Journal of materials chemistry. B最新文献_第9页

Surface functionalization strategies of ROS-scavenging nanozymes for synergistic therapy and efficient delivery. 清除活性氧纳米酶的表面功能化策略及其协同治疗和高效递送。

Journal of materials chemistry. B Pub Date : 2025-06-06 DOI: 10.1039/d5tb00877h

Xinyue Wu, Yiyun Zhang, Peipei Xing, Mengliang Zhu

{"title":"Surface functionalization strategies of ROS-scavenging nanozymes for synergistic therapy and efficient delivery.","authors":"Xinyue Wu, Yiyun Zhang, Peipei Xing, Mengliang Zhu","doi":"10.1039/d5tb00877h","DOIUrl":"https://doi.org/10.1039/d5tb00877h","url":null,"abstract":"Nanozymes, as synthetic nanomaterials that catalyze the conversion of enzyme substrates to products and follow enzymatic kinetics, have emerged as powerful agents for combating oxidative stress-related diseases by scavenging reactive oxygen species (ROS). In recent years, constructing multifunctional integrated systems by integrating nanozymes with therapeutic drugs or endowing them with efficient delivery capabilities through surface functionalization strategies has become one of the cutting-edge directions. This review explores recent progress in three key surface modification approaches-chemical conjugation, physical encapsulation, and drug loading-that collectively enable synergistic therapeutic effects, precise targeting, and effective penetration of biological barriers. Chemical conjugation allows for the direct attachment of molecules to nanozyme surfaces, enhancing synergistic efficacy and targeting specificity. Physical encapsulation using mesoporous structures, hydrogels, or microneedles improves nanozyme stability, extends in vivo retention, and facilitates controlled release. Drug-loading strategies further expand the therapeutic potential by enabling co-delivery of antioxidants and other functional agents to complex pathological environments. Despite these promising advancements, challenges remain in elucidating the fundamental catalytic mechanisms of nanozymes, ensuring long-term biocompatibility, and achieving scalable clinical translation. Future efforts should focus on developing dynamically responsive systems, achieving precision catalysis, and fostering interdisciplinary integration to accelerate the evolution of nanozyme-based therapeutics. This review systematically summarizes the modification strategies from a surface perspective, offering insights for constructing multifunctional systems.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A tumor-targeted MOF nanoplatform for synergistic ferroptosis-chemotherapy via cascade-activated enzyme-chlormethine prodrug. 一个肿瘤靶向MOF纳米平台，通过级联活化酶-氯甲基前药协同化疗。

Journal of materials chemistry. B Pub Date : 2025-06-06 DOI: 10.1039/d5tb00219b

Linye Jiang, Qingxia Wen, Yuxi Wang, Zhuoming Tan, Qiuyue Wang, Fangfang Zhang, Jingyan Ge

{"title":"A tumor-targeted MOF nanoplatform for synergistic ferroptosis-chemotherapy via cascade-activated enzyme-chlormethine prodrug.","authors":"Linye Jiang, Qingxia Wen, Yuxi Wang, Zhuoming Tan, Qiuyue Wang, Fangfang Zhang, Jingyan Ge","doi":"10.1039/d5tb00219b","DOIUrl":"https://doi.org/10.1039/d5tb00219b","url":null,"abstract":"H2O2-activated prodrugs have been developed to alleviate the severe side effects of chemotherapy. However, achieving precise and efficient delivery, along with high activation and release efficiency at the target site, remains a significant challenge. In this study, we combined a H2O2-generating enzyme (glucose oxidase, GOx) with a H2O2-sensitive chlormethine prodrug via ''reversible click'' chemistry between amino groups of the enzyme and phenyl boronic acid groups of the prodrug. The resulting enzyme-prodrug complex (G-P) was encapsulated in a glutathione (GSH)-responsive iron-based metal organic framework decorated with hyaluronic acid (HA) for tumor-targeted, synergistic ferroptosis-chemotherapy. With the assistance of HA, the resulting nanoparticles (G-P@MOF@HA) demonstrated selective intracellular delivery to CD44-overexpressed tumor cells. Once internalized, the nanoparticles disassembled in the presence of GSH, releasing the G-P complex. GOx catalyzed the conversion of glucose, leading to the generation of sufficient H2O2, enabling in situ activation of the prodrug to elicit chemotherapy. Simultaneously, the Fenton reaction between H2O2 and Fe2+ produced cytotoxic hydroxyl radicals, amplifying ferroptosis. As a consequence, the synergistic therapy group showed superiority over monotherapy in both in vitro and in vivo anticancer studies. This work provides a more efficient and precise strategy for future cancer therapies.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Versatility of LNPs across different administration routes for targeted RNA delivery. LNPs跨不同给药途径靶向RNA递送的多功能性。

