Annals of medicine最新文献

{"title":"Regarding: \"the impact of body mass index on the efficacy of CDK4/6 inhibitors in patients with metastatic breast cancer\".","authors":"Dong Li, Cong Sun, Chang Wang","doi":"10.1080/07853890.2026.2620175","DOIUrl":"10.1080/07853890.2026.2620175","url":null,"abstract":"","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"58 1","pages":"2620175"},"PeriodicalIF":4.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12862850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regarding: \"Associations between the completion rate of the unsupervised community swallowing training and swallowing function in older adults with mild dysphagia: a quasi-experimental pre-post study without control'.","authors":"Youtao Zhang","doi":"10.1080/07853890.2026.2626068","DOIUrl":"10.1080/07853890.2026.2626068","url":null,"abstract":"","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"58 1","pages":"2626068"},"PeriodicalIF":4.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12865820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146108633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of risk factors for postoperative wound healing in children with bone cysts.","authors":"Muhan Yu, Yuxi Su","doi":"10.1080/07853890.2026.2679358","DOIUrl":"10.1080/07853890.2026.2679358","url":null,"abstract":"<p><strong>Background: </strong>Bone cysts are common benign bone tumour-like lesions in children and adolescents. Postoperative wound healing complications significantly affect patient outcomes. Current research primarily focuses on cyst recurrence and bone healing, while studies targeting risk factors for poor postoperative wound healing in children are relatively scarce.</p><p><strong>Methods: </strong>This single-center retrospective cohort analysis included 99 children with bone cysts who were hospitalized and underwent surgical treatment between January 2021 and September 2025. We analyzed these data in November 2025. Univariate analysis and multivariate logistic regression were used to assess the association of demographic, lesion characteristics and surgery-related variables with poor wound healing.</p><p><strong>Results: </strong>Among the 99 children, 13 (13.1%) experienced poor wound healing. Multivariate analysis revealed that no or single-dose preoperative antibiotic prophylaxis (OR = 9.808, <i>p</i> = 0.031; OR = 34.161, <i>p</i> = 0.010), physeal involvement of the lesion (OR = 7.764, <i>p</i> = 0.023) and operative time ≥90 min (OR = 8.597, <i>p</i> = 0.026) were independent risk factors for poor surgical wound healing.</p><p><strong>Conclusion: </strong>Inadequate perioperative antibiotic prophylaxis (either no administration or a single preoperative dose only), physeal involvement of the lesion and prolonged operative time are independent risk factors for poor postoperative wound healing in children. Standardizing antibiotic protocols and identifying high-risk patients based on lesion anatomical characteristics are crucial for reducing the risk of complications.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"58 1","pages":"2679358"},"PeriodicalIF":4.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13244503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on 'the impact of body mass index on the efficacy of CDK4/6 inhibitors in patients with metastatic breast cancer'.","authors":"Xiao Chen, Sisi Gu, Shengliang Ding","doi":"10.1080/07853890.2026.2624893","DOIUrl":"10.1080/07853890.2026.2624893","url":null,"abstract":"","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"58 1","pages":"2624893"},"PeriodicalIF":4.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12912224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146204285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regarding: 'qualitative analysis of out-of-hospital self-management capabilities and ongoing care needs in patients with gynecological malignancies and venous thromboembolism'.","authors":"Yifan Ye","doi":"10.1080/07853890.2026.2638087","DOIUrl":"10.1080/07853890.2026.2638087","url":null,"abstract":"","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"58 1","pages":"2638087"},"PeriodicalIF":4.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological considerations for validating a machine learning model predicting recurrence after ESD in superficial esophageal cancer.","authors":"Dandan Song, Shufu Hou, Jing Gao","doi":"10.1080/07853890.2026.2634569","DOIUrl":"10.1080/07853890.2026.2634569","url":null,"abstract":"","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"58 1","pages":"2634569"},"PeriodicalIF":4.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12943806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147286544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The molecular mechanism of cuproptosis and research progress in pancreatic diseases.","authors":"Qizhi Wang, Huijun Chen, Zhen Lv, Peng Zhang, Yingxiao Li, Chuanliang Zhao, Shengqiang Li","doi":"10.1080/07853890.2025.2608490","DOIUrl":"10.1080/07853890.2025.2608490","url":null,"abstract":"<p><strong>Purpose: </strong>Cuproptosis has been proven to be a novel mode of cell death, distinct from other types of cell death such as necrosis, ferroptosis, pyroptosis, and apoptosis. This study aims to systematically review the molecular mechanisms of cuproptosis in recent years and its research progress in pancreatic diseases.