Annals of medicine最新文献

{"title":"Marine bioactive peptides as potential therapeutic agents for wound healing - a review.","authors":"Kai Zheng, Ziwei Yang, Te Ba","doi":"10.1080/07853890.2025.2530693","DOIUrl":"10.1080/07853890.2025.2530693","url":null,"abstract":"<p><strong>Context: </strong>Skin wounds resulting from dermatological diseases and other specific causes present significant challenges in health care. These wounds can lead to infections, chronic conditions, long-term complications and even mortality. Consequently, developing highly effective and viable therapies for wound healing is important. Marine bioactive peptides are increasingly being utilized because of their favourable biological properties, which include anti-inflammatory, antioxidant, antimicrobial, antiageing, antitumour and antihypertensive effects. These peptides offer several advantages, including high efficacy, excellent safety, clear target specificity and low allergenicity. Notably, scientific evidence has demonstrated that marine bioactive peptides promote skin injures repair and has underscored their substantial potential in wound healing.</p><p><strong>Objective: </strong>Our objective is to provide molecular insights that may facilitate the development of innovative therapeutic agents aimed at improving wound healing and skin repair.</p><p><strong>Materials & methods: </strong>This review synthesizes information from major databases, including ScienceDirect, Google Scholar, Scopus, PubMed and Springer Link. Publications were selected without date restrictions and used terms such as skin injures, wound healing, marine bioactive peptides, antimicrobial, ceRNA. Articles related to agriculture, ecology, or synthetic work or those published in languages other than English were excluded.</p><p><strong>Results and conclusions: </strong>In this review, we integrated and examined the current understanding of wound care. Additionally, we analysed the underlying molecular mechanisms involved to elucidate the characteristics of marine bioactive peptides.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2530693"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the burden of musculoskeletal disorders between China and worldwide data using the global burden of disease dataset from 1990 to 2021.","authors":"Zhongbiao Nie, Ran Zhang, Yaoyao Guo, Xiang Wang, Kai Zhang, Haoliang Zhao","doi":"10.1080/07853890.2025.2529578","DOIUrl":"10.1080/07853890.2025.2529578","url":null,"abstract":"<p><strong>Objectives: </strong>This study was to compare the worldwide burden of musculoskeletal (MSK) disorders with the age and gender-specific trends of MSK disorders in China and globally between 1990 and 2021.</p><p><strong>Methods: </strong>Using publicly available data from the Global Burden of Disease (GBD) database from 1990 to 2021. Examined the features of the burden of MSK disorders in China and globally, including age and gender-specific trends in incidence, prevalence, mortality, disability-adjusted life years (DALYs), and related age-standardized measures of MSK disorders. To represent the trends in the burden of MSK disorders, the average annual percentage change (AAPC) was computed using Joinpoint. Age, gender were important parameters that were used a comparative study of the disparities in the burden of MSK disorders between China and the global.</p><p><strong>Results: </strong>The worldwide ASIR of MSK disorders rose from 4641.50 to 4358.54 between 1990 and 2021, and China fell from 4039.13 to 3634.09 per 100,000. The worldwide ASPR rose from 19178.47 to 19836.76, China, went from 16966.24 to 17358.70 per 100,000. The ASMR in China declined from 1.22 to 1.10, while the worldwide decreased from 1.55 to 1.47 per 100,000. The ASDR in China declined from 1615.73 to 1578.71, while the worldwide ASDR decreased from 1886.22 to 1916.21 per 100,000. The worldwide AAPC of ASIR, ASPR, ASMR, and ASDR was -0.21%, 0.11%, -0.25%, and 0.04%, respectively. China was -0.34%, 0.09%, -0.41%, and -0.07%, respectively. The burden of MSK disorders was influenced similarly by age and gender.</p><p><strong>Conclusion: </strong>The burden of MSK disorders rose in China and globally between 1990 and 2021, and it varies with age. Women are more prone than men to acquire MSK disorders. Because of its vast and aging population, MSK disorders continue to be a major public health concern in China and globally.