Annals of medicine最新文献

{"title":"Impact of the COVID-19 pandemic on lung cancer screening utilization and outcome: a health examination center retrospective study.","authors":"Chi-Shen Chen, Cai-Sin Yao, Fu-Zong Wu","doi":"10.1080/07853890.2025.2525398","DOIUrl":"10.1080/07853890.2025.2525398","url":null,"abstract":"<p><strong>Background: </strong>The coronavirus disease 2019 (COVID-19) pandemic has disrupted healthcare systems, significantly affecting preventive services such as low-dose computed tomography (LDCT) for lung cancer screening. We aimed to evaluate the pandemic's impact on LDCT screening practices at Kaohsiung Veterans General Hospital, focusing on the changes in participation rates, Lung-RADS categories, and lung cancer diagnoses to guide the development of interventions for improving screening programs and early detection during health crises.</p><p><strong>Materials and methods: </strong>A retrospective cohort of 56,730 individuals who underwent health examinations between 2017 and 2023 was analyzed. Data on demographics, smoking history, family history of lung cancer, and eligibility for LDCT subsidies in Taiwan were obtained. Screening utilization and outcomes were cross-referenced with cancer registries and imaging databases. A subset of 17,743 individuals who underwent LDCT were examined to determine the pre- and post-COVID19 differences in smoking prevalence, family history, high-risk Lung Imaging Reporting and Data System (Lung-RADS) categories (3 or 4), and lung cancer diagnoses.</p><p><strong>Results: </strong>Following the implementation of the level 3 alert, notable shifts were observed in smoking habits and lung cancer screening eligibility. The prevalence of heavy smokers (≥30 pack-years) declined from 6.9% before the alert to 6.1% after (<i>p</i> = 0.002). Conversely, the proportion of individuals with a family history of lung cancer qualifying for LDCT screening increased significantly from 6.0% to 6.6% (<i>p</i> = 0.009). Additionally, the prevalence of lung cancer diagnoses among individuals with high-risk Lung-RADS categories (Lung-RADS 3 or 4) decreased significantly from 21.5% before the alert to 13.4% after (<i>p</i> = 0.037).</p><p><strong>Conclusion: </strong>The pandemic disrupted LDCT screening, reducing access for high-risk smokers while increasing non-smoker participation. High-risk nodules declined but partially recovered post-pandemic. Future policies must prioritize high-risk individuals, optimize resources, and enhance early detection to improve outcomes and crisis preparedness.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2525398"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home-based medication safety: constructing health education for community-dwelling older adults with chronic diseases in China.","authors":"Yuting Yang, Yongwei Yang, Miao Yao, Ting Lin","doi":"10.1080/07853890.2025.2522978","DOIUrl":"https://doi.org/10.1080/07853890.2025.2522978","url":null,"abstract":"<p><strong>Background: </strong>Chinese older adults with chronic diseases often require long-term medication use. While medication safety education can improve health outcomes and mitigate risks, existing programs lack systematic and comprehensive frameworks. This study aimed to develop Delphi-based consensus content to enhance home-based medication safety education for this population.</p><p><strong>Methods: </strong>A two-round Delphi study was conducted from June to August 2022 with 16 experts in clinical medicine and pharmacy (87.50% holding senior professional titles). Expertise levels included four experts with >10 years, five with >20 years, and seven with >30 years of experience. Using the WHO's 5 Moments for Medication Safety framework, a three-part questionnaire was designed: (a) sociodemographics; (b) expert familiarity and importance ratings of indicators; (c) evaluation form for home-based medication safety education. Key metrics included response rates, expert authority coefficient (Cr), coefficient of variation (CV), and Kendall's W for consensus.</p><p><strong>Results: </strong>Response rates were 80.00% (Round 1) and 100% (Round 2), meeting validity thresholds. High expert authority was demonstrated (Cr: 0.917 and 0.933). Consensus improved across rounds (CV: 0.22 and 0.13; Kendall's <i>W</i>: 0.354 and 0.257, both <i>p</i> < 0.001). After iterative revisions and panel discussions, a finalized system comprising five first-level and 22 second-level items was established.</p><p><strong>Conclusion: </strong>We specially designed a content system for medication safety education for older adults. Future researchers could focus on implementing this content system to provide medication safety education for patients.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2522978"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet transfusion response in critically ill patients with thrombocytopenia: a retrospective study and predictive nomogram in a general ICU population.","authors":"Hanyu Ge, Yanqing Liu, Tongyu Li, Rui Lv, Jieyi Wang, Wei You, Danni Song, Shilin Hu, Feng Zhao, Heng Fan, Dingfeng Lv","doi":"10.1080/07853890.2025.2525395","DOIUrl":"10.1080/07853890.2025.2525395","url":null,"abstract":"<p><strong>Background: </strong>Although suboptimal platelet transfusion (PT) response in critically ill patients with thrombocytopenia remains a challenge in clinical practice. This study aimed to investigate PT response during intensive care unit (ICU) stay among thrombocytopenic patients without underlying hematologic disease.