Jihène Houas, Mouna Belakhdher, Ghada Grassi, Taghrid Tlili, Monia Ghammam
{"title":"Cervical Thymopharyngeal Duct Cyst Mimicking a Thyroid Nodule in an Adult: A Rare Case Report.","authors":"Jihène Houas, Mouna Belakhdher, Ghada Grassi, Taghrid Tlili, Monia Ghammam","doi":"10.1177/01455613251343728","DOIUrl":"https://doi.org/10.1177/01455613251343728","url":null,"abstract":"<p><p>Thymopharyngeal duct cysts are rare congenital lesions resulting from the persistence of the embryonic thymopharyngeal tract, typically presenting in pediatric populations. Adult cases are exceedingly uncommon and often misdiagnosed due to their rarity and nonspecific clinical features. We report the case of a 34-year-old woman who presented with a slowly-enlarging, painless left cervical mass initially suggestive of a thyroid pathology. Imaging revealed a well-defined cystic lesion at the lower pole of the thyroid gland. Surgical excision via a low cervicotomy was performed, and a left lobo-isthmectomy was carried out due to the lesion's adherence to the thyroid. Final histopathological analysis confirmed a thymopharyngeal duct cyst. This case underscores the diagnostic challenges of lateral neck cysts in adults and highlights the importance of considering rare embryologic anomalies in the differential diagnosis, particularly when lesions mimic more common thyroid or branchial cleft pathologies.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251343728"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gene Therapy for Congenital Hearing Loss: Are You Ready to Anticipate the Genetic Tests?","authors":"Andrea Migliorelli, Andrea Ciorba","doi":"10.1177/01455613251346613","DOIUrl":"https://doi.org/10.1177/01455613251346613","url":null,"abstract":"","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251346613"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on \"Patient-Specific Factors to Differentiate Between Branchial Cleft Cysts and CUP Syndrome: A 10 Year Unicenter Study\".","authors":"Renu Sah, Ankita Mathur","doi":"10.1177/01455613251346604","DOIUrl":"https://doi.org/10.1177/01455613251346604","url":null,"abstract":"","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251346604"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Low-Temperature Plasma Radiofrequency Ablation for Congenital Epiglottic Cysts.","authors":"Hao Cai, Jinjian Gao","doi":"10.1177/01455613241259368","DOIUrl":"10.1177/01455613241259368","url":null,"abstract":"<p><p><b>Objectives:</b> Congenital epiglottic cysts are rare disorders of the larynx with symptoms such as laryngeal stridor and inspiratory dyspnea and are life-threatening in severe cases. This study aimed to investigate the usefulness of low-temperature plasma radiofrequency ablation for congenital epiglottic cysts and provide a reference for clinicians to develop treatment options. <b>Methods:</b> The clinical data of children (n = 7, 4 males and 3 females) with congenital epiglottic cysts, who were admitted to the Second Affiliated Hospital of Wenzhou Medical University and Yuying Children's Hospital from March 2018 to March 2023, were analyzed retrospectively. Following preoperative examinations, all patients underwent low-temperature plasma radiofrequency ablation under general anesthesia, and the curative effect was evaluated. Following surgery, regular patient follow-up examinations were conducted to monitor recurrence. <b>Results:</b> The age at the time of operation ranged from 1 day to 99 days, with an average of 37.57 ± 35.01 days. The surgical procedure was successfully completed in all the children; dyspnea disappeared and no surgical complications were observed. In addition, during the postoperative follow-up period of 6 months to 5 years, recurrence was not observed. <b>Conclusions:</b> Low-temperature plasma radiofrequency ablation is a safe and effective procedure for treating congenital epiglottic cysts and deserves clinical application and promotion.