</p><p><strong>Methods: </strong>By searching PubMed and Web of Science databases, 113 key literatures were included for thematic analysis, covering the molecular mechanism of cuproptosis and its role in the occurrence and development of pancreatic cancer, acute and chronic pancreatitis, diabetes, pancreatic cyst, pancreatic injury and pancreatic neuroendocrine tumor.</p><p><strong>Results: </strong>Cuproptosis refers to the accumulation of copper ions in cells, which leads to instability of ferritin and aggregation of acylated proteins, resulting in oxidative stress-related cell death. Recent studies have shown that cuproptosis plays an important role in the occurrence and development of various pancreatic diseases, such as pancreatic cancer, acute and chronic pancreatitis, diabetes, pancreatic cysts, pancreatic injuries and pancreatic neuroendocrine tumor. The inducers of cuproptosis, such as disulfiram, chloroquinolones, and perilla phenols, alleviate pancreatic cancer by promoting cell cuproptosis. Copper chelators such as tetraethylenepentamine and tetrathiomolybdate promote the recovery of pancreatic injury by inhibiting cell cuproptosis.</p><p><strong>Conclusions: </strong>Cuproptosis plays a crucial role in the pathogenesis of pancreatic diseases. Further research on the cuproptosis pathway may become a potential target for the treatment of pancreatic diseases.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"58 1","pages":"2608490"},"PeriodicalIF":4.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12777854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term mortality in pediatric sepsis: a systematic review and meta-analysis.","authors":"Yongbiao Lv, Jiayi Zheng, Junxiang Cai, Jingwei Shui, Yuntao Liu, Zhongde Zhang","doi":"10.1080/07853890.2026.2617403","DOIUrl":"10.1080/07853890.2026.2617403","url":null,"abstract":"<p><strong>Background: </strong>Pediatric sepsis represents a significant factor in the mortality rates among children, with survivors remaining highly fragile during the period following discharge. While in-hospital and short-term mortality have been widely studied, the long-term mortality of pediatric sepsis is not adequately synthesized or appreciated. This study aims to estimate the long-term mortality associated with pediatric sepsis, providing a basis for optimizing post-discharge surveillance and care protocols.</p><p><strong>Methods: </strong>This systematic review and meta-analysis followed PRISMA guidelines and was registered in PROSPERO (CRD420251137504). Exhaustive searches were conducted in PubMed, Embase, the Cochrane Library, and Web of Science for studies published from the inception of each database to June 30, 2025. Studies reporting long-term mortality in pediatric sepsis patients diagnosed using international consensus criteria were included. After literature screening, long-term mortality was pooled using a random effects meta-analysis in R statistical software.</p><p><strong>Results: </strong>A total of 72,065 records were identified through database searching. After removing duplicates and screening, six studies comprising 11,318 pediatric sepsis patients were included. The pooled long-term mortality in pediatric sepsis was 11% (95% CI: 7-16%), though significant heterogeneity was observed (<i>I</i>² = 98.2%, <i>p</i> < 0.001). Sensitivity analyses yielded similar results, and evidence of publication bias was limited.</p><p><strong>Conclusion: </strong>Long-term mortality after pediatric sepsis was 11%, highlighting the persistent risk of mortality after hospital discharge. Further high-quality longitudinal studies are required to identify modifiable risk factors and guide evidence-based follow-up and personalized care.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"58 1","pages":"2617403"},"PeriodicalIF":4.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12821344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coagulation dysfunction in children with secondary hemophagocytic lymphohistiocytosis: a comprehensive analysis.","authors":"Chaojun Duan, Qing Liao, Jiale Gong, Xiaofang Bai, Xiangdong Xu, Bo Zhang","doi":"10.1080/07853890.2026.2617724","DOIUrl":"10.1080/07853890.2026.2617724","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Coagulation dysfunction plays a critical role in the pathogenesis and prognosis of secondary haemophagocytic lymphohistiocytosis (sHLH) in children. This study aims to systematically analyze the coagulation profiles in paediatric sHLH patients, evaluate their prognostic value and provide an effective basis for reducing mortality in children with HLH.