Journal of materials chemistry. B Pub Date : 2025-06-06 DOI: 10.1039/d5tb00575b

Muhammed Boye Jallow, Kun Huang, Min Qiu

引用次数: 0

Decoding tissue complexity: multiscale mapping of chemistry-structure-function relationships through advanced visualization technologies. 解码组织复杂性：通过先进的可视化技术对化学-结构-功能关系进行多尺度映射。

Journal of materials chemistry. B Pub Date : 2025-06-06 DOI: 10.1039/d5tb00744e

Zhiyuan Zhao, Haijun Cui, Haitao Cui

{"title":"Decoding tissue complexity: multiscale mapping of chemistry-structure-function relationships through advanced visualization technologies.","authors":"Zhiyuan Zhao, Haijun Cui, Haitao Cui","doi":"10.1039/d5tb00744e","DOIUrl":"10.1039/d5tb00744e","url":null,"abstract":"Comprehensively acquiring biological tissue information is pivotal for advancing our understanding of biological systems, elucidating disease mechanisms, and developing innovative clinical strategies. Biological tissues, as nature's archetypal biomaterials, exhibit multiscale structural and functional complexity that provides critical principles for synthetic biomaterials. Tissues/organs integrate molecular, biomechanical, and hierarchical architectural features across scales, offering a blueprint for engineering functional materials capable of mimicking or interfacing with living systems. Biological visualization technologies have emerged as indispensable tools for decoding tissue complexity, leveraging their unique technical advantages and multidimensional analytical capabilities to bridge the gap between macroscopic observations and molecular insights. The integration of cutting-edge technologies such as artificial intelligence (AI), augmented reality, and deep learning is revolutionizing the field and enabling real-time, high-resolution, and predictive analyses that transcend the limitations of traditional imaging modalities. This review systematically explores the principles, applications, and limitations of state-of-the-art biological visualization technologies, with a particular emphasis on the transformative advancements in AI-driven image analysis, multidimensional imaging and reconstruction, and multimodal data integration. By analyzing these technological trends, we envision a future where biological visualization evolves towards greater intelligence, multidimensionality, and multiscale precision, offering unprecedented theoretical and methodological support for deciphering tissue complexity and further advancing biomaterials development. These advancements promise to accelerate breakthroughs in precision medicine, tissue engineering, and therapeutic development, ultimately reshaping the landscape of biomedical research and clinical practice.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sacrificial MOFs on usage: multifunctional compounds. 牺牲mof的用途：多功能化合物。

Journal of materials chemistry. B Pub Date : 2025-06-05 DOI: 10.1039/d5tb00764j

Radmehr Rahimi Moslehabadi, Zeinab Hedayati, Mohammad Mazraeh, Shakiba Asghar, Farzaneh Rouhani, Ali Morsali

