Annals of medicine最新文献

{"title":"Utility of whole exome sequencing in the evaluation of isolated fetal growth restriction in normal chromosomal microarray analysis.","authors":"Xiaomei Shi, Yanling Huang, Hongke Ding, Lina Zhao, Wei He, Jing Wu","doi":"10.1080/07853890.2025.2476038","DOIUrl":"10.1080/07853890.2025.2476038","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the application of whole exome sequencing (WES) in the prenatal diagnosis of isolated fetal growth restriction (FGR) with a normal result by chromosomal microarray analysis (CMA).</p><p><strong>Methods: </strong>This retrospective study included singleton fetuses with isolated FGR in Guangdong Women and Children Hospital between July 2018 and August 2023. All fetuses were subjected to invasive prenatal testing with CMA and WES. Only cases with negative CMA results were included.</p><p><strong>Results: </strong>r  A total of 135 fetuses were included. Ultrasonography identified short long bones in 39 fetuses and nonshort long bones in 96 cases. WES revealed pathogenic/likely pathogenic (P/LP) variants in 16(11.9%) fetuses and variants of uncertain significance (VUS) in 2 (1.5%) fetuses. Compared to the nonshort long bones group, the short long bones group had a significantly higher detection rate of P/LP variants (33.3% [13/39] vs. 3.1% [3/96], p < 0.001, OR=15.5(4.1-58.5)). No significant differences were observed in the detection rates between severe FGR and nonsevere FGR (12.3% [13/106] vs. 10.3% [3/29], p= .000, OR=1.2(0.3-4.6)), or between the early-onset (12.9% [15/116]) and the late-onset group (5.3%[1/19],p =0.565, OR=2.7(0.3-21.5)).</p><p><strong>Conclusions: </strong>P/LP variants are more prevalent in fetuses with short long bones. WES is recommended for isolated FGR with short long bones, but further studies are needed to assess its utility in cases with nonshort long bones.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2476038"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of thrombocytopenia and D-dimer elevation with in-hospital mortality in acute aortic dissection.","authors":"Xingwei He, Abudunaibi Balati, Wenhua Wang, Hongjie Wang, Baoquan Zhang, Chunwen Li, Dan Yu, Suping Guo, Hesong Zeng","doi":"10.1080/07853890.2025.2478477","DOIUrl":"10.1080/07853890.2025.2478477","url":null,"abstract":"<p><strong>Background: </strong>Data on the association between the degree of platelet and coagulative-fibrinolytic variables abnormalities and the risk of in-hospital mortality in acute aortic dissection (AAD) are limited.</p><p><strong>Materials and methods: </strong>This multicentre retrospective cohort study included patients diagnosed with AAD by aortic computed tomographic angiography between 2010 and 2021 in five tertiary hospitals in China. The primary outcome was defined as all-cause mortality during hospitalization. Associations between platelet counts, coagulation-fibrinolytic parameters and all-cause in-hospital mortality were assessed using Cox proportional hazards regression models.</p><p><strong>Results: </strong>Among the 2567 participants, the median age was 54 years (interquartile range, IQR: 47-63); 531 (20.7%) were female, and the in-hospital mortality rate was 589 (23.0%). The Cox proportional hazards regression model indicated that lower platelet count, prothrombin activity (PTA), and fibrinogen levels and longer prothrombin time (PT) and thrombin time (TT) were linearly positively associated with an increased risk of in-hospital mortality (<i>p</i> < 0.05). A non-linear and positive association was confirmed between D-dimer levels and in-hospital mortality risk (<i>p</i> < 0.05). Additionally, a significant interaction between platelet counts and D-dimer levels was observed (<i>p</i> = 0.029). According to the subgroup analysis, compared to those in the reference group, those with thrombocytopenia (<140 × 10⁹/L) and high D-dimer levels (>14.6 µg/mL) had a 3.59-fold increased risk of in-hospital mortality (HR, 3.59; 95% CI, 2.00-6.42).</p><p><strong>Conclusions: </strong>Our analysis revealed associations between changes in platelet count, PT, PTA, TT, fibrinogen and D-dimer levels and outcomes in patients with AAD. Furthermore, the combined effect of thrombocytopenia and high D-dimer levels significantly increased the risk of in-hospital mortality.