Prognostic impact of pre-treatment and post-treatment plasma Epstein-Barr virus DNA in peripheral T-cell lymphomas.

Annals of medicine Pub Date : 2025-12-01 Epub Date: 2025-03-20 DOI:10.1080/07853890.2025.2478315
Chu-Yi Chan, Tung-Liang Lin, Ming-Chung Kuo, Yu-Shin Hung, Hung Chang, Che-Wei Ou, Jin-Hou Wu, Hsuan-Jen Shih, Yi-Jiun Su, Lee-Yung Shih, Yuen-Chin Ong, Wen-Yu Chuang, Hsiao-Wen Kao
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Abstract

Background: Plasma Epstein-Barr virus (EBV) DNA levels predict the prognosis of extranodal NK/T-cell lymphoma, nasal type (NK/TCL), but its role in other peripheral T-cell lymphomas (PTCL) remains undetermined. This study aimed to determine the prognostic impact of plasma EBV DNA in PTCL patients.

Methods: We retrospectively enrolled 134 PTCL patients diagnosed between April 2008 and March 2022, with plasma EBV DNA data available at diagnosis in 124 patients and during post-treatment follow-up in 73 patients.

Results: International Prognostic Index or prognostic index for T-cell lymphoma scores > 1 was associated with higher median plasma EBV DNA levels in all analyzed patients. Plasma EBV DNA positivity at the time of diagnosis was not associated with treatment response, overall survival (OS), or progression-free survival (PFS) in non-NK/TCL patients. In NK/TCL patients, an EBV DNA level < 3255 copies/mL at diagnosis was significantly associated with higher five-year PFS (64.2% vs. 16.7%, p < 0.001) and OS rates (64.4% vs. 20.8%, p < 0.001). Plasma EBV DNA positivity at the time of complete remission and during post-treatment follow-up was significantly linked to lower PFS and OS rates in NK/TCL patients. Multivariate analysis revealed that advanced-stage disease, elevated β2-microglobulin, and EBV DNA level ≥ 3255 copies/mL at diagnosis were independent predictors for OS and PFS in NK/TCL patients.

Conclusions: Plasma EBV DNA at diagnosis and during follow-up predict survival for NK/TCL patients but not for patients with other PTCL subtypes. Detection and monitoring of plasma EBV DNA levels at diagnosis and post-treatment follow-up for NK/TCL patients is recommended.

外周血t细胞淋巴瘤治疗前后血浆eb病毒DNA对预后的影响
背景:血浆eb病毒(EBV) DNA水平预测结外NK/ t细胞淋巴瘤鼻型(NK/TCL)的预后,但其在其他外周t细胞淋巴瘤(PTCL)中的作用尚未确定。本研究旨在确定血浆EBV DNA对PTCL患者预后的影响。方法:我们回顾性纳入了2008年4月至2022年3月诊断的134例PTCL患者,其中124例患者在诊断时可获得血浆EBV DNA数据,73例患者在治疗后随访期间可获得血浆EBV DNA数据。结果:在所有分析的患者中,国际预后指数或t细胞淋巴瘤预后指数>.1与较高的血浆EBV DNA水平相关。诊断时血浆EBV DNA阳性与非nk /TCL患者的治疗反应、总生存期(OS)或无进展生存期(PFS)无关。在NK/TCL患者中,诊断时EBV DNA水平< 3255拷贝/mL与较高的5年PFS显著相关(64.2% vs. 16.7%, p)。结论:诊断时和随访期间的血浆EBV DNA预测NK/TCL患者的生存,但对其他PTCL亚型患者无效。建议在NK/TCL患者诊断和治疗后随访时检测和监测血浆EBV DNA水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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