Ginekologia polska最新文献

{"title":"A retrospective analysis of perinatal outcomes in mothers with gestational diabetes and their newborns during the COVID-19 pandemic in Poland.","authors":"Karolina Karcz, Barbara Krolak-Olejnik","doi":"10.5603/gpl.106552","DOIUrl":"https://doi.org/10.5603/gpl.106552","url":null,"abstract":"<p><strong>Objectives: </strong>The global pandemic caused by the SARS-CoV-2 virus resulted in a deterioration of access to healthcare services, with the increased utilization of telemedicine. The global pandemic has also had a significant impact on women's experiences of maternity care, which may have affected gestational diabetes perinatal outcomes, which are associated with the glycemic control of the mother. The objective of this study was to present and compare the results of maternal and neonatal perinatal outcomes in pregnancies affected by gestational diabetes mellitus (GDM) in the years preceding and during the period of the COVID-19 pandemic.</p><p><strong>Material and methods: </strong>The study was conducted as a retrospectively analyzed cohort study of neonates born from pregnancies complicated with GDM and their mothers born at gestational age of at least 34 + 0/7 weeks. The detailed analysis encompassed both neonatal and maternal perinatal outcomes. The patients' feedback was obtained regarding the availability of necessary consultations and the quality of care provided.</p><p><strong>Results: </strong>There was a notable decline in breastfeeding rates (p < 0.05). Few other perinatal outcomes differed between the years 2017-2019 and 2020-2021.</p><p><strong>Conclusions: </strong>The degree of maternal glycemic control, the quality of medical care provided, and the effectiveness of maternal treatment constitute crucial factors influencing maternal and neonatal outcomes, as well as breastfeeding rates.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preterm and premature rupture of fetal membranes.","authors":"Svetlana Shikanova, Ibrahim A Abdelazim, Ayagoz Nurmagambetova, Altynay Kabdygaliyeva","doi":"10.5603/gpl.102000","DOIUrl":"https://doi.org/10.5603/gpl.102000","url":null,"abstract":"<p><p>Premature rupture of fetal membranes (PRFM) is rupture of fetal membranes before onset of labor (pre-labor) and after 37 gestational weeks. Preterm premature rupture of fetal membranes (PPRFM) is rupture of fetal membranes before 37 gestational weeks. PRFM and PPRFM are associated with a significant perinatal infectious morbidity. Failure to diagnose rupture of fetal membranes (RFM) is associated with failure to implement standard management with subsequent increased perinatal infectious morbidity. Therefore, this review designed to summarize the risk factors, methods of diagnosis and management of RFM. The conventional diagnostic tests (i.e., nitrazine and fern) used to diagnose RFM have certain limitations. The amnio-dye test is the gold standard test used for diagnosing RFM, unfortunately it is an invasive test. Both the insulin-growth factor binding protein-1 (IGFBP-1) and AmniSure (placental alpha microglobulin-1) bedside tests have similar performance when used to confirm the diagnosis of RFM. Early PPRFM (< 34 gestational weeks) is managed expectantly. Late PPRFM (34-36 weeks + 6 days) is managed either by immediate delivery or expectantly after patient counselling and if there are no contraindications for the expectant management. The expectant management includes antibiotics for prevention of intra-amniotic infection, corticosteroids for acceleration of fetal lung maturity, tocolysis (in early PPRFM < 34 weeks), screening and prophylaxis for group-B streptococci. Magnesium sulfate for neuroprotection and lowering the risk of cerebral palsy if the PPRFM occurs before 32 gestational weeks. During the expectant management, both the mother and fetus should be strictly monitored for diagnosing causes which necessitate termination of the expectant managment.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of the CXCL6-CXCR1/CXCR2 chemokine signaling pathway in the peritoneal fluid of patients with endometriosis.","authors":"Marta Smycz-Kubanska, Kamil Religa, Andrzej Witek, Aleksandra Mielczarek-Palacz","doi":"10.5603/gpl.103215","DOIUrl":"https://doi.org/10.5603/gpl.103215","url":null,"abstract":"<p><p>Endometriosis is the presence of endometrial tissue outside the uterine cavity with an accompanying chronic inflammatory process. The etiology of the disease is still not fully understood. An important role is attributed to immune system disorders occurring within the peritoneal cavity with the participation of chemokines and their receptors. The