Ginekologia polska最新文献

{"title":"Ovarian malignant melanoma - rare ovarian pathology.","authors":"Michal Migda, Vigneswaren Ponnudurai, Szymon Bednarek, Magdalena Tomczak-Warchol, Malgorzata Swiatkowska-Freund, Krzysztof Preis","doi":"10.5603/gpl.105475","DOIUrl":"https://doi.org/10.5603/gpl.105475","url":null,"abstract":"","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the role of human chorionic gonadotropin increment in the 48 h prior methotrexate treatment for predicting the treatment success: a retrospective cohort study.","authors":"Lanxin Liu, Xiaofeng Wang, Zhen Huang, Huajing Yang, Weijian Zeng, Qin Lin, Mi Han","doi":"10.5603/gpl.103858","DOIUrl":"https://doi.org/10.5603/gpl.103858","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the role of human chorionic gonadotropin (hCG) change in the 48 h prior to methotrexate treatment as a predictor for treatment success of ectopic pregnancy.</p><p><strong>Material and methods: </strong>This was a retrospective cohort study. A total of 179 women who diagnosed with ectopic pregnancy and given a single dose (50 mg/m²) of methotrexate were included in this study from January 1, 2016 to December 31, 2017. Serum hCG levels and clinical data were collected and compared between the success and failure groups, the percentage increment of hCG levels during the 48 hours prior to methotrexate injection was used to create a receiver operating characteristic (ROC) curve to determine the optimal cut-off value for predicting treatment success.</p><p><strong>Results: </strong>The success rate of treating ectopic pregnancy with a single dose of methotrexate was 70.9%. The optimal cut-off value for percentage increment of serum hCG levels before methotrexate injection was determined to be 12.56%, with a specificity of 60.66% and sensitivity of 55.69%. The area under the receiver operating characteristic curve (AUC) was 0.646 (p < 0.01).</p><p><strong>Conclusions: </strong>A lower 2-day hCG percentage increment before methotrexate injection was found to be associated with successful treatment of ectopic pregnancy, with a cut-off value of 12.56%. However, caution should be exercised when deciding on methotrexate treatment versus surgery for ectopic pregnancy patients.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of antenatal magnesium sulfate on feeding intolerance and necrotizing enterocolitis in preterm infants.","authors":"Ipek Guney Varal, Gaffari Tunc, Hilal Kucuk, Dilge Sener, Ayse Oren","doi":"10.5603/gpl.104549","DOIUrl":"https://doi.org/10.5603/gpl.104549","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effects of antenatal magnesium sulfate administration on preterm gastrointestinal feeding intolerance and necrotizing enterocolitis in preterm infants.</p><p><strong>Material and methods: </strong>This observational cohort, single-centre study included preterm infants < 30 weeks gestational age or < 1250 g, who were admitted to the neonatal intensive care unit of a university hospital. These infants were divided into two groups on the basis of having received antenatal magnesium sulfate or not.</p><p><strong>Results: </strong>Overall, 118 preterm infants were enrolled. Fifty-four of these infants had received prenatal magnesium sulfate (Group 1), and 64 (42%) had not (Group 2) before their neonatal intensive care unit (NICU) admission. The number of days to full eneteral feeding and the days of total parenteral nutrition were significantly higher in Group 2 than in Group 1 (p < 0.05). When gestational age, birth weight, and small for gestational age (SGA) were included as factors affecting feeding intolerance, the logistic regression analysis results showed that the administration of magnesium sulfate was an independent risk factor (adjusted OR: 3.5; 95% CI: 1.462-8.615; p < 0.05). Antenatal magnesium sulfate administration was not observed to have an effect on spontaneous intestinal perforation and necrotising enterocolitis.</p><p><strong>Conclusions: </strong>The administration of antenatal magnesium sulfate has proven tocolytic and neuroprotective effects on preterm births. However, it must be taken into consideration that it can cause feeding intolerance in preterm infants without causing intestinal injury.