Ginekologia polska最新文献

{"title":"Serum homocysteine and lipid levels in the third trimester and their relationship with perinatal outcomes in diet-controlled gestational diabetes mellitus.","authors":"Yuting Li, Mingrui Wang, Na Zhang, Yueling Wu, Wei Ye, Weichan Chen","doi":"10.5603/gpl.101475","DOIUrl":"10.5603/gpl.101475","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigates the relationship between serum homocysteine, blood lipids, and perinatal outcomes in patients with diet-controlled gestational diabetes mellitus (GDM) and those with normal glucose tolerance (NGT).</p><p><strong>Material and methods: </strong>A prospective cohort of 150 diet-controlled GDM patients and 150 pregnant women with NGT, all delivering at our hospital, were selected based on predefined criteria. Data on demographics, physical parameters, and perinatal outcomes were compiled. Blood samples for fasting plasma glucose (FPG), homocysteine (Hcy), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apoB), and apolipoprotein A1 (apoA1) were collected before delivery.</p><p><strong>Results: </strong>GDM patients exhibited higher levels of FPG, Hcy, and the apoB/apoA1 ratio, but lower HDL-C and apoA1 levels compared to the NGT group. Adverse outcomes such as macrosomia, premature rupture of membranes, and postpartum hemorrhage were more prevalent in the GDM group. In GDM patients, neonatal birth weight positively correlated with FPG and TG levels. Stratified Hcy analysis in GDM showed no significant differences in perinatal outcomes. However, the third quartile of the apoB/apoA1 ratio had a lower incidence of macrosomia compared to the first quartile, and the second quartile showed a higher incidence of birth asphyxia.</p><p><strong>Conclusions: </strong>GDM patients demonstrated increased levels of Hcy, FPG, and the apoB/apoA1 ratio, correlating with more adverse perinatal outcomes than healthy pregnant individuals. The relationships between Hcy, lipids, and these outcomes remain inconclusive, highlighting the need for further research.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"175-183"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extreme pelvic organ prolapse complicated with massive urolithiasis - multiple steps repair.","authors":"Aleksandra Kolodynska, Aleksandra Struzyk, Ewa Rechberger-Krolikowska, Tomasz Rechberger","doi":"10.5603/gpl.101149","DOIUrl":"10.5603/gpl.101149","url":null,"abstract":"","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"76-77"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of pseudochylous ascites in the course of ovarian cancer.","authors":"Kinga Ksiezakowska-Lakoma, Maciej Slodki, Marek Brzezinski","doi":"10.5603/gpl.93812","DOIUrl":"10.5603/gpl.93812","url":null,"abstract":"","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"72-73"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140878212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with neonatal brachial palsy in shoulder dystocia: a longitudinal study.","authors":"Javier Sánchez-Romero, Almudena Jiménez-Méndez, Lucía Begoña Díaz-Meca, Alberto Rafael Guijarro-Campillo, Julián Jesús Arense-Gonzalo, Evdochia Adoamnei, Aníbal Nieto-Díaz, María Luisa Sánchez-Ferrer","doi":"10.5603/gpl.92611","DOIUrl":"10.5603/gpl.92611","url":null,"abstract":"<p><strong>Objectives: </strong>The main goal is to analyze factors related to brachial plexus injury (BPI) after Shoulder Dystocia (SD).</p><p><strong>Material and methods: </strong>Longitudinal prospective analysis of SD arose in a tertiary hospital from 1/1st/ 2019 to 12/31st/ 2020. A multivariable logistic regression for BPI after SD and a survival analysis for BPI recovery after SD were performed.</p><p><strong>Results: </strong>In this period 13,414 deliveries were attended, 10,676 of those were vaginal deliveries (79.6%) reporting 69 cases of SD, with an incidence of 0.65%. SD required 102.1 seconds (SD) 10.8 as an average for solving it. Internal maneuvers were needed in 42.0% of SD reported. Neonatal BPI was suspected in 23 newborns (33.3%) at birth. Neonatal BPI at 48 hours of life was statistically associated with maternal BMI above 30 kg/m² (OR = 7.91; CI 95% 1.3-47.7; p = 0.024), > 120 seconds for solving SD (OR = 14.4; CI95% 1.7-121.82; p = 0.014) and operative delivery (OR = 6.8; CI 95% 1.2-37.6; p = 0.028). The BPI recovery was statistically associated with clavicle fracture (HR = 0.31 CI 95% 0.10-0.96 p = 0.042) and specific rehabilitation treatment (HR = 9.2 CI 95% 1.87-45.23 p = 0.006).