Annals of medicine最新文献

{"title":"Reproduction outcomes and prognostic significance of pregnancy after nasopharyngeal carcinoma treatment.","authors":"Meijuan Luo, Liting Liu, Zhenchong Yang, Yujing Liang, Dongxiang Wen, Sailan Liu, Xiaoyun Li, Chuanmiao Xie, Linquan Tang, Qiuyan Chen, Shanshan Guo, Haiqiang Mai","doi":"10.1080/07853890.2025.2458196","DOIUrl":"10.1080/07853890.2025.2458196","url":null,"abstract":"<p><strong>Objective: </strong>Many female patients with nasopharyngeal carcinoma (NPC) desire to reproduce after treatment. To evaluate the outcomes of subsequent pregnancy after NPC and explore the prognostic effects of pregnancy in women.</p><p><strong>Methods: </strong>Female patients with locoregional NPC were included, and their pregnancy status, newborn information, and obstetric information were collected. Pregnant patients after therapy were matched to non-pregnant patients for survival analysis and overall survival (OS), disease-free survival (DFS), distant metastasis-free survival (DMFS), and locoregional relapse-free survival (LRFS) were assessed.</p><p><strong>Results: </strong>Of 895 patients, 79 conceived after NPC treatment. Of these, 52 women successfully delivered, and the rest had abortions. No abnormalities were recorded in any of the newborns and the caesarean section rate was 30.1%. The median birth weight of newborns was 3.11 kg. Patients who delivered successfully were younger than those who had an abortion. Among the pregnancies, four cases of spontaneous abortion and two cases of ectopic pregnancy were recorded. No significant differences in OS, DFS, LRFS, or DMFS were observed between the 79 subsequently pregnant patients and 315 matched non-pregnant patients.</p><p><strong>Conclusion: </strong>Pregnancy after NPC treatment was not associated with adverse clinical outcomes. Abortion may not be a remedial choice post-treatment in patients with NPC.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2458196"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidating cognitive processes in cardiac arrest team leaders: a virtual reality-based cued-recall study of experts and novices.","authors":"Vitaliy Popov, Bryan Harmer, Sophie Raphael, Isabella Scott, Alanson P Sample, James M Cooke, Michael Cole","doi":"10.1080/07853890.2025.2470976","DOIUrl":"10.1080/07853890.2025.2470976","url":null,"abstract":"<p><strong>Background: </strong>Team leadership during medical emergencies like cardiac arrest resuscitation is cognitively demanding, especially for trainees. These cognitive processes remain poorly characterized due to measurement challenges. Using virtual reality simulation, this study aimed to elucidate and compare communication and cognitive processes-such as decision-making, cognitive load, perceived pitfalls, and strategies-between expert and novice code team leaders to inform strategies for accelerating proficiency development.</p><p><strong>Methods: </strong>A simulation-based mixed methods approach was utilized within a single large academic medical center, involving twelve standardized virtual reality cardiac arrest simulations. These 10- to 15-minutes simulation sessions were performed by seven experts and five novices. Following the simulations, a cognitive task analysis was conducted using a cued-recall protocol to identify the challenges, decision-making processes, and cognitive load experienced across the seven stages of each simulation.</p><p><strong>Results: </strong>The analysis revealed 250 unique cognitive processes. In terms of reasoning patterns, experts used inductive reasoning, while novices tended to use deductive reasoning, considering treatments before assessments. Experts also demonstrated earlier consideration of potential reversible causes of cardiac arrest. Regarding team communication, experts reported more critical communications, with no shared subthemes between groups. Experts identified more teamwork pitfalls, and suggested more strategies compared to novices. For cognitive load, experts reported lower median cognitive load (53) compared to novices (80) across all stages, with the exception of the initial presentation phase.</p><p><strong>Conclusions: </strong>The identified patterns of expert performance - superior teamwork skills, inductive clinical reasoning, and distributed cognitive strategiesn - can inform training programs aimed at accelerating expertise development.