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of \"giant\" chorioangioma diagnosed prenatally.","authors":"Anna Wojtowicz, Anna Tomaszkiewicz, Tomasz Piskorz, Hubert Huras","doi":"10.5603/gpl.104317","DOIUrl":"https://doi.org/10.5603/gpl.104317","url":null,"abstract":"","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rectocele.","authors":"Krzysztof Lippki, Beata Rutkowska, Katarzyna Szczubelek-Pietrzykowska, Ewa Monika Barcz","doi":"10.5603/gpl.104320","DOIUrl":"https://doi.org/10.5603/gpl.104320","url":null,"abstract":"<p><p>Rectocele is one of the more common pathologies of the pelvic floor. It is a clinical problem that significantly worsens the quality of life by causing obstructed defecation symptoms such as anal digitation, incomplete emptying, and dyschesia. Proper differential diagnosis, distinguishing rectocele from enterocoele or perineal body descent, allows for making proper therapeutic decisions and consists of medical history, ultrasound examination, dynamic magnetic resonance imaging (MRI), and defecography. The most common treatment procedures are vaginal native tissue repair, transanal repair, and laparoscopic ventrorectopexy. Surgical treatment should aim to alleviate the symptoms of obstructed defecation and repair the anatomical issue.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of disease activity on pregnancy outcomes and risk factors for fetal loss in systemic lupus erythematosus: a single-center cohort study.","authors":"Lidan He, Yajun Ke, Feng Zhan, Jianbo Wu","doi":"10.5603/gpl.103389","DOIUrl":"https://doi.org/10.5603/gpl.103389","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the impact of systemic lupus erythematosus (SLE) disease activity on neonatal outcomes and analyze risk factors associated with fetal loss in SLE pregnancies.</p><p><strong>Material and methods: </strong>This retrospective study analyzed 102 pregnancies in 99 women with SLE at the First Affiliated Hospital of Fujian Medical University, China, between 2013 and 2020. Demographic data, live birth outcomes, and fetal loss were evaluated.</p><p><strong>Results: </strong>Significant differences were observed among SLE disease activity groups in early preterm birth (χ² = 9.825, p < 0.05), term birth (χ² = 13.320, p < 0.05), neonatal birth weight (F = 8.688, p < 0.05), small for gestational age (χ² = 12.291, p < 0.05), neonatal intensive care unit (NICU) admission (χ² = 9.820, p < 0.05), neonatal infection (χ² = 9.227, p < 0.05), and neonatal myocardial injury (χ² = 7.033, p < 0.05). Multivariate logistic regression analysis identified unplanned pregnancy [adjusted odds ratio (aOR) = 2.772, 95% confidence interval (CI): 1.321-5.814], moderate-to-severe SLE activity (aOR = 4.537, 95% CI: 2.103-9.789), preeclampsia (aOR = 6.223, 95% CI: 2.845-13.615), 24-hour urinary protein > 1.0 g (aOR = 3.682, 95% CI: 1.726-7.854), and positive antiphospholipid antibodies (aOR = 5.250, 95% CI: 2.437-11.308) as independent risk factors for fetal loss (all p < 0.05). Medication initiated at least six months before pregnancy, particularly hydroxychloroquine, was associated with reduced fetal loss (aOR = 0.378, 95% CI: 0.185-0.772, p < 0.05).</p><p><strong>Conclusions: </strong>Planned pregnancy, early initiation of hydroxychloroquine treatment, and close monitoring of disease activity, urinary protein, antiphospholipid antibodies, and blood pressure are crucial strategies to reduce fetal loss in SLE pregnancies. Early intervention for abnormal parameters may improve outcomes.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis of ultrasound features with ER, PR, HER-2, P53, nuclear proliferation factor Ki-67, TOPIIa, and cytokeratin CK5/6 immunohistochemistry in non-mass infiltrating ductal carcinoma of the breast.","authors":"Huihui Peng, Yuanyuan Zhu, Yao Li","doi":"10.5603/gpl.98797","DOIUrl":"https://doi.org/10.5603/gpl.98797","url":null,"abstract":"<p><strong>Objectives: </strong>The goal is for investigating the correlation between ultrasound features and molecular pathological markers such as estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), tumor protein p53, nuclear proliferation factor Ki-67, DNA topoisomerase IIα (Topo II), and cytokeratin CK5/6 in non mass infiltrating ductal carcinoma of the breast.