Ginekologia polska最新文献_第6页

Is it possible to predict severe postpartum hemorrhage and the need for massive transfusion in placenta previa cases? 能否预测前置胎盘病例中的严重产后出血和大量输血需求？

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2025-03-12 DOI: 10.5603/gpl.103049

Emre Köle, Bertan Akar, Emek Doğer, Merve Çakır Köle, Yonca Anık, Eray Çalışkan

{"title":"Is it possible to predict severe postpartum hemorrhage and the need for massive transfusion in placenta previa cases?","authors":"Emre Köle, Bertan Akar, Emek Doğer, Merve Çakır Köle, Yonca Anık, Eray Çalışkan","doi":"10.5603/gpl.103049","DOIUrl":"10.5603/gpl.103049","url":null,"abstract":"Objectives: The aim was to construct a reliable working model for patients with placenta previa (PP) that aids in the prediction of postpartum bleeding potential with data from antenatal imaging studies using both ultrasound (US) and magnetic resonance imaging (MRI).Material and methods: Forty-three patients with PP were evaluated initially with the US and then by 3-Tesla MRI. The Placenta Accreata Index (PAI) was used during the US evaluation in order to define the risks. Uterine bulging, heterogeneous signal, dark placental bands, focal interruption of myometrium and tenting of bladder wall were regarded as predictive criteria in MRI evaluation. The correlation between the findings from US and MRI studies and subsequent haemorrhage, < 1000 mL, > 1000 mL and severe haemorrhage ( > 2000 mL) and massive transfusion [ > 5 units of red blood cells (RBC)] were used to build this predictive model. The findings from the imaging studies were also confirmed histopathologically.Results: In the multivariate analysis of data from patients stratified by bleed size either < 1000 mL or > 1000 mL, none of the MRI and ultrasound findings were found to be predictive. The multivariate analysis was done using the second stratification cut-point of 2000 mL, in patients bleeding > 2000 mL PAI values [OR: 2.3 (1.4-3.8)] and overall MRI reported placenta accreata spectrum [OR: 4.9 (1.8-12.9)] were found to be predictive. While MRI findings were not discriminative between transfusion groups, grade 3 loculation on US examination was found to be predictive for the need of transfusion of > 5 units [OR: 67.5 (8.2-549.4)]. There were no cases needing hysterectomy.Conclusions: Ultrasound and MRI findings in cases of PP can be helpful in predicting postpartum bleeding.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"308-313"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations vulvar lichen sclerosus with autoimmune thyroid diseases. 外阴硬皮病与自身免疫性甲状腺疾病的关系

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2024-10-29 DOI: 10.5603/gpl.103145

Maja J Zieba-Domalik, Dominika Orszulak, Kacper Nizinski, Katarzyna Wilk, Marta Janik, Rafal Stojko, Agnieszka Drosdzol-Cop

{"title":"Associations vulvar lichen sclerosus with autoimmune thyroid diseases.","authors":"Maja J Zieba-Domalik, Dominika Orszulak, Kacper Nizinski, Katarzyna Wilk, Marta Janik, Rafal Stojko, Agnieszka Drosdzol-Cop","doi":"10.5603/gpl.103145","DOIUrl":"10.5603/gpl.103145","url":null,"abstract":"Objectives: Vulvar lichen sclerosus (VLS) is defined as a chronic inflammatory skin disease that most often involves lesions on the mucous membranes of the vulva with a tendency to progress to the anal skin. The etiopathogenesis of VLS remains unknown and is likely multifactorial. Data emphasize the role of immunological factors - more than 25% of VLS cases coexist with autoimmune diseases. The purpose of the present study was to determine the correlation of the prevalence of anti-thyroid antibodies - IgG class antibodies against thyroid peroxidase and IgG class antibodies against thyroglobulin in women with vulvar lichen sclerosus, and the appropriateness of screening tests for autoimmune thyroid diseases in women with vulvar lichen sclerosus.Material and methods: Fifty women with vulvar lichen sclerosus were enrolled in the study. The control group consisted of 41 healthy women. A detailed medical history was taken with all patients, followed by laboratory determinations - anti-thyroid antibodies - IgG class antibodies against thyroid peroxidase and IgG class antibodies against thyroglobulin.Results: Antibodies to thyroid peroxidase were present in 12% of the study group with vulvar lichen sclerosus and 4.88% of the control group, and this difference was not statistically significant (p = 0.41). Anti-thyroglobulin antibodies were detected in 4% of the patients with vulvar lichen sclerosus and 4.88% of the control group, and this difference was not statistically significant either (p = 0.76).Conclusions: The study did not confirm the association of VLS with autoimmune thyroid diseases. Undoubtedly, based on the data available in the literature, further studies are needed to determine the mechanisms behind the association between vulvar lichen sclerosus and autoimmune thyroid diseases.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"235-240"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Off-label letrozole for tubal pregnancy monotherapy is not an alternative to methotrexate: a prospective cohort study. 用于输卵管妊娠单药治疗的标签外来曲唑不能替代甲氨蝶呤：一项前瞻性队列研究。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2024-09-17 DOI: 10.5603/gpl.100131

