Mohammad Hamdi, Ahmad Alkheder, Kinana Jamal Hammoud, Mohammad Yasin Issa, Yasser ALGhabra, Abdulmajeed Yousfan
{"title":"Novel Otolaryngological and Radiological Manifestations in GAPO Syndrome.","authors":"Mohammad Hamdi, Ahmad Alkheder, Kinana Jamal Hammoud, Mohammad Yasin Issa, Yasser ALGhabra, Abdulmajeed Yousfan","doi":"10.1177/01455613241307753","DOIUrl":"https://doi.org/10.1177/01455613241307753","url":null,"abstract":"<p><p>GAPO syndrome is an exceptionally-rare autosomal recessive disorder characterized by growth retardation, alopecia, pseudoanodontia, and optic abnormalities, with fewer than 60 cases reported globally. We present the first documented case in Syria, highlighting novel otolaryngological and radiological findings that expand the clinical spectrum of this syndrome. A 27-year-old male presented with chronic right-sided otalgia, unilateral conductive hearing loss, and persistent sinonasal symptoms. Examination revealed hallmark features of GAPO syndrome, including craniofacial anomalies, external auditory canal stenosis, and pseudoanodontia. Computed tomography demonstrated total aplasia of the paranasal sinuses and mastoid air cells-findings not previously reported in GAPO syndrome. Audiological evaluation revealed moderate conductive hearing loss attributed to external auditory canal stenosis and eustachian tube dysfunction, contrasting with the predominantly-sensorineural hearing loss reported in earlier cases. Additionally, unique ophthalmic findings, including peripheral congenital cataracts and a myelinated retinal nerve fiber layer, were observed. This case underscores the importance of comprehensive evaluations, including advanced imaging and audiological assessments, in identifying subtle or atypical manifestations of GAPO syndrome. It also highlights challenges in airway management due to craniofacial anomalies. The findings emphasize the necessity for a multidisciplinary approach to optimize care and improve outcomes in patients with GAPO. Further research is needed to clarify genotype-phenotype correlations and refine diagnostic criteria.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613241307753"},"PeriodicalIF":0.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saruchi Bandargal, Daniel J Lee, Tanya Chen, Olivia Katsnelson, Teruko Kishibe, Christine Song, R Jun Lin, Yvonne Chan
{"title":"Therapeutic Potential of Intranasal Corticosteroids for Chronic Cough.","authors":"Saruchi Bandargal, Daniel J Lee, Tanya Chen, Olivia Katsnelson, Teruko Kishibe, Christine Song, R Jun Lin, Yvonne Chan","doi":"10.1177/01455613241307552","DOIUrl":"https://doi.org/10.1177/01455613241307552","url":null,"abstract":"<p><p><b>Background:</b> Chronic cough, a condition defined as a cough persisting for more than 8 weeks, remains a significant clinical challenge with a considerable impact on quality of life. Intranasal corticosteroids (INCS) are widely recommended in clinical guidelines for managing chronic cough, particularly in patients with associated upper airway conditions. However, the evidence base directly supporting this practice is surprisingly sparse, leaving clinicians to navigate a disconnect between guidelines and real-world applicability. <b>Objective:</b> This article offers a critical perspective on the role of INCS in chronic cough management, drawing attention to the paucity of direct evidence and proposing a roadmap for future research. <b>Discussion:</b> A recent systematic review aiming to evaluate the efficacy and safety of INCS for chronic cough yielded no eligible studies, despite extensive database searches. This unexpected outcome highlights a major gap in the literature and raises important questions about the foundation of current guideline recommendations. While INCS are biologically plausible and have demonstrated efficacy in related conditions, such as allergic rhinitis and chronic rhinosinusitis, their specific role in chronic cough remains unverified. The lack of robust clinical trials underscores the need for targeted research to determine whether INCS provide meaningful benefit in this population. <b>Conclusion:</b> The disconnect between recommendations and evidence in chronic cough management underscores a critical need for well-designed randomized controlled trials. Until such data are available, clinicians must balance existing guidelines with clinical judgment, individualizing treatment to address the unique needs of their patients. Bridging this evidence gap will not only enhance patient care but also refine guideline development, ensuring recommendations are firmly grounded in high-quality research.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613241307552"},"PeriodicalIF":0.0,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corrigendum to \"Psychopathologic Evaluation in Patients With Nasal Bone Fractures\".","authors":"","doi":"10.1177/01455613241309462","DOIUrl":"https://doi.org/10.1177/01455613241309462","url":null,"abstract":"","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613241309462"},"PeriodicalIF":0.0,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erica McArdle, Melissa Cummins, Sameer Shetty, Rafka Chaiban, Hassan H Ramadan, Chadi A Makary
