Annals of medicine最新文献

{"title":"The expression and clinical significance of serum exosomal-long non-coding RNA DLEU1 in patients with cervical cancer.","authors":"Yu Chen, Facai Cui, Xiaoyu Wu, Weifeng Zhao, Qingxin Xia","doi":"10.1080/07853890.2024.2442537","DOIUrl":"10.1080/07853890.2024.2442537","url":null,"abstract":"<p><strong>Background: </strong>Accumulating evidence has demonstrated that the long non-coding RNA (lncRNA) lymphocytic leukaemia deletion gene 1 (DLEU1) is abnormally overexpressed in many cancer types, including cervical cancer (CC). However, the potential clinical significance of DLEU1 in serum exosomes of patients with CC remains unclear.</p><p><strong>Methods: </strong>The expression of serum exosomal DLEU1 was detected by quantitative real-time polymerase chain reaction (qRT-PCR). A receiver operating characteristic (ROC) curve was plotted to evaluate the clinical diagnostic efficacy of DLEU1. The Kaplan-Meier survival curve and Cox proportional hazards model were used to assess the effect of DLEU1 on postoperative recurrence, metastasis and prognosis among patients with CC.</p><p><strong>Results: </strong>Our research showed that DLEU1 expression in the serum exosomes of patients with CC was significantly upregulated compared to that in patients with cervical intraepithelial neoplasia (CIN) and healthy controls (HCs) (both <i>p</i> < .001). DLEU1 relative expression was significantly correlated with tumour size, cervical invasion depth, pathological grade, International Federation of Gynecology and Obstetrics (FIGO) stage and lymph node metastasis among patients with CC (<i>p</i> < .01 all). The combined detection of DLEU1, carbohydrate antigen 125 (CA-125) and squamous cell carcinoma (SCC) exhibited significantly higher diagnostic efficiency (<i>p</i> < .01). Furthermore, the overall survival (OS) and disease-free survival (DFS) of CC patients in the high DLEU1 expression group were markedly lower than those in the low DLEU1 expression group (both <i>p</i> < .01). Cox univariate and multivariate regression analyses indicated that DLEU1 was an independent risk factor for postoperative recurrence and metastasis in CC patients.</p><p><strong>Conclusions: </strong>Our findings suggest that serum exosome DLEU1 has certain clinical value for diagnosing, monitoring recurrence and metastasis, and evaluating CC prognosis.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2442537"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter regarding 'demographic and clinical Features of rosacea in North Jordan: a 10-year University Hospital Retrospective study'.","authors":"Diala Alshiyab, Saleh A Ba-Shammakh","doi":"10.1080/07853890.2025.2482861","DOIUrl":"10.1080/07853890.2025.2482861","url":null,"abstract":"","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2482861"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regarding 'long-term cognitive and autonomic effects of COVID-19 in young adults: a cross-sectional study at 28 months'.","authors":"Lien-Chung Wei, Chun-Hung Lee","doi":"10.1080/07853890.2025.2464940","DOIUrl":"10.1080/07853890.2025.2464940","url":null,"abstract":"","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2464940"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Underdosing and response to pharmacotherapy in patients with status epilepticus: a retrospective study from Saudi Arabia.","authors":"Sultan M Alghadeer, Aseel Alsuwayegh, Hessa AlMuqati, Maha A Alammari, Omar A Almohammed","doi":"10.1080/07853890.2025.2496797","DOIUrl":"https://doi.org/10.1080/07853890.2025.2496797","url":null,"abstract":"<p><strong>Background: </strong>Despite the essential of understanding patterns of status epilepticus (SE) and investigating appropriate therapy for these patients, such data are limited in the Saudi population.</p><p><strong>Methods: </strong>A retrospective study including adult patients who were admitted to emergency departments (EDs) in two hospitals due to SE was conducted between May 2015 and July 2021. We aimed to describe the characteristics for patients who were admitted to ED with SE, describe the pattern of pharmacotherapy used in these patients, assess patients' response to these pharmacotherapy agents in different stages and investigate reasons for treatment failure.</p><p><strong>Results: </strong>A total of 420 SE episodes that received at least one dose of benzodiazepines (BDZs) or anti-seizure medications (ASMs) in ED were included. The mean age for them was 38.7 ±19.1 years and 89.0% had a history of epilepsy . BDZs or ASMs were used on first trial in 60.0% and 40.0% of episodes; and 20.6% and 84.5% (<i>p</i> < 0.0001) of these cases responded, respectively. The overall response to BDZs in all trials was 24.8% while it was 79.1% for the ASMs. The issue of under-dosing was more prevalent in BDZs' compared to ASMs trials (63.4% vs. 19.6%) and was significantly associated with lack of response to therapy (86.6% vs. 0.0%; <i>p</i> < 0.0001).