</p><p><strong>Conclusions: </strong>The following factors were associated with neonatal BPI at 48 hours of life: Maternal BMI above 30 kg/m², operative delivery, or shoulder dystocia that requires more than 120 seconds for solving it. The BPI recovery was associated with clavicle fracture and specific rehabilitation treatment.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"136-141"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of selected cytokines from the interleukin-1 family in the peritoneal fluid of women with endometriosis.","authors":"Marta Smycz-Kubanska, Dominika Wendlocha, Andrzej Witek, Aleksandra Mielczarek-Palacz","doi":"10.5603/gpl.101419","DOIUrl":"10.5603/gpl.101419","url":null,"abstract":"<p><strong>Objectives: </strong>Endometriosis is a complex, chronic inflammatory disease in which immune system disorders play an important role. Soluble mediators of the immune and inflammatory response, including cytokines, are involved in these processes. Therefore, the aim of the conducted research was to understand the role of selected cytokines belonging to the Interleukin-1(IL-1) family, including IL-36α, IL-36β, IL-36γ, IL-36R, IL-37 and IL-38, in the onset and development of endometriosis by analysing the concentration of the tested molecules and to determine whether their concentration depends on the stage of the disease.</p><p><strong>Material and methods: </strong>The study group included 60 women who had pelvic endometriosis diagnosed during laparoscopy and subsequently confirmed by histopathology. The reference group consisted of 20 women who had no endometriosis or other pelvic lesions during laparoscopy.</p><p><strong>Results: </strong>Immunoenzymatic assays were used to determine the concentration of the cytokines studied. In the peritoneal fluid of women with endometriosis, a statistically significant increase in the concentrations of all parameters tested was observed: IL-36α, IL-36β, IL-36γ, IL-36R, IL-37 and IL-38. The concentration of these cytokines depended on the severity of the disease.</p><p><strong>Conclusions: </strong>Disturbances of the immune system involving the network of cytokines belonging to the IL-1 family occurring in the peritoneal fluid environment testify to the involvement of these molecules in the development of the disease and are one of many factors involved in the pathogenesis of endometriosis. The use of some of them in the treatment of endometriosis may be a hope for effective causal treatment of this disease, but this requires further, more advanced research.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"126-135"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stroke in twin pregnancy: a rare case of acute ischemic stroke management.","authors":"Aleksandra Pawlucka, Magdalena Kolak, Andrzej Jaworowski, Hubert Huras","doi":"10.5603/gpl.100723","DOIUrl":"10.5603/gpl.100723","url":null,"abstract":"","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"157-158"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Importance of anogenital distance parameters on duloxetine success in women with stress urinary incontinence.","authors":"Mazhar Ortac, M Firat Ozervarli, Ufuk Caglar, Resat Aydin, Senol Tonyali, Omer Sarilar, Faruk Ozgor","doi":"10.5603/gpl.101635","DOIUrl":"10.5603/gpl.101635","url":null,"abstract":"<p><strong>Objectives: </strong>To clarify the impact of anogenital distance (AGD) on duloxetine success in the management of women with stress urinary incontinence (SUI).</p><p><strong>Material and methods: </strong>Patients who have been diagnosed with SUI, were evaluated for inclusion in the study. Distance between anus and clitoris (AGDAC), distance between anus and fourchette (AGDAF), and length of genital hiatus (GH) were measured. All patients started duloxetine 20 mg twice daily for 2 weeks, and then patients received 40 mg duloxetine twice daily. Patients were categorized into two groups (patients who benefited from duloxetine and patients who did not benefit from duloxetine). Patient characteristics and AGD parameters were compared between these two groups.