Ginekologia polska最新文献

{"title":"Adaptation to neoplastic disease among women diagnosed with breast cancer and cervical cancer, taking into account the type of surgical procedure and sociodemographic factors.","authors":"Paulina Bak, Maria Ciechacka, Mahdi Al-Jeabory, Joanna K Ziemianska, Daria A Ciechacka, Weronika Biber, Stefania Andrascikova, Boguslawa Kupczak-Wisniowska, Ewelina Bak","doi":"10.5603/gpl.111416","DOIUrl":"10.5603/gpl.111416","url":null,"abstract":"<p><strong>Objectives: </strong>A diagnosis of breast cancer is considered a highly psychologically distressing event, and coping with the disease constitutes a major challenge. Levels of psychological distress are often very high immediately after diagnosis. Cervical cancer is the most common malignant tumor in the global gynecological reproductive tract system among.</p><p><strong>Material and methods: </strong>The study was conducted among 155 females diagnosed with breast cancer and cervical cancer who underwent surgical treatment and took place between January 2024 and December 2025. The diagnostic survey method was employed, along with the following research tool: the Mental Adjustment to Cancer Scale (Mini-MAC), and self-administered questionnaire.</p><p><strong>Results: </strong>Patients diagnosed with breast cancer achieved the highest scores in the fighting spirit domain (M = 22.1; SD = 3.0), whereas patients with cervical cancer obtained the highest scores in the anxious preoccupation strategy (M = 20.1; SD = 2.4). The domains of anxious preoccupation, fighting spirit, helplessness-hopelessness, and positive reappraisal, analyzed in relation to the type of total surgical procedure performed in breast cancer were most frequently differentiated by the sociodemographic factor of education level. Other sociodemographic variables influenced only individual coping strategies. The education level of the respondents in breast cancer also significantly affected the constructive and destructive coping styles as defined by the Mini-MAC.</p><p><strong>Conclusions: </strong>The Mini-MAC showed that women with breast cancer more often activated a constructive coping style, and the highest scores in this group were observed for positive strategies. In contrast, women with cervical cancer more frequently activated a destructive coping style and negative strategies.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":"97 4","pages":"297-304"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital long QT syndrome in the pregnant women: a systematic review.","authors":"Martyna Drzycimska, Magdalena Bednarek-Jedrzejek, Adrianna Zahorowska, Ewa Kwiatkowska, Katarzyna Maksym, Aneta Cymbaluk-Ploska, Sebastian Kwiatkowski","doi":"10.5603/gpl.105472","DOIUrl":"10.5603/gpl.105472","url":null,"abstract":"<p><strong>Objective: </strong>Our goal was to summarize the previous management of pregnant women with LQTS, as well as to present the current guidelines in this area.</p><p><strong>Data sources: </strong>We conducted a systematic search in multiple databases, including PubMed, Scopus, and Medline/Embase between 1984 and 2022.</p><p><strong>Study selection: </strong>Original articles were eligible if they included pregnant patients suffering from congenital long QT syndrome with the three most common types 1-3.</p><p><strong>Data extraction and synthesis: </strong>The subject-related articles were processed according to Preferred Reporting Items in Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Two authors independently screened studies, extracted data, and assessed methodological quality. A total of 15 publications were included in the final report. In the literature, 18 cases of long QT syndrome with the most common types in pregnant women were included, for a final total of 20 cases.</p><p><strong>Conclusions: </strong>Despite the advances in medicine there is a lack of studies that can determine unequivocally, the only right way to manage pregnant women suffering from long QT syndrome. The question remains - does cesarean section objectively reduce the risk of cardiovascular complications in such cases? There is a strong need for further research in this scientific field, especially to create opportunities to reduce the performance of unjustified cesarean sections and thus improve mother and neonatal outcomes. It is believed that the actual incidence of LQTS is significantly higher than current statistics report, therefore, it is so vital to standardize the management of this group of patients.