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Experimental Research on the Process and Performance of Composite Dressing-Assisted Laser Joining of Ruptured Tendons.
Journal of biophotonics Pub Date : 2025-02-03 DOI: 10.1002/jbio.202400528
Jun Huang, Yanyu Li, Mintao Yan, Jinjin Wu, Kehong Wang
{"title":"Experimental Research on the Process and Performance of Composite Dressing-Assisted Laser Joining of Ruptured Tendons.","authors":"Jun Huang, Yanyu Li, Mintao Yan, Jinjin Wu, Kehong Wang","doi":"10.1002/jbio.202400528","DOIUrl":"https://doi.org/10.1002/jbio.202400528","url":null,"abstract":"<p><p>Tendon tissue plays an important role in transmitting the force, increasing the incidence of serious tendon injuries. The clinical method of tendon tissue repair is contact surgical suture, which has the problem of high requirements for surgery. Laser has a noncontact feature that can reduce postoperative complications. However, the tissue has low tensile strength due to the weak ability to absorb the energy. Dressing-assisted laser joining of ruptured tendons can improve the tensile strength of ruptured tendon tissue. The enhancement effect of the dressing was tested, and the mechanical properties and thermal damage of the tendon tissue were analyzed. The results show that with 0.005% SWCNTS +0.3% ICG, the tensile strength can be achieved at 1.30 MPa, the collagen content can be achieved at 27.68% and the degree of thermal denaturation is only 0.31. The results have important value for further research on tendon tissue repair techniques.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400528"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Portable Nd:YAG Laser-Enhanced Photoacoustic Spectral Sensing for Breast Tissues: Toward Oncological Theranostics.
Journal of biophotonics Pub Date : 2025-02-01 DOI: 10.1002/jbio.202400430
Suhel Khan, Sramana Mukhopadhyay, M S Ansari, R K Patidar, Saikat Das, Srivathsan Vasudevan
{"title":"Portable Nd:YAG Laser-Enhanced Photoacoustic Spectral Sensing for Breast Tissues: Toward Oncological Theranostics.","authors":"Suhel Khan, Sramana Mukhopadhyay, M S Ansari, R K Patidar, Saikat Das, Srivathsan Vasudevan","doi":"10.1002/jbio.202400430","DOIUrl":"https://doi.org/10.1002/jbio.202400430","url":null,"abstract":"<p><p>A solid-state laser is preferred for generating light in a photoacoustic (PA) system because of its high energy and coherence. However, conventional Nd:YAG lasers are bulky, complex, and expensive. This article introduces a portable alternative: a custom-built Nd:YAG laser with an in-house power supply that delivers 0-30 A current pulses with a 1500 μs pulse width, providing efficient thermal management. A pockels cell driver generates 10 ns pulses with 3.84 mJ/cm<sup>2</sup> laser energy density. Implemented for noninvasive breast cancer diagnosis, The peak frequency obtained from three different samples was 0.23 ± 0.1, 0.26 ± 0.13, and 1.80 ± 0.14 MHz, respectively, for Normal, Fibrotic, and Tumor tissues. In addition to the dominant frequency peaks the spectral energy of the PASR spectra has also been investigated to characterize the breast tissue samples. The developed laser successfully differentiates between carcinoma, fibrocystic disease, and normal breast tissue based on quantitative PA spectral parameters.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400430"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Relationship Between the Optical Properties of Articular Cartilage and the Biomechanical Parameters of the Tissue.
