Mustafa Cengiz Dura, Cihan Kaya, Berk Gürsoy, Özgür Aslan, Şükrü Yıldız, Murat Ekin
{"title":"Women's sexual quality of life after ectopic pregnancy surgery - vNOTES vs conventional laparoscopy - a retrospective cohort study.","authors":"Mustafa Cengiz Dura, Cihan Kaya, Berk Gürsoy, Özgür Aslan, Şükrü Yıldız, Murat Ekin","doi":"10.5603/gpl.104355","DOIUrl":"https://doi.org/10.5603/gpl.104355","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to compare the postoperative sexual function and recovery outcomes between women who underwent vNOTES (vaginal natural orifice transluminal endoscopic surgery) and those who underwent conventional laparoscopy (CL) for ectopic pregnancies.</p><p><strong>Material and methods: </strong>A retrospective cohort study was conducted with data from 98 patients who underwent CL or vNOTES for ectopic pregnancy. Postoperative sexual function and genital self-image were evaluated using the Female Sexual Function Index (FSFI) and Female Genital Self-Image Scale (FGSIS) surveys, respectively. Patients were divided into the vNOTES group (n = 40) and the CL group (n = 58).</p><p><strong>Results: </strong>The postoperative FSFI total scores did not significantly differ between the vNOTES group and the CL group (p = 0.384). However, the lubrication subgroup score of the FSFI was significantly higher in the CL group compared to the vNOTES group (p = 0.001). The FGSIS total score was significantly higher in the vNOTES group compared to the CL group (p = 0.009).</p><p><strong>Conclusions: </strong>While vNOTES surgery may offer some postoperative benefits in terms of genital self-image, it is associated with lower lubrication scores compared to conventional laparoscopy. These findings highlight the potential impact of vNOTES on sexual function, emphasizing the need for further research to optimize surgical approaches that balance sexual function and recovery outcomes.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Can Tercan, Emrah Dagdeviren, Ali Selcuk Yeniocak, Sultan Can
{"title":"The role of uterine anteversion and flexion angles in predicting pain severity during diagnostic hysteroscopy: a prospective cohort study.","authors":"Can Tercan, Emrah Dagdeviren, Ali Selcuk Yeniocak, Sultan Can","doi":"10.5603/gpl.102956","DOIUrl":"https://doi.org/10.5603/gpl.102956","url":null,"abstract":"<p><strong>Objectives: </strong>Diagnostic hysteroscopy (DH) is a gold standard diagnostic imaging tool in gynecology. There is insufficient data in the literature regarding the reduction of pain felt during the DH and there is no study in the literature that examines the relationship between the measurement of uterine version or flexion angles and the pain felt during DH procedure. The aim of this study was to investigate the effects of uterine version or flexion angles on pain severity during DH and to identify predictive factors for severe pain experienced during the procedure.</p><p><strong>Material and methods: </strong>This prospective single-center cohort study included patients who were eligible for DH within medical indications. Exclusion criteria comprised menopausal status, congenital uterine anomalies, uterine fibroids larger than 2 cm detected on ultrasonography, suspected malignancy, or retroverted uterus. Before hysteroscopy, all patients underwent transperineal ultrasonography to measure uterine version and flexion angles. Patients were asked to rate their pain levels using a 0-10 numerical visual analog scale (VAS). Patients with VAS scores ≥ 6 were categorized into the severe pain group, while those with scores < 6 were classified into the moderate pain group.</p><p><strong>Results: </strong>The study comprised 98 women undergoing DH. Multivariate binary logistic regression analysis identified anteversion angle and nulliparity as significant predictors of severe pain during DH. The optimal cut-off value for predicting severe pain during DH was identified as 74.5°, providing a sensitivity of 66.7% and specificity of 69.0% [area under curve (AUC) = 0.722, p = 0.001].</p><p><strong>Conclusions: </strong>This study demonstrates that a uterine anteversion angle narrower than 74.5° is associated with severe pain during DH.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of transforming growth factor-beta 1 concentrations in serum, peritoneal and endometrioma fluid in women operated on for ovarian endometriosis as a biomarker of endometrioma.","authors":"Mariusz Wojtowicz, Dariusz Zdun, Aleksander J Owczarek, Violetta Skrzypulec-Plinta, Magdalena Olszanecka-Glinianowicz","doi":"10.5603/gpl.97117","DOIUrl":"https://doi.org/10.5603/gpl.97117","url":null,"abstract":"<p><strong>Objectives: </strong>Some studies indicate the role of transforming growth factor-beta 1 (TGF-beta 1) in the development of endometriosis. However, the lack is studies assessed its plasma levels as a biomarker of endometrioma. Therefore, this study aimed to analyze plasma, peritoneal, and endometrioma fluid TGF-beta 1 concentrations in women operated on for ovarian endometriosis.