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2529578"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tobacco and alcohol use are the risk factors responsible for the greatest burden of head and neck cancers: a study from the Global Burden of Disease Study 2019.","authors":"Yue Yuan, Jing-Wen Huang, Jia-Lin Cao, Jian-Hui Wu, Lu-Ling Wang, Hui Gan, Jian-Hui Xu, Fei Ye","doi":"10.1080/07853890.2025.2500693","DOIUrl":"10.1080/07853890.2025.2500693","url":null,"abstract":"<p><strong>Background: </strong>The risk factors associated with cancers of the larynx, nasopharynx, lips, and oral cavity, as well as other pharyngeal cancers, share many similarities. To better understand how these risk factors manifest differently across various head and neck tumor types, we utilized data from the GBD database to conduct an in-depth analysis.</p><p><strong>Methods: </strong>Our study employed the 2019 GBD dataset to scrutinize trends in incidence, mortality, and DALYs related to these cancers. This analysis covered the period from 1990 to 2019 and was stratified by sex, age, geographical region, and the socio-demographic index.</p><p><strong>Findings: </strong>In 2019, lip and oral cavity cancers were found to have the highest incidence rates, with notably higher ASIRs observed in males compared to females. Interestingly, the ASIRs for laryngeal cancer showed a decreasing trend over the studied time frame from 1990 to 2019. Our findings revealed that smoking posed a significantly greater risk for laryngeal and lip and oral cavity cancers, whereas alcohol consumption was more strongly linked to NPC. Central Europe exhibited the ASDR for laryngeal cancer. For lip and oral cavity cancer, the impact of tobacco chewing on female ASDR was most pronounced in South Asia. In contrast, nasopharyngeal cancer had its highest ASDR in Asia.</p><p><strong>Conclusion: </strong>Our investigation underscores that smoking and alcohol consumption are leading risk factors for cancers of the head and neck, although their effects vary depending on the specific type of cancer, the sex of the patient, age group, and regional demographics. While occupational exposure to carcinogenic substances does not appear to be a predominant factor, it remains an important consideration that should not be overlooked in the comprehensive assessment of risk for these malignancies.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2500693"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Back to the pre-industrial age? FAOSTAT statistics of food supply reveal radical dietary changes accompanied by declining body height, rising obesity rates, and declining phenotypic IQ in affluent Western countries.","authors":"Pavel Grasgruber","doi":"10.1080/07853890.2025.2514073","DOIUrl":"10.1080/07853890.2025.2514073","url":null,"abstract":"<p><p>Meta-analyses of observational and clinical studies conducted in recent years have raised serious doubts about the validity of the low-fat dietary recommendations introduced in the late 1970s/early 1980s, due to the absence of any convincing link between saturated fat and the risk of cardiovascular diseases. At the same time, long-term food supply statistics from the FAOSTAT database show that these recommendations were at the root of fundamental dietary changes in Western countries, which resulted in a lower consumption of eggs and red meat, a higher consumption of cereals and poultry, a decline in average protein quality and, overall, in a higher glycemic load of the diet. Because current views on human nutrition are based primarily on highly unreliable questionnaire data from observational studies, the purpose of this commentary is to provide an alternative ecological (country-level) perspective and to trace the consequences of these nutritional changes using the FAOSTAT database in combination with available anthropological and health statistics. This comparison shows a close connection between the decline in protein quality and the sudden reversal of the positive height trend in some Western countries, after ∼150 years of continuous growth, which points to suboptimal levels of child nutrition. The sharp increase in the prevalence of obesity and type 2 diabetes is strongly correlated with the increasing consumption of high-glycemic carbohydrates and sweeteners, and is also interconnected with the decrease in body height, because a high-quality, growth-stimulating diet during adolescence is inversely related to obesity. Given the long-term association between height and phenotypic IQ, the lower quality of nutrients in children's diet may also seriously affect intellectual potential and future civilizational development. In light of these findings, current nutritional strategies should be seriously reconsidered and recommended protein intakes for children must be urgently reevaluated.