{"title":"The Safety and Efficacy of a Bioabsorbable Implant for Correction of Cartilaginous Septal Deviation.","authors":"Steven E Davis, Greg E Davis","doi":"10.1177/01455613251346589","DOIUrl":"https://doi.org/10.1177/01455613251346589","url":null,"abstract":"<p><strong>Introduction: </strong>Nasal septal deviation (NSD) is a leading cause of nasal airway obstruction, a condition that adversely affects quality of life. Septoplasty, typically performed with inferior turbinate reduction (ITR), is a common treatment to correct NSD.</p><p><strong>Methods: </strong>We conducted a prospective feasibility study of a novel, minimally-invasive implant (SeptAlign<sup>TM</sup>) to correct cartilaginous NSD as an alternative to traditional open septoplasty. The implant was inserted either in the operating room or at the medical office. ITR was performed in conjunction with the implant procedure.</p><p><strong>Results: </strong>We present 12 month results for 14 participants with mobile cartilaginous NSD. The procedure and implant were well-tolerated. At the 12th month post-procedure, the median Nasal Obstruction Symptom Evaluation (NOSE) score improved 71.8% from baseline (58-15; <i>P</i> = .001) and the median Sino-Nasal Outcome Test-22 (SNOT-22) score improved 60.3% from baseline score (37-8; <i>P</i> = .004). Most of the improvement in symptoms occurred within the first month following the procedure at which point 92.9% and 78.6% of participants were considered NOSE and SNOT-22 responders, respectively.</p><p><strong>Conclusion: </strong>These initial findings support the safety, tolerability, and early efficacy of the SeptAlign<sup>TM</sup> implant with concomitant ITR and suggest that the implant procedure can be safely performed in a medical office setting. Based on these promising initial data, larger, randomized, controlled studies should be conducted.</p><p><strong>Clinicaltrials: </strong>gov:NCT05967169; https://clinicaltrials.gov/study/NCT05967169?term=Spirair&rank=2.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251346589"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tracheal Hirudiniasis: A Case Report.","authors":"Shivam Pandey, Shravya Singh Karki, Sangita Bhandary, Suban Bhandari, Girban Pandey","doi":"10.1177/01455613251345419","DOIUrl":"https://doi.org/10.1177/01455613251345419","url":null,"abstract":"<p><strong>Introduction: </strong>Leeches are freshwater ectoparasites that inhabit streams, pools, and springs. Internal infestation occurs by ingestion of contaminated water or direct exposure while swimming. This report presents a rare case of tracheal hirudiniasis.</p><p><strong>Case description: </strong>A 34 year-old Nepalese woman presented with 1 week history of throat discomfort and dysphagia after the ingestion of river water. The initial clinical and endoscopic evaluations were unremarkable. Twelve hours after admission, a leech was visualized at the base of the tongue, but multiple failed extraction attempts led to its migration. Subsequently, rigid bronchoscopy under general anesthesia identified a leech in the trachea, 2 cm proximal to the carina. The parasite was successfully extracted with rigid bronchoscopy under general anesthesia, and the patient had a smooth recovery.</p><p><strong>Discussion: </strong>Internal hirudiniasis affects primarily the nasal cavity, oral cavity, pharynx, larynx, tracheobronchial tree, and esophagus, with rare cases in the abdomen, vagina, and eye. Symptoms depend on the site of infestation. Nasal cases present with epistaxis and obstruction, while tracheobronchial involvement may cause cough, dyspnea, and hemoptysis. Removal is challenging due to the mucosal attachment of the leech and its slippery nature. Various detachment techniques, including anesthetics, cryoprobes, and hypertonic solutions, have been described in the literature. In this case, general anesthesia likely facilitated detachment, enabling a successful extraction.</p><p><strong>Conclusions: </strong>Internal hirudiniasis should be considered in patients with freshwater exposure with relevant symptoms. Prompt recognition and appropriate extraction techniques are essential to prevent complications. Increased awareness among health care workers and the general population is essential for early diagnosis, prevention, and effective management.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251345419"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jihène Houas, Mouna Belakhdher, Ghada Grassi, Taghrid Tlili, Monia Ghammam