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2478477"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of systemic sclerosis in the Asia-Pacific region: a systematic review and meta-analysis.","authors":"Ajanee Mahakkanukrauh, Chetta Ngamjarus, Porjai Pattanittum, Siraphop Suwannaroj, Patnarin Pongkulkiat, Tippawan Onchan, Chingching Foocharoen","doi":"10.1080/07853890.2025.2479238","DOIUrl":"10.1080/07853890.2025.2479238","url":null,"abstract":"<p><strong>Background: </strong>The epidemiological profile of systemic sclerosis (SSc) in the population in Asia-Pacific countries might help in planning for improved future care and research direction.</p><p><strong>Objectives: </strong>We aimed to estimate the pooled incidence and pooled prevalence of systemic sclerosis (SSc) in Asia-Pacific countries.</p><p><strong>Methods: </strong>We conducted and reported the systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement of 2020. Databases searched include PubMed, SCOPUS, CINAHL, and ProQuest, and hand searching, with a focus on publications from 1 January 2000 to 31 July 2023.</p><p><strong>Results: </strong>A total of 456 records were identified from the searches, 10 articles were included for review: six reported the incidence of SSc; nine reported the prevalence of SSc. We noted considerable heterogeneity. Subgroup analyses categorized by the period of study before and after the launch of the 2013 ACR/EULAR Classification Criteria for SSc demonstrated that both incidence and prevalence of SSc were significantly different between subgroups. The incidence of SSc before and after the launch was 1.85 per 100,000 (4 studies, I² = 100%, 95%CI 0.53-6.40) and 9.61 per 100,000 (2 studies, I² = 100%, 95%CI 4.90-18.85), respectively. The prevalence of SSc before and after the launch was 6.47 per 100,000 (6 studies, I² = 97%, 95%CI 5.09-8.21) and 18.48 per 100,000 (3 studies, I² = 100%, 95%CI 7.19-47.50), respectively.</p><p><strong>Conclusion: </strong>The epidemiology of SSc varied widely across the Asia-Pacific region depending on the study methodology and study period. The incidence of SSc in the Asia-Pacific region was estimated to be higher after the launch of the new classification criteria.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2479238"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring NamiRNA networks and time-series gene expression in osteogenic differentiation of adipose-derived stem cells.","authors":"Xin Jin, Yi Lu, Zhihong Fan","doi":"10.1080/07853890.2025.2478323","DOIUrl":"10.1080/07853890.2025.2478323","url":null,"abstract":"<p><strong>Background: </strong>Adipose-derived stem cells (ADSCs) are a type of stem cell found in adipose tissue with the capacity to differentiate into multiple lineages, including osteoblasts. The differentiation of ADSCs into osteoblasts underlies osteogenic and pathological cellular basis in osteoporosis, bone damage and repair.</p><p><strong>Methods: </strong>Focused on ADSCs osteogenic differentiation, we conducted mRNA, microRNA expression and bioinformatics analysis, including gene differential expression, time series-based trend analysis, functional enrichment, and generates potential nuclear activating miRNAs (NamiRNA) regulatory network. The screened mRNAs in NamiRNA regulatory network were validated with correlation analysis.</p><p><strong>Results: </strong>The NamiRNA Regulatory Network reveals 4 mRNAs (C12orf61, MIR31HG, NFE2L1, and PCYOX1L) significantly downregulated in differentiated group and may be associated with ADSCs stemness. Furthermore, the significantly upregulated 10 genes (ACTA2, TAGLN, LY6E, IFITM3, NGFRAP1, TCEAL4, ATP5C1, CAV1, RPSA, and KDELR3) were significantly enriched in osteogenic-related pathways, and negatively correlated with ADSCs cell stemness <i>in vitro</i>.</p><p><strong>Conclusion: </strong>These findings uncover potential genes related to ADSCs osteogenic differentiation, and provide theoretical basis for underlying ADSCs osteogenic differentiation and related diseases.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2478323"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualized hysteroscopic artificial intelligence fertility assessment system for endometrial injury: an image-deep-learning study.","authors":"Bohan Li, Hui Chen, Hua Duan","doi":"10.1080/07853890.2025.2478473","DOIUrl":"10.1080/07853890.2025.2478473","url":null,"abstract":"<p><strong>Objective: </strong>Asherman's syndrome (AS) is a significant cause of subfertility in women from developing countries. Over 80% of AS cases in these regions are linked to dilation and curettage (D&C) procedures following pregnancy. The incidence of AS in patients with infertility and recurrent miscarriage can be as high as 10%, while the pregnancy rate in cases of moderate to severe adhesions can be as low as 34%. We aimed to establish a hysteroscopic artificial intelligence system using image-deep-learning algorithms for fertility assessment.