</p><p><strong>Conclusions: </strong>There is an immanent need for educational, drug regulation awareness programs, and protocols enforcement policies that aims to optimize patient care by improving physicians' adherence to clinical guidelines' recommendations to improve the status of managing patients with SE in Saudi Arabia.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2496797"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptation and validation of the Persian version of the foot Health Status Questionnaire in patients with plantar pain: evaluation of test-retest.","authors":"Leila Ahmadnezhad, Daniel López-López, Ricardo Becerro-de-Bengoa-Vallejo, Ana María Jiménez-Cebrián, Marta Elena Losa-Iglesias, Israel Casado-Hernández, Lisa Alves-Gomes, Emmanuel Navarro-Flores","doi":"10.1080/07853890.2025.2491665","DOIUrl":"https://doi.org/10.1080/07853890.2025.2491665","url":null,"abstract":"<p><strong>Background: </strong>The Foot Health Status Questionnaire (FHSQ) is a foot health psychometric tool for measuring foot health status that consists of eight dimensions. Currently, the FHSQ has been adapted to several languages. It was considered necessary to translate and adapt the FHSQ to the Persian language. Thus, the aim of this study was to assess the repeatability and reliability of the Foot Health Status Questionnaire (FHSQ) translated into Persian.</p><p><strong>Method: </strong>The translation into Persian and test-retest reliability methods came from the English version of the questionnaire. The questionnaire was distributed to 88 individuals diagnosed with plantar heel pain, who were recruited from a podiatry clinic in Iran. To assess test-retest reliability, the instrument was administered on two separate occasions, with a five-day interval between the initial and follow-up assessments.</p><p><strong>Results: </strong>As regards the total mark for each dimension, internal consistency and reliability were determined with the Cronbach <i>α</i> and intraclass correlation coefficient (ICC) with a confidence interval (CI) of 95%. High internal consistency was shown for the eight dimensions: (a) foot pain, with a Cronbach α of 0.773; (b) foot function and (c) general foot health with 0.788 and 0.776 respectively; (d) shoe with 0.793; (e) general health with 0.784; (f) physical function with 0.795; (g) social function with 0.801 and (h) vigour with 0.748. Excellent test-retest reliability (ICC = 0.911 [95% CI =0.844-0.949]) was shown for the total score.</p><p><strong>Conclusions: </strong>The Persian version of the FHSQ was shown to be a valid and reliable tool for acceptable use in the Iran population.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2491665"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a preliminary multivariable model predicting hamstring strain injuries during preseason screening in soccer players: a multidisciplinary approach.","authors":"Diane Baize, Stéphanie Mériaux-Scoffier, Anasthase Massamba, Thomas Hureau, Nicolas Reneaud, Yoann Garcia-Gimenez, Florian Marchand, Bastien Bontemps, Baptiste Corcelle, Vincent Maléjac, Amyn Jaafar, Emiliano Ippoliti, Florian Payet, Iliès Ajarai, Fabienne d'Arripe-Longueville, Enzo Piponnier","doi":"10.1080/07853890.2025.2494683","DOIUrl":"https://doi.org/10.1080/07853890.2025.2494683","url":null,"abstract":"<p><strong>Objective: </strong>Reducing the incidence of hamstring strain injuries (HSIs) is a priority for soccer clubs. However, robust multifactorial predictive models are lacking and potential predictors such as sprint kinematics, performance fatigability, and psychological variables have been overlooked. Thus, the aim of this study was to develop a preliminary parsimonious multifactorial model to predict players at risk of HSI through preseason screening.</p><p><strong>Materials and method: </strong>Psychological, physiological, kinematic, performance fatigability and health-related variables were collected for 120 regional and national soccer players during the 2022 preseason. HSIs were prospectively recorded over the entire soccer season. After variable selection, logistic regressions with the Wald backward stepwise method were used to refine the model. The predictive abilities of the model and of the individual variables were determined using the area under the receiver operating characteristic curve (AUC).</p><p><strong>Results: </strong>Twenty-nine players sustained an HSI during the follow-up period. The final model included eight variables: age, sex, HSI history, knee flexor performance fatigability, sprint performance (best sprint time and maximal theoretical velocity V₀), perceived vulnerability to injury, and subjective norms in soccer. While its model was preliminary, it showed good fit indices and strong predictive performance (true positive rate: 79%, AUC = .82). None of the variables evaluated independently demonstrated satisfactory performance in predicting HSI (AUC≤.65).