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2470976"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of early prognostic biomarkers in Severe Fever with Thrombocytopenia Syndrome using machine learning algorithms.","authors":"Jie Zhu, Jianmei Zhou, Chunhui Tao, Guomei Xia, Bingyan Liu, Xiaowei Zheng, Xu Li, Zhenhua Zhang","doi":"10.1080/07853890.2025.2451184","DOIUrl":"10.1080/07853890.2025.2451184","url":null,"abstract":"<p><strong>Objective: </strong>We aimed at identifying acute phase biomarkers in Severe Fever with Thrombocytopenia Syndrome (SFTS), and to establish a model to predict mortality outcomes.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on multicenter clinical data. Group-based trajectory modeling (GBTM) was utilized to demonstrate the overall trend of laboratory indicators and their correlation with mortality. Six different machine learning algorithms were employed to develop prognostic models based on the clinical features during the acute phase, which were reduced using Lasso regression.</p><p><strong>Results: </strong>Seven indicators (ALT, AST, BUN, LDH, a-HBDH, DD, and PLT) at 7-10 days post-onset and their change slopes were found to be crucial during disease progression. These, along with other clinical features, were reduced to 8 variables using Lasso regression for model construction. The random forest model demonstrated the best performance in both internal validation (AUC: 0.961) and external validation (AUC: 0.948). Decision Curve Analysis indicated a good balance between model benefits and risks.</p><p><strong>Conclusions: </strong>a-HBDH and its change slope along with central nervous symptom manifestations within 7-10 days after onset accurately predicted mortality in SFTS. Various algorithms provided a comprehensive overview of disease progression and constructed more stable and efficient models.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2451184"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal doses of intranasal esketamine plus dexmedetomidine for sedating toddlers during transthoracic echocardiography: a prospective, double-blind, randomized trial.","authors":"Dongjie Pei, Ting Xiao, Li Zeng, Siwei Wei, Lei Wang, Zhen Du, Shuangquan Qu","doi":"10.1080/07853890.2025.2453087","DOIUrl":"10.1080/07853890.2025.2453087","url":null,"abstract":"<p><strong>Introduction: </strong>Esketamine has unique advantages in combination with dexmedetomidine for sedation in young children, owing to its sympathetic activity and mild respiratory depression. However, the optimal dose is yet to be determined. In this study, we compared the different doses of intranasal esketamine combined with dexmedetomidine for sedation during transthoracic echocardiography in toddlers.</p><p><strong>Patients and methods: </strong>A total of 121 eligible children aged 13 years, who were scheduled for transthoracic echocardiography were randomized into three groups. They were treated with intranasal dexmedetomidine 1 mcg.kg^-1 + esketamine 0.5 mg.kg^-1 (group S1), dexmedetomidine 1 mcg.kg^-1 + esketamine 1 mg.kg^-1 (group S2), or dexmedetomidine 1 mcg.kg^-1 + esketamine 1.5 mg.kg^-1 (group S3). The primary outcome was the success rate of sedation, other outcomes included HR, SpO₂, onset time, wake-up time, and adverse effects.</p><p><strong>Results: </strong>The success rate of sedation was significantly higher in groups S2 (85.4%) and S3 (87.5%) than ingroup S1 (60%) (<i>p</i> = 0.004). The baseline HR and SpO₂ did not differ between the groups at the corresponding time points following drug administration. The onset time and duration of sedation in group S1 were significantly longer than those in groups S2 and S3 (<i>p</i> = 0.000). However, there were no differences in the wake-up time or adverse effects among the three groups.</p><p><strong>Conclusions: </strong>Intranasal administration of 1 mg.kg^-1 esketamine combined with 1 mcg.kg^-1 dexmedetomidine provided satisfactory sedation in young children undergoing transthoracic echocardiography. This sedative approach offers a rapid onset of awakening with few side effects.</p><p><strong>Clinical trial registration number: </strong>ChiCTR2200060976, 2022/06/14 (trail from August 2022 to January 2023).