Ginekologia polska最新文献

{"title":"Diet and supplementation as an element supporting the treatment of endometriosis - literature review.","authors":"Sabina Kowalczyk-Guzikowska, Dorota Olanin, Zofia Winczewska, Anna Bartnicka, Karolina Karabin, Agnieszka Drosdzol-Cop","doi":"10.5603/gpl.113814","DOIUrl":"https://doi.org/10.5603/gpl.113814","url":null,"abstract":"<p><p>Endometriosis is a chronic estrogen-dependent inflammatory disease affecting about 10% of women of reproductive age. Pharmacotherapy and surgery form the basis of treatment, but emerging evidence points towards the potential role of diet as an adjunct. The paper presents the pathophysiological basis of nutritional intervention in endometriosis, including chronic inflammation, oxidative stress and disturbances in estrogen metabolism related to the functioning of the intestinal microbiota and the estrobolome. The nutritional model based on an anti-inflammatory diet rich in omega-3 fatty acids, cruciferous vegetables and fiber, as opposed to routine elimination of food, as well as the need to individualize the recommendations depending on the patient's clinical phenotype, was discussed. Evidence on supplementation with selected compounds with potential anti-inflammatory and antioxidant effects and the role of probiotics and prebiotics in supporting intestinal and vaginal microbiota were also presented. The paper emphasizes that diet therapy should be treated as a supportive intervention, not as a causal treatment of endometriosis.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149208380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary keratinizing squamous cell carcinoma of the endometrium associated with ichthyosis uteri: a case report.","authors":"Ozgun Ceylan, Hande Nur Oncu, Firdevs Sahin Duran","doi":"10.5603/gpl.108989","DOIUrl":"https://doi.org/10.5603/gpl.108989","url":null,"abstract":"","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ophthalmic artery doppler in screening for preeclampsia - a systematic review of current evidence.","authors":"Izabela Walasik-Szewczyk, Ewelina Litwinska-Korcz, Monika Szpotanska-Sikorska, Aleksandra Ksiezopolska, Artur Ludwin, Magdalena Litwinska","doi":"10.5603/gpl.109665","DOIUrl":"https://doi.org/10.5603/gpl.109665","url":null,"abstract":"<p><p>Preeclampsia (PE) complicates 2-15% of all pregnancies and continues to be a leading cause of maternal morbidity and mortality. The incidence is about three times higher in multiple gestations compared to singleton pregnancies. Early identification of women at high risk for PE is crucial; first-trimester screening has become a standard component of prenatal care. This systematic review aims to summarize current evidence on the role of ophthalmic artery Doppler (OAD) in predicting PE among singleton and twins. Recent research has enabled the development of algorithms for PE prediction based on maternal factors, medical history, mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), and placental growth factor (PLGF). Within OAD parameters, the elevated PSV2/1 ratio has been consistently observed in women who later developed PE compared with normotensive pregnancies. OAD PSV ratio is widely used as a prediction tool for PE. In contrast, the pulsatility index (PI), resistance index (RI), and end-diastolic velocity (EDV) demonstrated limited predictive ability and contributed minimally to overall model performance. Integration of OAD parameters into established multimodal screening models may improve predictive accuracy for PE. OAD is a potentially cost-effective, accessible, and technically feasible modality that may support risk stratification, particularly in settings with limited access to biochemical testing. However, further large-scale prospective studies are needed to validate its clinical utility, standardize assessment protocols, and determine its role in routine PE screening algorithms.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory diet as an element supporting the treatment of selected gynecological diseases - literature review.","authors":"Sabina Kowalczyk-Guzikowska, Dorota Olanin, Zofia Winczewska, Anna Bartnicka, Karolina Karabin, Agnieszka Drosdzol-Cop","doi":"10.5603/gpl.113813","DOIUrl":"https://doi.org/10.5603/gpl.113813","url":null,"abstract":"<p><p>Low-grade chronic inflammation plays an important role in the pathogenesis of many gynecological diseases, including polycystic ovary syndrome (PCOS), uterine fibroids, premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD) and endometriosis. The aim of this paper was to present the assumptions of the anti-inflammatory diet and review the current state of knowledge about its potential importance in these diseases. An anti-inflammatory diet based