{"title":"Sacrificial MOFs on usage: multifunctional compounds.","authors":"Radmehr Rahimi Moslehabadi, Zeinab Hedayati, Mohammad Mazraeh, Shakiba Asghar, Farzaneh Rouhani, Ali Morsali","doi":"10.1039/d5tb00764j","DOIUrl":"https://doi.org/10.1039/d5tb00764j","url":null,"abstract":"Metal-organic frameworks (MOFs) have traditionally been valued for their stability, which is crucial for applications in catalysis, separation, and storage. However, instability, often considered a drawback, can serve as a functional advantage in specific applications. This study explores the benefits of unstable MOFs, particularly in areas where controlled degradation is desirable. Instability is an inherent characteristic of many MOFs, and rather than being viewed as a limitation, it can be harnessed to achieve remarkable outcomes. Sacrificial MOFs, which undergo complete or partial decomposition, present unique opportunities in biomedical applications, including drug delivery, bio-imaging, and wound healing, where structural breakdown can be advantageous. Furthermore, instability can be strategically utilized to create temporary scaffolds, controlled-release systems, and transient functional materials. By shifting the perspective from stability as a prerequisite to instability as an asset, this review highlights and underscores the high potential of labile MOFs and their emerging role in diverse fields beyond conventional applications. Therefore, it's critical to learn about potential future uses for sacrificial MOFs, and it's particularly opportune to offer a review in this field. Herein, we provide a description of all applications and characterization in sacrificial MOFs with recent examples and a full discussion about sacrificial MOFs.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Charge engineering controls cooperative assembly and loading in protein host-guest complexes. 电荷工程控制着蛋白质主客体复合物的协同组装和装载。

Journal of materials chemistry. B Pub Date : 2025-06-05 DOI: 10.1039/d5tb01202c

Zhiheng Wang, Dai-Bei Yang, Joshua A Bulos, Rui Guo, Thomas Troxler, Sergei Vinogradov, Jeffery G Saven, Ivan J Dmochowski

引用次数: 0

Construct an "immunogenic cell death" amplifier based on Fe-MOFs by accelerating Fe(III) reduction strategies for integration of tumor diagnosis, treatment, and prevention. 构建基于Fe- mof的“免疫原性细胞死亡”放大器，加速Fe（III）还原策略，实现肿瘤诊断、治疗和预防一体化。

Journal of materials chemistry. B Pub Date : 2025-06-05 DOI: 10.1039/d5tb00686d

Kexin Luo, Sasha You, Jingyu Chen, Bin Chi, Kai Zhang, Jian Tian, Xiyue Feng, Wang Ye, Yingxi Wang, Ling Li, Xiaolan Yu, Jing Wang

{"title":"Construct an \"immunogenic cell death\" amplifier based on Fe-MOFs by accelerating Fe(III) reduction strategies for integration of tumor diagnosis, treatment, and prevention.","authors":"Kexin Luo, Sasha You, Jingyu Chen, Bin Chi, Kai Zhang, Jian Tian, Xiyue Feng, Wang Ye, Yingxi Wang, Ling Li, Xiaolan Yu, Jing Wang","doi":"10.1039/d5tb00686d","DOIUrl":"https://doi.org/10.1039/d5tb00686d","url":null,"abstract":"Traditional tumor treatments focus on treating the location of the lesion, while immunogenic cell death (ICD) triggers systemic anti-tumor immunity and inhibits tumor metastasis. Therefore, there is a need to develop an inducer that amplifies ICD. Here, methotrexate (MTX) and MoO2 were loaded into a Cu2+-doped iron-based targeted metal-organic framework Fe-NH2-MIL-101 with nano-enzymatic activity to establish a novel ICD amplifier. The photothermal agent MoO2 generates heat under near-infrared (NIR) light excitation, inducing tumor ablation. Simultaneously, the released Mo+ combines with Fe2+ and Cu+ in the system, synergistically enhancing electron transfer efficiency based on the bimetallic system. Combined with thermal effects, this approach cooperatively elevates glutathione peroxidase (GPx)-like and peroxidase (POD)-like activities. This catalytic cascade depletes glutathione through Fenton-like reactions while amplifying hydroxyl radical (˙OH) generation, thereby remodeling the tumor microenvironment (TME), potentiating chemodynamic therapy (CDT), and triggering ICD. The chemotherapeutic agent MTX not only exerts direct cytotoxic effects but also serves as an inducer of ICD. In vitro and in vivo experiments have shown that the resulting synergistic treatment model based on the combination of CDT, photothermal therapy (PTT), and chemotherapy guided by T2-MRI imaging will amplify the ICD effect, enhance tumor treatment, and is expected to achieve the prevention of metastasis and recurrence of tumors and to realize the integration of tumor diagnosis, treatment, and prevention.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile Ag⁺-assisted bonding strategy to build a low-defect hybrid layer with intrinsic antibacterial and enzymolysis inhibitory properties. 易变Ag+辅助键合策略构建具有内在抗菌和酶解抑制性能的低缺陷杂化层。

