Ear, nose, & throat journal最新文献

{"title":"Radiofrequency Coblation Inferior Turbinoplasty with Modified UPPP for the Treatment of Obstructive Sleep Apnea-Hypopnea Syndrome.","authors":"Qiushi Tian, Teng Chu, Mingjie Pang","doi":"10.1177/01455613241307525","DOIUrl":"10.1177/01455613241307525","url":null,"abstract":"<p><p><b>Objective:</b> To compare the efficacy of surgical treatment in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) involving a standalone modified uvulopalatopharyngoplasty (mUPPP) and radiofrequency coblation inferior turbinoplasty with mUPPP. <b>Methods:</b> In this study, a retrospective analysis of 79 OSAHS patients with inferior turbinate hypertrophy and oropharyngeal obstruction undergoing surgical treatment was performed. According to the different surgical methods, the patients were divided into 2 groups (Group A and Group B). Group A included 36 patients treated with standalone mUPPP. Group B included 43 patients treated with mUPPP and bilateral radiofrequency coblation inferior turbinoplasty. Polysomnography (PSG), active anterior rhinomanometry, surgical success rate, and surgical complication were used to assess the patients in 2 groups. The successful surgical result was defined as a 50% or greater decrease in the apnea-hypopnea index (AHI) in postoperative PSG. <b>Results:</b> Before surgery, there were no significant differences in age, gender, neck circumference, body mass index, Friedman tongue position grade, tonsil size grade, Epworth sleepiness scale score, total inferior turbinate size grade, total nasal resistance (TNR), AHI and the lowest O₂ saturation (LSaO₂) between the 2 groups. After 6 months of follow-up visits, AHI, LSaO₂, and TNR in Group B showed a significant improvement compared to Group A. The surgical success rate was 76.74% in Group B compared to 52.78% in Group A (<i>P</i> = .025). There was no significant difference in the total surgical complication rate between the 2 groups (13.89% vs 23.26%, <i>P</i> = .290). <b>Conclusion:</b> For OSAHS patients with inferior turbinate hypertrophy and oropharyngeal obstruction, radiofrequency coblation inferior turbinoplasty with mUPPP appears to be a more effective surgical method than mUPPP alone.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"293-300"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Trajectory of Oral Mucositis in Head and Neck Cancer Patients Undergoing Radiotherapy and its Influencing Factors.","authors":"Meizi Liu, Ran An, Zitong Wu, Leping Dai, Qiaomiao Zeng, Wenfeng Chen","doi":"10.1177/01455613241228211","DOIUrl":"10.1177/01455613241228211","url":null,"abstract":"<p><strong>Background: </strong>Oral mucositis (OM) is a common and severe side effect of radiotherapy in head and neck cancer (HNC). The study aimed to investigate the longitudinal changes in OM and its influencing factors in patients with HNC during radiotherapy.</p><p><strong>Methods: </strong>This was a retrospective longitudinal observational study. From July 2022 to March 2023, patients with HNC undergoing radiation therapy were enrolled. OM, oral hygiene, oral infections, oral pain, feeding route, and laboratory indicators were measured at 7 times. The influencing factors of OM were analyzed using generalized estimation equations (GEEs).</p><p><strong>Results: </strong>A total of 160 patients were included in this study. The prevalence of severe OM at T0, T1, T2, T3, T4, T5, and T6 was 0, 0, 2.5%, 9.4%, 26.9%, 24.4%, and 26.9%, respectively. The prevalence of grade 1-2 OM at T0, T1, T2, T3, T4, T5, and T6 was 0, 16.3%, 53.1%, 65.1%, 61.9%, 70.7%, and 71.3%, respectively. Duration of diagnosis, clinical stage, N stage, M stage, surgery, diabetes, radiotherapy dose, oral hygiene, oral infection, oral pain, feeding route, and lymphocyte impacted OM significantly in the GEEs multivariate model.</p><p><strong>Conclusions: </strong>OM occurs in almost all patients with HNC who undergo radiotherapy. Changes in the severity of OM are a dynamic process, with the severity increasing with the cumulative radiotherapy dose. Specialist oral evaluation and oral care are needed to alleviate the severity of OM in HNC patients.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"NP257-NP269"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Typical Carcinoid Tumor of the Sphenoid Sinus: Case Report and Literature Review.","authors":"Zhe-Zheng Wang, Hong-Tao Zhen","doi":"10.1177/01455613251336890","DOIUrl":"https://doi.org/10.1177/01455613251336890","url":null,"abstract":"<p><p>Carcinoid tumors, a subset of neuroendocrine tumors, are exceptionally rare in the nose and paranasal sinuses. Owing to their indolent nature, nonspecific clinical symptoms, and variable radiological features, treatment of carcinoid tumors remains a challenge. In this report, we present a case involving a 49 year-old female patient who presented with a carcinoid tumor originating in the sphenoid sinuses. The patient underwent a surgical resection of the tumor and has been followed up in the outpatient clinic, recurrence-free. In addition, we performed an English literature search of cases of carcinoid tumor of the nose and paranasal sinuses from January 2000 through January 2024 in the MEDLINE, EMBASE, and Scopus databases. Furthermore, the clinical characteristics and interventions of carcinoid tumor of the nose and paranasal sinuses were discussed, which might enhance the early diagnosis and provide appropriate management strategies.