aim of this study was to assess the CXCL6-CXCR-1/CXCR-2 signaling axis in the peritoneal fluid of patients with endometriosis. The analysis showed a statistically significant increase in the concentration of CXCL6, CXCR-1 and CXCR-2 in the peritoneal fluid of women with endometriosis compared to the concentration in the control group (p < 0.001; p < 0.05; p < 0.01, respectively). In addition, statistically significant differences in CXCL6, CXCR1 and CXCR2 concentration were demonstrated between stages of disease. Changes in the concentrations of the chemokine CXCL6 and its receptors CXCR-1 and CXCR-2 in the peritoneal fluid of women with endometriosis indicate a disturbed immune response in the peritoneal cavity in the course of endometriosis related to the stage of the disease. The CXCL6/CXCR-1/CXCR-2 system plays an important role in the development and progression of endometriosis, which may have significant clinical significance as a potential therapeutic target but requires further investigation.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new technique for sacrospinous ligament fixation: endoscopic sacrospinous ligament fixation (Peker technique).","authors":"Nurullah Peker, Selda Bayat Balkan, Serhat Ege, Senem Yaman Tunç, Elif Ağaçayak, Mehmet Sıddık Evsen","doi":"10.5603/gpl.106176","DOIUrl":"https://doi.org/10.5603/gpl.106176","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study is to introduce a new technique, endoscopic sacrospinous ligament fixation (e-SSLF), and to present its success rate and advantages.</p><p><strong>Material and methods: </strong>The hospital records of women who underwent e-SSLF and simultaneous vaginal hysterectomy due to stage 4 pelvic organ prolapse (POP) were evaluated. Unlike the classical SSLF technique, in e-SSLF the sacrospinous ligament (SSL) was exposed with two retractors, then visualized with a 5 mm diagnostic hysteroscope. The SSLF was performed endoscopically with Deschamps ligature needles. In the 24th postoperative hour, a contrast-enhanced pelvic computerized tomography (CT) was performed, and images were taken to confirm that the suture was passed to the correct location (2 cm medial to the sacrospinous process). Patient demographic and clinical data, surgery duration,total operation time, pre- and postoperative Pelvic Organ Prolapse Quantification (POP-Q) levels, and complications were evaluated.</p><p><strong>Results: </strong>Based on the evaluated medical records, 26 patients underwent e-SSLF. Postoperative CT images showed that the suture had passed to the correct place in all cases. There were no intraoperative complications, and only 2 patients experienced transient leg pain in the postoperative period. The median surgery duration was 101 seconds (25th percentile 96 seconds, 75th percentile 110 seconds). The median total operation time was 62 minutes (25th percentile 52 minute, 75th percentile 78 minute). Upon POP-Q staging at the 6-month postoperative follow-up, 24 patients (92.3%) were found to be in stage 0 and 2 (7.7%) were found to be in stage 1 POP.</p><p><strong>Conclusions: </strong>e-SSLF is a new surgical technique that is reliable and highly effective, showing fewer complications and good postoperative results due to the imaging, it provides. Imaging in SSLF will make significant contributions to gynaecology assistant training and reduce the learning curve of SSLF.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uterine fibroids - why you should choose tailored therapies based on the joint decision of the physician and the patient.","authors":"Michal Ciebiera, Tomasz Lozinski, Ayman Al-Hendy","doi":"10.5603/gpl.107627","DOIUrl":"https://doi.org/10.5603/gpl.107627","url":null,"abstract":"<p><p>Uterine fibroids (UFs) are the most common benign tumors of the myometrium, affecting up to 70% women by age 50. Although many cases remain asymptomatic, symptomatic UFs can significantly reduce quality of life through excessive bleeding, anemia, pelvic pain, infertility, and obstetric complications. Despite the availability of various conservative treatments - including pharmacotherapy, uterine artery embolization, and ultrasound thermoablation - surgical interventions, particularly hysterectomy, remain the dominant approach in many countries. This discrepancy between evidence-based recommendations and routine practice highlights the persistence of a paternalistic model of care, where patients are often excluded from treatment decisions and not informed about alternatives. Emerging concepts such as shared decision making (SDM) and personalized therapy emphasize the need to adapt treatment plans