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2514073"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 5-week low-dose prednisolone regimen for progressive vitiligo: efficacy and safety in a single-center cohort study.","authors":"Yue-Tong Qian, Jia-Wei Liu, Dong-Lai Ma","doi":"10.1080/07853890.2025.2543523","DOIUrl":"10.1080/07853890.2025.2543523","url":null,"abstract":"<p><strong>Background: </strong>Progressive vitiligo lacks standardized glucocorticoid regimens, with prolonged treatments often causing adverse effects. This study evaluated a novel 5-week low-dose prednisolone strategy (0.5 mg/kg/day, tapered weekly) to balance efficacy and safety.</p><p><strong>Objective: </strong>To assess the efficacy and safety of this regimen in halting disease progression and inducing repigmentation in progressive vitiligo.</p><p><strong>Methods: </strong>In this single-center retrospective cohort study (January 2017 to January 2022), 319 progressive vitiligo patients (Vitiligo Disease Activity score, VIDA score ≥ +2) received the 5-week regimen. Outcomes included treatment efficacy (cessation of progression ± repigmentation), adverse events, and patient satisfaction (visual analog scale, VAS).</p><p><strong>Results: </strong>The efficacy rate was 88.71% (283/319), with 63.60% (180/283) achieving repigmentation (grade 1: 56.7%, grade 2: 25.6%, grade 3: 11.1%, grade 4: 6.7%). Disease severity significantly correlated with treatment response (<i>p</i> = 0.013). Mild-to-moderate adverse events occurred in 14.1% (45/319), including weight gain (8.2%), insomnia (3.1%), and gastrointestinal symptoms (2.8%), all resolving post-treatment. Patient satisfaction was high (mean VAS: 8.88/10; 65% scored 10/10).</p><p><strong>Conclusion: </strong>This 5-week low-dose prednisolone regimen rapidly stabilizes progressive vitiligo across ages and subtypes, with high efficacy, minimal adverse effects, and excellent patient compliance. It offers a practical alternative to prolonged steroid protocols, particularly for early intervention.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2543523"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A survival prediction model for biliary tract cancer based on least absolute shrinkage and selection operator-cox regression.","authors":"Shanshan Fan, Kexin Zhao, Ziwei Liang, Yang Ge","doi":"10.1080/07853890.2025.2555520","DOIUrl":"10.1080/07853890.2025.2555520","url":null,"abstract":"<p><strong>Background: </strong>Biliary tract cancer (BTC) is a digestive tract tumor with low incidence, high malignancy, and short survival times. Abnormal lipid metabolism may be related to the occurrence and development of tumors; therefore, we constructed a survival prediction model for patients with BTC using clinical data that included lipid indicators rarely considered in previous studies.</p><p><strong>Patients and methods: </strong>Clinical and pathological data were collected from 124 patients with BTC. Patients were divided into two groups according to the inclusion time. The training and validation cohorts included 70 patients from 2017 to 2021 and 54 patients from 2022 to 2023. Least absolute shrinkage and selection operator-Cox regression analysis was conducted on the survival data. The resulting prediction model was evaluated using discrimination and calibration analyses performed in R Studio.</p><p><strong>Results: </strong>Tumor location, lipoprotein (a), carcinoembryonic antigen, carbohydrate antigen 19-9, and therapy type were identified as key predictors for constructing the nomogram. The consistency indexes for the training and validation cohorts were 0.677 and 0.655, respectively, indicating moderate discrimination. The Hosmer-Lemeshow test provided a <i>p</i>-value of 0.188 for the validation cohort, suggesting a good model fit. The calibration accuracy of the model in the two cohorts was further evaluated by drawing calibration curves based on the follow-up time. Patients were classified into high- and low-risk groups according to the nomogram risk scores. Kaplan-Meier survival curves showed significant differences between the training cohort (<i>p</i> = 0.00041) and the validation cohort (<i>p</i> = 0.0028). The risk score scatter plot provided visual verification of the model's performance.</p><p><strong>Conclusions: </strong>The predictive model constructed in this retrospective study shows potential for guiding the clinical identification of groups at high risk of BTC, adjusting treatment intensity, and improving follow-up management.