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251336890"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Features of Otitis Media with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis and the Role of Routine Blood Tests in Its Diagnosis.","authors":"Runqin Yang, Zhuo Xu, Xingchen He, Zhihua Ge, Ying Lin, Dingjun Zha","doi":"10.1177/01455613251336864","DOIUrl":"https://doi.org/10.1177/01455613251336864","url":null,"abstract":"<p><strong>Background: </strong>To study the clinical features of otitis media with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) and its differences with other forms of ANCA-associated vasculitis (non-OMAAV) and to explore whether routine blood tests could be beneficial to diagnosing OMAAV.</p><p><strong>Methods: </strong>A retrospective study was conducted on 18 patients with OMAAV, 15 patients with non-OMAAV, and 23 patients with otitis media with effusion (OME). Basic and clinical information, laboratory data, and treatment outcomes were collected. The differences in the clinical characteristics between OMAAV and non-OMAAV patients were explored. Furthermore, the red cell distribution width (RDW), mean platelet volume (MPV), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) were compared between OME and OMAAV patients. The optimal cutoff values for the routine blood indicators were estimated via receiver operating characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>All eighteen OMAAV patients (100%) were initially misdiagnosed. Compared with non-OMAAV patients, involvement of nose, throat, and facial nerve was more common in OMAAV patients, whereas kidney damage was less common. However, neither of these differences was statistically significant. Relapse and disease-related death rates did not differ between the OMAAV and non-OMAAV groups. OMAAV patients presented with a lower MPV but a higher PLR and NLR than OME patients (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>OMAAV is often misdiagnosed as OME in elderly patients, but unlike OME, OMAAV is characterized by mixed hearing loss over its course. Low-cost routine blood tests may help otolaryngologists distinguish OMAAV from OME in the early stage. An abnormal middle ear condition with mixed hearing loss and a PLR ≥ 203.3 or NLR ≥ 4.7 may suggest a potential OMAAV diagnosis.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251336864"},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors of Pharyngocutaneous Fistula Following Primary and Salvage Total Laryngectomy.","authors":"Rania Kharrat, Moncef Sellami, Mariam Ben Ayed, Nesrine Sellami, Ghada Youssfi, Malek Mnejja, Mohamed Amin Chaabouni, Ilhem Charfeddine","doi":"10.1177/01455613251335526","DOIUrl":"https://doi.org/10.1177/01455613251335526","url":null,"abstract":"<p><strong>Objectives: </strong>Pharyngocutaneous fistula (PCF) is the most frequent complication following total laryngectomy (TL). Its incidence increases in the presence of multiple risk factors related to the patient, the tumor, and the surgical procedure. Our study aimed to determine the incidence of PCF and its risk factors.</p><p><strong>Methods: </strong>We performed a retrospective study including patients who underwent primary TL (PTL) or salvage TL (STL) between 2007 and 2023. We studied the factors that increased the risk of PCF occurrence, thar are related to the patient, the disease, and the received treatment.</p><p><strong>Results: </strong>We included 132 patients with a male-to-female ratio of 32, who received PTL (91%) or STL (9%). The tumor was staged as T4a in 62% of patients. PCF occurred in 17 patients (13%) after a median of 14 days (5-36). PCF was managed conservatively in 13 patients (76%), while a surgical re-suture was required in four patients (24%).In the univariate analysis, preoperative anemia, STL, widened forward TL, wound infection, and preoperative hypoproteinemia were significantly associated with PCF. In the multivariate analysis, preoperative anemia (<i>P</i> = .012), wound infection (<i>P</i> = .049), and STL (<i>P</i> = .005) were risk factors of PCF. At the multivariate analysis, preoperative anemia [<i>P</i> = .012, odds ratio (OR) = 6.9], wound infection (<i>P</i> = .049, OR = 6.5), and STL (<i>P</i> = .005, OR = 18.45) were independent risk factors of PCF.</p><p><strong>Conclusion: </strong>We demonstrated that preoperative anemia, wound infection, and STL were independent risk factors of PCF following TL. Avoiding these circumstances can help prevent PCF occurrence.