on increased intake of omega-3 fatty acids, fiber and polyphenols, while reducing the intake of pro-inflammatory foods, has the potential to reduce pro-inflammatory cytokine levels and alleviate clinical symptoms. The Mediterranean diet has the best documented dietary model with anti-inflammatory effects. Available scientific data indicate the beneficial effect of dietary interventions on the hormonal and metabolic profile of PCOS, pain severity in uterine fibroids and endometriosis and the exacerbation of somatic and affective discomfort in PMS/PMDD. However, the quality of scientific evidence remains variable, and an anti-inflammatory diet should be considered an adjunct to standard treatment, rather than an alternative to it. Further randomized clinical trials are required to conclusively define the role of individual components of the anti-inflammatory diet in this disease group.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal serum biomarkers and early pregnancy Doppler blood flow patterns.","authors":"Magdalena Karpow-Greiner, Oskar Komisarek, Malgorzata Glogiewicz, Wojciech Knypinski, Wojciech Cnota, Maciej Slodki, Mariusz Dubiel","doi":"10.5603/gpl.105355","DOIUrl":"https://doi.org/10.5603/gpl.105355","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the association between first‑trimester maternal serum biomarkers - β‑hCG, PAPP‑A, sFLT‑1, and PLGF - and Doppler ultrasound indices (uterine arteries and ductus venosus), and to determine their utility in predicting preeclampsia (PE).</p><p><strong>Material and methods: </strong>In this prospective study (2021-2022) at University Hospital No. 2, Bydgoszcz, 137 pregnant women in the first trimester (11+0-13+6 weeks) were enrolled. Participants were assigned to an experimental group (n = 86, with PE risk factors) or a control group (n = 51). Serum levels of β‑hCG, PAPP‑A, PLGF, and sFLT‑1 were measured using electrochemiluminescence immunoassay, and Doppler ultrasound was used to assess uterine artery and ductus venosus blood flow. Mean arterial pressure (MAP) was recorded, and PE risk was calculated using FMF software.</p><p><strong>Results: </strong>The experimental group had significantly lower PLGF levels (mean MoM 0.864 vs. 1.028, p = 0.0075) and higher sFLT‑1/PLGF ratios (34.32 vs 28.79, p = 0.0280) compared to controls. Additionally, MAP was significantly elevated (86.4 mmHg vs 79.5 mmHg, p < 0.0001) and the ductus venosus pulsatility index was lower (1.00 vs 1.07, p = 0.0132). Spearman analysis showed that increased PE risk correlated with lower PAPP‑A (R = -0.20, p = 0.0201) and PLGF (R = -0.54, p < 0.0001) and with a higher sFLT‑1/PLGF ratio (R = 0.40, p < 0.0001).</p><p><strong>Conclusions: </strong>Our findings support the utility of an integrated first‑trimester screening strategy that combines maternal risk factors, biochemical markers (PLGF and PAPP‑A), and biophysical parameters (MAP and Doppler indices) for early identification of pregnancies at elevated risk for PE. This approach may facilitate prophylactic interventions to improve maternal and perinatal outcomes.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful transplacental pharmacological treatment of a giant chorioangioma.","authors":"Karol Bielasik, Jan Jurgiel, Marzena Debska, Miroslaw Wielgos, Michal Lipa","doi":"10.5603/gpl.112760","DOIUrl":"https://doi.org/10.5603/gpl.112760","url":null,"abstract":"","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149129761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of follicular fluid on the proliferation of cancerous cell lines of human colon adenocarcinoma, human breast cancer, human glioblastoma multiforme and rat glioma.","authors":"Marek Szymanski, Wojciech Rzeski, Radoslaw Janicki, Karolina Wasilow, Marta Lemieszek, Justyna Janik-Mesjasz, Tomasz Wandtke","doi":"10.5603/gpl.113051","DOIUrl":"https://doi.org/10.5603/gpl.113051","url":null,"abstract":"<p><strong>Objectives: </strong>Follicular fluid (FF) constitutes the natural microenvironment of the ovarian follicle and contains numerous biologically active compounds, including hormones, cytokines, growth factors, and metabolites. Increasing evidence suggests that FF may be involved in carcinogenesis not only within the female reproductive system but also in distant tissues. The aim of this study was to evaluate the influence of ovarian follicular fluid on the proliferation of normal human skin fibroblasts (HSF), rat glioma cell line (C6), and human cancer cell lines, including human colon adenocarcinoma (LS180), human breast cancer (T47D), and human glioblastoma multiforme (T98G).</p><p><strong>Material and methods: </strong>Cell proliferation was assessed using the MTT assay after 96 h of exposure to FF at concentrations ranging from 0.5% to 10%.