</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2453087"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of dupilumab with concomitant topical calcineurin inhibitors treatment for preschool children with atopic dermatitis: a retrospective cohort study.","authors":"Wu Liming, Kamran Ali","doi":"10.1080/07853890.2025.2449589","DOIUrl":"10.1080/07853890.2025.2449589","url":null,"abstract":"<p><strong>Background/objective: </strong>Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease that typically occurs in childhood/infancy and is associated with complications like extracutaneous atopic morbidity. Providing systemic treatment for pediatric AD patients with unmet comprehensive medical needs remains challenging. We present a cohort study describing the efficacy and safety of dupilumab combined with topical calcineurin inhibitors (TCI) in children with moderate-to-severe atopic dermatitis under the age of 6 years.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted at a single center to analyze the use of dupilumab in combination with topical calcineurin inhibitors (TCI) in children aged 6 years and under moderate-to-severe AD that was inadequately controlled with topical therapy.</p><p><strong>Results: </strong>Overall, 23 preschool children (mean [<i>SD</i>] age, 4.78 [1.278] years); 10 boys (43.5%) and 13 girls (56.5%) received 300 mg dupilumab every four weeks and TCI. The primary outcome, the average Eczema Area and Severity Index (EASI) percentage reduction from baseline, was -70.85%. Significant improvement was also observed in secondary outcomes: caregiver-reported Peak Pruritus numerical rating scale (P-NRS) (-77.73%), Body Surface Area (BSA) (-62.11%), and Investigators Global Assessment (IGA) (-36.23%) at week 16. A 1-2 grade decrease in IGA after 16 weeks of treatment was achieved by 91.3% of patients. There was a significant improvement in P-NRS and EASI scores from baseline to week 16. Injection-site reaction (one patient) and facial redness (two patients) were recorded. No severe drug-related adverse events were observed.</p><p><strong>Conclusion: </strong>This study demonstrated that the combination of dupilumab and TCIs improved symptoms and quality of life in preschoolers with moderate-to-severe AD.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2449589"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic and clinicopathological value of C-reactive protein in patients with bladder cancer: a meta-analysis.","authors":"Xiangping Feng, Zongxin Zhang, Shuiying Mao","doi":"10.1080/07853890.2024.2445781","DOIUrl":"10.1080/07853890.2024.2445781","url":null,"abstract":"<p><strong>Background: </strong>The prognostic value of C-reactive protein (CRP) in patients with bladder cancer (BCa) has been widely analysed; however, the results remain conflicting. Therefore, we performed this meta-analysis to identify the precise role of CRP level in predicting BCa prognosis.</p><p><strong>Methods: </strong>PubMed, Web of Science, Embase and Cochrane Library databases were comprehensively searched until 19 April 2024. The impact of CRP level on predicting the prognosis of patients with BCa was examined using combined hazard ratios (HRs) and 95% confidence intervals (CIs). The relationship between CRP level and BCa clinicopathological characteristics was investigated by combining the odds ratios (ORs) with 95%CIs.</p><p><strong>Results: </strong>Twenty studies with 7276 patients were enrolled in this study. As revealed by pooled data, elevated CRP levels were markedly related to poor overall survival (OS) (HR = 2.02, 95%CI = 1.41-2.90, <i>p</i> < .001), inferior cancer-specific survival (CSS) (HR = 1.46, 95%CI = 1.29-1.66, <i>p</i> < .001), shortened recurrence-free survival (RFS) (HR = 1.25, 95%CI = 1.17-1.33, <i>p</i> < .001) and dismal progression-free survival (PFS) (HR = 2.28, 95%CI = 1.80-2.90, <i>p</i> < .001) in BCa patients. Nevertheless, there was no significant relationship between CRP level and sex, tumour size, tumour grade or lymph node metastasis (LNM) in BCa.</p><p><strong>Conclusions: </strong>Elevated CRP levels were significantly related to poor OS, CSS, RFS and PFS of BCa patients with BCa. CRP could act as a reliable biomarker for predicting the short- and long-term survival of patients with BCa in clinical practice.