Annals of medicine最新文献

{"title":"Factors affecting cervical cancer screening and human papilloma virus vaccination among Middle Eastern refugee women in Türkiye: indicators for social workers and nurses.","authors":"Yaser Snoubar, Baraka Abusafia, Zekiye Turan","doi":"10.1080/07853890.2025.2468261","DOIUrl":"10.1080/07853890.2025.2468261","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to generate knowledge regarding factors affecting cervical cancer screening and human papillomavirus vaccination that can be used practically by social workers and nurses while working with Middle Eastern refugee women living in Türkiye.</p><p><strong>Methods and results: </strong>This study involved the administration of a self-reported questionnaire to 227 female migrants. It identified sociodemographic variables, such as age, marital status, and education level, that influenced the participation of these women in preventive practices against cervical cancer. Despite their cultural beliefs, financial constraints, and language hurdles, the findings indicated that the likelihood of involvement in screening and vaccination for cervical cancer was greater among refugee women if they were well-informed and assisted.</p><p><strong>Conclusions: </strong>The results of this study suggest the necessity for specific training programs and improved initiatives for healthcare access to prevent cervical cancer among vulnerable groups. Healthcare providers can support preventive measures more effectively if these concerns are addressed with consideration of the sociocultural elements and language issues among Middle Eastern refugee women. Although some limitations associated with self-reported data collection methods may have introduced response bias, this study showed how social workers and nurses can act as facilitators to prevent cervical cancer.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2468261"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of transcutaneous auricular vagus nerve stimulation on postoperative pain in patients undergoing perianal surgery: a randomized trial.","authors":"Zhi-Yu Yin, Jing Wang, Pan Wei, Hao Gao, Long Sun, Jian-Gang Song, Wei Tang","doi":"10.1080/07853890.2025.2476045","DOIUrl":"10.1080/07853890.2025.2476045","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) on postoperative pain in patients following perianal surgery.</p><p><strong>Methods: </strong>96 patients were randomly assigned to either the taVNS group or the sham stimulation group. Patients received stimulation once 30 min before the operation and once more 24 h after the operation, with each session lasting 30 min. The VAS scores were recorded at 2, 6, 24, 48, and 72 h, as well as 7 days postoperatively. Data were collected on the first change of dressing, the first defecation, the frequency of supplementary analgesia, and the occurrence of adverse reactions. Patient satisfaction was assessed at the time of hospital discharge.</p><p><strong>Results: </strong>The VAS scores of patients in the taVNS group were significantly lower than those in the sham stimulation group at 2, 6, 24, 48, and 72 h postoperatively, at the time of the first dressing change, and at the time of the first defecation (<i>p</i> < 0.05). The rate of postoperative supplementary analgesic use was significantly higher in the sham stimulation group compared to the taVNS group (<i>p</i> < 0.05). The incidence of urinary retention was lower in the taVNS group (<i>p</i> < 0.05). No adverse reactions like hypotension or bradycardia were observed in either group. Patient satisfaction was higher in the taVNS group (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>taVNS effectively alleviates postoperative pain in patients undergoing perianal surgery without increasing the risk of complications.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2476045"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>CYP2D6</i> polymorphism rs1065852 significantly increases the risk of type 2 diabetes.","authors":"Huiyi Wei, Qingbin Zhao","doi":"10.1080/07853890.2025.2470956","DOIUrl":"10.1080/07853890.2025.2470956","url":null,"abstract":"<p><strong>Background: </strong>Genetic variations within the cytochrome P450 (CYP) gene family are significant determinants of type 2 diabetes mellitus (T2DM) susceptibility. This study aimed to investigate the association between <i>CYP2C8</i> and <i>CYP2D6</i> gene variants and the risk of T2DM.</p><p><strong>Methods: </strong>We conducted a case-control study involving 512 individuals with T2DM and 515 controls. Genotyping of <i>CYP2C8</i> and <i>CYP2D6</i> polymorphisms was performed using the Agena MassARRAY system. Logistic regression analysis was employed to estimate the odds ratios (ORs) and 95% confidence intervals (CIs), thereby assessing the relationship between these genetic variants and T2DM risk. Additionally, multifactor dimensionality reduction (MDR) was utilized to assess the potential interaction effects of SNPs on T2DM risk.