</p><p><strong>Methods: </strong>This retrospective single-center analysis included thrombocytopenic patients without primary hematologic disorders who received PT in ICU between June 2021 and December 2023. Clinical and laboratory variables were analyzed using a generalized linear mixed-effects model (GLMM), with the results visualized through a nomogram. The 28-day survival curves, stratified by receiving single or multiple PT episodes, were established using the Kaplan-Meier method.</p><p><strong>Results: </strong>Suboptimal PT response was observed in 522 episodes (77.9%, 522/670) and in 291 patients (79.9%, 291/364). The GLMM identified sepsis, splenomegaly, mechanical ventilation, higher APACHE II score, and longer time interval of post-PT platelet count as independent predictors of suboptimal response, while higher white blood cell count at ICU admission and the PT episode number in ICU were independently protective. A nomogram based on these seven variables demonstrated good predictive performance. Suboptimal PT episodes were associated with higher red blood cell and fresh frozen plasma requirements. The 28-day survival probability was significantly higher in the single transfusion group with optimal response versus the suboptimal response.</p><p><strong>Conclusions: </strong>Repeat PT may enhance the PT response and survival. Suboptimal PT response was associated with increased RBC and FFP transfusion requirements. The established nomogram demonstrated strong predictive accuracy and may provide a practical tool for optimizing PT practices in the ICU.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2525395"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12217101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic pathway for cardiac amyloidosis from the healthcare professional's perspective: results from the French DIAM-ATTR survey.","authors":"Silvia Oghina, Damien Legallois, Fabien Hyafil, Walid Amara, Emmanuel Andrès, Thomas Bardin, Pauline Fournier, Sandra Guignard, Céline Labeyrie, Nicolas Piriou, Olivier Toulza, Romain Tresorier, Giorgia Canali, Margaux Dubois, Benoit Bouquillon, Cédric Sauvage, Pierre Sabouret, Philippe Charron, Thibaud Damy","doi":"10.1080/07853890.2025.2525391","DOIUrl":"10.1080/07853890.2025.2525391","url":null,"abstract":"<p><strong>Background: </strong>Diagnosis of cardiac amyloidosis (CA) is complex and implicates several medical specialists. CA is usually suspected based on symptoms ('red flags') and non-invasive imagery. Early diagnosis and appropriate treatment are critical in patients with CA.</p><p><strong>Methods: </strong>The DIAM-ATTR survey assessed the diagnostic pathway, from the French healthcare professional's (HCPs) perspective, for patients with transthyretin amyloidosis (ATTR)-cardiomyopathy (CM). Between February and March 2023, 13,830 HCPs were solicited to complete a 35-question survey.</p><p><strong>Results: </strong>Among the 13,830 HCPs solicited, 1264 HCPs completed the survey: 471 cardiologists, 186 internists, 148 nuclear medicine physicians, 125 geriatricians, 120 orthopaedic surgeons, 112 neurologists, and 102 rheumatologists. In general, echocardiographic abnormalities, heart failure, and a family history of amyloid neuropathy evoked CA. The knowledge of the 22 'red flags' assessed varied among specialists. Among HCPs, 70% had suspected an ATTR-CM: from 96% of cardiologist to 6% of orthopaedic surgeons. Complete diagnosis was performed by 48% of both cardiologists and internists. The other HCPs referred patients to colleagues for complete diagnosis. Overall, echocardiography was performed first, then gammopathy assessment and bone scintigraphy. Delays for examinations and difficulties varied among specialists.</p><p><strong>Conclusion: </strong>Overall, French HCPs prioritize diagnostic examinations for ATTR-CM as recommended. However, HCPs need an increased awareness of 'red flags' and the importance of excluding monoclonal gammopathies during diagnosis.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2525391"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the clinical outcomes of an innovative bi-frame external fixation device compared to those of volar locking plate and external fixator device among patients with unstable distal radius fractures: a two-year retrospective comparative cohort study.","authors":"Zhi-Yuan Yao, Xu-Song Li, Jie-Feng Huang","doi":"10.1080/07853890.2025.2524090","DOIUrl":"10.1080/07853890.2025.2524090","url":null,"abstract":"<p><strong>Background: </strong>Volar locking plate (VLP) fixation for unstable distal radius fractures (DRF) requires extensive soft tissue dissection and is associated with implant-related complications. Conventional external fixator (EF) carries risks such as reduction loss, pin loosening, and unstable traction. This study retrospectively evaluates the clinical efficacy and safety of a novel bi-frame external fixation device (BEF) compared with VLP and EF over a two-year period.