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"510-517"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148207202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of circadian rhythm on doppler parameters ın patients with gestational diabetes mellitus.","authors":"Ezgi Darici Kurt, Burak Guler, Enis Ozkaya, Miray Nilufer Cimsit Kemahli, Ewa Rabiej-Wronska, Oya Demirci","doi":"10.5603/gpl.112599","DOIUrl":"10.5603/gpl.112599","url":null,"abstract":"<p><strong>Objectives: </strong>Circadian rhythm (CR) is a 24-hour biological cycle regulated by endogenous and environmental factors. Altered CR gene expression has been associated with gestational diabetes mellitus (GDM), potentially affecting vascular regulation and fetal hemodynamics. This study aimed to evaluate the effect of circadian rhythm on Doppler ultrasonographic parameters in pregnancies complicated by GDM.</p><p><strong>Material and methods: </strong>This prospective cross-sectional study included 80 pregnant women between 32-39 gestational weeks classified into control, diet-regulated GDM, and insulin-regulated GDM groups. Doppler measurements of the umbilical artery (UA), middle cerebral artery (MCA), and uterine arteries (UtA) were performed twice daily at sunrise and sunset. Peak systolic velocity (PSV), systole/diastole ratio (S/D), pulsatility index (PI), and resistance index (RI) were analyzed.</p><p><strong>Results: </strong>In the control group, MCA S/D and PI demonstrated significant diurnal variation (p = 0.03 and p = 0.01, respectively). In insulin-regulated GDM, MCA PI showed significant variation between morning and evening measurements (p = 0.006), whereas MCA PSV, S/D, and RI remained unchanged (p > 0.05). Right uterine artery S/D, PI, and RI values also differed significantly in insulin-regulated GDM (p = 0.014, p = 0.008, and p = 0.001, respectively). No significant variation was detected in the diet-regulated GDM group or in umbilical and left uterine artery Doppler parameters. Intraclass correlation coefficient analysis demonstrated moderate-to-good reproducibility for MCA and UA measurements and very good reliability for uterine artery S/D, PI, and RI indices.</p><p><strong>Discussion: </strong>The findings suggest that circadian rhythm influences Doppler parameters, particularly in insulin-regulated GDM pregnancies. These results are consistent with previous studies demonstrating vascular and metabolic alterations in GDM.</p><p><strong>Conclusions: </strong>Doppler parameters vary during the day, reflecting circadian influence, especially in insulin-regulated GDM.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"556-563"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the INTERGROWTH-21st fetal growth standards in a single-center cohort of uncomplicated pregnancies in Poland.","authors":"Katarzyna Pilecka, Rafal P Szpak, Alicja Zachara, Marcin Wiechec","doi":"10.5603/gpl.111700","DOIUrl":"10.5603/gpl.111700","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the applicability of the INTERGROWTH-21st prescriptive fetal growth standards for thirdtrimester biometry and estimated fetal weight (EFW) assessment in a Polish population.</p><p><strong>Material and methods: </strong>This retrospective single-center cohort study included 594 uncomplicated singleton pregnancies with reliable firsttrimester crown rump length dating and one routine thirdtrimester ultrasound performed at a tertiary center in Poland (2014-2021). Standard biometry and EFW were obtained per international guidelines, and EFW was calculated using the INTERGROWTH-21st formula. Zscores and centiles were derived from INTERGROWTH-21st standards. EFW Zscores were grouped into < 3rd, 3rd ≤ 10th, 10th-90th, 90th-97th and > 97th centile categories; observed vs expected proportions (3%, 7%, 80%, 7%, 3%) were compared using the chisquare test.</p><p><strong>Results: </strong>Mean Zscores approximated zero for all parameters (HC 0.00 ± 1.01, AC 0.00 ± 1.02, FL 0.00 ± 1.08, BPD 0.00 ± 1.01, EFW 0.00 ± 0.93); 95% confidence intervals included zero, indicating minimal bias. For EFW, proportions were 1.0%, 4.7%, 85.2%, 6.2%, and 2.9%, respectively, significantly deviating from the theoretical distribution (χ² = 14.8, df = 4).</p><p><strong>Conclusions: </strong>Third trimester fetal size in lowrisk Polish pregnancies is well described by the INTERGROWTH-21st standards regarding central tendencies. A slight underrepresentation of fetuses at the extremes suggests mild compression, warranting local audit and linking of centiles with perinatal outcomes to refine diagnostic thresholds.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"581-587"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148364377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative performance of four risk of malignancy indices (RMI) in predicting ovarian malignancy: a large retrospective cohort study.","authors":"Hasan Volkan Ege, Ayse Filiz Yavuz, Gokcen Ege, Huseyin Levent Keskin","doi":"10.5603/gpl.109129","DOIUrl":"10.5603/gpl.109129","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the predictive performance of four risk of malignancy index (RMI) in patients with adnexal masses.