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2555520"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144982199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and risk factors of acute kidney injury after abdominal surgery: a systematic review and meta-analysis.","authors":"Jian Liu, Shi-Hui Lin, Yi-Si Zhao, Ren-Jie Luo, Zheng-Tao Zhang, Liu-Yang Wang, Ke Xie, Jing Fan, Mu Zhang, Yu-Sen Chai, Hong Tang, Fang Xu","doi":"10.1080/07853890.2025.2547324","DOIUrl":"10.1080/07853890.2025.2547324","url":null,"abstract":"<p><strong>Objective: </strong>To determine the incidence of acute kidney injury (AKI) following abdominal surgery, assess its outcome associations, and identify factors associated with postoperative AKI development.</p><p><strong>Methods: </strong>We performed a systematic search of PubMed, Embase, and Cochrane Database of Systematic Reviews, from January 2004, to December 2024. We included studies reporting AKI based on consensus criteria (RIFLE, AKIN, or KDIGO) in adult abdominal surgery patients.</p><p><strong>Results: </strong>A total of 162 studies (675361 patients) were included. The pooled AKI incidence was 16% (95% CI: 14-17%), with significant variation by surgical procedure. Meta-analysis showed AKI was significantly associated with increased short-term mortality (risk ratio [RR], 6.46; 95% CI: 4.63-9.00) and long-term mortality (RR, 6.36; 95% CI: 3.32-12.16). Mortality risk demonstrated stage-dependent increase, with RR of 2.74 (95%CI: 1.77-4.24), 8.01 (95%CI: 3.18-20.18), and 15.73 (95%CI: 5.52-44.81) for AKI stages 1, 2, and 3, respectively. AKI was associated with prolonged hospital stay (weighted mean difference 4.72 days; 95%CI: 3.43-6.02), also showeing stage-dependent increase of 5.03, 11.16, and 14.46 days for stages 1, 2, and 3, respectively. Twenty-five risk factors were associated with AKI. Meta-analysis of randomized controlled trials revealed that individualized blood pressure target management significantly reduced AKI incidence (RR, 0.67; 95% CI: 0.52-0.88).</p><p><strong>Conclusions: </strong>AKI remains a common and important complication after abdominal surgery, with severity showing a graded association with mortality and hospital stay. Individualized blood pressure management demonstrates promise in AKI prevention.</p><p><strong>Registration: </strong>PROSPERO CRD42022304083.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2547324"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment consequence and adverse events of cyclin-dependent kinase 4/6 inhibitors on patients with hormone receptor-positive, HER2-negative metastatic breast cancer: a systematic review and meta-analysis.","authors":"Hsiang-Ying Wu, Chia-Sung Chang, Wei-Hong Cheng, Jin-Hua Chen, Yuan-Hung Wang","doi":"10.1080/07853890.2025.2557509","DOIUrl":"10.1080/07853890.2025.2557509","url":null,"abstract":"<p><strong>Background: </strong>Although some studies have indicated that CDK4/6 inhibitors are beneficial for the progression-free survival (PFS) and overall survival (OS) in breast cancer, evidence regarding the assessment of clinical response remains insufficient. Therefore, this study aims not only to evaluate the efficacy and safety of CDK4/6 inhibitors combined with endocrine therapy in HR(+)/HER2(-) metastatic breast cancer, but also to analyze the objective response rate (ORR) and clinical benefit rate (CBR), providing comprehensive clinical outcome insights.</p><p><strong>Materials and methods: </strong>A literature search was performed in PubMed, Embase, Cochrane Library, and ClinicalTrials.gov focusing on studies published before 2022. The meta-analysis followed PRISMA guidelines and used RevMan 5.3 to conduct the analysis.</p><p><strong>Results: </strong>Eleven clinical trials published between 2015 and 2022 were included in our meta-analysis, with a total of 5572 eligible patients. This meta-analysis found that HR(+)/HER2(-) metastatic breast cancer treated with CDK4/6 inhibitors plus endocrine therapy can significantly improve progression-free survival(PFS) (HR: 0.55; <i>p</i> < 0.001), overall survival (OS) (HR: 0.79; <i>p</i> < 0.001), objective response rate (RR = 1.50; <i>p</i> < 0.001), clinical benefit rate (RR = 1.18; <i>p</i> < 0.001) and decrease progressive disease rate (RR = 0.49; <i>p</i> < 0.001). Clinicians need to be aware of hematological toxicities, abnormal liver function, and venous thromboembolism in the use of CDK4/6 inhibitors. Furthermore, the combination regimen also showed longer PFS in subgroup analysis. However, Asians, the number of metastasis sites, and patients using letrozole subgroups did not demonstrate differences in OS between the combination regimen and endocrine therapy alone.</p><p><strong>Conclusion: </strong>This meta-analysis highlights the improvement of PFS, OS, ORR, and CBR in HR(+)/HER2(-) metastatic breast cancer for CDK4/6 inhibitors, with manageable and reversible toxicities. Clinicians should be aware of hematological toxicities, liver function abnormalities, and venous thromboembolism when using CDK4/6 inhibitors. These findings make CDK4/6 inhibitors a pivotal treatment option.