</p><p><strong>Methods: </strong>rA total of 131 patients with unstable DRF treated between 2015 and 2022 at the First Affiliated Hospital of Zhejiang Chinese Medical University were included (42 BEF, 44 EF, 45 VLP). Functional outcomes included wrist range of motion and grip strength. Patient-reported outcomes were assessed using the Visual Analog Scale (VAS), Patient-Rated Wrist Evaluation (PRWE), and Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) scores. Radiographic parameters and complications were recorded. Statistical comparisons used t-tests, Mann-Whitney U-tests, and chi-square or Fisher's exact tests.</p><p><strong>Results: </strong>Baseline characteristics were comparable. BEF showed significantly shorter time from injury to surgery than VLP (17.2±5.2 vs. 68.3±24.1 hours, <i>p</i> < 0.001), and shorter operation time than EF (<i>p</i> = 0.028) and VLP (<i>p</i> < 0.001). Early outcomes favored VLP, but long-term results were comparable (<i>p</i> > 0.05). Compared with EF, BEF better preserved radial height, ulnar variance, pronation, and ulnar deviation (all <i>p</i> < 0.05), with fewer overall complications (<i>p</i> = 0.005).</p><p><strong>Conclusions: </strong>BEF represents an innovative, viable and safe alternative for unstable DRF. Further multicenter randomized trials with extended follow-up are warranted.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2524090"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter regarding 'association between ex vivo thrombogenicity and ischemic outcome in off-pump coronary surgery'.","authors":"Sungmin Suh, Young-Lan Kwak, Jae-Kwang Shim","doi":"10.1080/07853890.2025.2543977","DOIUrl":"10.1080/07853890.2025.2543977","url":null,"abstract":"","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2543977"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144805461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of exposure duration, modality, and polycythaemia with hyperuricaemia among han male immigrants at high altitudes: a cross-sectional study.","authors":"Yanlin Zhu, Liwen Mo, Jie He, Xianglian Li, Yi Li, Dan Xiao, Huichang Jia, Jian Li, Fan Zhang, Yue Cheng","doi":"10.1080/07853890.2025.2543065","DOIUrl":"10.1080/07853890.2025.2543065","url":null,"abstract":"<p><strong>Background: </strong>Hyperuricaemia is associated with increased metabolic syndrome, cardiovascular disease, and mortality risk in the adult population and is more common in plateau areas. Han male immigrants are a high-risk population and deserve more attention. The correlations between different altitude exposure durations and exposure modalities with hyperuricaemia have not yet been reported.</p><p><strong>Methods: </strong>In this cross-sectional study, qualified subjects were selected from two units on the Qinghai-Tibet Plateau and underwent a questionnaire survey (age, altitude exposure time, altitude exposure form), anthropometric measurements (body mass index [BMI], blood pressure [BP], and heart rate [HR]), and laboratory tests (white blood cell count [WBC], haemoglobin [HB], platelet count [PLT], and serum uric acid [SUA]). Univariate and multivariate logistic regression models were used to detect factors associated with hyperuricaemia.</p><p><strong>Results: </strong>The overall prevalence of hyperuricaemia was 40.8% (73 cases) among 179 Han male immigrants. Multivariate logistic regression analysis revealed that hyperuricaemia was significantly related to altitude exposure time (OR 6.744, 95% CI 1.263-36.019), altitude exposure form (OR 2.580, 95% CI 1.068-6.231) and high-altitude polycythaemia (OR 2.125, 95% CI 1.011-4.465).</p><p><strong>Conclusion: </strong>High-altitude polycythaemia, exposure to high altitudes for 1-5 years, and long-term exposure to the same high-altitude areas when the high-altitude exposure dose is equal are important factors associated with hyperuricemia.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2543065"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144791033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between knee osteoarthritis and foot deformities: epidemiological analysis of hallux valgus and flatfoot.","authors":"Yu-Feng Liang, Xu-Song Li, Fang-Di Zha, Rong-Zhen Xie, Wei-Qiang Zhao, Fang-Yu Yi, Ming-Chao Yuan, Jie-Feng Huang","doi":"10.1080/07853890.2025.2536213","DOIUrl":"10.1080/07853890.2025.2536213","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between knee osteoarthritis (KOA) and the presence of hallux valgus and flat feet.</p><p><strong>Method: </strong>This retrospective study analyzed KOA patients from January 2022 to March 2024, investigating the correlation between KOA and hallux valgus and flatfoot. The diagnosis of KOA and assessment of its symptoms were conducted using the diagnostic criteria and grading system established by the American College of Rheumatology, specifically the Kellgren-Lawrence (K-L) grading system and measurement of the femorotibial angle (FTA). Physical examination, weight-bearing X-ray examination and MRI evaluation of the knee were performed. Foot examination included weight-bearing and lateral X-ray imaging to determine the presence of hallux valgus and flat feet.