{"title":"Cervical Thymopharyngeal Duct Cyst Mimicking a Thyroid Nodule in an Adult: A Rare Case Report.","authors":"Jihène Houas, Mouna Belakhdher, Ghada Grassi, Taghrid Tlili, Monia Ghammam","doi":"10.1177/01455613251343728","DOIUrl":"https://doi.org/10.1177/01455613251343728","url":null,"abstract":"<p><p>Thymopharyngeal duct cysts are rare congenital lesions resulting from the persistence of the embryonic thymopharyngeal tract, typically presenting in pediatric populations. Adult cases are exceedingly uncommon and often misdiagnosed due to their rarity and nonspecific clinical features. We report the case of a 34-year-old woman who presented with a slowly-enlarging, painless left cervical mass initially suggestive of a thyroid pathology. Imaging revealed a well-defined cystic lesion at the lower pole of the thyroid gland. Surgical excision via a low cervicotomy was performed, and a left lobo-isthmectomy was carried out due to the lesion's adherence to the thyroid. Final histopathological analysis confirmed a thymopharyngeal duct cyst. This case underscores the diagnostic challenges of lateral neck cysts in adults and highlights the importance of considering rare embryologic anomalies in the differential diagnosis, particularly when lesions mimic more common thyroid or branchial cleft pathologies.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251343728"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gene Therapy for Congenital Hearing Loss: Are You Ready to Anticipate the Genetic Tests?","authors":"Andrea Migliorelli, Andrea Ciorba","doi":"10.1177/01455613251346613","DOIUrl":"https://doi.org/10.1177/01455613251346613","url":null,"abstract":"","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251346613"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sang-Hyun Lee, Hong Kyu Lee, Mi Jung Kwon, Heejin Kim, Jeong Wook Kang
{"title":"Anatomical Location as a Predictor of Treatment Response in Globus Pharyngeus.","authors":"Sang-Hyun Lee, Hong Kyu Lee, Mi Jung Kwon, Heejin Kim, Jeong Wook Kang","doi":"10.1177/01455613251336895","DOIUrl":"https://doi.org/10.1177/01455613251336895","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate whether the anatomical location of the globus sensation influences treatment outcome in patients with globus pharyngeus.</p><p><strong>Methods: </strong>A prospective cohort study was conducted between March 2023 and May 2024 with 55 patients who presented with globus sensation. The participants were categorized into the upper and lower globus groups based on the anatomical location of globus sensation relative to the upper esophageal sphincter. All patients received proton pump inhibitor (PPI) therapy for up to 12 weeks, and treatment response was assessed using the Reflux Symptom Index (RSI) and Reflux Finding Score (RFS). Log-rank tests and logistic regression analysis were performed to identify the factors associated with treatment response.</p><p><strong>Results: </strong>Patients with upper globus showed a significantly-higher rate of symptom improvement (78.6%) than those with lower globus (40.7%). Symptom severity (measured by the RSI) was higher in the lower globus group, while posterior commissure hypertrophy (measured by the RFS) was more prevalent in the upper globus group. Factors positively associated with symptom improvement included the location of the upper globus and coffee cessation. The lower globus group showed resistance to PPI therapy.</p><p><strong>Conclusion: </strong>Patients with upper globus respond better to PPI therapy, whereas those with lower globus do not. The anatomical location of the globus sensation may affect treatment outcomes.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251336895"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jérôme R Lechien, Sarah Saxena, Luigi A Vaira, Stephane Hans, Antonino Maniaci
