Ginekologia polska最新文献_第2页

The role of vulvar, vaginal, and gut microbiota in the pathogenesis and clinical course of vulvar lichen sclerosus: a narrative review. 外阴、阴道和肠道微生物群在外阴硬化苔藓的发病机制和临床过程中的作用：一个叙述性的回顾。

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Ginekologia polska Pub Date : 2026-09-29 DOI: 10.5603/gpl.110586

Katarzyna Karlowicz-Bodalska, Kornelia Paluch, Zuzanna Szpyra, Karolina Klosowska-Burylo, Grazyna Bodalska

引用次数: 0

Fetal closure of ductus arteriosus in monochorionic diamniotic twins. 单绒毛膜双羊膜双胞胎胎儿动脉导管闭合。

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Ginekologia polska Pub Date : 2026-09-25 DOI: 10.5603/gpl.112135

Maciej Ziebakowski, Oskar Sylwestrzak, Lukasz Sokolowski, Michal Krekora, Katarzyna Zych-Krekora

引用次数: 0

Comparison of ultrasound accuracy versus clinical fetal weight estimation - a retrospective cross-sectional study. 超声准确性与临床胎儿体重估计的比较-一项回顾性横断面研究。

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Ginekologia polska Pub Date : 2026-09-25 DOI: 10.5603/gpl.110276

Agnieszka A Strojny, Stepan Feduniw, Arkadiusz Baran, Dagmara Filipecka-Tyczka, Radoslaw B Maksym, Michal Rabijewski, Jan Modzelewski, Grazyna Baczek, Grzegorz Szewczyk, Anna Scholz

{"title":"Comparison of ultrasound accuracy versus clinical fetal weight estimation - a retrospective cross-sectional study.","authors":"Agnieszka A Strojny, Stepan Feduniw, Arkadiusz Baran, Dagmara Filipecka-Tyczka, Radoslaw B Maksym, Michal Rabijewski, Jan Modzelewski, Grazyna Baczek, Grzegorz Szewczyk, Anna Scholz","doi":"10.5603/gpl.110276","DOIUrl":"https://doi.org/10.5603/gpl.110276","url":null,"abstract":"Objectives: Estimating fetal weight (EFW) is essential for decisions regarding mode of delivery, labour induction, and identification of at-risk fetuses. Deviations from expected weight may lead to labour complications and maternal or neonatal injury; therefore, abnormalities must be detected before delivery. There are two most used methods of EFW: ultrasound (US) biometry, requiring highly skilled staff and equipment, and widely available clinical examination (O/E) based on measurements of the dimensions of a mother. To compare the accuracy of two EFW methods: US examination performed according to ISUOG guidelines, with Hadlock IV (BPD-HC-AC-FL) formula vs O/E performed by midwives in a real-life clinical setting.Material and methods: The study was conducted using the dataset from electronic patient records (2742 records) of gestational-age patients between 37 and 42 weeks who gave birth between January 2017 and July 2020 in St. Sophia's Hospital in Warsaw. Both methods' accuracy was judged by comparing the variations between the EFW in both forms and the actual birth weight (ABW) for each patient.Results: Results measured using US, and O/E, compared to ABW varied significantly (p < 0.001). The study revealed that, on average, ultrasound tended to underestimate fetal weight, whereas O/E frequently overestimated it. The discrepancy in EFW using these methods was most pronounced at the extreme ends of fetal weight measurements. Additionally, factors such as fetal age, fetal length, and gestational age significantly influenced the accuracy of these measurements, as evidenced by multivariate regression analysis.Conclusions: Clinical examination can complement ultrasound in fetal weight estimation, but further studies are needed to improve EFW accuracy and support safer obstetric decision-making.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of physical activity on placental glucose transporter expression in women with early gestational diabetes (eGDM): a secondary analysis of the randomised clinical trial. 运动对妊娠早期糖尿病（eGDM）妇女胎盘葡萄糖转运蛋白表达的影响：一项随机临床试验的二次分析

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Ginekologia polska Pub Date : 2026-09-21 DOI: 10.5603/gpl.112906

Mateusz Sochacki, Rafal Sibiak, Urszula Mantaj, Lukasz Adamczak, Malgorzata Blatkiewicz, Marcin Rucinski, Ewa Wender-Ozegowska