</p><p><strong>Results: </strong>Low concentrations of FF stimulated or did not affect HSF proliferation, whereas higher concentrations exerted inhibitory effects depending on the individual FF sample. In contrast, significant anti-proliferative effects were observed in all examined cancer cell lines, particularly following treatment with FF1.</p><p><strong>Conclusions: </strong>These findings indicate that follicular fluid contains components with selective anti-proliferative activity against cancer cells.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149120909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the concentration of new adipokines in serum and peritoneal fluid of patients with serous ovarian cancer as a target for potential use in new diagnostic and therapeutic strategies.","authors":"Sebastian Stepien, Marta Smycz-Kubanska, Agnieszka Wikarek, Tomasz Cichon, Andrzej Witek, Aleksandra Mielczarek-Palacz","doi":"10.5603/gpl.112756","DOIUrl":"https://doi.org/10.5603/gpl.112756","url":null,"abstract":"<p><strong>Objectives: </strong>Adipokines are currently the subject of numerous intensive studies due to their multidirectional effects in the formation and development of many cancers, including ovarian cancer. Therefore, the purpose of the present study was to analyse the concentration of new adipokines, including asprosin, follistatin-like protein 1, isthmin-1, meteorin and neuregulin-4 in serum and peritoneal fluid of patients with serous ovarian cancer and to determine whether there is a relationship between the concentration of the studied parameters and the degree of histological differentiation of the cancer.</p><p><strong>Material and methods: </strong>The study group consisted of 32 patients diagnosed with serous carcinoma of the ovary (Cystadenocarcinoma papillare serosum IIIc). The reference group consisted of 16 patients diagnosed with benign neoplasm (Cystadenoma serosum). Concentration of asprosin, follistatin-like protein 1, isthmin-1, meteorin and neuregulin-4 were determined using ELISA immunoenzymatic assay.</p><p><strong>Results: </strong>Significant fluctuations in the concentrations of the measured markers were observed in the serum and peritoneal fluid of patients with ovarian cancer and the existence of an association of the concentrations of some of them with the degree of histological differentiation of the tumour.</p><p><strong>Conclusions: </strong>The occurring systemic and local changes in the immune system involving the tested adipokines indicate the potential involvement of these markers in ovarian cancer pathogenesis, serving as key immune mechanisms that drive tumor progression and modulate the associated inflammatory response. Determination of the concentration of the adipokines studied, in combination with other markers, could prove valuable for developing future diagnostic and treatment approaches in ovarian cancer care, though additional studies are required.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149120814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of vulvar, vaginal, and gut microbiota in the pathogenesis and clinical course of vulvar lichen sclerosus: a narrative review.","authors":"Katarzyna Karlowicz-Bodalska, Kornelia Paluch, Zuzanna Szpyra, Karolina Klosowska-Burylo, Grazyna Bodalska","doi":"10.5603/gpl.110586","DOIUrl":"https://doi.org/10.5603/gpl.110586","url":null,"abstract":"<p><p>Vulvar lichen sclerosus (VLS) is a chronic disease of unclear aetiology, leading to progressive atrophic changes in the skin and mucous membranes of the anogenital region. The condition is associated with an increased risk of developing vulvar squamous cell carcinoma. Increasing evidence suggests that dysbiosis of the vulvar, vaginal and gut microbiota plays an important role in the pathogenesis of VLS. Patients with VLS show a reduced abundance of beneficial bacteria, mainly of the genus Lactobacillus, and an increase in potentially pathogenic microorganisms, including Prevotella, Enterobacter and Parvimonas. These changes correlate with symptom severity and immunological disturbances. Mendelian randomisation analyses suggest that selected taxa of the gut microbiota may have a protective function by modulating the inflammatory response. Further research is needed on the potential use of probiotics as an adjunct to VLS therapy.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal closure of ductus arteriosus in monochorionic diamniotic twins.","authors":"Maciej Ziebakowski, Oskar Sylwestrzak, Lukasz Sokolowski, Michal Krekora, Katarzyna Zych-Krekora","doi":"10.5603/gpl.112135","DOIUrl":"https://doi.org/10.5603/gpl.112135","url":null,"abstract":"","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}