Fenglan Huang, Li Chen, Xin Zhang, Shengqian Tian, Yuxin Han, Minghui Hu, Lili He and Rong Luo
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引用次数: 0
Abstract
Liver cancer stem cells (LCSCs) are a population of cells with self-renewal and self-differentiation capacities, widely recognized as critical for hepatocellular carcinoma (HCC) development. Accordingly, eliminating LCSCs is considered a viable strategy for HCC treatment. However, conventional chemotherapy and radiation therapy struggle to eradicate LCSCs, underscoring the critical need for LCSC-targeted therapies. Nanotechnology offers unique advantages for LCSC targeting via the selective delivery of drugs to tumor sites. Various engineered nanomedicines—including polymeric nanoparticles, biological nanomaterials, and inorganic nanoparticles—have been developed for their elimination. This article primarily reviews the biological concepts and biomarkers of LCSCs. In addition, it summarizes various strategies for targeting LCSCs using engineered nanomedicines.
期刊介绍：
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive：
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices
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