</p><p><strong>Material and methods: </strong>This retrospective study included 703 patients who underwent surgery for adnexal masses. Preoperative ultrasonographic findings, menopausal status, and serum CA-125 levels were used to calculate RMI-1, -2, -3, and -4. Histopathology served as the reference standard. Sensitivity, specificity, positive and negative predictive values, and overall accuracy were analyzed.</p><p><strong>Results: </strong>Among 703 patients, 77.2% had benign lesions, 3.3% borderline tumors, and 19.5% malignant disease. RMI-1 demonstrated sensitivity 74.4%, specificity 91.3%, PPV 71.7%, NPV 92.4%; RMI-2 sensitivity 80.6%, specificity 86.2%, PPV 63.2%, NPV 93.8%; RMI-3 sensitivity 75.6%, specificity 90.1%, PPV 69.1%, NPV 92.6%; and RMI-4 sensitivity 78.8%, specificity 89.9%, PPV 69.6%, NPV 93.5%. ROC analysis showed areas under the curve of 0.900, 0.896, 0.893, and 0.893 for RMI-1 to RMI-4, respectively. RMI-1 had the highest specificity and overall accuracy, whereas RMI-2 achieved the highest sensitivity. Pairwise comparisons revealed statistically significant differences among RMIs.</p><p><strong>Conclusions: </strong>All four RMIs effectively differentiate benign from malignant adnexal masses. RMI-1 offers the highest overall accuracy and specificity, and RMI-2 the highest sensitivity. These indices provide valuable preoperative risk stratification to guide clinical management and referral to specialized care. Institutional resources should inform the choice of RMI.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"550-555"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148364388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the cost-effectiveness of implementing HPV vaccination in Turkiye's National Immunization Program using the PRIME model.","authors":"Erhan Ersoy, Ali Gursoy, Husna Guder","doi":"10.5603/gpl.104730","DOIUrl":"10.5603/gpl.104730","url":null,"abstract":"<p><strong>Objectives: </strong>HPV vaccines have been proven effective against genital warts and various cancers, including cervical, anal, penile, vulvar, vaginal, and oropharyngeal cancers. This study aimed to evaluate the cost-effectiveness of including the 9-valent HPV vaccine in the Turkish National Immunization Program (NIP).</p><p><strong>Material and methods: </strong>The Papillomavirus Rapid Interface for Modeling and Economics (PRIME) framework was applied to project the potential financial and societal outcomes of introducing HPV vaccination into Turkiye's 2024 National Immunization Schedule. Demographic data were obtained from the Turkish Statistical Institute (TUIK, Turkiye Istatistik Kurumu). The cost of vaccine was gathered from Ministry of Health. Epidemiologic inputs, treatment expenditure data, and additional modeling parameters were derived from previously published research sources. Model outputs included projected vaccination expenses, savings from avoided treatment, net costs, prevented cases and deaths, gained life-years, averted disability-adjusted life-years (DALYs), and estimated incremental cost-effectiveness ratios. Potential variability in model projections was examined through deterministic sensitivity testing.</p><p><strong>Results: </strong>At the national level, with the 9-valent HPV vaccination of a single age cohort in the base year, an estimated 772 cervical cancer cases and 369 related deaths could be avoided through implementation of the vaccination program. With an estimated US$13,754 per DALY gained, the 9-valent HPV vaccine fell within the acceptable cost-effectiveness threshold, defined as three times the GDP per capita. Sensitivity testing confirmed consistent outcomes across parameter variations, identifying the discount rate as the major driver influencing baseline estimates.</p><p><strong>Conclusions: </strong>Findings from this analysis support the inclusion of HPV vaccination within the National Immunization Program (NIP) as a cost-effective public health strategy capable of reducing the burden of cervical cancer. Even when considering only cervical cancer, HPV vaccination proves to be cost-effective; when benefits against genital warts and other HPV-related cancers are included, the overall impact increases significantly.