</p><p><strong>Methods: </strong>This diagnostic study included 555 cases with 4922 hysteroscopic images from a Chinese intrauterine adhesions cohort clinical database (NCT05381376). The study evaluated two image-deep-learning algorithms' effectiveness in predicting pregnancy within one year, using AUCs and decision curve analysis. The models' performance was evaluated for two-year prediction <i>via</i> concordance index and cumulative time-dependent ROC. A quantifiable visualization panel of the system was established.</p><p><strong>Results: </strong>The proportional hazard CNN system accurately predicted conception, with AUCs of 0.982, 0.992, and 0.990 in three randomly assigned datasets, superior to the InceptionV3 framework, and achieved a net benefit of 69.4% for subfertility assessment. The system fitted well with c-indexes of 0.920-0.940 and was time-stable. The quantifiable visualization panel displayed four intrauterine pathologies intuitively. The performance was comparable to senior hysteroscopists, with a kappa value of 0.84-0.89.</p><p><strong>Conclusions: </strong>The CNN based on the proportional hazard approach accurately assesses fertility postoperatively. The quantifiable visualization panel could assist in intrauterine pathologies assessment, optimize treatment strategies, and achieve individualized and cost-efficient practices.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2478473"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of oromotor functions on motor development and feeding outcomes in children with cerebral palsy.","authors":"Amira F Ibrahim, Sara Y Elsebahy, Monira I Aldhahi, Mai M Khalaf, Ahmed A Torad, Mona Mohamed Taha, Amira F El-Sheikh","doi":"10.1080/07853890.2025.2479587","DOIUrl":"10.1080/07853890.2025.2479587","url":null,"abstract":"<p><strong>Background/objective(s): </strong>Children with cerebral palsy often face feeding and swallowing issues, the most common of which include aspiration during feeding and potential pulmonary complications. This impairment can influence other areas of development, including gross motor function, fine motor skills, and oromotor functions involved in feeding and swallowing. This study aimed to investigate the relationship between the level of gross motor function, feeding level, oromotor structural dysfunction, tongue thrust, and eating performance in children with cerebral palsy (CP).</p><p><strong>Patients/materials and methods: </strong>This cross-sectional study included a total of fifty-five children diagnosed with spastic diplegic cerebral palsy, with a mean age of 4.84  years and a mean weight of 12.46  kg. Participants' ages ranged from 2 to 14  years. All patients underwent evaluations to determine their level of gross motor function using the Gross Motor Function Classification System (GMFCS), feeding level assessed using the Functional Oral Intake Scale, assessment of oromotor structural dysfunction using the Orofacial Motor Functional Assessment Scale, tongue thrust using the Tongue Thrust Rating Scale, and feeding performance using the Oral Motor Assessment Scale.</p><p><strong>Results: </strong>Correlational analysis revealed that children with better gross motor function tended to exhibit improved feeding levels, orofacial motor function, and feeding performance (<i>p</i> < 0.05); however, no significant relationship was observed between gross motor function and tongue thrust. Regression models showed moderate positive correlations for age, weight, and height, with respective <i>R</i>² values of 0.21, 0.23, and 0.28, indicating some influence on outcomes, but with much unexplained variability.</p><p><strong>Conclusions: </strong>Gross motor function significantly influences feeding and orofacial motor function. These findings suggest that individuals with higher feeding levels tend to have better overall orofacial motor function and feeding performance. Understanding these relationships can inform interventions aimed at improving feeding outcomes and the overall quality of life of children with CP.