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251335526"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasopharyngeal Adenoid Cystic Carcinoma With Extension Into the Internal Auditory Canal: A Case Report.","authors":"Taimur Khalid, Emily S Sagalow, Nathan Lloyd, Jo-Lawrence Martinez Bigcas, Javi Hartenstine, Matthew Ng","doi":"10.1177/01455613251336901","DOIUrl":"https://doi.org/10.1177/01455613251336901","url":null,"abstract":"<p><p>Adenoid cystic carcinoma (ACC) is a malignancy most commonly found in the major salivary glands. It can, however, arise from minor salivary glands throughout the upper aerodigestive tract. It is typically slow-growing and asymptomatic, though presentation varies with tumor location, pattern of infiltration, and degree of perineural invasion. ACC is characterized as an aggressive malignancy due to high rates of local recurrence and distant metastasis, with the lungs, bone, and liver commonly implicated. ACC spreading to the internal auditory canal (IAC) is highly unusual and has not been reported. We present the case of a 40 year-old male with no significant past medical history, found to have nasopharyngeal ACC that spread to the IAC resulting in multiple cranial neuropathies. The challenging location and complex path of spread along the skull base presented a significant barrier to surgery, though after completion of definitive radiation therapy, the patient experienced substantial reductions in mass effect and symptomatic relief. This report offers additional insight into the patterns of spread for ACC, emphasizing the importance of recognizing the IAC as a potential site of involvement. Early identification may significantly expedite management and prevent serious morbidities.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251336901"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extranasopharyngeal Angiofibroma in the Tongue: A Case Report With Literature Review.","authors":"Ahmad Alkheder, Abdulmajeed Yousfan","doi":"10.1177/01455613251336869","DOIUrl":"https://doi.org/10.1177/01455613251336869","url":null,"abstract":"<p><p>Angiofibroma is a rare, benign vascular tumor traditionally associated with the nasopharynx of adolescent males. In contrast, extranasopharyngeal angiofibromas (ENAs) exhibit a wider demographic distribution and may arise in diverse anatomical sites. We report a case involving a 45 year-old woman presenting with a 4 month history of a mass located on the lateral border of the anterior tongue. Complete excision under local anesthesia was performed. Histopathological analysis demonstrated a proliferation of irregular vascular channels lined by benign endothelial cells, set within a fibrovascular stroma, findings consistent with angiofibroma, and devoid of malignant features. Given that lingual involvement is exceptionally rare, this represents only the second documented case of tongue angiofibroma. The diagnostic challenge is compounded by its overlapping clinical and histological characteristics with other vascular lesions. Surgical removal proved curative, with no evidence of recurrence after 1 year of follow-up. This case underscores the importance of thorough clinicopathological correlation in establishing an accurate diagnosis and expands the recognized spectrum of ENA, reminding clinicians to include this entity in the differential diagnosis of oral soft tissue masses. Our findings significantly enhance clinical awareness and management.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251336869"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Alpha-Smooth Muscle Actin in Nasal Polyp Tissue of Chronic Rhinosinusitis Patients With and Without Aspirin Hypersensitivity.","authors":"Milica Labus, Milena Jović, Stevan Matić, Biserka Vukomanović Đurđević, Aleksandar Perić","doi":"10.1177/01455613251335470","DOIUrl":"https://doi.org/10.1177/01455613251335470","url":null,"abstract":"<p><strong>Background: </strong>Previous research has shown that myofibroblasts in the nasal/sinus mucosa are not only structural cells but also a rich source of inflammatory mediators. Thus, they influence the immune response and play an essential role in the pathogenesis of chronic rhinosinusitis with nasal polyposis. Previous research did not provide a clear answer to the question of whether the number of myofibroblasts in nasal polyps (NPs) affects the extent of sinus disease. This cross-sectional study investigates the relationship between the number of active myofibroblasts, eosinophil count, and clinical parameters in patients with NPs with and without aspirin sensitivity.</p><p><strong>Methods: </strong>Patients diagnosed with NPs, with and without aspirin sensitivity, and healthy subjects were assessed according to the severity of their symptoms as well as endoscopic and radiological findings. The quantification of myofibroblasts present in the surgically excised polyp tissue/healthy nasal mucosa was conducted based on the expression of alpha-smooth muscle actin (α-SMA) in the subepithelial and perivascular compartments. Eosinophils were counted in the subepithelium of the tissue samples from all subjects.</p><p><strong>Results: </strong>Forty-nine subjects were included: 23 NP patients without, 14 NP patients with aspirin sensitivity, and 12 control participants. The highest levels of α-SMA expression and eosinophil count were observed in NP patients with aspirin sensitivity and the lowest in healthy subjects (<i>P</i> < .001; <i>P</i> < .001, respectively). A strong correlation was noted between α-SMA expression and clinical parameters, particularly with disease extent evaluated radiologically and endoscopically.