{"title":"The Association Between Obesity and the Unified Airway in Children.","authors":"Erica McArdle, Melissa Cummins, Sameer Shetty, Rafka Chaiban, Hassan H Ramadan, Chadi A Makary","doi":"10.1177/01455613241307679","DOIUrl":"https://doi.org/10.1177/01455613241307679","url":null,"abstract":"<p><p><b>Introduction:</b> Chronic rhinosinusitis (CRS) and asthma frequently coexhist in children leading to the unified airway theory. Although obesity has been associated with CRS and asthma in adults, studies exploring that association in children are limited. The goal of this study was to evaluate the association between obesity and the unified airway in children. <b>Methods:</b> A retrospective case-control study was performed in children aged 2 to 18 years presenting to our clinic between July 2020 and February 2024. Patient's demographics and comorbidities were reviewed. Children's obesity was classified based on their percentile body mass index of 95% and more. Asthma and CRS diagnoses were determined based on published guidelines. <b>Results:</b> A total of 406 pediatric patients met criteria, with 130 children (32%) with obesity. Children with CRS had a mean computed tomography (CT) Lund-Mackay score of 7.2 (SD of 6.3) and a mean endoscopy modified Lund-Kennedy score of 2.7 (SD of 2.9). Children with obesity were older (11.3 years vs 10.2 years, <i>P</i> = .039) and more likely to have asthma (28.5% vs 15.2%, <i>P</i> = .002) and obstructive sleep apnea (26.2% vs 13%, <i>P</i> = .001). Multivariate logistic regression showed an association between obesity and asthma (OR = 1.84, <i>P</i> = .029), but not with CRS (OR = 1.08, <i>P</i> = .856) or allergic rhinitis (OR = 1.05, <i>P</i> = .856). <b>Conclusion:</b> This study suggests an association between obesity and asthma but not with CRS in children. Further studies should explore whether there is any role for obesity in the treatment of CRS.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613241307679"},"PeriodicalIF":0.0,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Using the Glottic Angle and Area in Cases of Bilateral Vocal Fold Paralysis.","authors":"Tzu-Ying Chen, Hsing-Won Wang","doi":"10.1177/01455613241306961","DOIUrl":"https://doi.org/10.1177/01455613241306961","url":null,"abstract":"<p><p><b>Objective:</b> Establish, through the determination of the glottic angle and area, a decision regarding safe and necessary interventions in bilateral vocal fold paralysis to maintain airway. <b>Methods:</b> From January 2008 to December 2023, we looked back at laryngoscopic photographs of subjects with bilateral vocal fold paralysis. The average vocal fold length for each gender was used to calculate the glottic areas and measure the corresponding glottic angles in a total of 26 cases. In order to determine the angles between the anterior commissure and each vocal process, 2 clinicians separately measured the lines and took their average measurement. The average vocal cord length by gender in the Taiwanese data was used to compute the glottic area. <b>Results:</b> The results showed the average glottic angle was 10.3° ± 7.3°. The intervention group (N = 17) had an average glottic angle of 7.1° ± 3.7°. The nonintervention group (N = 9) had an average glottic angle of 16.3° ± 8.9°. The average glottic area was 18.7 ± 10.2 mm<sup>2</sup>, with 14.2 ± 7.5 mm<sup>2</sup> in the intervention group and 27.2 ± 9. 4 mm<sup>2</sup> in the nonintervention group. <b>Conclusion:</b> We concluded that emergent airway intervention including intubation or tracheostomy was suggested when the glottic angle <12.2° or glottic area <25.2 mm<sup>2</sup>.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613241306961"},"PeriodicalIF":0.0,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dean M Clerico, Antoine Khoudary, Shravan Asthana, Jordon Wagner, Benjamin Keiser
{"title":"Prevalence of Mucosal Contact and Correlation with Migraine: The Predominance of the Superior Turbinate.","authors":"Dean M Clerico, Antoine Khoudary, Shravan Asthana, Jordon Wagner, Benjamin Keiser","doi":"10.1177/01455613241306953","DOIUrl":"https://doi.org/10.1177/01455613241306953","url":null,"abstract":"<p><p><b>Background:</b> Mucosal contact between the turbinates and septum is implicated as a cause of headache and migraine. The prevalence of mucosal contact is reported to be as low as 4%. However, the inclusion criteria in that study were restrictive, and no data on the superior turbinate were reported. We sought to determine the prevalence of mucosal contact on nasal endoscopy and its association with migraine. <b>Methods:</b> A cohort study of 355 subjects was conducted. All patients underwent nasal endoscopy and were queried as to migraine history. The prevalence of mucosal contact in the migraine cohort was compared to that in the non-migraine cohort, and the prevalence of migraine in the contact cohort was compared to that in the non-contact group. The frequency of mucosal contact at each turbinate involved was noted. <b>Results:</b> The overall prevalence of mucosal contact was 49.3% (175/355). The superior turbinate was most frequently involved (34.9%: 124/355), followed by the inferior turbinate (14.6%; 52/355), the middle turbinate (14.1%: 50/355), and multiple turbinate involvement (13.5%; 48/355). Migraine history was elicited in 31.8% of subjects (113/355); 52% (91/175) of patients with mucosal contact reported migraine history; 65.3% (81/124) with superior turbinate contact, 50% (25/50) with middle turbinate contact, and 21.1% (12/52) with inferior turbinate contact; 80.5% (91/113) of patients with migraine demonstrated mucosal contact; 71.7% (81/113) with superior turbinate contact, 22.1% (25/113) with middle turbinate contact, and 10.6% (12/113) with inferior turbinate contact. Multivariate analysis demonstrated that superior and middle turbinate contact were associated with migraine (<i>P</i> < .001 and <i>P</i> = .034, respectively), but inferior turbinate contact was not (<i>P</i> = .272). <b>Conclusion:</b> Mucosal contact is much more prevalent than previously reported and is associated with migraine, especially at the superior turbinate level.