{"title":"Artificial Intelligence-Assisted Diagnosis of an Unusual Cause of Periodic Epistaxis: A Case Report.","authors":"Jérôme R Lechien, Sarah Saxena, Luigi A Vaira, Stephane Hans, Antonino Maniaci","doi":"10.1177/01455613251335385","DOIUrl":"https://doi.org/10.1177/01455613251335385","url":null,"abstract":"<p><p>Epistaxis is a common cause of consultation in otolaryngology, manifesting either as isolated episodes or recurrent events. In this paper, we report the history of an 8-year-old African male who presented with periodic epistaxis temporally associated with joint inflammation. The diagnostic work-up, supported by artificial intelligence-based clinical decision support, led to the diagnosis of rheumatic fever. This case describes a very rare etiology of periodic epistaxis and demonstrates the potential usefulness of artificial intelligence as an adjunctive clinical tool. To our knowledge, this is the first reported case of rheumatic fever presenting with periodic epistaxis in the pediatric population.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251335385"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on \"Patient-Specific Factors to Differentiate Between Branchial Cleft Cysts and CUP Syndrome: A 10 Year Unicenter Study\".","authors":"Renu Sah, Ankita Mathur","doi":"10.1177/01455613251346604","DOIUrl":"https://doi.org/10.1177/01455613251346604","url":null,"abstract":"","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251346604"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Low-Temperature Plasma Radiofrequency Ablation for Congenital Epiglottic Cysts.","authors":"Hao Cai, Jinjian Gao","doi":"10.1177/01455613241259368","DOIUrl":"10.1177/01455613241259368","url":null,"abstract":"<p><p><b>Objectives:</b> Congenital epiglottic cysts are rare disorders of the larynx with symptoms such as laryngeal stridor and inspiratory dyspnea and are life-threatening in severe cases. This study aimed to investigate the usefulness of low-temperature plasma radiofrequency ablation for congenital epiglottic cysts and provide a reference for clinicians to develop treatment options. <b>Methods:</b> The clinical data of children (n = 7, 4 males and 3 females) with congenital epiglottic cysts, who were admitted to the Second Affiliated Hospital of Wenzhou Medical University and Yuying Children's Hospital from March 2018 to March 2023, were analyzed retrospectively. Following preoperative examinations, all patients underwent low-temperature plasma radiofrequency ablation under general anesthesia, and the curative effect was evaluated. Following surgery, regular patient follow-up examinations were conducted to monitor recurrence. <b>Results:</b> The age at the time of operation ranged from 1 day to 99 days, with an average of 37.57 ± 35.01 days. The surgical procedure was successfully completed in all the children; dyspnea disappeared and no surgical complications were observed. In addition, during the postoperative follow-up period of 6 months to 5 years, recurrence was not observed. <b>Conclusions:</b> Low-temperature plasma radiofrequency ablation is a safe and effective procedure for treating congenital epiglottic cysts and deserves clinical application and promotion.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"351-354"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141201600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case Report on the Short-Term Recurrence of Low-Grade Fibromyxoid Sarcoma in the Maxillary Sinus.","authors":"Dan Zhao, Jian Dai, Yu Hu, Tao Wang","doi":"10.1177/01455613241276673","DOIUrl":"10.1177/01455613241276673","url":null,"abstract":"<p><p>Low-grade fibromyxoid sarcoma (LGFMS) represents an exceptionally rare soft-tissue tumor, challenging to diagnose, and notorious for relentless recurrence and proliferation postsurgical resection. Primary symptoms of LGFMS include nasal congestion and rhinorrhea, accompanied by cheek numbness and distension. In this article, we report the diagnosis and treatment of a case of low-grade LGFMS originating in the maxillary sinus (MS). A 64-year-old male diagnosed with LGFMS of the left MS, undergoing 3 surgeries over a 1-year period with subsequent local recurrence. Following inconclusive postoperative pathology after the initial surgery, the patient experienced recurrence 2 months postsurgery, necessitating a second operation, which confirmed the LGFMS diagnosis pathologically. Radiation therapy commenced 1 month after the second surgery; however, recurrence transpired 6 months later, leading to a third operation. Subsequently, recurrence occurred again 8 months post third surgery, with the patient currently undergoing targeted therapy. This case underscores the distinct characteristics and therapeutic challenges inherent in LGFMS through the narrative of diagnosis and progression of LGFMS originating in the MS.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"346-350"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}