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2557509"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic modifications of immune cells in rheumatoid arthritis.","authors":"Xiaoyu Cai, Yao Yao","doi":"10.1080/07853890.2025.2533432","DOIUrl":"10.1080/07853890.2025.2533432","url":null,"abstract":"<p><strong>Background: </strong>Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by synovial inflammation, joint destruction, and systemic features. Dysregulated immune cells-particularly T cells, B cells, and macrophages-drive its onset and progression. Epigenetic mechanisms, including DNA methylation, histone modifications, RNA editing, and non-coding RNAs, critically shape immune cell activation, differentiation, and effector functions, perpetuating autoimmunity and chronic inflammation.</p><p><strong>Purpose: </strong>Although individual epigenetic changes in RA have been widely studied, an integrated overview connecting these alterations to disease pathogenesis and clinical application is lacking. This review aims to synthesize current knowledge on how epigenetic modifications affect key immune populations in RA, evaluate their potential as biomarkers for diagnosis and prognosis, and discuss future directions for precision epigenetic therapies.</p><p><strong>Discussion: </strong>In RA, T cells show locus-specific hypomethylation and lncRNA-mediated regulation that boost inflammatory cytokine production. Macrophages undergo histone modification changes and altered RNA editing that amplify inflammation. B cells exhibit abnormal DNA methylation and microRNA profiles promoting autoantibody production. Together, these processes form a self-sustaining loop of immune activation. Clinically, epigenetic profiles may aid early detection and patient stratification. Targeting epigenetic enzymes and RNA-based therapies is promising but faces challenges in cell specificity, delivery, and variability.</p><p><strong>Conclusion: </strong>Advances in epigenetics could enable personalized RA management. Integrative multi-omics and cell-specific interventions may restore immune balance, control inflammation, and prevent damage. Overcoming barriers to targeted delivery and clinical translation will be key for precision epigenetic therapies in RA.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2533432"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of preoperative CA19-9 and neutrophil-to-lymphocyte ratio for early recurrence in patients with resected pancreatic ductal adenocarcinoma.","authors":"Wei-Kang Ye, Xiao-Yu Lin, Si-Qi Liu, Jie Zheng, Jin Wang, Yi-Nong Zhou, Xin-Ming Lei","doi":"10.1080/07853890.2025.2564293","DOIUrl":"10.1080/07853890.2025.2564293","url":null,"abstract":"<p><strong>Objectives: </strong>Pancreatic ductal adenocarcinoma (PDAC) has a high recurrence rate post-curative surgery. This study aimed to evaluate the combined predictive value of preoperative carbohydrate antigen 19-9 (CA19-9) and neutrophil-to-lymphocyte ratio (NLR) for early recurrence in resected PDAC patients.</p><p><strong>Methods: </strong>This was a single-centre retrospective study involving 151 patients diagnosed with PDAC. Data on patient demographics, clinical characteristics and preoperative haematological parameters were collected. Early recurrence was defined as recurrence within the first 12 months after surgery. Univariate and multivariate logistic regression analyses were conducted to identify factors associated with early recurrence. Receiver Operating Characteristic (ROC) curves and Area Under the Curve (AUC) analyses were used to assess the diagnostic performance of CA19-9, NLR and their combination.</p><p><strong>Results: </strong>Among 151 patients (median follow-up: 21 months), 32.45% (<i>n</i> = 49) experienced early recurrence. Multivariate logistic regression analysis revealed that preoperative CA19-9 levels and NLR were independently associated with early recurrence. ROC curve analysis demonstrated that the combination of NLR and CA19-9 had significantly better performance in predicting early recurrence compared to NLR or CA19-9 alone.</p><p><strong>Conclusion: </strong>The combination of preoperative CA19-9 and NLR enhances predictive accuracy for early recurrence in PDAC, offering a useful tool for postoperative risk stratification.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2564293"},"PeriodicalIF":4.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12486449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}