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"641-646"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148474896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical value of intraoperative frozen section in the surgical management of ovarian tumors: diagnostic accuracy and correlation with final histopathology.","authors":"Natalia Mlodziankowska, Malgorzata M Kampioni, Katarzyna Tomczyk, Witold W Kedzia, Pawel Rzymski, Malgorzata Kedzia","doi":"10.5603/gpl.112823","DOIUrl":"10.5603/gpl.112823","url":null,"abstract":"<p><strong>Objectives: </strong>Intraoperative frozen section (FS) analysis is widely used during surgery for ovarian tumors to guide the extent of the operative procedure. It plays a particularly significant role in young women, in whom fertility-sparing surgery is considered. Despite its high clinical utility, FS has technical limitations that may result in discrepancies compared with final histopathological diagnosis. To assess the concordance between intraoperative frozen section diagnosis and final histopathological examination of ovarian tumors, and to evaluate the diagnostic accuracy, sensitivity, specificity, and predictive values of FS.</p><p><strong>Material and methods: </strong>The analysis included finally 100 women aged 11-78 years from among 114 who were hospitalized and underwent surgery for ovarian tumors conducted at a tertiary Gynecology and Obstetrics Clinical Hospital from January to June 2025. Frozen section diagnoses were compared with final histopathological results. Concordance rates, patterns of diagnostic discrepancies, and diagnostic performance parameters (sensitivity, specificity, positive predictive value [PPV], and negative predictive value [NPV]) were calculated using final histopathology as the reference standard.</p><p><strong>Results: </strong>Overall concordance between frozen section and final histopathology was 85%. Diagnostic discrepancies were observed in 15% of cases, with only 2% considered clinically significant. Frozen section showed excellent diagnostic performance for benign tumors (sensitivity 100%, specificity 94.1%) and malignant tumors (specificity and PPV 100%). The lowest diagnostic accuracy was observed for borderline tumors, which accounted for most clinically relevant discrepancies. The most frequent source of discordance involved hemorrhagic cysts, which were ultimately diagnosed as endometriotic cysts on final histopathology.</p><p><strong>Conclusions: </strong>Intraoperative frozen section analysis is a reliable and safe diagnostic tool that effectively supports surgical decision-making in ovarian tumors. Its high diagnostic accuracy and predictive values confirm its clinical value, particularly in tailoring the extent of surgery. Special caution is warranted in the interpretation of borderline tumors, for which final histopathological examination remains essential.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"647-654"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148674846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letrozole in ectopic pregnancy: exploring a promising frontier in non-surgical therapy - a narrative review.","authors":"Rashad Mammadov, Lara Sawah, Ismet Gun","doi":"10.5603/gpl.108493","DOIUrl":"10.5603/gpl.108493","url":null,"abstract":"<p><strong>Background: </strong>Ectopic pregnancy (EP) is a potentially life-threatening condition affecting 1-2% of pregnancies, traditionally managed via surgical or methotrexate (MTX)-based medical approaches. However, MTX is associated with significant systemic side effects and potential impairment of ovarian reserve. Aromatase inhibitors (AIs), particularly letrozole, have recently emerged as promising fertility-preserving alternatives.</p><p><strong>Objective: </strong>To synthesize and evaluate the available evidence regarding the efficacy, safety, and mechanistic rationale for the use of letrozole in the medical management of EP, and to compare outcomes with those of conventional MTX therapy.</p><p><strong>Methods: </strong>A systematic search of PubMed, Scopus, ScienceDirect, and Web of Science was conducted for English-language studies published from 1990 to April 2025. Eligible studies included randomized trials, prospective cohorts, or case reports that evaluated letrozole, MTX, or their combination for the treatment of tubal ectopic pregnancy and reported extractable clinical outcomes. Descriptive statistics and chi-square tests were used for comparative analysis.</p><p><strong>Results: </strong>Seven studies met the inclusion criteria, encompassing 249 patients treated with letrozole and 206 with MTX. The overall treatment success rate was 74.7% for letrozole and 80.1% for MTX (p = 0.172), with comparable surgical intervention rates (13.1% vs 13.4%, p = 0.941). The highest success rate with letrozole (90.5%) was observed with a 10-day 5 mg twice-daily regimen. Combination therapy with MTX and letrozole demonstrated superior outcomes (90.6% success, 9.4% surgery) compared to monotherapy. Letrozole was associated with minimal side effects and no observed detriment to ovarian reserve.