Journal of materials chemistry. B Pub Date : 2025-06-05 DOI: 10.1039/d5tb00584a

Yajie Cheng, Yadong Chen, Chang Shu, Chenying Zhou, Zhenzhen Zhang, Yan Tu, Qiaojie Luo, Xiaodong Li

{"title":"Facile Ag+-assisted bonding strategy to build a low-defect hybrid layer with intrinsic antibacterial and enzymolysis inhibitory properties.","authors":"Yajie Cheng, Yadong Chen, Chang Shu, Chenying Zhou, Zhenzhen Zhang, Yan Tu, Qiaojie Luo, Xiaodong Li","doi":"10.1039/d5tb00584a","DOIUrl":"https://doi.org/10.1039/d5tb00584a","url":null,"abstract":"As the most widely used material for dental tissue repair, dental resin composites face durability challenges, and their longevity critically depends on the hybrid layer's integrity. Incomplete adhesive infiltration within demineralized dentin matrix (DDM) creates structural defects in this layer, rendering it vulnerable to stress, enzymatic degradation, and bacterial invasion. These factors contribute to secondary caries, the predominant complication of resin-based restorations. Enhancing adhesive infiltration and the hybrid layer's antibacterial capacity is thus pivotal to extending the restoration lifespan. Previous studies have revealed that strong metal ion chelation can release confined water to facilitate hydrophobic monomer infiltration, significantly improving dentin bonding efficacy and durability. Therefore, in this study, leveraging the dual advantages of Ag+-potent chelation and antibacterial activity-we treated a DDM with Ag+. A brief 20-second application chemically modified the DDM, enabling confined water release, enhancing adhesive infiltration and conferring a durable antibacterial functionality. Additionally, matrix metalloproteinases (MMPs) activated during bonding were effectively inhibited. Notably, subsequent light irradiation reduced Ag+ to metallic silver, enhancing structural stability by orders of magnitude. This approach successfully established a stable low-defect hybrid layer. This strategy offers a clinically viable solution for achieving durable dentin restoration with integrated antibacterial properties.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suppression of the HSP90-HIF1α pathway with SNX2112-encapsulated nano-micelles for effective triple-negative breast cancer photothermal combined photodynamic therapy. snx2112包封纳米胶束抑制HSP90-HIF1α通路对三阴性乳腺癌光热联合光动力治疗的效果

Journal of materials chemistry. B Pub Date : 2025-06-05 DOI: 10.1039/d5tb00071h

Zhiqi Zhang, Fangzheng Tian, Shiwei Lai, Xiaoxuan Xu, Mei Zhou, Zhenyu Hou, Siyu Li, Jianqiong Zhang, Xue Yang, Jinbing Xie, Shenghong Ju