to each woman's clinical profile, reproductive goals, and preferences. SDM fosters trust, better adherence to therapy, and improved acceptance of complications by actively involving patients in choosing their care. The development of modern pharmacological options, like GnRH analogs, further expands possibilities for effective, reversible, fertility-preserving treatments. A paradigm shift toward patient-centered, individualized management is essential to address ethical challenges, reduce unnecessary hysterectomies, and improve outcomes. Implementing SDM and expanding access to conservative therapies require systemic changes in reimbursement, training, and patient education to ensure that care focuses not only on the disease but on the woman as a whole.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Affective temperament and emotional processing difficulties in women with PCOS and their potential impact on PCOS clinical presentation.","authors":"Witold Urban, Krzysztof Rutkowski, Katarzyna Klasa, Robert Jach, Olga Kacalska-Janssen, Michal Mielimaka","doi":"10.5603/gpl.103884","DOIUrl":"https://doi.org/10.5603/gpl.103884","url":null,"abstract":"<p><strong>Objectives: </strong>To assess alexithymia and affective temperament in patients with polycystic ovary syndrome (PCOS) and compare these patients to a group of patients undergoing endocrinological evaluation without a diagnosis of PCOS (non-PCOS). Additionally, the study explored the relationship between affective temperament, alexithymia, body mass index (BMI), and the severity of hirsutism in the PCOS group.</p><p><strong>Material and methods: </strong>A total of 46 patients with PCOS and 28 non-PCOS patients were recruited for the study. All participants underwent endocrinological and gynecological diagnostics. Alexithymia was assessed using the TAS-20 questionnaire, while affective temperament was evaluated with the TEMPS-A questionnaire.</p><p><strong>Results: </strong>Both PCOS and non-PCOS patients were found to fall within the \"intermediate alexithymic\" range. Patients with PCOS exhibited more pronounced cyclothymic temperament (p=0,019), and the difference in irritable temperament was close to statistical significance (p=0,072). In a stepwise linear regression analysis, total alexithymia emerged as a statistically significant positive predictor of BMI in PCOS group (β=0.368, p=0.012).</p><p><strong>Conclusions: </strong>Patients with PCOS exhibit higher cyclothymic temperament compared to the non-PCOS group. Both groups show \"intermediate alexithymia\", which could impact treatment adherence and mental health, highlighting the importance of psychological interventions for improving outcomes and quality of life.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidisciplinary management of an isolated pelvic hydatid cyst: a rare case of laparoscopic cystectomy with colpotomy and endobag extraction.","authors":"Enes Serhat Coşkun, Davut Can Güner, Ali Selçuk Yeniocak, Havva Betül Bacak, Süleyman Salman","doi":"10.5603/gpl.104697","DOIUrl":"https://doi.org/10.5603/gpl.104697","url":null,"abstract":"","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of ethanol sclerotherapy on pain and quality of life in patients with endometrial cysts.","authors":"Izabela Dymanowska, Karolina Frankowska, Monika Abramiuk, Malgorzata Charytanowicz, Barbara Terpilowska, Grzegorz Polak","doi":"10.5603/gpl.100816","DOIUrl":"https://doi.org/10.5603/gpl.100816","url":null,"abstract":"<p><strong>Objectives: </strong>Endometriosis is a prevalent chronic gynecological condition resulting in infertility, and severe pain that strongly deteriorates patients' quality of life. In addition to surgery and pharmacotherapy, there are also other methods of endometriosis management, such as sclerotherapy, which is used in patients with endometrial cysts. So far, there is a shortage of knowledge regarding sclerotherapy's influence on pain symptoms and quality of life. Therefore, the main objective of our study was to assess the effects of sclerotherapy on pain relief and quality of life.</p><p><strong>Material and methods: </strong>Study participants consisted of patients with ovarian endometriomas who have undergone ultrasound-guided transvaginal sclerotherapy with the use of high-percentage ethanol. Patients had no history of chronic diseases, besides endometriosis. They completed self-constructed both pre-procedural and post-procedural questionnaires between 3 and 6 months after sclerotherapy.