Annals of medicine最新文献

{"title":"The extent of intestinal involvement is closely related to the severity of IgAV: a risk stratification study based on CT.","authors":"Yuanqiu Li, Ziman Xiong, Yufan Wang, Yuchen Jiang, Yaqi Shen, Xuemei Hu, Daoyu Hu, Zhen Li","doi":"10.1080/07853890.2025.2462260","DOIUrl":"10.1080/07853890.2025.2462260","url":null,"abstract":"<p><strong>Objectives: </strong>To analyze the differences in clinical manifestations between children and adults with intestinal involvement in IgAV and to identify the specific subtypes requiring particular attention.</p><p><strong>Methods: </strong>A systematic review of the HIS system was conducted on patient data from four centers at Tongji Hospital between January 2015 and October 2022. Patients with a diagnosis of IgAV with intestinal involvement were further analyzed. Clinical manifestations, laboratory data, and CT findings at the time of initial hospitalization were recorded. The differences in clinical manifestations between children and adults were analyzed. The extent of intestinal involvement, linked to disease severity, was quantitatively assessed by evaluating the number of affected intestinal segments on CT imaging. Laboratory markers that could reflect severe intestinal involvement were explored. Furthermore, patients were classified based on the sites of involved intestinal segments: L1 type (duodenum and/or jejunum), L2 type (ileum), L3 type (duodenum and/or jejunum and ileum), and L4 type (limited to the colorectum). A comparison of the first three types was performed.</p><p><strong>Results: </strong>A total of 148 patients were enrolled (67 children and 81 adults). The proportion of joint pain and renal involvement was higher in adults. D-dimer level was an independent risk factor for severe intestinal involvement (OR = 1.104, <i>p</i> = .016). In the first three types patients based on the sites of involved intestinal segments, it found that L3 type patients had a longer hospital stay.</p><p><strong>Conclusion: </strong>With the exception of joint pain and renal involvement, there were no significant differences in clinical symptoms between children and adults. CT imaging provided objective insights into the extent of intestinal involvement, which correlated with disease severity. Patients with widespread small bowel involvement displayed a more severe disease state.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2462260"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of endoscopic ultrasound as a predictor of histological healing in ulcerative colitis.","authors":"Jin Tian, Wei Wang, Yongshuai Liu, Xin Zhang, Hanqing Zhao, Hongmei Qu","doi":"10.1080/07853890.2025.2499961","DOIUrl":"https://doi.org/10.1080/07853890.2025.2499961","url":null,"abstract":"<p><strong>Background: </strong>Ulcerative colitis (UC) is a chronic inflammatory bowel disease with rising global prevalence.Histological healing (HH) is a key treatment target associated with better long-term outcomes. Although endoscopic ultrasound (EUS) is known to be related to both clinical and endoscopic activity in UC, its role in defining HH remains unclear. Therefore, this study was aimed at investigating the association between EUS and histological activity (HA), as well as the predictive potential of EUS for HH.</p><p><strong>Method: </strong>In this cross-sectional analysis, 68 UC adults underwent EUS and colonoscopy with biopsies. We used the Mayo Endoscopic Score (MES) for endoscopic activity, the Nancy Index (NI) for biopsy grading, and the Endoscopic Ultrasound-Ulcerative Colitis (EUS-UC) score for EUS analysis, defining endoscopic remission as MES ≤ 1 and HH as NI ≤ 1.A receiver operating characteristic (ROC) curve was employed to evaluate the ability of the indices to predict HH.</p><p><strong>Results: </strong>Totally 23 patients (33.80%) achieved HH, while 45 (66.20%) showed HA. The EUS-UC scores were significantly lower in the HH group (<i>p</i> < 0.001) and correlated strongly with NI (ρ = 0.73). EUS-UC score was an independent risk factor for HH (adjusted OR = 1.918, 95% CI: 1.195-3.080, <i>p</i> = 0.007). The EUS-UC score demonstrated a strong predictive value for HH, with an AUC of 0.840, a sensitivity of 75.56%, and a specificity of 78.26%.</p><p><strong>Conclusion: </strong>The EUS-UC score has a significant correlation with histological outcomes and shows strong potential as a reliable, invasive predictor of HH in UC, with implications for improved disease monitoring.