{"title":"Suppression of the HSP90-HIF1α pathway with SNX2112-encapsulated nano-micelles for effective triple-negative breast cancer photothermal combined photodynamic therapy.","authors":"Zhiqi Zhang, Fangzheng Tian, Shiwei Lai, Xiaoxuan Xu, Mei Zhou, Zhenyu Hou, Siyu Li, Jianqiong Zhang, Xue Yang, Jinbing Xie, Shenghong Ju","doi":"10.1039/d5tb00071h","DOIUrl":"https://doi.org/10.1039/d5tb00071h","url":null,"abstract":"Combined photothermal and photodynamic therapy is a promising strategy for the treatment of triple-negative breast cancer (TNBC) as it can accurately target tumor tissues and improve therapeutic efficacy. However, its efficacy is still insufficient owing to the heat resistance resulting from the upregulation of heat shock protein 90 (HSP90) and diminished reactive oxygen species (ROS) levels due to the accumulation of its client protein hypoxia-inducible factor-1α (HIF1α). Herein, SNX2112 (HSP90 inhibitor) and IR825 (photosensitizer) are loaded into a pH-responsive nano-micelle for efficient photothermal and photodynamic therapy. SNX2112 inhibits HSP90 activity to reduce heat resistance for enhanced photothermal therapy. Furthermore, HIF1α accumulation is reduced to increase ROS production to amplify photodynamic therapy efficacy. Consequently, the combined therapy enhanced by inhibiting HSP90-HIF1α effectively suppresses tumor growth via synergistic effects, with high photothermal conversion and ROS productivity under mild temperature (42 °C). Furthermore, using SNX2112 improves the efficacy of the combined photothermal and photodynamic therapy, showing its eminent potential in TNBC treatment.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced yield and proteomic profile of osteoblast-derived extracellular vesicles from 3D MEW mPCL scaffolds. 3D MEW mPCL支架的成骨细胞外囊泡产量和蛋白质组学特征增强。

Journal of materials chemistry. B Pub Date : 2025-06-05 DOI: 10.1039/d5tb00021a

Chun Liu, Chenyi Zhang, Shu Hua, Carlos Salomon, Sašo Ivanovski, Pingping Han

{"title":"Enhanced yield and proteomic profile of osteoblast-derived extracellular vesicles from 3D MEW mPCL scaffolds.","authors":"Chun Liu, Chenyi Zhang, Shu Hua, Carlos Salomon, Sašo Ivanovski, Pingping Han","doi":"10.1039/d5tb00021a","DOIUrl":"https://doi.org/10.1039/d5tb00021a","url":null,"abstract":"Biomaterials could influence the production and composition of cell derived extracellular vesicles (EVs), including osteoblast-derived EVs (OB-EVs), which are essential for cell-to-cell communication and hold potential for bone regeneration. Despite their promise, methods for enhancing OB-EVs yields, especially from 3D highly porous microfibrous polymeric scaffolds, remain limited. In this study, we cultured mouse osteoblasts cell line MC3T3-E1 on 3D melt electrowritten (MEW) medical grade polycaprolactone (mPCL) scaffolds and 2D tissue culture plates (TCPs) to compare EV yield, subtypes (small EVs, microvesicles, apoptotic bodies), and proteome profile using liquid chromatography coupled with Tandem mass spectrometry (LC/MS-MS). Our results revealed that OB cultured on MEW mPCL scaffolds significantly increased small EVs yield, with increased particles of small EVs and reduced apoptotic bodies. Notably, two 30 × 30 mm, 0.8 mm-thick MEW mPCL scaffolds (5.07 × 108 sEVs per scaffold) produced the same sEVs yield comparable to that of a T175 TCP flask (9.37 × 108 sEVs per flask). The LC-MS/MS results showed that MEW mPCL sEVs were enriched for 34 proteins associated with tight junction, cell adhesion, gap junction, proteasome, apoptosis and complement pathways. Key proteins such as tubulin superfamily members, myosin heavy chain 9, ezrin, complement 3, CD9, Decorin, and Biglycan were identified, all potentially contributing to tissue repair and regeneration. These findings suggest that 3D MEW mPCL scaffolds not only enhanced OB-sEVs production but also enriched sEVs-protein profiles, particularly those involved in cell-cell junctions and phagosome secretion, suggesting their strong potential in bone tissue engineering.","PeriodicalId":94089,"journal":{"name":"Journal of materials chemistry. B","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0