</p><p><strong>Material and methods: </strong>A cross-sectional cohort study involved 56 women operated on for ovarian endometriosis. Body mass, height, and waist circumference were measured, as well as body mass index (BMI) being calculated. Plasma, peritoneal, and endometrioma fluid TGF-beta 1 concentrations were determined by enzyme-linked immunosorbent assay (ELISA).</p><p><strong>Results: </strong>Levels TGF-beta 1 were significantly higher in plasma than in both fluids (1286.1 pg/mL vs 114.7 pg/mL; p < 0.001 and 114.7 pg/mL vs 33.6 pg/mL; p < 0.001) and in endometrioma fluid than in peritoneal fluid (114.7 pg/mL vs 33.6 pg/mL; p < 0.001). There were also positive correlations between TGF-beta 1 levels in endometrioma and peritoneal fluids and plasma (r = 0.46; p < 0.001; r = 0.30; p < 0.05, respectively). There were no associations between TGF-beta 1 in plasma, endometrioma, peritoneal fluid, and endometriosis stage.</p><p><strong>Conclusions: </strong>Our results suggest that plasma TGF-beta 1 concentration can be considered as a biomarker of endometrioma.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Malgorzata Swornik, Grzegorz Mirocki, Marcin Przybylski, Dominik Pruski, Klaudia Kotynia, Sonja Millert-Kalinska, Tomasz Szmatola, Robert Jach
{"title":"Evaluation of the sperm DNA Fragmentation Index in men from infertile couples diagnosed under the health policy program of the Minister of Health, entitled \"Government Program for Comprehensive Protection of Procreative Health in Poland\" in the Cracow University Hospital.","authors":"Malgorzata Swornik, Grzegorz Mirocki, Marcin Przybylski, Dominik Pruski, Klaudia Kotynia, Sonja Millert-Kalinska, Tomasz Szmatola, Robert Jach","doi":"10.5603/gpl.102193","DOIUrl":"https://doi.org/10.5603/gpl.102193","url":null,"abstract":"<p><p>Sperm DNA integrity assessment provides essential information that traditional semen parameters may not detect. Studies indicate that DNA fragmentation is an independent indicator of semen quality and fertility, which can explain cases of male infertility, especially when basic semen tests show normal results. Using sperm DNA fragmentation assessment techniques should be considered as an addition to traditional semen tests in male infertility diagnostics.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monika Szarszewska, Janina Markowska, Marian Grybos, Anna Grybos, Andrzej Marszalek, Anna Malicka-Durczak, Violetta Filas, Michal Michalak, Anna Markowska
{"title":"Irisin - a new biomarker for endometrial cancer?","authors":"Monika Szarszewska, Janina Markowska, Marian Grybos, Anna Grybos, Andrzej Marszalek, Anna Malicka-Durczak, Violetta Filas, Michal Michalak, Anna Markowska","doi":"10.5603/gpl.104455","DOIUrl":"https://doi.org/10.5603/gpl.104455","url":null,"abstract":"<p><strong>Objectives: </strong>Irisin is an adipomyokine that has an inhibitory effect on inflammation and possesses anticancer activity. It inhibits cancer cell proliferation, metastasis, and invasion through various signaling pathways associated with carcinogenesis. It has been described to be associated with a number of malignancies in various locations. It has been recognized that it may be a biomarker and prognostic factor in some malignancies. In addition, studies indicate irisin's possible role in treating malignant lesions.</p><p><strong>Material and methods: </strong>In material including 129 cases of endometrial cancer and normal endometrium in a control group of 18 women with uterine myomas.</p><p><strong>Results: </strong>There were no statistical differences in irisin protein expression. There were also no differences in irisin expression according to clinical stage, type, and histopathological differentiation.</p><p><strong>Conclusions: </strong>Further clinical studies are needed to evaluate irisin activity in endometrial cancer.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chi Yuan Liao, Fuh Jinn Luo, Fang Ling Chiu, Jan Sing Hsieh