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2445781"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of time from blood specimens collection to centrifugation on the diagnosis of gestational diabetes mellitus.","authors":"Binbin Yin, Yongying Bai, Jinghua Zhang, Yan Zhang, Xia Li, Yue Jin, Xinyi Mou, Kexin Fang, Yan Chen, Yue Cheng, Bo Zhu","doi":"10.1080/07853890.2025.2452352","DOIUrl":"10.1080/07853890.2025.2452352","url":null,"abstract":"<p><strong>Objective: </strong>The process of glycolysis from blood collection to centrifugation impacts the diagnosis of gestational diabetes mellitus (GDM). However, the specific characteristics of the working environment in China and its influence on GDM diagnosis still need to be clarified.</p><p><strong>Methods: </strong>Firstly, 15 pregnant women were recruited, and six specimens were collected from each in a fasting state. The specimens were left at room temperature for different times (0.5, 1, 2, 3, 4, and 5 h) and then centrifuged. Subsequently, data were collected from pregnant women who underwent oral glucose tolerance test (OGTT) between June 1, 2021, and July 30, 2022. Pregnant women were categorized into different groups based on different pre-treatment times, and the incidence of GDM was calculated for each group.</p><p><strong>Results: </strong>Glucose levels gradually decreased as the specimen remained longer before centrifugation, a decrease of 1.15 mmol/L (27.58%) from the initial glucose level (3.02 ± 0.30 mmol/L <i>VS.</i> 4.17 ± 0.28 mmol/L, <i>p</i> < 0.001). 2-h specimens had the longest pre-treatment time (29.92 ± 14.94 min (min)), accounting for half of the specimens exceeding 90 min. The longer the specimen pre-treatment time, the greater the impact on the diagnosis of GDM. Timely centrifugation prevented 3.42%, 3.35%, and 2.21% missed GDM diagnoses.</p><p><strong>Conclusions: </strong>In the Chinese healthcare environment, prolonging specimen pre-treatment time can affect GDM diagnosis. Therefore, standardizing specimen pre-treatment is crucial to minimize potential effects.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2452352"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11727059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the role of natural killer cells in ankylosing spondylitis: identifying diagnostic biomarkers and therapeutic targets.","authors":"Yuling Chen, Yan Li, Yuan Xu, Qing Lv, Yuanchun Ye, Jieruo Gu","doi":"10.1080/07853890.2025.2457523","DOIUrl":"10.1080/07853890.2025.2457523","url":null,"abstract":"<p><strong>Background: </strong>Ankylosing spondylitis (AS) is a chronic autoimmune disease that primarily affects the axial joints. Immune cells play a key role in the pathogenesis of AS. This study integrated bioinformatics methods with experimental validation to explore the role of natural killer (NK) cells in AS.</p><p><strong>Methods: </strong>Two microarray datasets, GSE25101 and GSE73754, were selected, and the scRNA-seq data were obtained from GSE194315 and Liu's research. Differentially expressed genes (DEGs) and functional enrichment analysis were performed respectively. Weighted gene co-expression network analysis (WGCNA) was conducted to identify key modules of co-expressed genes and genes involved in NK cell function. The diagnostic value of the identified key genes was evaluated using ROC curves, logistic regression analysis, and a nomogram. Real-time PCR (RT-PCR) was used to quantified the expression of genes. Statistical analysis was conducted using the R software package, and a <i>p</i>-value of less than 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Pathways enrichment analysis revealed the involvement of NK cell-mediated immune pathways and regulation of the innate immune response, indicating the crucial role of innate immunity, especially NK cells, in AS pathogenesis. The construction of a co-expression network revealed that the MElightyellow module was most relevant to the NK cell-mediated immune pathway. <i>IL2RB, CD247, PLEKHF1, EOMES, S1PR5, FGFBP2</i> from the MElightyellow module were identified as key genes involved in NK cell-mediated immune response and served as potential diagnostic biomarkers for AS, with moderate to high diagnostic values based on AUC values. Further analysis using scRNA-seq profiling revealed the higher expression level of <i>IL2RB, CD247, PLEKHF1, S1PR5, FGFBP2</i> in NK cells compared to that in other cell types. <i>CD247, PLEKHF1, EOMES, S1PR5,</i> and <i>FGFBP2</i> were reduced expressed in AS patients as compare to control group verified by scRNA-seq data, <i>CD247, EOMES, FGFBP2, IL2RB</i> and S1PR5 were reduced expressed verified by RT-PCR, and <i>PLEKHF1, S1PR5,</i> and <i>FGFBP2</i> was upregulated after TNF-α blocker therapy.