</p><p><strong>Results: </strong>In total, 178 women were included in study and mean duration of SUI was 2.9 years. The mean body mass index (BMI) was significantly higher in patients with unsuccessful therapy (p = 0.001). In contrast, nulliparous rate was significantly higher in patients who benefited from duloxetine (p = 0.043). The distance of AGDAC (71.4 mm vs 77.9 mm, p = 0.001) and distance of GH were significantly shorter (21.7 mm and 26.7 mm, p = 0.001) in patients who were successfully treated with duloxetine. Multivariate regression analysis found that BMI < 30 kg/m², shorter AGDAC, and GH lengths were significantly related with duloxetine success (p = 0.037, p = 0.036, and p = 0.039, respectively).</p><p><strong>Conclusions: </strong>This study showed that duloxetine improved SUI in more than half of women and obesity was a predictive factor for duloxetine failure. In addition, shorter AGDAC length and shorter GH distance were significantly associated with duloxetine success in the management of SIU.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"241-246"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-sample Mendelian randomization analysis of the causal relationship between lipid metabolism/fatty acid metabolism and pre-eclampsia.","authors":"Dan Yang, Jin Chen, Xiaoyin Wang, Lin Zhuang, Hongjun Feng, Xue Liao, Ting Mo","doi":"10.5603/gpl.101256","DOIUrl":"10.5603/gpl.101256","url":null,"abstract":"<p><strong>Objectives: </strong>A causal relationship has been found between the abundance of some flora in the gut microbiota and the development of pre-eclampsia (PE). Short-chain fatty acids in gut microbes are an important source of lipids. The causal effect of lipid metabolism/fatty acid metabolism pathways on PE exposure is unknown.</p><p><strong>Material and methods: </strong>This study was based on single nucleotide polymorphism (SNP) data related to lipid metabolism/fatty acid metabolism and PE from the genome-wide association study (GWAS) in the GWAS Catalog database and finngen database, and a two-sample Mendelian randomization (MR) analysis was performed to explore the causal relationship between lipid/fatty acid metabolism and PE exposure. Five MD analysis methods were used in this study, inverse-variance weighted (IVW), MR-Egger regression, weighted median (WM), weighted median estimator (WME), MR-PRESSO. The intercept term of MR-Egger regression was tested for the presence of genetic pleiotropy between SNPs and PEs. Cochran's Q test was performed to investigate the heterogeneity between variables. The leave-one-out method was used for sensitivity analysis to determine the robustness of the results.</p><p><strong>Results: </strong>Inverse-variance weighted results showed that gamma-glutamyl glutamine levels [odds ratio (OR) = 0.40, 95% confidence interval (CI): 0.21-0.78; p = 0.01], 1-arachidonoylglycerophosphocholine [1-arachidonoyl-sn-glycero-3-phosphocholine levels (OR = 0.57; 95% CI: 0.38-0.87; p = 0.01), X-14304--leucylalanine levels (OR = 0.72; 95% CI :0.56-0.93; p = 0.01), citrulline levels (OR = 0.48; 95% CI: 0.26-0.89; p = 0.02), inosine levels (OR = 0.88; 95% CI: 0.78-0.98; p = 0.02), and HWESASXX levels (OR = 0.64; 95% CI: 0.42-1.00; p = 0.05) were negatively correlated with PE. There was a positive trend for X-14205--alpha-glutamyltyrosine levels (OR = 1.55; 95% CI: 1.12-2.14; p = 0.01), X-11787 levels (OR = 3.29; 95% CI: 1.23-8.78; p = 0.02) to be associated with PE. No significant heterogeneity or pleiotropy was found for instrumental variables or levels pleiotropy.</p><p><strong>Conclusions: </strong>This study demonstrated a causal relationship between eight fatty acid metabolisms and PE. Follow-up in-depth randomized controlled trials are needed to reveal the promotional or protective effects of fatty acid metabolism on PE.