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2499961"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple radiations and its effect on biological system - a review on <i>in vitro</i> and <i>in vivo</i> mechanisms.","authors":"Deepika Balasubramanian, Gopikrishna Agraharam, Agnishwar Girigoswami, Koyeli Girigoswami","doi":"10.1080/07853890.2025.2486595","DOIUrl":"https://doi.org/10.1080/07853890.2025.2486595","url":null,"abstract":"<p><strong>Purpose: </strong>We are exposed to different types of radiation from natural sources or for biomedical diagnostic and therapeutic purposes at different doses or times. The dose, duration, and number of exposures can cause multiple effects both <i>in vivo</i> and <i>in vitro</i>. Several researchers have explored the effects of ionizing and non-ionizing radiation in cell lines and animal models. Macromolecules, such as DNA, RNA, and proteins, are the primary targets of damage and can lead to several diseases, including cancer and even cell death. Chronic low-dose exposure of cells to radiation can cause alterations in gene expression and can be deleterious to the fate of the cells. We aim to discuss the implications of multiple radiations on different biological systems, including how nanotechnology can facilitate the effects of radiation in therapeutics.</p><p><strong>Conclusion: </strong>In this review, we discuss the <i>in vitro</i> and <i>in vivo</i> changes that occur due to exposure to different types of radiation used in diagnosis, therapeutics, and other means, such as radiation equipment operators and patients being exposed. The effects of ionizing and non-ionizing radiation have been discussed separately. We have also mentioned in detail about the human-caused accidents of Hiroshima and Chernobyl in this article. The application of nanotechnology in facilitating the effects of radiation in the therapy and management of radioresistance of cells has also been discussed. The radio resistance and method to improve the radiosensitivity have also been mentioned. This review article can reflect the recent developments in the various uses of ionizing and non-ionizing radiation in biomedical field and will open up new avenues to utilize radiation in a more prudent way. The role of nanotechnology in reducing the harmful effects of radiation is also discussed.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2486595"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium butyrate alleviates DSS-induced inflammatory bowel disease by inhibiting ferroptosis and modulating ERK/STAT3 signaling and intestinal flora.","authors":"Yingyin Liu, Nachuan Chen, Huaxing He, Lulin Liu, Suxia Sun","doi":"10.1080/07853890.2025.2470958","DOIUrl":"10.1080/07853890.2025.2470958","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), can seriously impact patients' quality of life. Sodium butyrate (NaB), a product of dietary fiber fermentation, has been shown to alleviate IBD symptoms. Some studies have shown that it is related to ferroptosis. However, the precise mechanism linking NaB, IBD, and ferroptosis is not clear.</p><p><strong>Objective: </strong>This study aimed to demonstrate that NaB suppresses ferroptosis, thereby alleviating inflammatory bowel disease (IBD) through modulation of the extracellular regulated protein kinases/signal transducer and activator of transcription 3 (ERK/STAT3) signaling pathway and intestinal flora.</p><p><strong>Methods: </strong>An IBD model was established using 2.5% (<i>w/v</i>) dextran sulfate sodium (DSS). Mice were orally administered low-dose NaB, high-dose NaB , or 5-aminosalicylic acid (5-ASA). Ferroptosis-related molecules were measured using specific kits, and western blotting (WB) and real-time polymerase chain reaction (RT-qPCR) were used to determine the levels of the target molecules.</p><p><strong>Results: </strong>NaB alleviated symptoms in IBD mice, including reduced weight loss, prolonged colon length, reduced disease activity index (DAI), and reduced spleen index and mRNA expression of inflammatory factors. Additionally, NaB reduced the content of Fe²⁺ and myeloperoxidase (MPO) and increased the content of GSH and the activity of superoxide dismutase (SOD), which reflected NaB-inhibited ferroptosis. Moreover, western blotting showed that NaB enhanced STAT3 and ERK phosphorylation. In addition, NaB regulates the composition and functions of flora related to IBD.</p><p><strong>Conclusion: </strong>NaB alleviates IBD by inhibiting ferroptosis and modulating ERK/STAT3 signaling and the intestinal flora.