</p><p><strong>Conclusion: </strong>The study revealed the potential role of NK cells and identified <i>IL2RB, CD247, PLEKHF1, EOMES, S1PR5</i>, and <i>FGFBP2</i> as key genes associated with NK cells in the pathogenesis of AS.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2457523"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right versus left thoracic approach esophagectomy for patients with neoadjuvant immunochemotherapy.","authors":"Kexi Wang, Xuan Xie, Jianqun He, Shuogui Fang, Yiming Zhong, Duoguang Wu, Kefeng Wang, Minghui Wang","doi":"10.1080/07853890.2025.2456691","DOIUrl":"10.1080/07853890.2025.2456691","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this study was to investigate the safety and efficacy of left thoracic approach (LTA) and right thoracic approach (RTA) in patients with esophageal squamous cell carcinoma (ESCC) after neoadjuvant immunochemotherapy (NICT).</p><p><strong>Methods: </strong>This study included 83 ESCC patients who underwent right transthoracic esophagectomy (<i>n</i> = 61) and left transthoracic esophagectomy (<i>n</i> = 22) after NICT in our hospital from October 2019 to September 2023. The data of these patients were retrospectively analyzed.</p><p><strong>Results: </strong>Compared with the LTA group, the RTA group had a longer operation time (245.6 ± 27.8 min vs. 356.5 ± 83.2 min, <i>p</i> < 0.001) and more lymph nodes were removed (21.0 ± 7.9 vs. 29.3 ± 10.8, <i>p</i> = 0.001). The 3-year disease free survival (DFS) of the LTA group and the RTA group were 61.0% and 65.7% (<i>p</i> = 0.861), and the 3-year overall survival (OS) were 60.7% and 77.4% (<i>p</i> = 0.753) respectively. There was no significant difference in prognosis between the two groups. Lymphovascular invasion was an independent risk factor for DFS (HR = 4.042, <i>p</i> = 0.004) and OS (HR = 4.607, <i>p</i> = 0.003) in patients with ESCC undergoing NICT combined with surgery.</p><p><strong>Conclusion: </strong>There was no difference in postoperative complications and short-term survival in patients with ESCC underwent surgery after NICT regardless of left or right thoracic approach. It is worth noting that lymphovascular invasion has an important impact on the prognosis of these patients.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2456691"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of genetic variants of the <i>IL18R1</i> gene in association with COPD susceptibility.","authors":"Jiaoyuan Xu, Meilan Xian, Linhui Huang, Yamei Zheng, Lei Zhang, Jie Zhao, Jie Chen, Siguang Li, Lingsang Lin, Yi Zhong, Zehua Yang, Haihong Wu, Tian Xie, Yipeng Ding","doi":"10.1080/07853890.2024.2446690","DOIUrl":"10.1080/07853890.2024.2446690","url":null,"abstract":"<p><strong>Background: </strong>Although existing studies have identified some genetic loci associated with chronic obstructive pulmonary disease (COPD) susceptibility, many variants remain to be discovered. The aim of this study was to further explore the potential relationship between <i>IL18R1</i> single nucleotide polymorphisms (SNPs) and COPD risk.</p><p><strong>Methods: </strong>Nine hundred and ninety-six subjects were recruited (498 COPD cases and 498 healthy controls). Five candidate SNPs of <i>IL18R1</i> were selected and genotyped using MassARRAY iPLEX platform. Logistic regression analysis was performed to assess the association of these SNPs with COPD risk. Multifactor dimensionality reduction (MDR) software was applied to calculate the interaction of SNP-SNP on COPD risk.</p><p><strong>Results: </strong><i>IL18R1</i> rs9807989 (OR = 0.42, <i>p</i> < .001), rs3771166 (OR = 0.40, <i>p</i> < .001) and rs6543124 (OR = 0.44, <i>p</i> < .001) were associated with the reduced COPD risk, while rs2287037 (OR = 2.71, <i>p</i> < .001) and rs2058622 (OR = 2.06, <i>p</i> < .001) might be the risk-increasing factor for COPD occurrence in both the overall analysis and subgroup analysis (age, gender, drinking, and smoking). The best multi-locus model was the combination of rs2058622 and rs3771166.</p><p><strong>Conclusion: </strong>Our study provided a reference and basis for investigating the association of <i>IL18R1</i> polymorphisms with COPD risk.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2446690"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}