</p><p><strong>Conclusion: </strong>Letrozole represents a safe, non-cytotoxic alternative to MTX for managing selected cases of unruptured ectopic pregnancy, particularly in fertility-conscious populations. While current evidence is encouraging, further randomized controlled trials are essential to establish optimal dosing regimens, long-term reproductive outcomes, and treatment algorithms.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"761-767"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of superficial fascial suture on early postoperative pain after cesarean section: a single-center observational study.","authors":"Akihito Morita, Kanako Toyoda, Risa Uehara, Ayuko Tanaka, Daisuke Higeta, Tatsuya Sato, Akira Iwase","doi":"10.5603/gpl.106673","DOIUrl":"10.5603/gpl.106673","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to clarify the association between superficial fascia sutures in cesarean section and postoperative pain.</p><p><strong>Material and methods: </strong>We conducted a single-center, retrospective observational study of pregnant women who underwent cesarean section at Gunma University Hospital. The patients were classified into two groups according to the presence or absence of superficial fascial sutures, and the Numerical Rating Scale (NRS) pain score at rest and with movement at 24, 48, 72, and 96 h after delivery was used as the primary endpoint. A pain score of 5 or higher was defined as moderate to severe pain, and multivariate logistic regression analysis adjusted for confounding factors was performed.</p><p><strong>Results: </strong>At 24 and 48 h postoperatively, the NRS score was significantly higher in the superficial fascial suture group than in the non-sutured group (at rest: p = 0.004 and p = 0.01, respectively; with movement: p = 0.001 and p = 0.015, respectively). No differences were observed between the groups at 72 and 96 h. Multivariate analysis revealed that superficial fascial sutures were an independent risk factor for pain augmentation.</p><p><strong>Conclusions: </strong>Superficial fascial sutures may be associated with increased pain 24-48 h after delivery. Therefore, clinicians should recognize this potential trade-off when selecting closure techniques.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"744-750"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of intraovarian Platelet Rich Plasma injection during hysterectomy on ovarian reserve and sexual life.","authors":"Ayşe Betül Albayrak Denizli, Özgür Aktaş, Pelin Özdemir, Eralp Bulutlar, Mehmet Koçak, Çetin Kılıçcı","doi":"10.5603/gpl.105291","DOIUrl":"10.5603/gpl.105291","url":null,"abstract":"<p><strong>Objectives: </strong>Low ovarian reserve is a major concern as older women seek pregnancy. Women 35 and older who want to conceive have fewer high-quality oocytes, which is linked to a drop in Anti-Müllerian Hormone (AMH). Women in this age bracket may need hysterectomy for abnormal uterine bleeding, leiomyomas, and pre-/malignant reasons. Those with preserved ovaries after hysterectomy nevertheless experience menopause. This circumstance impacts women's sexuality. Interventions to improve ovarian function in this age group may illuminate both concerns.</p><p><strong>Material and methods: </strong>We did an observational case-control study of 35-50-year-old individuals who had hysterectomy for a benign disease. The trial group received perioperative PRP for their ovaries, while the control group received no treatment. Patients' preoperative AMH and Female Sexual Function Index (FSFI) scores were compared to those 3 months following surgery.</p><p><strong>Results: </strong>Our study found a substantial drop in postoperative AMH levels in the control group (p < 0.001), whereas the PRP group showed a slight increase in AMH levels. The PRP group has a significant difference in preoperative and postoperative AMH levels (p = 0.0001). The PRP group had a much higher total FSFI score. Subgroup analysis shows this variation in lubrication, orgasm, contentment, and pain. The PRP group had substantial differences in orgasm, pleasure, and pain pre- and post-operation.</p><p><strong>Conclusions: </strong>PRP supports ovarian regeneration but has limited benefits. This information should be used to build standardized PRP protocols and undertake more extensive investigations by applying PRP to numerous organs, including the ovaries.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":"102-109"},"PeriodicalIF":1.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145812492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}