{"title":"Effect of physical activity on placental glucose transporter expression in women with early gestational diabetes (eGDM): a secondary analysis of the randomised clinical trial.","authors":"Mateusz Sochacki, Rafal Sibiak, Urszula Mantaj, Lukasz Adamczak, Malgorzata Blatkiewicz, Marcin Rucinski, Ewa Wender-Ozegowska","doi":"10.5603/gpl.112906","DOIUrl":"https://doi.org/10.5603/gpl.112906","url":null,"abstract":"Objectives: Glucose is the primary energy substrate for the developing foetus, and placental glucose transport is a key element of pregnancy physiology. In early gestational diabetes mellitus, metabolic alterations may disrupt the expression of glucose transporters (GLUTs). This study evaluated the influence of physical activity, monitored using pedometers, on the expression of the SLC2A1 (GLUT-1), SLC2A3 (GLUT-3), and SLC2A4 (GLUT-4) genes in the placentas of women with early gestational diabetes, and analysed associations between GLUT expression and clinical parameters.Material and methods: Fifteen women with early gestational diabetes were enrolled in the study and divided into an intervention group (using pedometers) and a control group. Clinical, anthropometric, and biochemical parameters were assessed across each visit. Placental glucose transporter mRNA expression was evaluated using RT-qPCR.Results: No statistically significant differences in GLUT-1, GLUT-3, and GLUT-4 expression levels were observed between groups; however, a trend toward lower glucose transporter expression was noted in the intervention group. GLUT-1 expression correlated positively with subscapular skinfold thickness and systolic blood pressure at the first visit (V1). In contrast, GLUT-4 expression showed a strong negative correlation with glycated haemoglobin (HbA1c) and body mass at the second and third visits (V2, V3). No significant differences in obstetric and neonatal outcomes were found between the groups.Conclusions: Regular physical activity, as measured by pedometers, may influence the molecular regulation of placental glucose transporters in women with early gestational diabetes. Further studies with larger cohorts are needed to confirm these observations and to assess the long-term impact on offspring health.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149013442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy of microbiome transplantation in treating vaginosis and its impact on vaginosis recurrence: a meta-analysis of randomized controlled trials. 微生物组移植治疗阴道病的疗效及其对阴道病复发的影响：随机对照试验的荟萃分析。

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Ginekologia polska Pub Date : 2026-08-07 DOI: 10.5603/gpl.106234

Shanshan Yang, Chuang Guo, Jingxin Zhang, Ming Ma, Jinlong Tian, Yixiang Zhang

{"title":"The efficacy of microbiome transplantation in treating vaginosis and its impact on vaginosis recurrence: a meta-analysis of randomized controlled trials.","authors":"Shanshan Yang, Chuang Guo, Jingxin Zhang, Ming Ma, Jinlong Tian, Yixiang Zhang","doi":"10.5603/gpl.106234","DOIUrl":"https://doi.org/10.5603/gpl.106234","url":null,"abstract":"Objectives: Bacterial vaginosis (BV) is a recurrent condition with significant health implications. Microbiome transplantation has emerged as a potential treatment strategy. This meta-analysis assesses its efficacy in treating vaginosis and preventing recurrence.Methods: A systematic review and meta-analysis of randomized controlled trials (RCTs) evaluating microbiome transplantation for vaginosis treatment were conducted. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated for short- and long-term efficacy. Sensitivity and publication bias analyses were performed.Results: In the short-term follow-up, microbiome transplantation significantly reduced vaginosis recurrence (pooled RR = 0.628, 95% CI: 0.543-0.726, p < 0.001). However, heterogeneity was moderate (I² = 60.8%). Sensitivity analyses confirmed the robustness of findings. Long-term follow-up results showed a pooled RR of 0.746 (95% CI: 0.670-0.831, p < 0.001), though with higher heterogeneity (I² = 72.8%). After sensitivity adjustments, meta-analysis yielded a pooled RR of 0.865 (95% CI: 0.735-1.019, p = 0.083), suggesting reduced long-term efficacy. No significant publication bias was detected.Conclusions: Microbiome transplantation effectively reduces short-term vaginosis recurrence. However, long-term efficacy diminishes upon sensitivity adjustment, necessitating further investigation.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148687190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and validation of novel marker genes to predict potential gestational diabetes mellitus patients by WGCNA and machine learning. 利用WGCNA和机器学习预测妊娠期糖尿病的新标记基因的鉴定和验证。

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Ginekologia polska Pub Date : 2026-01-01 Epub Date: 2025-10-21 DOI: 10.5603/gpl.101605