Journal of biophotonics Pub Date : 2025-01-31 DOI: 10.1002/jbio.202400460
Iman Kafian-Attari, Mohammad Ebrahimi, Ervin Nippolainen, Arash Mirhashemi, Petri Paakkari, Florian Bergmann, Florian Foschum, Alwin Kienle, Juha Töyräs, Isaac Afara
{"title":"The Relationship Between the Optical Properties of Articular Cartilage and the Biomechanical Parameters of the Tissue.","authors":"Iman Kafian-Attari, Mohammad Ebrahimi, Ervin Nippolainen, Arash Mirhashemi, Petri Paakkari, Florian Bergmann, Florian Foschum, Alwin Kienle, Juha Töyräs, Isaac Afara","doi":"10.1002/jbio.202400460","DOIUrl":"https://doi.org/10.1002/jbio.202400460","url":null,"abstract":"<p><p>This study investigates the relationship between the optical properties of articular cartilage with its biomechanical parameters. The absorption and reduced scattering coefficients of articular cartilage, and average maximum penetration depth, average maximum lateral spread, and average path length of photons were estimated by optical measurements and Monte Carlo simulation. The equilibrium and instantaneous moduli, and initial fibrillar network, strain-dependent fibrillar network, and nonfibrillar network moduli, and initial and deformation-dependent permeability of the tissue were estimated by multistep stress-relaxation measurement and fibril-reinforced poroelastic modeling. The relationship between the optical properties and biomechanical parameters was assessed using predictive regression modeling. A strong relationship was found between reduced scattering coefficients, averaged maximum penetration depth, averaged maximum lateral spread, and average path length of photons with equilibrium, instantaneous, and initial fibrillar network moduli. We attribute this relationship to the collagen fibers as the main contributor to the scattering and biomechanical properties of the tissue.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400460"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Non-invasive Lung Disease Study of Exhaled Breath Nitric Oxide Based on Ultraviolet Differential Absorption Spectroscopy Techniques.
Journal of biophotonics Pub Date : 2025-01-28 DOI: 10.1002/jbio.202400481
Chaoyang Li, Xiaoning Chen, Wei Li, Xuan Zhou, Huiyuan Gong
{"title":"A Non-invasive Lung Disease Study of Exhaled Breath Nitric Oxide Based on Ultraviolet Differential Absorption Spectroscopy Techniques.","authors":"Chaoyang Li, Xiaoning Chen, Wei Li, Xuan Zhou, Huiyuan Gong","doi":"10.1002/jbio.202400481","DOIUrl":"https://doi.org/10.1002/jbio.202400481","url":null,"abstract":"<p><p>In this study, a non-invasive device based on ultraviolet differential absorption spectroscopy (UV-DOAS) technology for detecting fractional exhaled nitric oxide (FeNO)was developed and clinically validated in patients with various lung diseases. The diagnostic potential of FeNO was explored by analysing subgroups of patients with lung cancer, nodules, and other disease. The results showed that FeNO concentrations were significantly higher in patients with malignant tumours than in healthy controls (p < 0.01). The diagnostic efficacy of FeNO in different lung diseases was confirmed by ROC analysis: the AUC values were 0.925 for malignant tumours, 0.925 for suspected malignant/benign tumours, 0.792 for benign lesions, and 0.938 for infectious/inflammatory diseases. The significant postoperative FeNO level decrease supports the diagnostic use of FeNO in different stages of the disease. Compared with conventional electrochemical, chemiluminescent and fluorescent probe methods, the UV-DOAS technique has significant advantages regarding sensitivity and portability, suggesting its potential for clinical application.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400481"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep Learning and Hyperspectral Imaging for Liver Cancer Staging and Cirrhosis Differentiation.
Journal of biophotonics Pub Date : 2025-01-28 DOI: 10.1002/jbio.202400557
Tianyi Hang, Danfeng Fan, Tiefeng Sun, Zhengyuan Chen, Xiaoqing Yang, Xiaoqing Yue
{"title":"Deep Learning and Hyperspectral Imaging for Liver Cancer Staging and Cirrhosis Differentiation.","authors":"Tianyi Hang, Danfeng Fan, Tiefeng Sun, Zhengyuan Chen, Xiaoqing Yang, Xiaoqing Yue","doi":"10.1002/jbio.202400557","DOIUrl":"https://doi.org/10.1002/jbio.202400557","url":null,"abstract":"<p><p>Liver malignancies, particularly hepatocellular carcinoma (HCC), pose a formidable global health challenge. Conventional diagnostic techniques frequently fall short in precision, especially at advanced HCC stages. In response, we have developed a novel diagnostic strategy that integrates hyperspectral imaging with deep learning. This innovative approach captures detailed spectral data from tissue samples, pinpointing subtle cellular differences that elude traditional methods. A sophisticated deep convolutional neural network processes this data, effectively distinguishing high-grade liver cancer from cirrhosis with an accuracy of 89.45%, a sensitivity of 90.29%, and a specificity of 88.64%. For HCC differentiation specifically, it achieves an impressive accuracy of 93.73%, sensitivity of 92.53%, and specificity of 90.07%. Our results underscore the potential of this technique as a precise, rapid, and non-invasive diagnostic tool that surpasses existing clinical methods in staging liver cancer and differentiating cirrhosis.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400557"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wearable Multimodal Optical Analyzers: Physiological Variability and Reproducibility of Measurements.