</p><p><strong>Results: </strong>The study found a strong correlation between rs1065852 and increased risk of T2DM in overall (A vs. G: OR = 1.22, 95% CI: 1.03-1.45, <i>p</i> = .024; AA vs. GG: OR = 1.46, 95% CI: 1.04-2.06, <i>p</i> = .031; AA-AG vs. GG: OR = 1.36, 95% CI: 1.04-1.79, <i>p</i> = .026; additive: OR = 1.21, 95% CI: 1.02-1.44, <i>p</i> = .027), males and age < 59 subgroups. However, there is no significant association between the <i>CYP2C8</i> polymorphisms (rs1934953, rs1934951, rs2275620 and rs17110453) and T2DM risk. MDR analysis results showed that the best model was the one locus model (rs1065852, testing accuracy = 0.534; OR = 1.39; 95% CI: 1.05-1.85; <i>p</i> = .023; CVC = 10/10), indicating that rs1065852 is an independent risk factor for T2DM.</p><p><strong>Conclusions: </strong>This study suggests that rs1065852 (<i>CYP2D6</i>) is an independent risk factor for T2DM. Further research is warranted to validate these results and explore their clinical implications.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2470956"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regarding 'long-term cognitive and autonomic effects of COVID-19 in young adults: a cross-sectional study at 28 months'.","authors":"Lien-Chung Wei, Chun-Hung Lee","doi":"10.1080/07853890.2025.2464940","DOIUrl":"10.1080/07853890.2025.2464940","url":null,"abstract":"","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2464940"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A real-world study on the influence of unplanned reoperations on hospitalized patients using the diagnosis-related group.","authors":"Rui Fan, Qifeng Chen, Shang Gao, Lili Wang, Shuqi Mao, Zhiyu Yan","doi":"10.1080/07853890.2025.2473633","DOIUrl":"10.1080/07853890.2025.2473633","url":null,"abstract":"<p><strong>Objective: </strong>The issue of unplanned reoperations poses significant challenges within healthcare systems, with assessing their impact being particularly difficult. The current study aimed to assess the influence of unplanned reoperations on hospitalized patients by employing the diagnosis-related group (DRG) to comprehensively consider the intensity and complexity of different medical services.</p><p><strong>Methods: </strong>A retrospective cohort study of surgical patients was conducted at a large tertiary hospital with two hospital districts employing data sourced from a DRG database. Hospital length of stay (LOS) and hospitalization costs were measured as the primary outcomes. Discharge to home was measured as the secondary outcome. Frequency matching based on DRG, regression modeling, subgroup comparison and sensitivity analysis were applied to evaluate the influence of unplanned reoperations.</p><p><strong>Results: </strong>We identified 20820 surgical patients distributed across 79 DRGs, including 188 individuals who underwent unplanned reoperations and 20632 normal surgical patients in the same DRGs. After DRG-based frequency matching, 564 patients (188 with unplanned reoperations, 376 normal surgical patients) were included. Unplanned reoperations led to prolonged LOS (before matching: adjusted difference, 12.05 days, 95% confidence interval [CI] 10.36-13.90 days; after matching: adjusted difference, 14.22 days, 95% CI 11.36-17.39 days), and excess hospitalization costs (before matching: adjusted difference, $4354.29, 95% CI: $3,817.70-$4928.67; after matching: adjusted difference, $5810.07, 95% CI $4481.10-$7333.09). Furthermore, patients who underwent unplanned reoperations had a reduced likelihood of being discharged to home (before matching: hazard ratio [HR] 0.27, 95% CI 0.23-0.32; after matching: HR 0.31, 95% CI 0.25-0.39). Subgroup analyses indicated that the outcomes across the various subgroups were mostly uniform. In high-level surgery subgroups (levels 3-4) and in relation to complex diseases (relative weight ≥ 2), the increase in hospitalization costs and LOS was more pronounce after unplanned reoperations. Similar results were observed with sensitivity analysis by propensity score matching and excluding short LOS.</p><p><strong>Conclusions: </strong>Incorporating the DRG allows for a more effective assessment of the influence of unplanned reoperations. In managing such reoperations, mitigating their influence, especially in the context of high-level surgeries and complex diseases, remains a significant challenge that requires special consideration.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2473633"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143559827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of adipose-related parameters on mortality in patients with liver cirrhosis: a meta-analysis.","authors":"Zhang Wen, Shuyue Tuo, Qiuju Ran, Jia Yuan, Yong Li, Ying Zhang, Danyan Chang, Chan Li, Shejiao Dai, Jinhai Wang, Xinxing Tantai","doi":"10.1080/07853890.2025.2473627","DOIUrl":"10.1080/07853890.2025.2473627","url":null,"abstract":"<p><strong>Background: </strong>Some adipose-related parameters exhibit distinct prognostic value in patients with cirrhosis. However, the magnitude and direction of the association between individual adipose parameter and mortality in patients with cirrhosis are unclear.</p><p><strong>Aim: </strong>This study aimed to evaluate the association between individual adipose parameter and mortality in patients with cirrhosis using the meta-analysis method.