{"title":"Comment on \"The Relationship Between Tumor Size and Electrocardiographic Findings in Carotid Body Paragangliomas: A Retrospective Observational Study\".","authors":"Shyam Sundar Sah, Abhishek Kumbhalwar","doi":"10.1177/01455613251386786","DOIUrl":"https://doi.org/10.1177/01455613251386786","url":null,"abstract":"","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251386786"},"PeriodicalIF":0.7,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of Olfactory Training on Olfactory and Cognitive Function: A Systematic Review.","authors":"Yangzi Tan, Xiangxian Liu, Yankun Li, Xiaolu Liu, Yali Du, Danhua Zhao, Dawei Wu","doi":"10.1177/01455613251384121","DOIUrl":"https://doi.org/10.1177/01455613251384121","url":null,"abstract":"<p><strong>Background: </strong>Olfactory training (OT) interventions exhibit dual therapeutic potential, enhancing both chemosensory function and multiple cognitive domains through neuroplastic mechanisms.</p><p><strong>Objective: </strong>To systematically review the efficacy of OT on olfaction, cognition, and neuroimaging changes across a range of populations, from healthy adults to patients with olfactory and cognitive impairments.</p><p><strong>Methods: </strong>A systematic review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search of PubMed, Embase, Web of Science, and Cochrane databases performed to identify studies that evaluate the effect of OT on olfaction and cognition in different populations, focusing on its potential to enhance cognition and mitigate the progression of cognitive decline.</p><p><strong>Results: </strong>Of the initial 412 abstracts reviewed, 24 full-text articles were included. Risk-of-bias assessment revealed 7/12 randomized controlled studies (RCTs) had high risk and 11/12 non-RCTs had serious bias. The duration of OT interventions mostly ranged from 3 to 6 months. In healthy adults (6 studies) and adults with olfactory dysfunction (13 studies), OT improved olfactory function in a population-dependent manner and exerted domain-specific cognitive benefits. Meta-analysis revealed that the pooled proportion of individuals achieving a clinically-significant olfactory improvement was 27.01% (95% confidence interval, 0.16-0.40). Improvements were observed in global cognition, verbal fluency, and working memory. In adults with cognitive impairment (5 studies), classical OT showed limited olfactory and cognitive improvements; however, intensive OT with enriched odors, longer sessions, and greater adherence demonstrated potential for enhanced cognitive and emotional outcomes in patients with dementia. Furthermore, the reviewed neuroimaging studies consistently demonstrate that OT can increase volumes in several brain regions and promote neuronal reorganization, providing a potential mechanism of OT in olfactory recovery and cognitive improvement.</p><p><strong>Conclusions: </strong>OT effectively improves olfaction, cognition, and brain health, particularly in cognitively-normal populations.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251384121"},"PeriodicalIF":0.7,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frank Rizzuto, Abdul Khan, Jagan D Gupta, Neel D Gupta, Triet M Do, Enrique Palacios
{"title":"Septic Arthritis and Abscess of the Temporomandibular Joint.","authors":"Frank Rizzuto, Abdul Khan, Jagan D Gupta, Neel D Gupta, Triet M Do, Enrique Palacios","doi":"10.1177/01455613251383282","DOIUrl":"https://doi.org/10.1177/01455613251383282","url":null,"abstract":"","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251383282"},"PeriodicalIF":0.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David M Yen, Greg E Davis, Randall A Ow, Ellen M O'Malley, Anthony G Del Signore
{"title":"Two-Year Clinical Outcomes After Multipoint Impedance-Controlled Radiofrequency Ablation of the Posterior Nasal Nerve for Treatment of Chronic Rhinitis.","authors":"David M Yen, Greg E Davis, Randall A Ow, Ellen M O'Malley, Anthony G Del Signore","doi":"10.1177/01455613251382759","DOIUrl":"https://doi.org/10.1177/01455613251382759","url":null,"abstract":"<p><strong>Objective: </strong>A person's quality of life can be deeply impacted by chronic rhinitis. We report 2-year outcomes in patients after treatment using a novel, multipoint, impedance-controlled, radiofrequency ablation device.</p><p><strong>Methods: </strong>A prospective, multicenter, single-arm clinical study of posterior nasal nerve ablation in adults with chronic rhinitis. Efficacy assessments included the reflective total nasal symptom score (rTNSS), postnasal drip, cough, Eustachian Tube Dysfunction Questionnaire-7 (ETDQ-7), nasal obstruction symptom evaluation (NOSE), and mini-Rhinoconjunctivitis Quality of Life Questionnaire (mini-RQLQ).