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"256-270"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular profile score (CVPS) and selected cardiac parameters in fetuses with Vein of Galen Malformation.","authors":"Aleksandra Juras, Tomasz Wloch, Wojciech Cnota, Agata Wloch","doi":"10.5603/gpl.102062","DOIUrl":"https://doi.org/10.5603/gpl.102062","url":null,"abstract":"<p><strong>Objectives: </strong>Vein of Galen Malformation (VGAM) is a rare congenital cerebrovascular anomaly. Early detection and monitoring of concurrent fetal heart failure in VGAM are crucial for improving outcomes. The study aims to evaluate heart anatomy, systolic and diastolic heart function, and indicators of heart failure in fetuses referred to a tertiary center due to VGAM detected in the second or third trimester.</p><p><strong>Material and methods: </strong>This single-center retrospective study of echocardiographic data from five fetuses with VGAM examined between 2008 and 2023. Parameters analyzed included gestational age, reason for referral, cardiovascular profile score (CVPS), systolic and diastolic heart function and selected cardiac parameters RESULTS: Cardiomegaly as a sign of congestive heart failure was the main reason for referral most of the fetuses (4/5 - 80%) diagnosed later as VGAM in our center. Abnormal cerebral vessel flow was visualized in all cases, with normal umbilical arterial flow. Three fetuses were treated prenatally with digoxin due to congestive heart failure. Monophasic tricuspid valve inflow and decreased shortening fraction (SF) were observed in three fetuses (60%) at the time of diagnosis. CVPS scores ranged from 2 to 10, correlating with the severity of cardiac compromise. All five patients demised, three died in utero, and two shortly after birth.</p><p><strong>Conclusions: </strong>This study emphasizes the severe cardiac implications of VGAM detected in utero and the need for early and comprehensive fetal assessment. Despite early diagnosis, outcomes remain poor, necessitating further research into effective prenatal treatments and management protocols to enhance survival for affected fetuses.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between vulvar lichen sclerosus and celiac disease in woman.","authors":"Maja J Zieba-Domalik, Kacper Nizinski, Dominika Orszulak, Marta Janik, Aleksandra Fratczak, Beata Bergler-Czop, Rafal Stojko, Agnieszka Drosdzol-Cop","doi":"10.5603/gpl.103181","DOIUrl":"https://doi.org/10.5603/gpl.103181","url":null,"abstract":"<p><strong>Objectives: </strong>Vulvar lichen sclerosus (VLS) is a chronic inflammatory condition involving mainly the genital area with an undetermined aetiology. Recent studies show that in up to 34% of cases in adult women, VLS coexists with allergies or autoimmune diseases like celiac disease (CD), among others. However, literature data relating strictly to the co-occurrence of celiac disease and Duhring's disease (DH) in patients with VLS are very limited.</p><p><strong>Material and methods: </strong>In our study, we sought to clarify the possible relationship between vulvar lichen sclerosus in adult women and celiac disease in its cutaneous form. The aim of the study was to demonstrate the presence of celiac disease-specific antibodies in women with VLS. The control group consisted of 41 healthy women, and the study group consisted of 50 women aged 24-83 years with diagnosed vulvar lichen sclerosus who were hospitalized in the Department of Gynaecology, Obstetrics and Gynaecologic Oncology of the Bonifraters Medical Centre in Katowice.</p><p><strong>Results: </strong>There were no significant differences in blood serum levels of CD-specific antibodies between both groups.</p><p><strong>Conclusions: </strong>The study conducted did not confirm the association between vulvar lichen sclerosus and celiac disease or Duhring's disease. The main limitation of the research was the small size of the study and control groups. Further studies on a larger group of patients are needed. They could clarify the possible mechanisms behind the co-occurrence of these two conditions. Earlier diagnostic will help prevent the development of severe and irreversible complications.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}