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"351-354"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141201600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case Report on the Short-Term Recurrence of Low-Grade Fibromyxoid Sarcoma in the Maxillary Sinus.","authors":"Dan Zhao, Jian Dai, Yu Hu, Tao Wang","doi":"10.1177/01455613241276673","DOIUrl":"10.1177/01455613241276673","url":null,"abstract":"<p><p>Low-grade fibromyxoid sarcoma (LGFMS) represents an exceptionally rare soft-tissue tumor, challenging to diagnose, and notorious for relentless recurrence and proliferation postsurgical resection. Primary symptoms of LGFMS include nasal congestion and rhinorrhea, accompanied by cheek numbness and distension. In this article, we report the diagnosis and treatment of a case of low-grade LGFMS originating in the maxillary sinus (MS). A 64-year-old male diagnosed with LGFMS of the left MS, undergoing 3 surgeries over a 1-year period with subsequent local recurrence. Following inconclusive postoperative pathology after the initial surgery, the patient experienced recurrence 2 months postsurgery, necessitating a second operation, which confirmed the LGFMS diagnosis pathologically. Radiation therapy commenced 1 month after the second surgery; however, recurrence transpired 6 months later, leading to a third operation. Subsequently, recurrence occurred again 8 months post third surgery, with the patient currently undergoing targeted therapy. This case underscores the distinct characteristics and therapeutic challenges inherent in LGFMS through the narrative of diagnosis and progression of LGFMS originating in the MS.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"346-350"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Papillary Thyroid Microcarcinoma Revealed by Contralateral Cystic Metastasis Mimicking a Branchial Cleft Cyst.","authors":"Chiraz Halwani, Anas Ammar, Salma Elbessi, Karima Tlili, Khemaies Akkari, Sonia Esseghaier","doi":"10.1177/01455613251343725","DOIUrl":"https://doi.org/10.1177/01455613251343725","url":null,"abstract":"<p><strong>Introduction: </strong>Papillary thyroid microcarcinomas (PTMC) can exhibit invasive behavior with lymph node metastasis despite their small size. In some cases, they may present as cystic lymph node metastases, clinically and radiologically mimicking benign lesions such as branchial cleft cysts. These misleading presentations may delay the diagnosis of an underlying thyroid malignancy. We report a rare and atypical presentation of PTMC as a large contralateral cystic lymph node metastasis initially diagnosed as a branchial cleft cyst, highlighting the need to consider metastatic thyroid carcinoma in the differential diagnosis of lateral neck cysts.</p><p><strong>Observation: </strong>A 51-year-old woman presented with a left lateral cervical mass diagnosed as a second branchial cleft cyst. Surgical excision and histology revealed a metastatic lymph node from papillary thyroid carcinoma. Subsequent workup identified a 4 mm PTMC in the right thyroid lobe. The patient underwent total thyroidectomy, lymph node dissection, and radioactive iodine therapy.</p><p><strong>Conclusion: </strong>PTMC may behave aggressively and present with misleading cystic nodal metastases. Clinicians should include metastatic papillary thyroid carcinoma in the differential diagnosis of isolated cystic neck masses, even in the absence of an identifiable thyroid lesion on initial imaging.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251343725"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Unusually-Large Adult Rhabdomyoma of the Larynx in an Elderly Female: A Rare Case of Airway Obstruction and Diagnostic Challenges.","authors":"Ambuj Bhalla, Sidney Stewart","doi":"10.1177/01455613251344025","DOIUrl":"https://doi.org/10.1177/01455613251344025","url":null,"abstract":"<p><p>Adult rhabdomyoma is a rare benign tumor of striated muscle origin, predominantly occurring in the head and neck region of middle-aged males. Herein, we present a unique case of a 78 year-old woman with a 7.3 × 3.8 × 5.4 cm supraglottic rhabdomyoma causing progressive dysphagia, dysphonia, and life-threatening airway obstruction over 5 to 7 years. Despite its benign histology, the tumor's size and location necessitated emergent airway stabilization and partial resection. This report highlights the tumor's atypical presentation in an elderly female, its unprecedented dimensions, and the clinical challenges of managing large, obstructive benign neoplasms.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251344025"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Majd Werda, Ahmed Ben Akacha, Salim Amouri, Malek Mnejja, Ilheme Charfeddine