{"title":"Clear cell carcinoma with lung metastasis arising from endometriosis in the abdominal surgical scar - management with a multidisciplinary mode.","authors":"Chi Yuan Liao, Fuh Jinn Luo, Fang Ling Chiu, Jan Sing Hsieh","doi":"10.5603/gpl.103947","DOIUrl":"https://doi.org/10.5603/gpl.103947","url":null,"abstract":"","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is there a relationship between genital hiatus distance and the presence of pelvic organ prolapse?","authors":"Erdinç Dinçer, Fatih Tarhan","doi":"10.5603/gpl.104178","DOIUrl":"https://doi.org/10.5603/gpl.104178","url":null,"abstract":"<p><strong>Objectives: </strong>Pelvic organ prolapse (POP) is an important disease affecting the quality of life of women. We aimed to investigate the relationship of genital hiatus (GH) and anogenital distance (AGD) measurements with POP in patients with lower urinary tract symptoms.</p><p><strong>Material and methods: </strong>1696 Patients who underwent urodynamic investigations in our clinics were evaluated retrospectively. Demographic data, physical examination data and urodynamic investigation results of all patients were evaluated. Those beyond POPQ stage 2 and above were considered to have pelvic organ prolapse.</p><p><strong>Results: </strong>The mean age was 49.44 ± 0.27 years, and the mean body-mass index was 30.08 ± 0.16 kg/m². While 682 patients (40.2%) were considered as having no POP, 1014 patients (59.8%) were considered as having POP. A statistically significant difference was found between the groups in terms of POP status respect of the parity, mean GH and AGD, and hysterectomy rate (p < 0.05). Mean GH, PB and AGD were significantly different among POP stage groups. (p < 0.05). In the correlation analysis, there was a positive correlation between POP stage parity (p = 0.0003, r = 0.059), GH (p < 0.0001, r = 0.353) and AGD (p < 0.0001, r = 0.299). The logistic regression revealed that genital hiatus distance and hysterectomy were statistically significant factors associated with POP. In ROC analysis, when the GH distance measurement is > 2.5 cm, the probability of POP status was found with sensitivity of 77.4% and specificity of 53.2% (p < 0.001).</p><p><strong>Conclusions: </strong>GH measurement can be marker for POP in a population of women being evaluated for urinary incontinence. GH measurement > 2.5 cm may associated with POP status.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriela Mierzwa, Julia Jurga, Justyna Kuciel, Magdalena Kolak, Andrzej Jaworowski, Hubert Huras
{"title":"Pregnant women's knowledge of and attitudes toward pertussis, influenza and COVID-19 vaccination.","authors":"Gabriela Mierzwa, Julia Jurga, Justyna Kuciel, Magdalena Kolak, Andrzej Jaworowski, Hubert Huras","doi":"10.5603/gpl.103799","DOIUrl":"https://doi.org/10.5603/gpl.103799","url":null,"abstract":"<p><strong>Objectives: </strong>Despite the robust scientific evidence supporting the safety and efficacy of vaccinations in preventing severe illness, complications, and death, trust in immunizations has been declining, among others, in a particularly vulnerable group, such as pregnant women. This study aimed to present women's attitudes towards vaccinations against pertussis, influenza, and COVID-19 during pregnancy, their knowledge of the subject, and their motivations for getting vaccinated.</p><p><strong>Material and methods: </strong>An anonymous, self-reported questionnaire developed for this study was distributed to postpartum women hospitalized at the Department of Obstetrics and Perinatology, Jagiellonian University Medical College in Cracow, Poland, between February and April 2023. Participants provided sociodemographic and obstetric information, reasons for getting vaccinated or not, and their sources of vaccination knowledge.</p><p><strong>Results: </strong>Women's primary motivation (96.4%) for vaccinating during pregnancy was to protect their children from severe cases of pertussis, influenza or COVID-19. Among the reasons for not getting vaccinated against pertussis and influenza during pregnancy, most patients cited the belief in the lack of necessity for vaccination (42.9%, 34.3% respectively), and in the case of COVID-19 - receiving the vaccine before pregnancy (27.6%). Obstetricians provided information about recommended vaccinations only to 49.3% of respondents. 64.2% of surveyed patients expressed a willingness to vaccinate their child in the future with both mandatory and recommended vaccines.</p><p><strong>Conclusions: </strong>Our results indicate that a lack of knowledge leads to an insufficient vaccination rate during pregnancy. We see a crucial role for physicians, especially obstetricians, in providing patient information while underlining undeniable benefits of maternal vaccination to the children's health.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrycja Pietak, Konrad Futyma, Ewa Rechberger-Krolikowska, Aleksandra Struzyk, Aleksandra Kolodynska, Tomasz Rechberger