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2470958"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Waist-to-hip ratio better reflect beta-cell function and predicts diabetes risk in adult with overweight or obesity.","authors":"Na Liu, Bian Wang, Guanxiong Zhang, Minxue Shen, Peng Cheng, Zhanjun Guo, Linhui Zuo, Junya Yang, Min Guo, Min Wang, Zhenqi Liu, Jing Wu","doi":"10.1080/07853890.2025.2462447","DOIUrl":"10.1080/07853890.2025.2462447","url":null,"abstract":"<p><strong>Objective: </strong>Controversy remains as to which obesity measures better predict type 2 diabetes (T2D) risk in overweight or obese individuals. The objective of this study is to determine which commonly used obesity measures better reflect beta cell function and predict T2D risk in participants with overweight or obesity and to validate the findings using prospective cohort data.</p><p><strong>Patients and methods: </strong>Cross-sectional data from the Obesity Clinic of the Xiangya Hospital of the Central South University and prospective cohort from UK Biobank. BMI, waist circumference (WC), waist-to-hip ratio (WHpR), and waist-to-height ratio (WHtR) were measured. Primary outcomes included beta cell function indices in the cross-sectional study and the occurrence of diabetes obtained from UK Biobank data.</p><p><strong>Results: </strong>One thousand four hundred and ninety-seven participants with overweight or obesity (median age 29 years, 41% males) and 322,023 UK Biobank participants without diabetes at baseline (mean age 56.83 years, 50.4% males) were studied. WHpR had a stronger association with beta cell function and central body fat distribution than the other three obesity measures irrespective of glucometabolic states. WHpR associated positively with diabetes risk in participants using the hazard ratio scale (HR per SD increase of WHpR, 2.311, 95% CI 2.250-2.374).</p><p><strong>Conclusions: </strong>WHpR is a superior index in reflecting central body obesity, estimating beta cell function, and predicting T2D risk in people with overweight or obesity compared to BMI, WC, and WHtR.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2462447"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylactic effects of nutrition, dietary strategies, exercise, lifestyle and environment on nonalcoholic fatty liver disease.","authors":"Xiangyong Hao, Hao Song, Xin Su, Jian Li, Youbao Ye, Cailiu Wang, Xiao Xu, Guanglong Pang, Wenxiu Liu, Zihan Li, Tian Luo","doi":"10.1080/07853890.2025.2464223","DOIUrl":"10.1080/07853890.2025.2464223","url":null,"abstract":"<p><strong>Background: </strong>Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease and its prevalence has risen sharply. However, whether nutrition, dietary strategies, exercise, lifestyle and environment have preventive value for NAFLD remains unclear.</p><p><strong>Methods: </strong>Through searching 4 databases (PubMed, Web of Science, Embase and the Cochrane Library) from inception to January 2025, we selected studies about nutrition, dietary strategies, exercise, lifestyle and environment in the prevention of NAFLD and conducted a narrative review on this topic.</p><p><strong>Results: </strong>Reasonable nutrient intake encompassing macronutrients and micronutrients have an independent protective relationship with NAFLD. Besides, proper dietary strategies including mediterranean diet, intermittent fasting diet, ketogenic diet, and dietary approaches to stop hypertension diet have their inhibitory effects on the developmental process of NAFLD. Moreover, right exercises including walking, jogging, bicycling, and swimming are recommended for the prevention of NAFLD because they could effectively reduce weight, which is an important risk factor for NAFLD, and improve liver function. In addition, embracing a healthy lifestyle including reducing sedentary behavior, not smoking, sleeping well and brushing teeth regularly is integral since it not only could reduce the risk of NAFLD but also significantly contribute to overall prevention and control. Finally, the environment, including the social and natural environments, plays a potential role in NAFLD prevention.</p><p><strong>Conclusion: </strong>Nutrition, dietary strategies, exercise, lifestyle and environment play an important role in the prevention of NAFLD. Moreover, this review offers comprehensive prevention recommendations for people at high risk of NAFLD.