{"title":"Rare Epiglottic Granulomatosis: Diagnostic Challenges and Therapeutic Implications.","authors":"Majd Werda, Ahmed Ben Akacha, Salim Amouri, Malek Mnejja, Ilheme Charfeddine","doi":"10.1177/01455613251343740","DOIUrl":"https://doi.org/10.1177/01455613251343740","url":null,"abstract":"<p><p>We report a rare case of epiglottic granulomatosis with polyangiitis (GPA) in a 72-year-old woman presenting with 5 years of progressive dysphagia and dyspnea. Initial laboratory studies revealed leukocytosis (White Blood Cells 14.2 × 10³/µL), eosinophilia (8%), elevated inflammatory markers (C-Reactive Protein 42 mg/L, Erythrocyte Sedimentation Rate 78 mm/hour), and Proteinase 3 Anti-Neutrophil Cytoplasmic Antibody (PR3-ANCA) positivity (65 IU/mL). Laryngoscopy identified supraglottic edema with a right-sided mass, confirmed by Computed Tomography as localized epiglottic thickening without cartilage destruction. Histopathology of the biopsied lesion demonstrated necrotizing granulomas, vasculitis, and multinucleated giant cells, establishing the GPA diagnosis. Treatment with high-dose corticosteroids (1 mg/kg/day prednisone) and rituximab (375 mg/m²/week × 4) induced rapid symptom resolution within 2 weeks. Follow-up laryngoscopy at 1 month showed complete mucosal healing, and the patient remains recurrence-free during 18 month surveillance with maintenance immunosuppression (5 mg/day prednisone). This case highlights 3 critical insights: (1) isolated epiglottic GPA, although rare, should be considered in chronic upper airway obstruction unresponsive to conventional therapy; (2) PR3-ANCA serology and histopathology are indispensable for diagnosis; and (3) rituximab-based regimens achieve excellent outcomes in laryngeal GPA, but prolonged monitoring is essential given relapse risks. Our findings reinforce the need for multidisciplinary management of otolaryngologic GPA manifestations.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251343740"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Survival Analysis and Prognostic Factors for Nasopharyngeal Mucoepidermoid Carcinoma.","authors":"Yuting Lai, Xiaole Song, Huankang Zhang, Wanpeng Li, Jingyi Yang, Xicai Sun, Quan Liu, Dehui Wang, Hongmeng Yu","doi":"10.1177/01455613251336876","DOIUrl":"https://doi.org/10.1177/01455613251336876","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to explore survival outcomes of and prognostic factors in nasopharyngeal mucoepidermoid carcinoma (NPMEC).</p><p><strong>Patients and methods: </strong>We reviewed a total of 57 patients diagnosed with NPMEC, including 19 patients in our center and 38 patients with detailed individual survival data in the literature. The Kaplan-Meier method and the log-rank test were used to assess overall survival (OS) and progression-free survival (PFS). Furthermore, the multivariate survival analysis was evaluated using the Cox regression model.</p><p><strong>Results: </strong>The average age of the patients was 45.8 years (range 13-71 years), with a male-to-female ratio of 0.84. During the mean follow-up time of 49 months (range, 3-149 months), the OS rates at 1, 3 and 5 years were 96.1%, 78.7%, and 62.8%, respectively, and the PFS rates at 1, 3 and 5 years were 91.4%, 71.6%, and 51.3%, respectively. The log-rank test showed that lymphatic metastasis affected OS and PFS, while stage T affected PFS. Multivariate regression analysis showed that lymphatic metastasis was associated with worse OS and PFS, that stage T was associated with unfavorable PFS, and that combined therapy improved PFS independently.</p><p><strong>Conclusions: </strong>Patients with NPMEC have favorable 5 year OS and PFS. Lymphatic metastasis was the independent factor for OS, while lymphatic metastasis, stage T, and treatment modality were the independent factors for PFS.</p>","PeriodicalId":93984,"journal":{"name":"Ear, nose, & throat journal","volume":" ","pages":"1455613251336876"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}