</p><p><strong>Material and methods: </strong>A total of 125 sufferers with non mass infiltrating ductal carcinoma of the breast were included in the ultrasound images and immunohistochemical results. This study analyzed the characteristics of ultrasound images, including maximum cross-sectional diameter, morphology, peripheral hyperechoic halo, hair prick sign, and micro-calcification, as well as the positive expression of molecular pathological markers (ER, PR, HER-2, p53, Ki-67, Topo II, CK5/6); It uses statistical methods for evaluating the correlation between ultrasound features and molecular pathological markers.</p><p><strong>Results: </strong>In 125 patients, the maximum cross-sectional diameter was markedly related to positive expression of CK5/6 (r = 0.176, p < 0.05), Ki-67 (r = 0.328, p < 0.05), and HER-2 (r = 0.468, p < 0.05). There is a marked relation between posterior echo attenuation and ER positivity (r = 0.096, p < 0.05) and Topo II positivity (r =-0.021, p < 0.05). However, there was no marked relation in morphology, peripheral hyperechoic halo, hairline sign, and micro-calcification with prognostic molecular pathological markers (p > 0.05).</p><p><strong>Conclusions: </strong>This study found a marked relation in the maximum cross-sectional diameter of non mass infiltrating ductal carcinoma of the breast and the positive expression of CK5/6, Ki-67, and HER-2. This finding suggests that the maximum cross-sectional diameter may serve as a potential indicator for prognostic evaluation and is closely related to the expression of cytokeratin CK5/6, nuclear proliferation factor Ki-67, and HER-2 in tumors. Posterior echo attenuation is closely related to ER positive and Topo II expression. No significant correlation was observed between morphology, peripheral hyperechoic halo, hairline sign, and micro-calcification with prognostic molecular pathological markers. These results provide new insights for the prognosis evaluation of patients with non mass infiltrating ductal carcinoma of the breast and contribute to the development of individualized treatment strategies, but further research and validation are still needed.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolactin's diverse physiological roles and the clinical significance of hyperprolactinemia.","authors":"Katarzyna Bocianska, Hubert Bochynski, Maksymilian Markwitz, Krzysztof Katulski","doi":"10.5603/gpl.105311","DOIUrl":"https://doi.org/10.5603/gpl.105311","url":null,"abstract":"<p><strong>Objectives: </strong>This review aims to provide a comprehensive overview of prolactin biology, encompassing its molecular heterogeneity, neuroendocrine regulation, and multifaceted roles in human health and disease, focusing on hyperprolactinemia.</p><p><strong>Material and methods: </strong>A comprehensive literature search was conducted to identify relevant articles on prolactin biology, physiology, and related disorders.</p><p><strong>Results: </strong>Prolactin exists in various molecular forms, including monomeric prolactin, 'big prolactin', and macroprolactin, each with distinct biological activities. Prolactin secretion is tightly regulated by a complex interplay of hypothalamic factors, primarily dopamine and thyrotropin-releasing hormone (TRH). Prolactin exerts diverse physiological effects, including roles in lactation, reproduction, metabolic homeostasis, immune function, and neuroprotection. Dysregulation of prolactin secretion, particularly hyperprolactinemia, can lead to significant clinical manifestations. Accurate diagnosis of hyperprolactinemia requires a thorough evaluation of potential etiologies, including pituitary adenomas, medications, and systemic diseases. Management strategies encompass pharmacological therapies, such as dopamine agonists and surgical interventions.</p><p><strong>Conclusions: </strong>Prolactin is a multifaceted neuroendocrine hormone with a diverse range of physiological functions and clinical implications. Understanding the complexities of prolactin biology is essential for recognizing and managing prolactin-related disorders, such as hyperprolactinemia, and for developing novel therapeutic strategies that target prolactin signaling pathways.