Association between MMP-9-C1562Tpolymorphism and susceptibility to preeclampsia: a systematic review and meta-analysis.

Ginekologia polska Pub Date : 2024-10-16 DOI:10.5603/gpl.100274

Ruihong Lan, Yang Yang, Jie Song, Hong Yang, Ling Wang, Humin Gong

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引用次数: 0

Abstract

Objectives: This meta-analysis aims to explore the association between MMP-9-C1562T polymorphism and susceptibility to preeclampsia (PE).

Material and methods: Four English databases were searched to collect relevant records up to April 2024. The pooled odds ratio (OR) was calculated using Stata 15.0.

Results: A total of 10 studies were enrolled in our systematic review. The results showed that genotype CT at MMP-9-C1562T locus increased the risk of PE versus genotype TT (Genotype CT vs TT: OR = 2.32, 95% CI: 1.27-4.24, P = 0.006), but no significant differences were found in other gene models (C vs T: OR = 0.88, 95% CI: 0.71-1.08, P = 0.225; Genotype CC vs TT: OR = 1.51, 95% CI: 0.87-2.61, P = 0.139; Genotype CC + CT vs TT: OR = 1.63, 95% CI: 0.95-2.81, P = 0.079; Genotype CC vs CT + TT: OR = 0.80, 95% CI: 0.63-1.03, P = 0.086). Subgroup analysis by ethnicity showed a statistically significant difference in the heterozygous model in China (Genotype CT vs TT: OR = 2.38, 95% CI: 1.15 -4.91, P = 0.019).

Conclusions: Association of MMP-9-C1562T polymorphism with susceptibility to PE exists. Specifically, genotype CT increases the risk of PE versus genotype TT, particularly in Caucasian populations.

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MMP-9-C1562T多态性与先兆子痫易感性之间的关系：系统回顾和荟萃分析。

目的本荟萃分析旨在探讨MMP-9-C1562T多态性与子痫前期（PE）易感性之间的关系：检索了四个英文数据库，以收集截至2024年4月的相关记录。使用 Stata 15.0 计算汇总的几率比（OR）：结果：我们的系统综述共纳入了 10 项研究。结果显示，与基因型 TT 相比，MMP-9-C1562T 基因座的基因型 CT 会增加 PE 的风险（基因型 CT vs TT：OR = 2.32，95% CI：1.27-4.24，P = 0.006），但在其他基因模型中未发现显著差异（C vs T：OR = 0.88，95% CI：0.71-1.08，P = 0.225；基因型 CC vs TT：OR = 1.51，95% CI：0.87-2.61，P = 0.139；基因型 CC + CT vs TT：OR = 1.63，95% CI：0.95-2.81，P = 0.079；基因型 CC vs CT + TT：OR = 0.80，95% CI：0.63-1.03，P = 0.086）。按种族进行的亚组分析表明，中国杂合子模型的差异具有统计学意义（基因型 CT vs TT：OR = 2.38，95% CI：1.15 -4.91，P = 0.019）：结论：MMP-9-C1562T 多态性与 PE 易感性有关。结论：MMP-9-C1562T 多态性与 PE 易感性存在关联，特别是在白种人中，基因型 CT 与基因型 TT 相比会增加 PE 的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ginekologia polska

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