Shasha Yu, Huayun Tan

{"title":"Identification and validation of novel marker genes to predict potential gestational diabetes mellitus patients by WGCNA and machine learning.","authors":"Shasha Yu, Huayun Tan","doi":"10.5603/gpl.101605","DOIUrl":"10.5603/gpl.101605","url":null,"abstract":"Objectives: To identify novel marker genes to predict potential gestational diabetes mellitus (GDM) patients.Material and: METHODS: Based on Gene Expression Omnibus (GEO) datasets, the differentially expressed genes (DEGs) between control and GDM were identified, followed by enrichment analysis and protein-protein interaction (PPI) network construction. Then, Weighted gene co-expression network analysis (WGCNA) was conducted to screen the key module genes, then the important genes were obtained. In addition, Least Absolute Shrinkage and Selection Operator (LASSO) logistic regression, Support Vector Machine - Recursive Feature Elimination (SVM-RFE), and random forest (RF) were employed to identify the key genes. Receiver operating characteristic (ROC) analysis was performed to assess the diagnostic efficacy of key genes, and a nomogram was developed. The correlation between key genes and immune cells was analyzed, and miRNA-mRNA-TF network was constructed.Results: A total of 257 DEGs were screened between control and GDM groups, and these DEGs were involved in p53 signaling pathway, cell cycle and oocyte meiosis pathways. Then PPI network was constructed, including 163 nodes and 5502 interaction relationships. After WGCNA and machine learning, a total of 4 key genes were obtained, including SNRPD3, NGDN, ANKRD36 and TAS2R20, followed by a nomogram was constructed. SNRPD3 was positively correlated with CD8 T cells. miRNA-mRNA-TF network was conducted, including 56 miRNAs, 4 mRNAs, and 32 TFs. Besides, luteolin PC3 UP, alsterpaullone PC3 UP, and solanine HL60 UP were associated with NGDN, and MeIQx CTD 00001739 was related to TAS2R20.Conclusions: Four key marker genes for predicting potential GDM were identified, including SNRPD3, NGDN, ANKRD36 and TAS2R20, and a nomogram was established for predicting potential GDM patients.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"261-271"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eclampsia - stairway to heaven. 子痫——通往天堂的阶梯。

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Ginekologia polska Pub Date : 2026-01-01 Epub Date: 2026-03-25 DOI: 10.5603/gpl.104931

Szymon Bednarek, Michal Migda, Estera Mieczkowska, Malgorzata Swiatkowska-Freund, Krzysztof Preis

引用次数: 0

3D ultrasound mesh position and long-term outcomes after TVT surgery. TVT术后三维超声补片位置与远期疗效。

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Ginekologia polska Pub Date : 2026-01-01 DOI: 10.5603/gpl.108193

Arif Onur Atay, Ismail Mete Itil, Ahmet Ozgur Yeniel, Feride Atay

{"title":"3D ultrasound mesh position and long-term outcomes after TVT surgery.","authors":"Arif Onur Atay, Ismail Mete Itil, Ahmet Ozgur Yeniel, Feride Atay","doi":"10.5603/gpl.108193","DOIUrl":"10.5603/gpl.108193","url":null,"abstract":"Objectives: This study evaluated the long-term outcomes after tension-free vaginal tape (TVT) surgery and examined whether 3D transvaginal ultrasound (US) mesh position parameters (providing multiplanar visualization and improved measurement reproducibility compared with 2D imaging) are associated with urinary symptoms and quality-of-life changes in women with stress urinary incontinence (SUI). We hypothesized that mesh position would correlate with long-term patient-reported outcomes.Material and methods: In this retrospective cohort, 30 women underwent TVT surgery for SUI between 2012 and 2014 at a tertiary referral center. In 2024, at a median follow-up of 11 years (interquartile range [IQR] 10-12), all patients had clinical evaluation, completed the Urinary Distress Inventory-6 (UDI-6), Incontinence Impact Questionnaire-7 (IIQ-7), and Overactive Bladder Questionnaire Short Form (OAB-q SF), and underwent 3D transvaginal US to measure total urethral length, mesh-to-bladder neck distance, mesh-to-midurethra ratio, and minimal mesh-to-urethral lumen distance. Preoperative and follow-up scores were compared using paired t-tests or Wilcoxon signed-rank tests. Correlations between mesh parameters and score changes were analyzed with Spearman's correlation.Results: Long-term treatment success was achieved in all patients, with negative postoperative stress tests and no retreatment. UDI-6, IIQ-7, and OAB-q SF scores improved significantly from baseline (p < 0.001 for all). No mesh erosion occurred. De novo overactive bladder (OAB) developed in six patients (20%). No strong correlations were found between mesh parameters and score changes (all |ρ| < 0.30).Conclusions: TVT surgery provided excellent long-term outcomes with sustained symptom and quality-of-life improvement. Mesh position measured by 3D US at long-term follow-up was not strongly associated with patient-reported outcomes.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":"97 5","pages":"369-374"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148207279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endometriosis in adolescent: a review of current diagnostic and therapeutic guidelines and expert consensus. 青少年子宫内膜异位症：当前诊断和治疗指南和专家共识的回顾。