</p><p><strong>Conclusion: </strong>Our results suggest a positive correlation between the quantity of myofibroblasts and the severity of chronic inflammation in the sinonasal region. The number of myofibroblasts in the NP tissue may serve as a reliable marker for assessing the clinical status of the disease.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251335470"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Ewing Sarcoma of the Ethmoid Sinus With Intracranial Involvement: A Rare Case and Literature Review.","authors":"Ameni Amri, Rim Braham, Salma Kamoun, Omar Feki, Alia Methnani, Mohamed Dhaha, Souheil Jbali, Sawssen Dhambri, Skander Kedous","doi":"10.1177/01455613251333184","DOIUrl":"https://doi.org/10.1177/01455613251333184","url":null,"abstract":"<p><p>Ewing sarcoma (ES) is a rare and highly-aggressive tumor. This malignancy derives from primitive neuroectodermal cells. The most frequently-affected population is adolescents and young adults, and the tumor typically grows in the bones. ES of the sinonasal tract is an exceedingly-rare situation. Particularly, primary occurrence in the ethmoid sinus is extremely scarce, with only 27 cases documented worldwide. Extension to the anterior cranial fossa is even thinner on the ground with limited cases in literature. We report the case of a 20-year-old female with history of Hodgkin disease presenting with facial pain, anosmia, and visual impairment on the right side. Imaging revealed a large invasive tumor originating from the right ethmoid sinus, with extension into the orbit and anterior cranial fossa. On biopsy, the tumor showed focal expression of Epithelial membrane antigen (EMA) and CD99 and EWSR1 rearrangement. The diagnosis of ES was confirmed. The patient underwent neoadjuvant chemotherapy with etoposide. Given the stability of the tumor, the patient was deemed inoperable. The decision was to proceed with chemoradiotherapy. Unfortunately, the patient passed away during treatment due to intracranial hypertension with seizures 12 months after diagnosis. This case underscores the rarity of sinonasal ES, particularly with primary involvement in the ethmoid sinus with anterior cranial fossa invasion. We conducted an exhaustive review of literature on similar cases to highlight the importance of a multidisciplinary approach combining advanced imaging, molecular diagnostics, chemotherapy, surgical intervention, and radiotherapy to optimize patients' survival. Sinonasal ES, especially in the ethmoid sinus with cranial extension, is a rare and challenging situation. Detection at an early stage through meticulous imaging, immunohistochemistry, and molecular biology tools is crucial to initiate a multimodal treatment approach. Through this case report and literature review, we aimed to contribute to the growing literature on rare sinonasal malignancies.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251333184"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a Multimodal Treatment of Auricular Keloids on the Patient's Health-Related Quality of Life: A Prospective Study.","authors":"Alexander Helmer, Marcio Cantillo, Lena Zaubitzer, Benedikt Kramer, Nicole Rottery, Haneen Sadick, Daniel Haeussler","doi":"10.1177/01455613251333673","DOIUrl":"https://doi.org/10.1177/01455613251333673","url":null,"abstract":"<p><strong>Introduction: </strong>Auricular keloids may be associated with social stigma and impair patients' quality of life (QoL) significantly. Little is known about the effect of different therapeutic concepts on the patient's QoL. This study aims to investigate the QoL in patients with auricular keloids undergoing a specific multimodal therapeutic regimen.</p><p><strong>Materials and methods: </strong>Patients suffering from auricular keloids were treated by a multimodal treatment comprising surgical excision, intralesional triamcinolone acetonide, and subsequent application of customized magnetic pressure splints. A prospective assessment of QoL was conducted using the validated Keloid Intervention Benefit Inventory-21 questionnaire at three time points.</p><p><strong>Results: </strong>In total, 22 auricular keloids were included in our study. All patients completed a comprehensive 1-year follow-up assessment, with an average follow-up duration of 29 months post-surgery. Quantitative analysis of QoL metrics demonstrated significant improvement of QoL at the three times of measurement (<i>P</i> < .0001). Significant results were also found for the subcategories general health, physical health, social interaction, and self-esteem.</p><p><strong>Conclusion: </strong>This study underscores the necessity of assessment of QoL in keloid treatment. Our findings highlight the advantages of multimodal treatment in enhancing patients' QoL throughout the treatment period and managing auricular keloids with low recurrence.</p><p><strong>Trial registration: </strong>The study was registered at the German Clinical Trials Register (Register ID: DRKS00016348, https://drks.de/search/en/trial/DRKS00016348).</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251333673"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}