Jieying Wu, Yingsheng Xu, Tielun Yin, Nan Zhang, Dongsheng Fan, Shan Ye
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The UMN-D ALS patients were categorized into two groups based on the direction of symptom spread, including 25 patients with horizontal spread (group H) and 20 patients with vertical spread (group V). Diffusivity indices were derived through whole-brain analysis and probabilistic fiber tracking.</p><p><strong>Results: </strong>According to the voxel-based analysis and tract-based spatial statistics, differences in axial diffusivity (AD) in the CC were observed between disease subgroups, with patients in group H showing higher AD values than those in group V. Fiber tracking analysis revealed persistent differences in the AD indices of CC-primary motor cortex (PMC) fibers between the two disease subgroups.</p><p><strong>Conclusion: </strong>In UMN-D ALS patients, the direction of symptom spread may be related to the degree of CC involvement. The AD metric may be a more specific indicator of CC damage.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2490822"},"PeriodicalIF":0.0000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001847/pdf/","citationCount":"0","resultStr":"{\"title\":\"Unveiling structural damage of the corpus callosum in amyotrophic lateral sclerosis through diffusion tensor imaging and spread direction perspectives.\",\"authors\":\"Jieying Wu, Yingsheng Xu, Tielun Yin, Nan Zhang, Dongsheng Fan, Shan Ye\",\"doi\":\"10.1080/07853890.2025.2490822\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Damage to the corpus callosum (CC) in amyotrophic lateral sclerosis (ALS) patients has been confirmed <i>via</i> electrophysiological, neuroimaging, and autopsy studies. Additionally, the CC is hypothesized to serve as a pathway for the spread of pathological information. This study aimed to investigate whether the CC plays a mediating role in the symptomatic spread of ALS.</p><p><strong>Methods: </strong>In this observational study, diffusion tensor imaging (DTI) data were acquired from 45 individuals with the upper motor neuron-dominant (UMN-D) phenotype of ALS. The UMN-D ALS patients were categorized into two groups based on the direction of symptom spread, including 25 patients with horizontal spread (group H) and 20 patients with vertical spread (group V). Diffusivity indices were derived through whole-brain analysis and probabilistic fiber tracking.</p><p><strong>Results: </strong>According to the voxel-based analysis and tract-based spatial statistics, differences in axial diffusivity (AD) in the CC were observed between disease subgroups, with patients in group H showing higher AD values than those in group V. Fiber tracking analysis revealed persistent differences in the AD indices of CC-primary motor cortex (PMC) fibers between the two disease subgroups.</p><p><strong>Conclusion: </strong>In UMN-D ALS patients, the direction of symptom spread may be related to the degree of CC involvement. 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引用次数: 0
摘要
目的:肌萎缩侧索硬化症(ALS)患者的胼胝体(CC)损伤已通过电生理、神经影像学和尸检研究得到证实。此外,CC被假设为病理信息传播的途径。本研究旨在探讨CC是否在ALS的症状性扩散中起中介作用。方法:在本观察性研究中,获取45例ALS上运动神经元显性(UMN-D)表型患者的弥散张量成像(DTI)数据。根据症状扩散方向将UMN-D ALS患者分为水平扩散25例(H组)和垂直扩散20例(V组)。扩散指数通过全脑分析和概率纤维跟踪得到。结果:根据基于体素的分析和基于束的空间统计,不同疾病亚组之间CC的轴向扩散系数(AD)存在差异,H组患者的AD值高于v组。纤维跟踪分析显示,两个疾病亚组之间CC-primary motor cortex (PMC)纤维的AD指数存在持续差异。结论:UMN-D型ALS患者的症状扩散方向可能与CC受累程度有关。AD指标可能是CC伤害的一个更具体的指标。
Unveiling structural damage of the corpus callosum in amyotrophic lateral sclerosis through diffusion tensor imaging and spread direction perspectives.
Objective: Damage to the corpus callosum (CC) in amyotrophic lateral sclerosis (ALS) patients has been confirmed via electrophysiological, neuroimaging, and autopsy studies. Additionally, the CC is hypothesized to serve as a pathway for the spread of pathological information. This study aimed to investigate whether the CC plays a mediating role in the symptomatic spread of ALS.
Methods: In this observational study, diffusion tensor imaging (DTI) data were acquired from 45 individuals with the upper motor neuron-dominant (UMN-D) phenotype of ALS. The UMN-D ALS patients were categorized into two groups based on the direction of symptom spread, including 25 patients with horizontal spread (group H) and 20 patients with vertical spread (group V). Diffusivity indices were derived through whole-brain analysis and probabilistic fiber tracking.
Results: According to the voxel-based analysis and tract-based spatial statistics, differences in axial diffusivity (AD) in the CC were observed between disease subgroups, with patients in group H showing higher AD values than those in group V. Fiber tracking analysis revealed persistent differences in the AD indices of CC-primary motor cortex (PMC) fibers between the two disease subgroups.
Conclusion: In UMN-D ALS patients, the direction of symptom spread may be related to the degree of CC involvement. The AD metric may be a more specific indicator of CC damage.