</p><p><strong>Methods: </strong>The PubMed, Embase, Web of Science, China Biological Medicine, WanFang, and China National Knowledge Infrastructure databases were searched from inception through December 15, 2023, to identify eligible studies. The impact of each adipose parameter on mortality was assessed by the pooled unadjusted or adjusted hazard ratio (HR) with 95% confidence intervals (CIs) using the random effects model.</p><p><strong>Results: </strong>A total of 33 studies involving 9626 patients were included in our analysis, with 11 adipose parameters evaluated. The pooled prevalence of sarcopenic obesity (SO) and myosteatosis in patients with cirrhosis was 15.5% and 34.4%, respectively. In adjusted analysis, each unit increase in subcutaneous adipose tissue index (SATI) (HR: 0.99, 95% CI: 0.98-1.00) or muscle attenuation (MA) (HR: 0.94, 95% CI: 0.90-0.98) and each unit decrease in visceral-to-subcutaneous adipose tissue ratio (VSR) (HR: 1.92, 95% CI: 1.45-2.54) showed an independent association with a decreased risk of mortality. However, concurrent myosteatosis (HR: 1.88, 95% CI: 1.48-2.40) or SO (HR: 2.77, 95% CI: 1.95-3.93) significantly increased the risk of mortality in patients with cirrhosis.</p><p><strong>Conclusion: </strong>Decreased SATI or MA, increased VSR, and concurrent myosteatosis or SO were independently associated with a higher risk of mortality in patients with cirrhosis.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2473627"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143559828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Educating women to prevent and treat low back and pelvic girdle pain during and after pregnancy: a systematized narrative review.","authors":"Sabine Vesting, Annelie Gutke, Liesbet de Baets","doi":"10.1080/07853890.2025.2476046","DOIUrl":"10.1080/07853890.2025.2476046","url":null,"abstract":"<p><strong>Purpose: </strong>This review evaluated the effectiveness of patient education and information on low back pain (LBP) and pelvic girdle pain (PGP) in pregnant and postpartum women and evaluated their alignment with modern pain education principles rooted in the biopsychosocial model.</p><p><strong>Method: </strong>A systematized narrative review was performed, including a systematic search of three databases and reference screening from relevant systematic reviews. The methodological quality of the included randomized controlled trials (RCT) was evaluated using the PEDro scale.</p><p><strong>Results: </strong>Eighteen studies, including nine RCTs with PEDro scores ranging from to 2-8, indicated that patient education during pregnancy can help reduce pain and related disability. Most studies did not differentiate between LBP and PGP, which limits the specificity and targeted approach of educational interventions. Education alone is less effective without accompanying active treatment. Current programs primarily emphasize biomechanics, covering anatomy and physical changes, but often neglect lifestyle factors, such as stress and sleep.</p><p><strong>Conclusion: </strong>Although patient education is important for managing pregnancy-related LBP and PGP, its effectiveness may be improved by tailoring programs to specific pain conditions and integrating a biopsychosocial perspective on pain.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2476046"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainability in food-based dietary guidelines: a review of recommendations around meat and dairy consumption and their visual representation.","authors":"Maddie Sinclair, Emilie Combet, Tess Davis, Esther K Papies","doi":"10.1080/07853890.2025.2470252","DOIUrl":"10.1080/07853890.2025.2470252","url":null,"abstract":"<p><strong>Background: </strong>The transition away from high meat and dairy consumption and towards more plant-based diets is vital for environmental sustainability targets, including reducing greenhouse gas (GHG) emissions and land use associated with food. Food-based dietary guidelines (FBDG) communicate nutrition information to a country's general public. However, it is unknown how different countries' FBDG communicate reducing meat and dairy intake in the context of sustainability.</p><p><strong>Methods: </strong>To address this gap, we reviewed global consumer-facing FBDG (<i>n</i> = 58) in middle- and high-income countries to examine recommendations and information around meat and dairy consumption, and to explore the pictorial representation of these foods.</p><p><strong>Results: </strong>Few countries used a sustainability argument to recommend reducing meat (6/58) or dairy consumption (2/58). The proportion of dairy images within food guides was consistently higher than meat images. Some countries' guidelines are starting to consider meat intake in the context of sustainability and implementing meat reduction recommendations. However, this is not the case for dairy, potentially due to complex nutritional implications.</p><p><strong>Conclusion: </strong>Overall, our review shows that very few countries recommend reducing either meat or dairy consumption. To reduce the environmental impact of food systems, clearer guidelines backed by current evidence are needed, which provide justification behind recommendations, actionable advice for how to meet the recommendations, and appropriate quantified food targets or limits. This well-rounded advice is imperative to empower citizens to take action on their dietary habits, to reduce global meat and dairy consumption and replace these with more sustainable alternatives for human and planetary health.