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 209 paediatric patients with sHLH were enrolled in this study. Coagulation parameters at admission were collected and compared across groups stratified by aetiology, prognosis and presence of disseminated intravascular coagulation (DIC). The dynamic evolution of coagulation parameters was analyzed using LOWESS curve fitting. LASSO regression was applied to screen for potential risk factors for DIC in sHLH patients, followed by univariate and multivariate logistic regression to identify independent risk factors. Similarly, Kaplan-Meier survival analysis along with univariate and multivariate logistic regression models were used to determine independent risk factors associated with prognosis in sHLH patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Paediatric patients with secondary haemophagocytic lymphohistiocytosis (sHLH) presented with significant coagulation abnormalities upon hospital admission, as evidenced by markedly elevated prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT), thrombin time (TT) and D-dimer (DD) levels (all &lt;i&gt;p&lt;/i&gt; &lt; 0.01). Those with infection-associated HLH demonstrated significantly prolonged PT (&lt;i&gt;p&lt;/i&gt; = 0.009), APTT (&lt;i&gt;p&lt;/i&gt; &lt; 0.001) and TT (&lt;i&gt;p&lt;/i&gt; = 0.0028), along with significantly lower fibrinogen (FIB) levels (&lt;i&gt;p&lt;/i&gt; &lt; 0.001), compared to patients with autoimmune-associated HLH. Compared to survivors, deceased HLH patients had significantly higher PT and INR (&lt;i&gt;p&lt;/i&gt; &lt; 0.01), as well as significantly elevated DD (&lt;i&gt;p&lt;/i&gt; = 0.014). Significant differences were observed in coagulation parameters - PT, INR, APTT, TT, DD, FIB, thrombin-antithrombin complex (TAT) and tissue-type plasminogen activator-inhibitor complex (t-PAIC) - between HLH patients with and without disseminated intravascular coagulation (DIC) (all &lt;i&gt;p&lt;/i&gt; &lt; 0.05), and the dynamic changes in these parameters (particularly PT, FIB and DD) also differed notably between the two groups. Neurological involvement, hyper-ferritinaemia and elevated INR were identified as independent risk factors for DIC, while neurological involvement and the presence of DIC itself were independent predictors of mortality in paediatric patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Coagulation dysfunction serves as a core pathological driver in paediatric sHLH, being especially severe in infection-associated cases. Dynamic monitoring of key coagulation parameters and ferritin levels is crucial for early risk warning and timely intervention. Targeted management of coagulation abnormalities, together with","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"58 1","pages":"2617724"},"PeriodicalIF":4.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12818304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proband-independent noninvasive prenatal diagnosis for spinal muscular atrophy: early detection paving the way for early prenatal treatment.","authors":"Huanyun Li, Shanshan Gao, Shaojun Li, Zhenhua Zhao, Xinyu Fu, Jingqi Zhu, Jun Feng, Weiqin Tang, Di Wu, Xiangdong Kong","doi":"10.1080/07853890.2025.2610892","DOIUrl":"10.1080/07853890.2025.2610892","url":null,"abstract":"<p><strong>Background: </strong>To validate the clinical efficacy of non-invasive prenatal diagnosis (NIPD) for spinal muscular atrophy (SMA) in the first trimester and extend its applicability to families without probands.</p><p><strong>Method: </strong>From December 2020 to October 2024, 288 high-risk pregnancies were recruited prospectively, with 81 qualifying for NIPD after genetic counseling. Among the eligible cases, parent-based haplotypes were successfully constructed in 75 families (92.6%), while grandparent-based haplotype reconstruction was performed for the remaining 6 cases (7.4%) where proband samples were unavailable. Through targeted sequencing of the <i>SMN1/SMN2</i> gene and flanking informative SNPs in maternal plasma, fetal haplotypes were inferred by analyzing dosage changes in cell-free DNA (cfDNA) using Bayes factor. All NIPD results were subsequently validated through invasive diagnostic procedures (chorionic villus sampling or amniocentesis).</p><p><strong>Results: </strong>The haplotypes were successfully constructed in 81 families through parents or grandparents of the identified variant carriers. 76 families (93.8%) successfully obtained NIPD results, among which the earliest gestational week for successful NIPD was 7⁺³weeks, with a minimum fetal fraction of 1.9%. 5 cases were classified 'no call' results due to pathogenic variant-adjacent recombination events (2/5), insufficient or unevenly distributed informative SNPs (2/5), and subthreshold fetal fraction (1/5). The average gestational age of NIPD blood drawing is 9 weeks. Validation test showed the NIPD results accuracy was 100%.</p><p><strong>Conclusion: </strong>This study demonstrates the clinical feasibility of grandparent-assisted haplotype construction for SMA families without probands and enables accurate early prenatal diagnosis of SMA in first-trimester pregnancies.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"58 1","pages":"2610892"},"PeriodicalIF":4.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12777998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}