{"title":"Should we abandon the use of transvaginal mesh in woman's pelvic floor reconstructive surgery? - 10 years of experience in the field of vaginal pelvic floor surgery.","authors":"Patrycja Pietak, Konrad Futyma, Ewa Rechberger-Krolikowska, Aleksandra Struzyk, Aleksandra Kolodynska, Tomasz Rechberger","doi":"10.5603/gpl.104105","DOIUrl":"https://doi.org/10.5603/gpl.104105","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the study was to investigate how surgical management strategies for pelvic organ prolapse (POP) have changed in a single-centre department over the last decade, as Food and Drug Administration (FDA) warnings have changed worldwide attitudes to mesh augmented reconstruction.</p><p><strong>Material and methods: </strong>The study group consisted of 4180 patients who were operated on due to advanced symptomatic POP (≥ 2 POP-Q scale) from January 2010 to December 2020. Patients were divided into three groups depending on the type of POP vaginal surgery performed: group 1 - vaginal native tissue repair (VNTR) - (n = 1376); group 2 - transvaginal mesh repair (TVM; anterior, posterior, or both) - (n = 2494), and group 3 - transvaginal hysterectomy (TVH) - (n = 310). The clinical effectiveness of each type of procedure was estimated by means of the NIH Pelvic Floor Disorders Network criteria.</p><p><strong>Results: </strong>The number of VNTR surgeries has significantly increased since 2017, following FDA warnings about the safety of these surgeries. The reoperation rate during the follow-up period did not differ between the investigated groups. However, urgency occurrence was significantly lower in the VNTR group when compared to the TVM and TVH groups (p < 0.05).</p><p><strong>Conclusions: </strong>In most cases of symptomatic POP, vaginal native tissue repair is a safe and effective primary treatment. Based on the reoperation rate and the functional outcome we have not found any evidence of benefits from augmenting surgical prolapse repairs with polypropylene mesh inlays.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Slavica Aksam, Dusica Kocijancic Belojevic, Jelena Dotlic, Miljana Jovandaric, Ivana Babovic, Milena Mitrovic, Ivana Vukovic, Jovan Bila, Snezana Vukajlovic
{"title":"Pregnancy and neonatal outcomes in women with myasthenia gravis: two decades experience from a university clinic.","authors":"Slavica Aksam, Dusica Kocijancic Belojevic, Jelena Dotlic, Miljana Jovandaric, Ivana Babovic, Milena Mitrovic, Ivana Vukovic, Jovan Bila, Snezana Vukajlovic","doi":"10.5603/gpl.102412","DOIUrl":"https://doi.org/10.5603/gpl.102412","url":null,"abstract":"<p><strong>Objectives: </strong>Myasthenia gravis (MG) can increase pregnancy complications and cause adverse pregnancy outcome, while pregnancy can deteriorate the course of MG. The study evaluated pregnancy and neonatal outcomes in women with myasthenia gravis and factors that impact these outcomes.</p><p><strong>Material and methods: </strong>The study included all 94 pregnant women with MG who were examined and delivered between 2000 and 2020 in our referral university clinic. Data on the mothers' medical history, symptoms and therapies during pregnancy along with overall condition after delivery were collected. Regarding neonates we registered gestational weeks and types of deliveries, anthropometric parameters, Apgar scores, symptoms, complications and therapies upon birth.</p><p><strong>Results: </strong>Examined women were mostly primiparous with an average age of 30.81 ± 4.47 years. MG lasted for 4.3 ± 2.96 years before pregnancy and was treated with thymectomy and acetylcholinesterase inhibitors. Myasthenia gravis was mostly stable or improved during pregnancy, but deteriorated in 6.4% cases during and 3.2% cases after pregnancy. The predictor of maternal condition after delivery was MG symptoms severity during pregnancy. Delivery mostly occurred in term (84.3%). Cesarean sections rate was 37.2%. All investigated newborns were in good condition upon birth (average Apgar score 8.75 ± 0.57). Although 12.8% of newborns had mild symptoms of transient neonatal MG, none had any consequences. A higher MG class and an earlier week of delivery were predictors for complications of neonates upon birth.</p><p><strong>Conclusions: </strong>With close monitoring and appropriate current therapies pregnancy of MG patients can be uneventful with favorable outcomes for both mothers and neonates.</p>","PeriodicalId":94021,"journal":{"name":"Ginekologia polska","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}