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between plasma Afamin and gestational diabetes mellitus during pregnancy.","authors":"Xiang Cheng, Hongyan Cui, Xinran Xu, Nini Jiang","doi":"10.5603/gpl.103660","DOIUrl":"https://doi.org/10.5603/gpl.103660","url":null,"abstract":"<p><strong>Objectives: </strong>We investigated the correlation of plasma Afamin levels with gestational diabetes mellitus (GDM) during pregnancy and assessed its predictive value for the risk and prognosis of GDM.</p><p><strong>Material and methods: </strong>A total of 993 pregnant women were included in this nested case-control study. The fasting blood samples in their first trimester were collected. Ninety-one women were diagnosed with GDM, and they were subdivided into insulin treatment group (Group A1, 30 cases) and non-insulin treatment group (Group A2, 61 cases) according to whether they needed to treat with insulin. Another 91 pregnant women with normal glucose tolerance were as the control group (NC group). The plasma and umbilical cord blood levels of Afamin were measured in the first and second trimesters using enzyme-linked immunosorbent assay (ELISA). The correlation of Afamin levels with GDM during pregnancy and its predictive value were assessed.</p><p><strong>Results: </strong>Plasma Afamin levels in both GDM groups (A1 and A2) were significantly higher than in the control group at all pregnancy stages (p < 0.01). Afamin levels in the second trimester were significantly higher in Group A1 than those in Group A2 (p < 0.05). Multivariate logistic regression identified that plasma Afamin levels in the first trimester (OR = 1.126, 95% CI: 1.032-1.228, p = 0.008) and in the second trimester (OR = 1.173, 95% CI: 1.092-1.259, P = 0.000) were the independent risk factors for GDM, along with insulin resistance index (OR = 1.62, 95% CI: 1.036-2.534, p = 0.034). ROC analysis showed optimal cut-off value of plasma Afamin was 65.90 mg/L in the first trimester (AUC = 0.858, sensitivity = 75.8%, specificity = 85.7%) and 85.09 mg/L in the second trimester (AUC = 0.874, sensitivity = 92.3%, specificity = 76.9%).</p><p><strong>Conclusions: </strong>Elevated plasma Afamin levels during the first and second trimesters are associated with GDM, supporting Afamin level as a potential biomarker for early GDM risk prediction.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of clear cell carcinoma based on iatrogenic endometriosis - case series.","authors":"Michal Stojko, Szymon Stojko, Natalia Leszczynska, Kamil Nikel, Agnieszka Drosdzol-Cop","doi":"10.5603/gpl.105718","DOIUrl":"https://doi.org/10.5603/gpl.105718","url":null,"abstract":"<p><p>Iatrogenic endometriosis, a rare form of endometriosis resulting from surgical interventions, has become increasingly recognized as a complication of cesarean sections. This study examines the development of clear cell carcinoma (CCC) arising from endometrial tissue implanted in cesarean section scars. Based on a review of 41 clinical cases, the study highlights the challenge in diagnosis and management of this uncommon aggressive malignancy. The average delay from cesarean section to diagnosis was 18 years, with common symptoms being painful masses and scar tenderness. Imaging modalities such as magnetic resonance imaging (MRI) and computed tomography (CT) were the first diagnostic tools, while biopsy confirmed malignancy in most cases. The outlook for patients who had CCC in cesarean scars was extremely poor, and scant long-term survival data existed. These observations serve to reemphasize the necessity of increased awareness by gynecologists and obstetricians of the risk potential associated with cesarean delivery. Improved diagnostic scrutiny, especially in the patient who comes to the doctor with unexplained symptoms involving the scar, is recommended in this study. A strong role is also supported in informed choice before surgical modes of delivery are attempted.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}