</p><p><strong>Results: </strong>Our study included 59 patients. Sclerotherapy resulted in a significant alleviation of pain regardless of primary cyst volume, history of endometriosis surgery, post-procedural hormonal treatment, and elapsed time between two questionnaires collection. There was a significant decreasing in Visual Analog Scale (VAS) scores measured for pain during menstruation, sexual intercourse, and chronic pelvic pain after sclerotherapy. Moreover, this procedure resulted in significant improvement in life quality. Most patients reported that they would recommend this treatment method to other patients.</p><p><strong>Conclusions: </strong>Sclerotherapy is characterized by a great ability to alleviate pain and improve quality of life.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression and clinical significance of miR-10a-5p in patients with hypertension during pregnancy.","authors":"Zhu Hu, Long Zhong, Zhenmei Lai","doi":"10.5603/gpl.104092","DOIUrl":"https://doi.org/10.5603/gpl.104092","url":null,"abstract":"<p><strong>Objectives: </strong>Dysregulated miR-10a-5p is associated with a variety of cardiovascular diseases and fetal growth in the second trimester. This study aimed to investigate the expression and clinical significance of serum miR-10a-5p in patients with hypertension during pregnancy (HDP).</p><p><strong>Material and methods: </strong>103 healthy pregnant women (control group) and 120 pregnant women with HDP (HDP group) were enrolled in this study. The relative miR-10a-5p was analyzed by qRT-PCR and its association with clinical indicators was performed by Pearson's correlation analysis. The diagnostic and prognostic value were by receiver operator characteristic (ROC) curve and Kaplan-Meier curve analysis, respectively. The risk factor evaluation of HDP was performed by multivariate logistic regression analysis. Adverse pregnancy outcomes were recorded during follow-up.</p><p><strong>Results: </strong>The miR-10a-5p level was significantly declined in HDP patients compared to control (p < 0.001). The reduced miR-10a-5p was negatively related to SBP (r = -0.6777, p < 0.0001), DBP (r = -0.6026, p < 0.0001), TNF-α (r = -0.7020, p < 0.0001) and IL-6 (r = -0.7149, p < 0.0001). MiR-10-5p was a risk factor of HDP (OR = 0.433, 95% CI: 0.247-0.759, p = 0.003). HDP pregnant women with low miR-10a-5p expression levels (13/68) faced more probability of adverse pregnancy outcomes than those of high miR-10a-5p expression levels (8/52).</p><p><strong>Conclusions: </strong>Declined miR-10a-5p contributed to the diagnosis and prognosis of HDP and was also a risk factor of HDP.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of apparent diffusion coefficient in the diagnosis of endometrial carcinoma and its pathohistological features.","authors":"Milica Zorić, Milica Šarošković, Jelena Vuković, Igor Nosek, Nataša Prvulović Bunović, Miloš Vuković","doi":"10.5603/gpl.103995","DOIUrl":"https://doi.org/10.5603/gpl.103995","url":null,"abstract":"<p><strong>Objectives: </strong>MR differentiation between endometrial cancer, hyperplasia, and the normal endometrium using ADC values and their correlation with the pathohistological characteristics of endometrial cancer.</p><p><strong>Material and methods: </strong>The retrospective study included 131 patients, 55 with endometrial cancer, 21 with hyperplasia, and 55 patients with normal endometrium. Mean ADC values were obtained by measuring the region of interest (ROI) in the corresponding part of the endometrium.</p><p><strong>Results: </strong>The mean ADC values of endometrial cancer (0.646 ± 0.112 × 10⁻³ mm²/s) were significantly lower than those of endometrial hyperplasia (1.660 ± 0.394 × 10⁻³ mm²/s) and normal endometrium (1.503 ± 0.312 × 10⁻³ mm²/s) (p<0.001), while the ADC values of endometrial hyperplasia did not differ from normal endometrium. No difference was found between ADC values in different grades of endometrial cancer (p=0.219; p>0.05), depending on the depth of myometrial invasion (p=0.506; p>0.05), the presence of metastases in lymph nodes (p=0.202; p>0.05), and lymphovascular invasion (p=0.366; p>0.05). Regarding the FIGO stage, the only significant difference in ADC values was obtained for stage 4b (p=0.023; p<0.05). ADC values below 1.120 × 10⁻³ mm²/s with 100% sensitivity and 94.5% specificity indicate the presence of cancer, with a positive predictive value of 94.8% and a negative predictive value of 100%.</p><p><strong>Conclusions: </strong>The ADC is a useful diagnostic tool in the differentiation between endometrial cancer and hyperplasia with high sensitivity and specificity, but its use in differentiating pathohistological characteristics of endometrial cancer is not possible.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}