</p><p><strong>Results: </strong>Seventy-five of 80 (94%) participants completed 2-year follow-up. Statistically significant improvements were observed in rhinitis symptoms, postnasal drip, cough, ear symptoms, and quality of life as evidenced by the mean change in rTNSS (-4.3), postnasal drip (-0.9), cough (-0.7), ETDQ-7 (-1.1), NOSE (-31.7), and mini-RQLQ (-1.7; <i>P</i> < .0001 for all). Allergic and nonallergic rhinitis subgroups demonstrated similar, significant improvement. No serious related adverse events were reported between the 9-month and 2-year follow-ups.</p><p><strong>Conclusions: </strong>The data demonstrate consistent long-term efficacy and safety of a multipoint, impedance-controlled, radiofrequency ablation device for the treatment of chronic rhinitis. Significant improvements were observed in rhinitis symptoms, postnasal drip, cough, ear symptoms, and quality of life through 2-year follow-up.</p><p><strong>Study registration: </strong>www.</p><p><strong>Clinicaltrials: </strong>gov. Unique identifier NCT05591989.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251382759"},"PeriodicalIF":0.7,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparing the Outcomes of Tracheostomy in COVID-19 and Non-COVID-19 Patients.","authors":"Atiporn Kittipattana, Phawin Keskool, Vannipa Vathanophas, Paiboon Sureepong, Sarunya Thipphayarom","doi":"10.1177/01455613251382742","DOIUrl":"https://doi.org/10.1177/01455613251382742","url":null,"abstract":"<p><strong>Objective: </strong>To assess and compare tracheostomy outcomes between COVID-19 patients and non-COVID-19 patients.</p><p><strong>Materials and methods: </strong>This retrospective and prospective cohort study included patients over 18 years of age who underwent tracheostomy at a tertiary care hospital. We divided patients into 2 groups: 41 with COVID-19 and 156 without COVID-19. Primary outcomes were successful tracheostomy tube downsizing and removal, ventilator weaning, length of hospital stay, and mortality rate. Statistical analyses compared outcomes between groups.</p><p><strong>Results: </strong>COVID-19 patients achieved higher rates of successful tracheostomy tube downsizing (54.2% vs 9.6%, <i>P</i> < .001) and removal (36.6% vs 7.1%, <i>P</i> = .05) than non-COVID-19 patients. Mortality was lower in COVID-19 patients (29.3% vs 40.4%), although ventilator liberation rates were similar (<i>P</i> = .346). COVID-19 patients had longer hospital stays (64 vs 56 days); however, this difference was not statistically significant. We observed no significant differences in postoperative or long-term complications between groups. COVID-19 infection and age ≤60 years were factors associated with accelerated decannulation. COVID-19 patients demonstrated significantly higher rates of invasive pulmonary aspergillosis (<i>P</i> < .001).</p><p><strong>Conclusions: </strong>Despite lower mortality, COVID-19 patients achieved higher rates of tracheostomy tube downsizing and decannulation than non-COVID-19 patients. Ventilator liberation, hospital stay duration, and complication rates remained similar between groups.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251382742"},"PeriodicalIF":0.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Orbital Complications of Acute Sinusitis in Pediatrics: A Narrative Review.","authors":"Hannah G Luk, Austin S Rose","doi":"10.1177/01455613251366039","DOIUrl":"https://doi.org/10.1177/01455613251366039","url":null,"abstract":"<p><strong>Background: </strong>Orbital complications of acute pediatric rhinosinusitis, such as subperiosteal and orbital abscess, meningitis, and intracranial extension, represent time-sensitive conditions requiring prompt diagnosis and management. Improved understanding of the anatomic, microbiologic, and clinical factors contributing to these complications is essential for optimizing outcomes.</p><p><strong>Methods: </strong>This review synthesizes current literature on the diagnosis and management of orbital complications in pediatric acute sinusitis, with emphasis on risk stratification, imaging indications, and surgical decision-making. Two representative case studies are included to illustrate diagnostic and therapeutic considerations.</p><p><strong>Results: </strong>While pediatric patients may improve with medical therapy alone, abscess formation or progressive complications despite antibiotics often necessitate surgical intervention. Clinical presentation, ophthalmologic examination findings, and abscess characteristics are critical in risk stratification and determinants for surgical management.