</p><p><strong>Results: </strong>A total of 168 patients met KOA criteria: 162 with genu varum, 6 with genu valgum and 39 with pes anserine tendinitis. Among those with genu varum, 145 had hallux valgus, 136 had flatfoot and 39 had pes anserine tendinitis. Gender distribution: 37 male (22.02%) and 131 female (77.98%). The mean age was 73.84 ± 4.96 years. Spearman correlation analysis showed significant associations between the severity of KOA (K-L grade) and hallux valgus (<i>r</i> = 0.681, <i>p</i> < 0.05) and flatfoot (<i>r</i> = 0.689, <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>There was a significant correlation between KOA, hallux valgus and flatfoot. However, due to the study's cross-sectional design, causality cannot be established. There was also a significant link between knee varus and pes anserine bursitis.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2536213"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for the HALDI study-conceptual framework for investigating health and living conditions in an arctic area of Sweden with a multiethnic population.","authors":"Katarina Nägga, Per Axelsson, Christina Storm Mienna","doi":"10.1080/07853890.2025.2537914","DOIUrl":"10.1080/07853890.2025.2537914","url":null,"abstract":"<p><strong>Objectives: </strong>Despite increasing research interest in the health and well-being of the Indigenous Sámi people, knowledge remains fragmented and insufficient. The HALDI study aims to examine health status, well-being, and associated determinants within a multi-ethnic context, focusing on the Sámi people in Sweden. This protocol outlines the study's objectives, design, and methodology, with the goal of generating representative data to inform future research, policy, and interventions targeting Sámi health.</p><p><strong>Design: </strong>To ensure relevance, initial focus groups discussions identified key health issues for the Sámi people in Swedish Sápmi. Based on these findings, a comprehensive questionnaire was developed, encompassing socioeconomic status, ethnicity, psychiatric and somatic disorders, and self-perceived health. All adults in Jokkmokk municipality (<i>n</i> = 4077) were invited to participate. The following year, a clinical examination was conducted, including measures such as blood pressure, pulse, height, weight, blood sampling, and an updatet questionnaire on health status, dietary habits, and, for those aged 65 years and above, assessments of frailty and cognition. A total of 1682 individuals (41%) responded to the first questionnaire; 68% identified as Swedish, 22% as Sámi, and 7% with other ethnic identities. In the clinical study, 706 participated with similar ethnic proportions.</p><p><strong>Conclusion: </strong>This is the first study in Sweden to incorporate ethnic self-identification in a multi-ethnic population. By presenting the study protocol and sample characteristics, we highlight the potential for future analyses to inform evidence-based health interventions and policy to improve outcomes for the multi-ethnic Arctic population.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2537914"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognosis of pain and function in people with hand and thumb base osteoarthritis: a systematic review.","authors":"Victoria Jansen, Anna Selby, Suzanne Toft, Joanna Greenway, Michelle Marshall, Elaine Nicholls, Danielle A van der Windt","doi":"10.1080/07853890.2025.2532113","DOIUrl":"10.1080/07853890.2025.2532113","url":null,"abstract":"<p><strong>Background: </strong>This systematic review has summarized evidence regarding the course of hand pain, hand function, and prognostic factors that predict changes in symptoms in people with hand and thumb base osteoarthritis.</p><p><strong>Methods: </strong>A systematic search of electronic databases was conducted for longitudinal studies on hand osteoarthritis. Two reviewers assessed eligibility quality appraisal, and extracted data on pain, function and prognostic factors. A narrative synthesis was undertaken, and the strength of the evidence was appraised using a modified Grading of Recommendations, Assessment, Development, and Evaluations approach.</p><p><strong>Results: </strong>Of 9523 articles identified, 24 papers with 8,496 patients met the inclusion criteria. Twelve studies reported on the course of hand pain and 13 on hand function. 25-29% of participants reported worsening pain and 23-59% a deterioration in hand function over 10 years. There is moderate evidence that, on average, function and grip strength deteriorate over time with minimal changes in average hand pain. Twelve studies assessed the prognostic factors for hand OA. Moderate evidence suggests baseline pain and diabetes are associated with changes in hand function and pain; lower quality evidence for other health and psychological factors.</p><p><strong>Conclusions: </strong>Over 10 years, there is, little change in hand pain, but some deterioration in hand function. Deterioration in hand pain and function is associated with diabetes and higher baseline pain severity. Further research is very likely to improve our understanding of prognostic factors for symptomatic progression in hand OA.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2532113"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}