and matrix metalloproteinases (MMPs), thereby hindering wound healing. However, low concentration ROS also function as a signaling molecule for maintaining cell function and promoting vascularization. Therefore, it is important to regulate ROS levels adaptively to match the healing process. Here, a nanozyme hydrogel was developed to intelligently clear wound ROS in response to dynamic changes of matrix metalloproteinase-9 (MMP9). Specifically, Prussian blue nanoparticle (PBNP) loaded-gelatin nanospheres (PGs) were encapsulated in polyvinyl alcohol (PVA) hydrogel to obtain a nanozyme hydrogel (PGs@PVA). Hydrogen bonding between PGs and PVA not only improves the mechanical properties of the PGs@PVA hydrogel but also ensures the controlled release of PBNPs. With the release of PBNP from the PGs@PVA hydrogel in response to the high level of MMP9 in the pro-inflammatory stage, excessive ROS were cleared. The phenotype of the macrophages was regulated correspondingly. The in vivo results proved that the PGs@PVA hydrogel promoted healing speed, epithelialization, vascularization, and collagen deposition of diabetic wounds by adaptive immunomodulation. The MMP9-responsive nanozyme hydrogel shows great potential in diabetic wound healing by reconstructing the balance of pro-inflammation and anti-inflammation.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhodamine-derived ratiometric fluorescent probes for high-sensitivity detection and real-time imaging of mitochondrial pH and viscosity in HeLa cells and Drosophila melanogaster. 罗丹明衍生的比例荧光探针用于HeLa细胞和黑胃果蝇线粒体pH和粘度的高灵敏度检测和实时成像。

Journal of materials chemistry. B Pub Date : 2025-06-09 DOI: 10.1039/d5tb00747j

Subash Pandey, Dilka Liyana Arachchige, Ronald J Schwandt, Sushil K Dwivedi, Ishana Kathuria, Haiying Liu, Rudy L Luck

{"title":"Rhodamine-derived ratiometric fluorescent probes for high-sensitivity detection and real-time imaging of mitochondrial pH and viscosity in HeLa cells and Drosophila melanogaster.","authors":"Subash Pandey, Dilka Liyana Arachchige, Ronald J Schwandt, Sushil K Dwivedi, Ishana Kathuria, Haiying Liu, Rudy L Luck","doi":"10.1039/d5tb00747j","DOIUrl":"https://doi.org/10.1039/d5tb00747j","url":null,"abstract":"The spirolactam on/off switch attached to rhodamine dye is known to be a highly selective and sensitive fluorescent probe, yet few studies have explored extending the π-conjugation system within its skeleton for pH detection in live cells. An extended π-conjugated rhodamine section should enable ratiometric pH detection in the near-infrared region. In this study, we synthesized probes A and B by coupling a rhodamine derivative with 7-nitrobenzofurazan and 7-(diethylamino)-2-oxo-3,8a-dihydro-2H-chromene-3-carbaldehyde sections, respectively. Probe A exhibits emission via a Förster resonance energy transfer (FRET) mechanism. Under excitation at 370 nm, the conjugated 7-nitrobenzofurazan in probe A exhibits fluorescence at 465 nm in the ring-closed state, while fluorescence at 660 nm appears in the ring-open state due to increased conjugation in the rhodamine moiety. Excitation of probe B at 325 nm resulted in reduced emission around 350 nm and a significantly enhanced response at 525 nm. Probe A was evaluated for mitochondrial pH detection through ratiometric fluorescence emission measurements. Additional tests in living HeLa cells, including responses to stimuli such as carbonyl cyanide-4(trifluoromethoxy)phenylhydrazone (FCCP), hydrogen peroxide (H2O2), N-acetyl cysteine (NAC), mitophagy induced by nutrient deprivation, and hypoxia triggered by cobalt chloride (CoCl2) treatment, as well as pH changes in fruit fly larvae, further validated its applicability for ratiometric measurement of mitochondrial pH variations. Probe A's emission was dependent on the pH level under basic conditions, but under acidic conditions, the change in conformation upon ring opening resulted in the emission also being affected by viscosity.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune microenvironment modulation for treating inflammatory periodontal bone defects using a dynamic dual-responsive hydrogel. 使用动态双反应水凝胶治疗炎症性牙周骨缺损的免疫微环境调节。

Journal of materials chemistry. B Pub Date : 2025-06-06 DOI: 10.1039/d5tb00784d

Jiufan Yao, Chi Zhang, Chuanying Yu, Lingzhi Wu, Lingping Tan, Weichang Li, Li Gao, Chuanjiang Zhao

{"title":"Immune microenvironment modulation for treating inflammatory periodontal bone defects using a dynamic dual-responsive hydrogel.","authors":"Jiufan Yao, Chi Zhang, Chuanying Yu, Lingzhi Wu, Lingping Tan, Weichang Li, Li Gao, Chuanjiang Zhao","doi":"10.1039/d5tb00784d","DOIUrl":"https://doi.org/10.1039/d5tb00784d","url":null,"abstract":"Periodontitis is a chronic inflammatory condition affecting the structures supporting teeth, primarily induced by bacteria. Plaque control and maintenance of local periodontal immune homeostasis are crucial for treating periodontitis and achieving bone regeneration. In this study, we prepared a pH/ROS dual-responsive hydrogel system (CDFBCS@SA) composed of modified carboxymethyl cellulose (CMCDA) and carboxymethyl chitosan (CCS) through dynamic chemical crosslinking to load sinapic acid (SA), a natural phenolic acid with antibacterial and immunomodulatory properties. This hydrogel system can dynamically regulate the long-term and precise release of SA, effectively improve the periodontal inflammatory microenvironment, and enhance its effects in the periodontal microenvironment. In vitro and in vivo experiments demonstrated that this hydrogel system maintains local periodontal immune homeostasis by inhibiting the expression of inflammatory factors, reducing oxidative stress, and regulating macrophage polarization, thereby providing a favorable environment for bone regeneration in the inflammatory periodontal environment and significantly enhancing the regenerative effect of periodontal bone defects. This dynamic cross-linked hydrogel system incorporating SA provides an effective strategy for the regenerative treatment of periodontal bone defects.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0