</p><p><strong>Conclusion: </strong>A high likelihood of suspicion of an underlying sinus disease is warranted when evaluating children with periorbital redness and swelling. Monitoring and further evaluation with imaging are critical to prevent acute rhinosinusitis with orbital complications and vision-threatening sequelae.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251366039"},"PeriodicalIF":0.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Salena Ringenbach, Shriya Airen, Jarrod Keeler, Ravi Samy, Chetan Nayak, Jason F Ohlstein
{"title":"A Comprehensive Review of the PENTOCLO Protocol and Its Applications in the Head and Neck.","authors":"Salena Ringenbach, Shriya Airen, Jarrod Keeler, Ravi Samy, Chetan Nayak, Jason F Ohlstein","doi":"10.1177/01455613251381176","DOIUrl":"https://doi.org/10.1177/01455613251381176","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical use of pentoxifylline and tocopherol (PENTO), with or without clodronate (PENTOCLO), in the treatment and prevention of osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ).</p><p><strong>Methods: </strong>A literature review was conducted using PubMed from database inception to May 2025. Studies were included if they evaluated PENTO or PENTOCLO for the treatment or prevention of ORN or MRONJ. Only human studies with full-text availability were included. Data extracted included patient population, intervention details, duration, co-interventions, outcomes, and adverse events.</p><p><strong>Results: </strong>Twenty-two studies met inclusion criteria, comprising randomized trials, prospective cohorts, and retrospective case series. In ORN treatment, PENTO/PENTOCLO achieved complete healing in 54% to 100% of patients, with improved symptoms and reduced need for surgery. The addition of clodronate (PENTOCLO) showed mixed results, with 1 large cohort suggesting no additional benefit over PENTO alone. PENTO prophylaxis before dental extractions in irradiated patients resulted in low ORN incidence (0%-5%). In MRONJ, PENTO improved pain, radiographic healing, and mucosal coverage; the only RCT showed significantly-lower relapse rates after surgery with adjunctive PENTO. Across all studies, adverse effects were minimal.</p><p><strong>Conclusion: </strong>PENTO is an effective and well-tolerated therapy for ORN and MRONJ, with emerging evidence supporting its use in prevention protocols. While PENTOCLO may benefit select ORN cases, further trials are needed to define optimal regimens. PENTO offers a noninvasive, accessible alternative to surgery and hyperbaric oxygen therapy.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251381176"},"PeriodicalIF":0.7,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Observation of the Therapeutic Effect of Aspiration Combined With Magnet Compression in the Treatment of Auricular Pseudocyst.","authors":"Yubin Lai, Xingchen He, Feng Wang, Linbo Dai, Jian Wang, Yu Han, Dingjun Zha, Xiaodong Chen","doi":"10.1177/01455613251381196","DOIUrl":"https://doi.org/10.1177/01455613251381196","url":null,"abstract":"<p><strong>Background: </strong>To summarize the therapeutic effect of aspiration combined with magnet compression in the treatment of auricular pseudocyst and to explore a simple and effective treatment regimen for auricular pseudocyst.</p><p><strong>Methods: </strong>The clinical data of 45 patients with auricular pseudocysts treated in the outpatient department from March 2019 to May 2021 were retrospectively analyzed. Treatment outcomes were categorized into cure, excellence, and invalid to evaluate the therapeutic effect. The visual analog scale (VAS) was used to assess patients' satisfaction with the treatment.</p><p><strong>Results: </strong>After treatment with aspiration combined with magnet compression, 31 cases (68.9%) were cured, 8 cases (17.8%) demonstrated excellence, and 6 cases were invalid. The VAS score ranged from 2 to 8 points with a mean value of 7.3 points.</p><p><strong>Conclusions: </strong>The treatment that aspiration combined with magnet compression shows significant advantages. It can be considered as the first choice for patients with good local skin conditions during their initial visit, especially in primary hospitals lacking surgical facilities or where access to medical care is difficult.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251381196"},"PeriodicalIF":0.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}