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2479587"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of pre-treatment and post-treatment plasma Epstein-Barr virus DNA in peripheral T-cell lymphomas.","authors":"Chu-Yi Chan, Tung-Liang Lin, Ming-Chung Kuo, Yu-Shin Hung, Hung Chang, Che-Wei Ou, Jin-Hou Wu, Hsuan-Jen Shih, Yi-Jiun Su, Lee-Yung Shih, Yuen-Chin Ong, Wen-Yu Chuang, Hsiao-Wen Kao","doi":"10.1080/07853890.2025.2478315","DOIUrl":"10.1080/07853890.2025.2478315","url":null,"abstract":"<p><strong>Background: </strong>Plasma Epstein-Barr virus (EBV) DNA levels predict the prognosis of extranodal NK/T-cell lymphoma, nasal type (NK/TCL), but its role in other peripheral T-cell lymphomas (PTCL) remains undetermined. This study aimed to determine the prognostic impact of plasma EBV DNA in PTCL patients.</p><p><strong>Methods: </strong>We retrospectively enrolled 134 PTCL patients diagnosed between April 2008 and March 2022, with plasma EBV DNA data available at diagnosis in 124 patients and during post-treatment follow-up in 73 patients.</p><p><strong>Results: </strong>International Prognostic Index or prognostic index for T-cell lymphoma scores > 1 was associated with higher median plasma EBV DNA levels in all analyzed patients. Plasma EBV DNA positivity at the time of diagnosis was not associated with treatment response, overall survival (OS), or progression-free survival (PFS) in non-NK/TCL patients. In NK/TCL patients, an EBV DNA level < 3255 copies/mL at diagnosis was significantly associated with higher five-year PFS (64.2% vs. 16.7%, <i>p</i> < 0.001) and OS rates (64.4% vs. 20.8%, <i>p</i> < 0.001). Plasma EBV DNA positivity at the time of complete remission and during post-treatment follow-up was significantly linked to lower PFS and OS rates in NK/TCL patients. Multivariate analysis revealed that advanced-stage disease, elevated β2-microglobulin, and EBV DNA level ≥ 3255 copies/mL at diagnosis were independent predictors for OS and PFS in NK/TCL patients.</p><p><strong>Conclusions: </strong>Plasma EBV DNA at diagnosis and during follow-up predict survival for NK/TCL patients but not for patients with other PTCL subtypes. Detection and monitoring of plasma EBV DNA levels at diagnosis and post-treatment follow-up for NK/TCL patients is recommended.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2478315"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of infective endocarditis-associated acute kidney injury: benefits of low-dose amikacin and surgery.","authors":"SanXi Ai, XinPei Liu, Nan Zhao, Qi Miao, Yan Qin, XueMei Li","doi":"10.1080/07853890.2025.2482023","DOIUrl":"10.1080/07853890.2025.2482023","url":null,"abstract":"<p><strong>Objective: </strong>Acute kidney injury (AKI) is a frequent presentation in patients with infective endocarditis (IE), and is associated with poor outcomes. The primary aim of the study was to determine the risk factors for AKI in patients with IE.</p><p><strong>Methods: </strong>A retrospective study was conducted in a tertiary hospital in China from August 2012 to April 2022. The primary outcome was AKI. Logistic regression was used to identify risk factors for AKI.</p><p><strong>Results: </strong>A total of 594 patients with IE were included, of which 256 (43.1%) experienced AKI. The following variables were found to be independent risk factors for AKI: hypertension (OR 1.96, <i>p</i> = 0.011), <i>Staphylococcus aureus</i> infection (OR 2.69, <i>p</i> = 0.008), heart failure (OR 5.99, <i>p</i> < 0.001), shock (OR 5.93, <i>p</i> = 0.015) and hematuria (OR 2.38, <i>p</i> < 0.001). The use of low-dose amikacin (400 mg daily) was associated with a lower incidence of AKI (OR 0.38, <i>p</i> < 0.001). Among patients with IE complicated by heart failure, surgery was associated with a lower incidence of AKI (OR 0.21, <i>p</i> = 0.010).</p><p><strong>Conclusion: </strong>AKI is common in IE. Hypertension, <i>Staphylococcus aureus</i> infection, heart failure, shock and hematuria are risk factors of IE-associated AKI, whereas low-dose amikacin is a protective factor. Surgery is a protective factor of AKI in the setting of IE complicated by heart failure.