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2470252"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding East-West differences in subsolid nodules: prevalence and overdiagnosis implications in lung cancer screening.","authors":"Yeun-Chung Chang, Yi-Chi Hung, Yun-Ju Wu, En-Kuei Tang, Fu-Zong Wu","doi":"10.1080/07853890.2025.2478321","DOIUrl":"10.1080/07853890.2025.2478321","url":null,"abstract":"<p><strong>Background: </strong>Owing to the widespread opportunistic LDCT screening leading to increased overdiagnosis in Asian countries, such as South Korea, mainland China, and Taiwan, this study seeks to analyze the divergence in SSN prevalence between Eastern and Western nations, focusing on the influence of SSN on the growing overdiagnosis trend, notably among females.</p><p><strong>Methods: </strong>This retrospective study collected data from 4166 participants who underwent baseline LDCT in a hospital-based cohort between January 2014 and August 2021. Clinical parameters, including age, sex, lung imaging reporting and data system (Lung-RADS) categories, smoking history, pack-year dose, and SSN characteristics, were extracted from electronic medical records. Additionally, a narrative review and pooled analysis integrated relevant published studies on the prevalence of subsolid nodules and sex disparities.</p><p><strong>Results: </strong>The study encompassed 4166 participants, with females accounting for 49.3% and males for 50.7%, with a mean age of 53.38 ± 10.89. The prevalence of SSNs was significantly higher in females (20.1%) than in males (12.6%). Pooled analysis across seven studies revealed a significantly higher prevalence of SSN in Eastern countries (12.6%) compared to the prevalence in Western countries (3.6%) (test for subgroup differences: <i>p</i> < 0.01; I² = 100%). Additionally, a notable sex difference was observed in the prevalence of SSNs (risk ratio = 0.489, 95% CI: 0.301-0.796, <i>p</i> < 0.01; reference group: male group).</p><p><strong>Conclusions: </strong>Apart from differences in clinical management and health literacy regarding SSNs between Eastern and Western countries, the high prevalence of SSNs in Asian nations, particularly among females, significantly contributes to the issue of overdiagnosis in opportunistic lung cancer screening in Asian countries. Tailored sex-specific strategies and risk prediction models are essential for effective screening optimization.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2478321"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term prognostic value of thyroid hormone levels in chronic critical illness patients.","authors":"Zhaoxiang Li, Liang Wang, Jianling Shi, Weiying Han, Chengrui Zhu, Tingrui Zhang, Xiaochun Ma, Yingjian Liang","doi":"10.1080/07853890.2025.2479583","DOIUrl":"10.1080/07853890.2025.2479583","url":null,"abstract":"<p><strong>Background: </strong>Chronic critical illness (CCI) can manifest as dysfunction of thyroid hormones. This study aimed to investigate the predictive value of the nonthyroidal illness syndrome (NTIS) for the prognosis of CCI patients, establish a predictive model for the prognosis of CCI patients, and evaluate the efficacy of the model to provide a theoretical basis for clinical intervention.</p><p><strong>Methods: </strong>This was a prospective observational study in which patients ≥18 years old who met the CCI criteria were enrolled. The primary outcome of the study was 90-day mortality after intensive care unit (ICU) admission. A nomogram was constructed to predict the prognosis of CCI patients, and the model was evaluated via the concordance index, calibration curve and decision curve analysis.</p><p><strong>Results: </strong>A total of 545 patients were included, and NTIS patients accounted for 65.3% of the patients. CCI patients with NTIS had more ventilator days and higher 90-day mortality. Lower free triiodothyronine (FT3) levels (<1.19 pmol/L) or reduced free thyroxine (FT₄) levels (<9.655 pmol/L) were significantly associated with reduced survival in CCI patients with NTIS. Older age, a higher Sequential Organ Failure Assessment (SOFA) score, an emergency other than a traumatic operation, and a lower FT4 and thyroid-stimulating hormone level were found to be independent prognostic factors for a fatal outcome in CCI patients. The <i>C</i>-index for the prediction nomogram was 0.734, and the bias-corrected <i>C</i>-index was 0.727. The area under the receiver operating characteristic curve of our prediction model was superior to that of the SOFA and Acute Physiology and Chronic Health Evaluation II scores.</p><p><strong>Conclusions: </strong>Decreased serum FT3 and FT4 concentrations in patients with CCI at admission to the ICU on day 10 are associated with 90-day mortality. Early detection of serum FT3 and FT4 levels could help clinicians target CCI patients at high risk of clinical deterioration.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2479583"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}