Iwona M Gawron, Dorota Babczyk, Robert Jach

{"title":"Off-label letrozole for tubal pregnancy monotherapy is not an alternative to methotrexate: a prospective cohort study.","authors":"Iwona M Gawron, Dorota Babczyk, Robert Jach","doi":"10.5603/gpl.100131","DOIUrl":"10.5603/gpl.100131","url":null,"abstract":"Objectives: Inhibition of estradiol production by letrozole may interfere with physiological effects of progesterone necessary to maintain the pregnancy. Treatment of tubal pregnancy (TP) with letrozole would allow to avoid the disadvantages of methotrexate (MTX). The aim was to compare the effectiveness of letrozole with MTX in the management of TP.Material and methods: A prospective open-label cohort study was conducted among women with TP and increasing B-human chorionic gonadotropin (B-hCG) concentrations. MTX was administered in a single dose of 100 mg intravenously, while letrozole in a dose of 5 mg orally for 10 days. Blood parameters (B-hCG, hemoglobin, creatinine, urea, transaminases, bilirubin) were tested on days 0, 4 and 7.Results: Out of 22 eligible women, 14 received MTX and received 8 letrozole. Mean age, lesion diameter, gestation age in the MTX vs letrozole arm were: 31 vs 32 years (p = 0.3), 13.2 vs 16.3 mm (p = 0.1), 7 + 1 vs 7 + 0 weeks (p = 0.6), respectively. In case of 4 women treated with letrozole and in 2 treated with MTX (4/8, 50% vs 2/14, 14.3%, p = 0.07) the treatment was unsuccessful. There were no significant differences in blood parameters on days 0, 4 and 7 between both arms, except for the increasing urea concentration in the letrozole arm (p = 0.01).Conclusions: Even though the results did not reach statistical significance, it is likely that a larger study sample would confirm the trend of letrozole being less effective. The results did not support the use of letrozole in the studied regimen as an alternative to MTX.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"51-57"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142304680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fetal cardiac function is altered by circumvallate placenta. 胎儿心功能被环瓣胎盘改变。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2024-11-29 DOI: 10.5603/gpl.101714

Oskar Sylwestrzak, Katarzyna Zych-Krekora, Lukasz Sokolowski, Maciej Ziebakowski, Michal Krekora

引用次数: 0

Association between MMP-9-C1562Tpolymorphism and susceptibility to preeclampsia: a systematic review and meta-analysis. MMP-9-C1562T多态性与先兆子痫易感性之间的关系：系统回顾和荟萃分析。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2024-10-16 DOI: 10.5603/gpl.100274

Ruihong Lan, Yang Yang, Jie Song, Hong Yang, Ling Wang, Humin Gong

{"title":"Association between MMP-9-C1562Tpolymorphism and susceptibility to preeclampsia: a systematic review and meta-analysis.","authors":"Ruihong Lan, Yang Yang, Jie Song, Hong Yang, Ling Wang, Humin Gong","doi":"10.5603/gpl.100274","DOIUrl":"10.5603/gpl.100274","url":null,"abstract":"Objectives: This meta-analysis aims to explore the association between MMP-9-C1562T polymorphism and susceptibility to preeclampsia (PE).Material and methods: Four English databases were searched to collect relevant records up to April 2024. The pooled odds ratio (OR) was calculated using Stata 15.0.Results: A total of 10 studies were enrolled in our systematic review. The results showed that genotype CT at MMP-9-C1562T locus increased the risk of PE versus genotype TT (Genotype CT vs TT: OR = 2.32, 95% CI: 1.27-4.24, P = 0.006), but no significant differences were found in other gene models (C vs T: OR = 0.88, 95% CI: 0.71-1.08, P = 0.225; Genotype CC vs TT: OR = 1.51, 95% CI: 0.87-2.61, P = 0.139; Genotype CC + CT vs TT: OR = 1.63, 95% CI: 0.95-2.81, P = 0.079; Genotype CC vs CT + TT: OR = 0.80, 95% CI: 0.63-1.03, P = 0.086). Subgroup analysis by ethnicity showed a statistically significant difference in the heterozygous model in China (Genotype CT vs TT: OR = 2.38, 95% CI: 1.15 -4.91, P = 0.019).Conclusions: Association of MMP-9-C1562T polymorphism with susceptibility to PE exists. Specifically, genotype CT increases the risk of PE versus genotype TT, particularly in Caucasian populations.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"65-71"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Initial paraneoplastic presentation of advanced choriocarcinoma. 晚期绒毛膜癌的初期副肿瘤性表现。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2024-08-14 DOI: 10.5603/gpl.100439

Julia Rudnicka, Aleksandra Urban, Julia Gorny, Anna Danska-Bidzinska, Ewa Romejko-Wolniewicz

引用次数: 0

Transvaginal single posterior incision extraperitoneal bilateral sacrospinous ligament suspension combined with reconstruction of pericervical ring through cervical cerclage. 经阴道单后切口腹膜外双侧骶棘韧带悬吊术，通过宫颈环扎重建宫颈环。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2024-10-16 DOI: 10.5603/gpl.102089