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2482023"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ITGA3-MET interaction promotes papillary thyroid cancer progression via ERK and PI3K/AKT pathways.","authors":"Youmian Lan, Dongchen Liu, Bin Liang, Xuhong Song, Lingzhu Xie, Hanwei Peng, Haipeng Guo, Chaoqun Hong, Xuwu Weng, Xiaolong Wei, Xiaoqi Liao, Rui Liang, Dongyang Huang, Muyuan Liu","doi":"10.1080/07853890.2025.2483379","DOIUrl":"10.1080/07853890.2025.2483379","url":null,"abstract":"<p><strong>Background: </strong>Studies have examined the role of integrin α3 (ITGA3) in papillary thyroid carcinoma (PTC). However, the functional and molecular mechanism by which ITGA3 is involved in the progression of PTC remains poorly understood.</p><p><strong>Methods: </strong>To investigate the role of ITGA3 in PTC, raw PTC transcriptome data underwent comprehensive bioinformatics analyses, including differential expression, co-expression network, and enrichment analyses. ITGA3 expression was validated <i>via</i> immunohistochemistry and western blotting in PTC tissues. Cell functional assays and xenograft models assessed PTC cell behaviour. The potential mechanisms of ITGA3 were elucidated using bioinformatics analyses, western blotting, co-immunoprecipitation, and immunofluorescence. Finally, integration of ITGA3 expression with clinical parameters enabled nomogram construction for precise prediction of cervical lymph node metastasis (CLNM) in PTC.</p><p><strong>Results: </strong>ITGA3 was upregulated in PTC and associated strongly with CLNM (79.5% <i>vs.</i> 53.84%, <i>p</i> = 0.016). ITGA3 expression enhanced PTC proliferation and migration <i>in vitro</i> and <i>in vivo via</i> cooperating with the MET protein tyrosine kinase, followed by phosphorylation of MET at Tyr1234/1235, and activation of ERK and PI3K/AKT signaling pathways. Furthermore, upregulation ITGA3 reduced phosphorylation at FAK-Tyr397 and Src-Tyr416 in PTC cells. Finally, a nomogram combining ITGA3 expression and clinical parameters for predicting CLNM was constructed and validated, achieving a ROC curve AUC of 0.719, suggesting potential application for PTC diagnosis.</p><p><strong>Conclusions: </strong>ITGA3 promotes PTC cell proliferation and migration by cooperating with MET to activate MET-ERK and MET-PI3K-AKT signalling. ITGA3-MET cooperation may serve as a potential therapeutic target.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2483379"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle fat content correlates with postoperative survival of viral-related cirrhosis patients after the TIPS: a retrospective study.","authors":"Sai Li, Yong Li, Chunhui Zhou, Haiping Li, Yazhuo Zhao, Xiaoping Yi, Changyong Chen, Changli Peng, Tianming Wang, Fei Liu, Juxiong Xiao, Liangrong Shi","doi":"10.1080/07853890.2025.2484460","DOIUrl":"10.1080/07853890.2025.2484460","url":null,"abstract":"<p><strong>Purpose: </strong>Early prediction of the prognosis of viral-related cirrhosis patients after transjugular intrahepatic portosystemic shunt (TIPS) is beneficial for clinical decision-making. The aim of this study is to explore a comprehensive prognostic assessment model for evaluating the survival outcomes of patients post-TIPS.</p><p><strong>Materials and methods: </strong>A total of 155 patients treated with TIPS were included in the study. The data were collected from electronic records. The nutritional status of the patient is evaluated using imaging examinations measuring by the axial CT images from the L3 vertebral level. The primary endpoint was set as death within 1 year after TIPS. Multivariate Cox regression was performed to determine the factors associated with mortality.</p><p><strong>Results: </strong>The Cox regression analysis revealed that the lower PMFI was associated with a lower risk of all-cause mortality after TIPS (hazard ratio [HR] 1.159, 95% confidence interval [CI] 1.063-1.263, <i>p</i> = 0.001). Furthermore, subgroup analyses according to gender revealed the PMFI was associated with postoperative death both in male (HR 2.125, 95% CI, 1.147-3.936, <i>p</i> = 0.017) and female patients (HR 1.070, 95% CI, 1.001-1.144, <i>p</i> = 0.047). The area under the curve (AUC) for predicting death within 1 year was 0.807. The clinical impact curve analysis showed that PMFI had higher levels of risk threshold probability and a smaller gap between actual and predicted curves.</p><p><strong>Conclusions: </strong>In viral-related cirrhosis patients with portal hypertension, increased muscle fat content might be a potential prognostic marker and associated with postoperative death after TIPS.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2484460"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}