Expression and clinical significance of miR-10a-5p in patients with hypertension during pregnancy.

Abstract

Objectives: Dysregulated miR-10a-5p is associated with a variety of cardiovascular diseases and fetal growth in the second trimester. This study aimed to investigate the expression and clinical significance of serum miR-10a-5p in patients with hypertension during pregnancy (HDP).

Material and methods: 103 healthy pregnant women (control group) and 120 pregnant women with HDP (HDP group) were enrolled in this study. The relative miR-10a-5p was analyzed by qRT-PCR and its association with clinical indicators was performed by Pearson's correlation analysis. The diagnostic and prognostic value were by receiver operator characteristic (ROC) curve and Kaplan-Meier curve analysis, respectively. The risk factor evaluation of HDP was performed by multivariate logistic regression analysis. Adverse pregnancy outcomes were recorded during follow-up.

Results: The miR-10a-5p level was significantly declined in HDP patients compared to control (p < 0.001). The reduced miR-10a-5p was negatively related to SBP (r = -0.6777, p < 0.0001), DBP (r = -0.6026, p < 0.0001), TNF-α (r = -0.7020, p < 0.0001) and IL-6 (r = -0.7149, p < 0.0001). MiR-10-5p was a risk factor of HDP (OR = 0.433, 95% CI: 0.247-0.759, p = 0.003). HDP pregnant women with low miR-10a-5p expression levels (13/68) faced more probability of adverse pregnancy outcomes than those of high miR-10a-5p expression levels (8/52).

Conclusions: Declined miR-10a-5p contributed to the diagnosis and prognosis of HDP and was also a risk factor of HDP.