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613241306953"},"PeriodicalIF":0.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Characteristics and Prognosis of Acute Hearing Loss in Military Personnel.","authors":"Ting-Li Hung, Chih-Hung Wang, Shu-Chu Cheng, Hsin-Chien Chen","doi":"10.1177/01455613241305983","DOIUrl":"https://doi.org/10.1177/01455613241305983","url":null,"abstract":"<p><p><b>Introduction:</b> The military population is one of the high-risk groups for acute hearing loss. This retrospective study aims to examine acute acoustic trauma (AAT) and idiopathic sudden sensorineural hearing loss (ISSNHL) among military personnel. <b>Materials and Methods:</b> A total of 111 cases of acute hearing loss from a tertiary hospital between 2009 and 2021 were divided into AAT (53 cases) and ISSNHL (58 cases) groups. The time interval between trauma and treatment initiation, accompanying symptoms, and hearing thresholds before and after treatment were examined for all cases. <b>Results:</b> Two-thirds of the AAT group participants experienced damage to the left ear, and all individuals in this group presented with tinnitus at the time of trauma, but vertigo was less common in the AAT group than in the ISSNHL group. Hearing improvement after treatment was significant in both groups. An intergroup comparison of post-treatment hearing recovery revealed that prognosis was primarily determined by the initial severity of hearing loss rather than the underlying condition of AAT or ISSNHL. <b>Conclusions:</b> This finding emphasizes the importance of prompt and aggressive treatment in severe cases and the need for tailored strategies within military healthcare systems to improve hearing outcomes.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613241305983"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reconstruction Using a Bilobed Flap in a Patient With Recurrent Neck Soft Tissue Metastasis From Oral Cancer: A Case Report.","authors":"Jiun-Yi Wu, Li-Jen Liao, Po-Wen Cheng, Wu-Chia Lo","doi":"10.1177/01455613241306018","DOIUrl":"https://doi.org/10.1177/01455613241306018","url":null,"abstract":"<p><p>Soft tissue defects in the head and neck are frequently encountered, often resulting from trauma or the surgical management of malignancies. Flap reconstruction plays a critical role in the closure of these defects, aiming to minimize complications and improve cosmetic outcomes. While various flap techniques are commonly utilized in head and neck reconstruction, to the best of our knowledge, the bilobed flap has not been previously reported in this anatomical region. We present a case involving a patient with a complex underlying medical condition, which elevated the risks associated with prolonged anesthesia. In light of these considerations, we opted to use a bilobed flap, which was successfully employed for the reconstruction of an intermediate-sized soft tissue defect in the right submental area following resection of recurrent oral cancer. After undergoing multiple surgeries and concurrent chemoradiotherapy, the 65-year-old male patient developed significant neck stiffness, making direct closure unfeasible and traditional local flap techniques ineffective for wound management. The bilobed flap was meticulously planned, with the first lobe positioned over the adjacent site of the right submental defect and the second lobe located next to the first lobe, employing a double transposition design. The flap healed without complications, and the patient experienced a good recovery. This case report underscores the effectiveness of bilobed flaps in reconstructing moderate-sized soft tissue defects in patients with recurrent neck metastatic oral cancer after previous neck dissection and concurrent chemoradiotherapy.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613241306018"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmad Alkheder, Nasser Alia, Muhammad Abbas, Abdulrahman Shubat, Ghina Aljammal
{"title":"Subcutaneous Emphysema as a Complication of Tonsillectomy: Comprehensive Literature Review.","authors":"Ahmad Alkheder, Nasser Alia, Muhammad Abbas, Abdulrahman Shubat, Ghina Aljammal","doi":"10.1177/01455613241305602","DOIUrl":"https://doi.org/10.1177/01455613241305602","url":null,"abstract":"<p><p>Subcutaneous emphysema is a rare but potentially-serious complication of tonsillectomy. This case report presents a 14-year-old male who developed subcutaneous emphysema following tonsillectomy. A comprehensive literature review was conducted to identify and analyze cases of emphysema following tonsillectomy. The review revealed a diverse range of clinical presentations, from mild neck swelling to severe respiratory distress. Most cases resolved spontaneously with conservative management, but a small subset required surgical intervention. Early recognition, prompt evaluation, and appropriate management are essential to prevent complications and ensure favorable outcomes. This case highlights the importance of considering subcutaneous emphysema as a differential diagnosis in patients presenting with neck swelling or respiratory symptoms following tonsillectomy.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613241305602"},"PeriodicalIF":0.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}