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2464223"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11827040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of oromotor functions on motor development and feeding outcomes in children with cerebral palsy.","authors":"Amira F Ibrahim, Sara Y Elsebahy, Monira I Aldhahi, Mai M Khalaf, Ahmed A Torad, Mona Mohamed Taha, Amira F El-Sheikh","doi":"10.1080/07853890.2025.2479587","DOIUrl":"10.1080/07853890.2025.2479587","url":null,"abstract":"<p><strong>Background/objective(s): </strong>Children with cerebral palsy often face feeding and swallowing issues, the most common of which include aspiration during feeding and potential pulmonary complications. This impairment can influence other areas of development, including gross motor function, fine motor skills, and oromotor functions involved in feeding and swallowing. This study aimed to investigate the relationship between the level of gross motor function, feeding level, oromotor structural dysfunction, tongue thrust, and eating performance in children with cerebral palsy (CP).</p><p><strong>Patients/materials and methods: </strong>This cross-sectional study included a total of fifty-five children diagnosed with spastic diplegic cerebral palsy, with a mean age of 4.84  years and a mean weight of 12.46  kg. Participants' ages ranged from 2 to 14  years. All patients underwent evaluations to determine their level of gross motor function using the Gross Motor Function Classification System (GMFCS), feeding level assessed using the Functional Oral Intake Scale, assessment of oromotor structural dysfunction using the Orofacial Motor Functional Assessment Scale, tongue thrust using the Tongue Thrust Rating Scale, and feeding performance using the Oral Motor Assessment Scale.</p><p><strong>Results: </strong>Correlational analysis revealed that children with better gross motor function tended to exhibit improved feeding levels, orofacial motor function, and feeding performance (<i>p</i> < 0.05); however, no significant relationship was observed between gross motor function and tongue thrust. Regression models showed moderate positive correlations for age, weight, and height, with respective <i>R</i>² values of 0.21, 0.23, and 0.28, indicating some influence on outcomes, but with much unexplained variability.</p><p><strong>Conclusions: </strong>Gross motor function significantly influences feeding and orofacial motor function. These findings suggest that individuals with higher feeding levels tend to have better overall orofacial motor function and feeding performance. Understanding these relationships can inform interventions aimed at improving feeding outcomes and the overall quality of life of children with CP.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2479587"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring NamiRNA networks and time-series gene expression in osteogenic differentiation of adipose-derived stem cells.","authors":"Xin Jin, Yi Lu, Zhihong Fan","doi":"10.1080/07853890.2025.2478323","DOIUrl":"10.1080/07853890.2025.2478323","url":null,"abstract":"<p><strong>Background: </strong>Adipose-derived stem cells (ADSCs) are a type of stem cell found in adipose tissue with the capacity to differentiate into multiple lineages, including osteoblasts. The differentiation of ADSCs into osteoblasts underlies osteogenic and pathological cellular basis in osteoporosis, bone damage and repair.</p><p><strong>Methods: </strong>Focused on ADSCs osteogenic differentiation, we conducted mRNA, microRNA expression and bioinformatics analysis, including gene differential expression, time series-based trend analysis, functional enrichment, and generates potential nuclear activating miRNAs (NamiRNA) regulatory network. The screened mRNAs in NamiRNA regulatory network were validated with correlation analysis.</p><p><strong>Results: </strong>The NamiRNA Regulatory Network reveals 4 mRNAs (C12orf61, MIR31HG, NFE2L1, and PCYOX1L) significantly downregulated in differentiated group and may be associated with ADSCs stemness. Furthermore, the significantly upregulated 10 genes (ACTA2, TAGLN, LY6E, IFITM3, NGFRAP1, TCEAL4, ATP5C1, CAV1, RPSA, and KDELR3) were significantly enriched in osteogenic-related pathways, and negatively correlated with ADSCs cell stemness <i>in vitro</i>.</p><p><strong>Conclusion: </strong>These findings uncover potential genes related to ADSCs osteogenic differentiation, and provide theoretical basis for underlying ADSCs osteogenic differentiation and related diseases.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2478323"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of pre-treatment and post-treatment plasma Epstein-Barr virus DNA in peripheral T-cell lymphomas.","authors":"Chu-Yi Chan, Tung-Liang Lin, Ming-Chung Kuo, Yu-Shin Hung, Hung Chang, Che-Wei Ou, Jin-Hou Wu, Hsuan-Jen Shih, Yi-Jiun Su, Lee-Yung Shih, Yuen-Chin Ong, Wen-Yu Chuang, Hsiao-Wen Kao","doi":"10.1080/07853890.2025.2478315","DOIUrl":"10.1080/07853890.2025.2478315","url":null,"abstract":"<p><strong>Background: </strong>Plasma Epstein-Barr virus (EBV) DNA levels predict the prognosis of extranodal NK/T-cell lymphoma, nasal type (NK/TCL), but its role in other peripheral T-cell lymphomas (PTCL) remains undetermined. This study aimed to determine the prognostic impact of plasma EBV DNA in PTCL patients.