Luo Puying, Yi Sijie, Luo Wenqun, Xiong Yuanhuan

引用次数: 0

Clinical application of synthetic osmotic cervical dilator in labor pre-induction: departmental protocol and literature review. 人工合成渗透性宫颈扩张器在引产前的临床应用：部门规程和文献综述。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2024-11-08 DOI: 10.5603/gpl.100984

Maisa Manasar-Dyrbus, Katarzyna Wilk, Maja Zieba-Domalik, Jakub Staniczek, Rafal Stojko

引用次数: 0

Using the National Nosocomial Infections Surveillance risk index to determine risk factors associated with surgical site infections following gynecologic surgeries. 使用国家医院感染监测风险指数来确定妇科手术后与手术部位感染相关的风险因素。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2023-10-20 DOI: 10.5603/gpl.95073

Dong Wang, Jinlin Wu, Jianjun Deng, Ming Luo, Jie Ruan, Zhan Yang

{"title":"Using the National Nosocomial Infections Surveillance risk index to determine risk factors associated with surgical site infections following gynecologic surgeries.","authors":"Dong Wang, Jinlin Wu, Jianjun Deng, Ming Luo, Jie Ruan, Zhan Yang","doi":"10.5603/gpl.95073","DOIUrl":"10.5603/gpl.95073","url":null,"abstract":"Objectives: We used the National Nosocomial Infections Surveillance (NNIS) risk index to determine risk factors associated with surgical site infections (SSIs) following gynecologic surgeries.Material and methods: A retrospective study was conducted based on the medical records of 185 patients with SSIs, following gynecologic surgeries at a Grade A tertiary gynecologic and obstetric hospital in southwest China during September 2013-June 2021.Results: Suspected risk factors associated with SSIs were: length of hospital stay, age, whether the patient had cancer, whether the patient had chemotherapy or high-dose antibiotic therapy before surgery, duration of surgery, amount of blood loss, and whether a blood transfusion was done. It was found that SSIs were more likely to occur in cancer patients with an NNIS risk index score of 1 and in patients with preoperative chemotherapy and an NNIS risk index score of 2. Among the patients with an NNIS risk index score of 2, the older the patient, the higher incidence of SSIs.Conclusions: Gynecologic surgery teams should pay more attention to the independent risk factors associated with SSIs determined by the NNIS risk index score to prevent SSIs following gynecologic surgeries, thus ensuring patient safety.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"7-12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49686619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the utility of the sFlt-1/PlGF ratio in pregnancy complicated by pre-eclampsia - single-center study. Preliminary analysis. 评估sFlt-1/PlGF比值在妊娠合并子痫前期的应用-单中心研究初步分析。

Ginekologia polska Pub Date : 2025-01-01 Epub Date: 2025-01-29 DOI: 10.5603/gpl.101484

Justyna A Kuciel, Jagoda N Sarad, Natalia M Mroczek, Andrzej Jaworowski, Magdalena L Kolak, Hubert K Huras

{"title":"Evaluation of the utility of the sFlt-1/PlGF ratio in pregnancy complicated by pre-eclampsia - single-center study. Preliminary analysis.","authors":"Justyna A Kuciel, Jagoda N Sarad, Natalia M Mroczek, Andrzej Jaworowski, Magdalena L Kolak, Hubert K Huras","doi":"10.5603/gpl.101484","DOIUrl":"10.5603/gpl.101484","url":null,"abstract":"Objectives: To evaluate relationship between sFlt-1/PlGF ratio, clinical characteristics and outcomes of pre-eclampsia.Material and methods: Retrospective analysis of 29 pregnant women with pre-eclampsia who had measured sFlt-1/PlGF ratio was conducted using electronic medical records from Obstetrics and Perinatology ward of University Hospital in Cracow.Results: Women median age: 33.5 years, number of pregnancies: one 52%, two 15%, three 18%,more than three 15%, number of deliveries: one 59.3%, two 37%, three 3.7%, median body mass index during hospitalization: 29.4 kg/m². Chronic diseases apart from hypertension: 67% of women (diabetes 37%, hypothyroidism 26%, obesity 11%). Median newborns birth weight: 1640 g, median Apgar score at 5 minutes: 8, median umbilical cord blood pH: 7.32. Fetal growth restriction: 28.6% of cases. All deliveries were by c-section. Median gestational age at delivery: 32 weeks. sFlt-1/PlGF ratio was inversely correlated with gestational age at delivery (r = -0.42, p = 0.02). The median sFlt-1/PlGF ratio was higher in women with severe pre-eclampsia (n = 15) than in those with mild pre-eclampsia (n = 14) (211 vs. 57, p < 0.001). sFlt-1/PlGF ratio of > 85 had a sensitivity of 80% and a specificity of 71% for predicting severe pre-eclampsia.Conclusions: sFlt-1/PlGF ratio is useful in assessing the severity and prognosis of pre-eclampsia. sFlt-1/PlGF ratio should not be used as a sole criterion for making clinical decisions, but as an adjunct to other clinical and laboratory parameters.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"148-152"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0