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Ginekologia polska Pub Date : 2026-01-01 Epub Date: 2026-01-12 DOI: 10.5603/gpl.110361

Katarzyna Wilk-Sikora, Agnieszka Drosdzol-Cop

{"title":"Endometriosis in adolescent: a review of current diagnostic and therapeutic guidelines and expert consensus.","authors":"Katarzyna Wilk-Sikora, Agnieszka Drosdzol-Cop","doi":"10.5603/gpl.110361","DOIUrl":"10.5603/gpl.110361","url":null,"abstract":"Objectives: Endometriosis is a widespread gynecological condition characterized by the presence of endometrial like tissue outside the uterine cavity. According to the literature, the frequency of endometriosis in adolescents remains unclear; however, studies suggest that histologically confirmed disease may be present in up to 47% of girls with chronic pelvic pain (CPP) and in nearly 70% of girls with primary dysmenorrhoea unresponsive to nonsteroidal anti-inflammatory drugs (NSAIDs) or hormonal therapy. The aim of this study was to review and compare current diagnostic and therapeutic recommendations and expert consensus for adolescent endometriosis.Material and methods: A descriptive qualitative review of the clinical guidelines and expert consensus statements by the American College of Obstetricians and Gynecologists (ACOG), the European Society of Human Reproduction and Embryology (ESHRE), the North American Society for Pediatric and Adolescent Gynecology (NASPAG), and the Polish Society of Gynecologists and Obstetricians (PTGiP) was conducted. NASPAG guaidance present a textbook-based expert consensus and was included due to the limited availability of high-quality evidence in adolescent populations.Results: Adolescent endometriosis remains underrecognized and insufficiently studied. Current clinical guidelines and expert consensus statements emphasize the importance role of through symptom assessment and detailed medical history in the diagnostic process. The reviewed literature supports a clinical diagnosis based on symptoms presentations and response to hormonal therapy, without routine laparoscopic confirmation.Conclusions: Endometriosis in adolescents requires an age-specific diagnostic and therapeutic process. Adherence to current clinical guidelines and expert consensus may help reduce diagnostic delays, limit unnecessary invasive procedures, and improve long-term quality of life.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"146-153"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145954724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of single blastocyst selection strategy on pregnancy outcomes in frozen embryo transfer. 单囊胚选择策略对冷冻胚胎移植妊娠结局的影响。

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Ginekologia polska Pub Date : 2026-01-01 Epub Date: 2026-03-09 DOI: 10.5603/gpl.105798

Jiao Xu, Ning Yang, Huaiyun Tang

{"title":"Impact of single blastocyst selection strategy on pregnancy outcomes in frozen embryo transfer.","authors":"Jiao Xu, Ning Yang, Huaiyun Tang","doi":"10.5603/gpl.105798","DOIUrl":"10.5603/gpl.105798","url":null,"abstract":"Objectives: This study aimed to evaluate the impact of cleavage stage embryo ratings on pregnancy outcomes following frozen embryo transfer (FET) and their correlation with blastocyst grades.Material and methods: A retrospective cohort study was conducted on 854 FET cycles from January 2018 to August 2024. Participants were women undergoing FET with cryopreserved embryos. Exclusion criteria included multiple initial in vitro fertilization (IVF) attempts, advanced age, chromosomal abnormalities, and uterine anomalies. Embryo quality was assessed at the cleavage and blastocyst stages, and FET protocols were tailored to each patient. The primary outcome was clinical pregnancy rate, defined by ultrasound-detected fetal heartbeat. Data was analyzed using SPSS 19.0, with logistic regression to adjust for confounders.Results: The overall pregnancy rate was 53.98% (461/854). Significant differences in pregnancy rates were observed among blastocyst grades, with Grade 1 achieving the highest rate (60.37%). Lower cleavage stage embryo grades (Grade 3 and Grade 4) were associated with reduced pregnancy odds (OR = 0.63 and OR = 0.50, respectively, p < 0.05). Other factors influencing pregnancy outcomes included female age and anti-Müllerian hormone (AMH) levels. The study underscores the importance of cleavage stage embryo ratings, particularly for Grade 2 embryos, in the context of FET procedures using ovulation induction cycle (OIC) and intracytoplasmic sperm injection (ICSI).Conclusions: Cleavage stage embryo ratings significantly affect pregnancy outcomes following FET. Higher ratings correlate with better pregnancy rates, highlighting the importance of comprehensive embryo quality assessment.","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"312-317"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147380195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0