</p><p><strong>Methods: </strong>We retrospectively enrolled 134 PTCL patients diagnosed between April 2008 and March 2022, with plasma EBV DNA data available at diagnosis in 124 patients and during post-treatment follow-up in 73 patients.</p><p><strong>Results: </strong>International Prognostic Index or prognostic index for T-cell lymphoma scores > 1 was associated with higher median plasma EBV DNA levels in all analyzed patients. Plasma EBV DNA positivity at the time of diagnosis was not associated with treatment response, overall survival (OS), or progression-free survival (PFS) in non-NK/TCL patients. In NK/TCL patients, an EBV DNA level < 3255 copies/mL at diagnosis was significantly associated with higher five-year PFS (64.2% vs. 16.7%, <i>p</i> < 0.001) and OS rates (64.4% vs. 20.8%, <i>p</i> < 0.001). Plasma EBV DNA positivity at the time of complete remission and during post-treatment follow-up was significantly linked to lower PFS and OS rates in NK/TCL patients. Multivariate analysis revealed that advanced-stage disease, elevated β2-microglobulin, and EBV DNA level ≥ 3255 copies/mL at diagnosis were independent predictors for OS and PFS in NK/TCL patients.</p><p><strong>Conclusions: </strong>Plasma EBV DNA at diagnosis and during follow-up predict survival for NK/TCL patients but not for patients with other PTCL subtypes. Detection and monitoring of plasma EBV DNA levels at diagnosis and post-treatment follow-up for NK/TCL patients is recommended.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2478315"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of psychological health effects of nurses during 2022-2023 of the COVID-19 pandemic: a descriptive study in Southern Taiwan.","authors":"Hui-Ru Lin, Yung-Kuo Lee, Chen-Lin Chang, Ching-Hui Kuo, Hsin-Yun Ho, Chi-Jen Wu, Yi-Qian Chen, Cheng-Chun Wu, Yu-Cheng Ho, Tian-Huei Chu, Cheng-Hsin Chuang, Chou-Yuan Ko","doi":"10.1080/07853890.2024.2447405","DOIUrl":"10.1080/07853890.2024.2447405","url":null,"abstract":"<p><strong>Background: </strong>Nurses on the frontlines of the pandemic have increased workloads, burnout, and virus exposure, leading to mental health challenges and a lack of resources for patient care. Mental health support for nurses during the COVID-19 outbreak has become a priority. This study evaluated psychological health outcomes of among nurses during the 2022-2023 COVID-19 pandemic in Taiwan, focusing on personal and work-related fatigue as key contributors to emotional distress.</p><p><strong>Methods: </strong>A cross-sectional questionnaire was distributed to 200 nurses in a southern Taiwan hospital between 2022 and 2023. Emotional distress and mental health were assessed using the BSRS-5 (Brief Symptom Rating Scale) and CHQ-12 (Chinese Health Questionnaire). Correlation and regression analyses were conducted to identify factors influencing emotional distress and mental health outcomes.</p><p><strong>Results: </strong>Nurses aged 40-59 (52.85, <i>p</i> = 0.01), those in emergency departments (56.71, <i>p</i> = 0.001), and those caring for COVID-19 patients (50, <i>p</i> = 0.007) reported higher personal exhaustion. Significant differences in work-related fatigue levels were observed based on working environments (52.78, <i>p</i> < 0.001), no beliefs regarding religion (46.53, <i>p</i> = 0.036), care for COVID-19 patients (47, <i>p</i> < 0.001) and previously diagnosed with COVID-19 (46.58, <i>p</i> = 0.005). Key factors influencing emotional distress included marital status, number of children, and workplace (<i>p</i> < 0.05), while mental health variations were noted  in age, marital status, number of children, workplace, and years of experience (<i>p</i> < 0.05). During the COVID-19 pandemic, nurses' emotional distress and mental health were significantly correlated with specific stressors such as age, workplace, care for confirmed COVID-19 patients, and previous COVID-19 diagnoses (<i>p</i> < 0.001).</p><p><strong>Conclusions and implications for nursing management: </strong>This study highlights the stressors affecting nurses' mental health during the 2022-2023 COVID-19 pandemic, emphasizing the need for stress-specific mental health support. Understanding these stress-specific factors is important for figuring out what nurses need to improve their mental health, which can lead to better care for patients.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2447405"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}