Journal of biophotonics Pub Date : 2025-01-28 DOI: 10.1002/jbio.202400527
Yu I Loktionova, E V Zharkikh, V E Parshakova, V V Sidorov, A V Dunaev
{"title":"Wearable Multimodal Optical Analyzers: Physiological Variability and Reproducibility of Measurements.","authors":"Yu I Loktionova, E V Zharkikh, V E Parshakova, V V Sidorov, A V Dunaev","doi":"10.1002/jbio.202400527","DOIUrl":"https://doi.org/10.1002/jbio.202400527","url":null,"abstract":"<p><p>The work is devoted to the study of the physiological variability of the microcirculatory-tissue system (MTS) parameters under normal conditions and during functional tests. The results were obtained in vivo using multimodal wearable analyzers implementing methods of laser Doppler flowmetry and fluorescence spectroscopy. Comprehensive data analysis and calculation of the coefficients of variation of the MTS parameters of the human body for various topographic and anatomical areas of the skin were carried out. The obtained results showed higher values of the coefficient of variation of MTS parameters in the area of the toes and wrists, while the fingers and forehead skin showed lower levers of variation. In all areas of the study, reproducibility of the parameters obtained for the right and left areas of the study is observed.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400527"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diabetes Mellitus Impairs Blood-Brain Barrier Integrality and Microglial Reactivity.
Journal of biophotonics Pub Date : 2025-01-27 DOI: 10.1002/jbio.202400482
Shaojun Liu, Jie Hao, Tingting Yu, Valery V Tuchin, Junming Li, Dongyu Li, Dan Zhu
{"title":"Diabetes Mellitus Impairs Blood-Brain Barrier Integrality and Microglial Reactivity.","authors":"Shaojun Liu, Jie Hao, Tingting Yu, Valery V Tuchin, Junming Li, Dongyu Li, Dan Zhu","doi":"10.1002/jbio.202400482","DOIUrl":"https://doi.org/10.1002/jbio.202400482","url":null,"abstract":"<p><p>Diabetes mellitus (DM), a chronic metabolic disorder that adversely affects the blood-brain barrier (BBB) and microglial function in the central nervous system (CNS), contributing to neuronal damage and neurodegenerative diseases. However, the underlying molecular mechanisms linking diabetes to BBB dysfunction and microglial dysregulation remain poorly understood. Here, we assessed the impacts of diabetes on BBB and microglial reactivity and investigated its mechanisms. We found diabetes severely disrupted the BBB integrity and microglial response to vascular injury. We also revealed a potential relationship between BBB disruption and impaired microglial function, whereby increasing BBB permeability led to a downregulation of microglial P2RY12 expression, thereby impairing microglial protection against cerebrovascular injury. Understanding these mechanisms may contribute to the developing of therapeutic strategies for diabetes-related neurological complications.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400482"},"PeriodicalIF":0.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optical Based Methods for Water Monitoring in Biological Tissue.
Journal of biophotonics Pub Date : 2025-01-24 DOI: 10.1002/jbio.202400438
Sergei Perkov, Julijana Cvjetinovic, Altynai Sydygalieva, Sergey Gorodkov, Guoqiang Li, Dmitry Gorin
{"title":"Optical Based Methods for Water Monitoring in Biological Tissue.","authors":"Sergei Perkov, Julijana Cvjetinovic, Altynai Sydygalieva, Sergey Gorodkov, Guoqiang Li, Dmitry Gorin","doi":"10.1002/jbio.202400438","DOIUrl":"https://doi.org/10.1002/jbio.202400438","url":null,"abstract":"<p><p>Skin homeostasis is strongly dependent on its hydration levels, making skin water content measurement vital across various fields, including medicine, cosmetology, and sports science. Noninvasive diagnostic techniques are particularly relevant for clinical applications due to their minimal risk of side effects. A range of optical methods have been developed for this purpose, each with unique physical principles, advantages, and limitations. This review provides an in-depth examination of optical techniques such as diffuse reflectance spectroscopy, optoacoustic spectroscopy, optoacoustic tomography, hyperspectral imaging, and Raman spectroscopy. We explore their efficacy in noninvasive monitoring of skin hydration and edema, which is characterized by an increase in interstitial fluid. By comparing the parameters, sensitivity, and clinical applications of these techniques, this review offers a comprehensive understanding of their potential to enhance diagnostic precision and improve patient care.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400438"},"PeriodicalIF":0.0,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Functional Breast Imaging: A sCMOS Camera-Based Lock-in Implementation for Dynamic Tomography.
Journal of biophotonics Pub Date : 2025-01-23 DOI: 10.1002/jbio.202400473
Yujie Zheng, Limin Zhang, Weijie Song, Feng Gao, Dongyuan Liu
{"title":"Enhancing Functional Breast Imaging: A sCMOS Camera-Based Lock-in Implementation for Dynamic Tomography.","authors":"Yujie Zheng, Limin Zhang, Weijie Song, Feng Gao, Dongyuan Liu","doi":"10.1002/jbio.202400473","DOIUrl":"https://doi.org/10.1002/jbio.202400473","url":null,"abstract":"<p><p>Diffuse optical tomography (DOT) enables the in vivo quantification of tissue chromophores, specifically the discernment of oxy- and deoxy-hemoglobin (HbO and HbR, correspondingly). This specific criterion is useful in detecting and predicting early-stage neoadjuvant breast cancer treatment response. To address the issues of the limited channels in the fiber-dependent breast DOT system and limited signal-to-noise ratio in the camera-dependent systems, we hereby present a camera-based lock-in detection scheme to achieve dynamic DOT with improved SNR, which adopted orthogonal frequency division multiplexing technology. The evaluation of the system performance was conducted on tissue phantoms and neoplastic rats, and the results show that this system boasts the capability of executing parallel measurement utilizing a camera detector, enabling the achievement of highly sensitive, and dynamic tomography for breast screening applications.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400473"},"PeriodicalIF":0.0,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photobiomodulation Combined With Human Umbilical Cord Mesenchymal Stem Cells Modulates the Polarization of Microglia. 光生物调节联合人脐带间充质干细胞对小胶质细胞极化的调节。
Journal of biophotonics Pub Date : 2025-01-22 DOI: 10.1002/jbio.202400468
Chunyan Ma, Hongyu Zhu, Yuanhao Cai, Na Li, Zhibo Han, Huancheng Wu, Hongli Chen
{"title":"Photobiomodulation Combined With Human Umbilical Cord Mesenchymal Stem Cells Modulates the Polarization of Microglia.","authors":"Chunyan Ma, Hongyu Zhu, Yuanhao Cai, Na Li, Zhibo Han, Huancheng Wu, Hongli Chen","doi":"10.1002/jbio.202400468","DOIUrl":"https://doi.org/10.1002/jbio.202400468","url":null,"abstract":"<p><p>Neuroinflammation plays a key role in the development of neurodegenerative diseases, with microglia regulating this process through pro-inflammatory M1 and anti-inflammatory M2 phenotypes. Studies have shown that human umbilical cord mesenchymal stem cells (hUCMSCs) modulate neuroinflammation by secreting anti-inflammatory cytokines. Photobiomodulation (PBM), a non-invasive therapy, has demonstrated significant potential in alleviating neuroinflammation. This study examines the combined effects of PBM and hUCMSCs in an in vitro microglial inflammation model and an LPS-induced mouse model. The results show that PBM-pretreated hUCMSCs promoted M2 polarization and improved cognitive function in mice by downregulating the Notch signaling pathway, suggesting a promising new approach for treating neurodegenerative diseases.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":" ","pages":"e202400468"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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