</p><p><strong>Conclusion: </strong>Using a multidisciplinary approach and measurements of only a few variables during preseason screening, the current model tends to demonstrate high accuracy in identifying soccer players at risk of HSI.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2494683"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saddle pressures distribution at different pedaling intensities in young off-road cyclists: focus on sex.","authors":"Domenico Savio Salvatore Vicari, Antonino Patti, Valerio Giustino, Flavia Figlioli, Daniele Zangla, Nemanja Maksimovic, Patrik Drid, Antonio Palma, Antonino Bianco","doi":"10.1080/07853890.2025.2495764","DOIUrl":"https://doi.org/10.1080/07853890.2025.2495764","url":null,"abstract":"<p><strong>Background: </strong>The pressures on the saddle depend on several factors and can compress specific neurovascular tissues, leading to acute and chronic genital pathologies. Based on the pelvic differences between males and females, the aim of this study was to explore any differences on saddle pressures distribution according to sex.</p><p><strong>Methods: </strong>Twenty young off-road cyclists (10 m, 10 f) were recruited. Each participant was evaluated on own bike installed on a specific bike roller with a magnetic resistance. Firstly, each participant was asked to warm-up for 10 min at a self-selected cadence and intensity. Then, saddle pressures distribution was measured at three different pedaling intensities (100, 140, 180 W) with a pedaling cadence of 90 rpm, using a device equipped with sensors capable of acquiring pressures.</p><p><strong>Results: </strong>A significant difference in the ischial distance was found between males and females (<i>p</i> = 0.007). As pedaling intensity increased, results showed a significant higher pressure in the pubic region (<i>p</i> = 0.004) in males and a significant higher pressure in the posterior region in females (<i>p</i> = 0.034). <i>Post hoc</i> multiple comparisons test revealed a significant increase from 100 to 180 W (<i>p</i> = 0.003) in the pubic region pressure in males, while no significant differences were detected in the posterior region pressure in females.</p><p><strong>Conclusions: </strong>In male off-road cyclists, the pressure in the pubic region is higher with increasing pedaling intensity. Hence, to prevent acute and chronic genital pathologies, it would be advisable to fix the saddle in the best possible way during the bike fitting.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2495764"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular targets and mechanisms of traditional Chinese medicine combined with chemotherapy for gastric cancer: a meta-analysis and multi-omics approach.","authors":"Jie Lin, Jincheng Wang, Kai Zhao, Yongzhi Li, Xuewen Zhang, Jiyao Sheng","doi":"10.1080/07853890.2025.2494671","DOIUrl":"https://doi.org/10.1080/07853890.2025.2494671","url":null,"abstract":"<p><strong>Background: </strong>The combination of traditional Chinese medicine (TCM) with chemotherapy has been widely applied in the treatment of gastric cancer (GC). However, previous clinical studies have been constrained by small sample sizes and a lack of investigation into the molecular mechanisms of TCM. This study aims to assess the efficacy of TCM in treating GC by leveraging the strengths of meta-analysis and multi-omics approaches while also summarizing the underlying pharmacological mechanisms.</p><p><strong>Methods: </strong>A systematic literature review and meta-analysis were conducted using online databases to collect data before May 2024. This was to investigate the association between TCM combined with chemotherapy and the prognosis in GC. The molecular targets between the high-frequency TCMs and GC were identified through network pharmacology. The underlying mechanisms were investigated using multi-omics.</p><p><strong>Results: </strong>9 studies with 2,158 patients were included. The meta-analysis results demonstrated that the combination of TCM and chemotherapy significantly improved the overall survival (OS) of GC patients (OR = 2.91; 95% CI: 2.70-3.12, <i>p</i> < 0.00001) and enhanced their quality of life (OR = 4.00; 95% CI: 1.99-8.03, <i>p</i> < 0.0001). Network pharmacology analysis identified 13 potential molecular targets of TCM in GC; additionally, multi-omics analysis highlighted the significant roles of MK, MIF, GALECTIN, and CypA signaling pathways in GC.</p><p><strong>Conclusion: </strong>The combination of TCM with chemotherapy significantly improves the prognosis of GC; future research can focus on these key molecular targets and signaling pathways. This supports the application of precision medicine in cancer treatment and suggests the rational use of TCM in managing GC.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2494671"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between preoperative thyroid parameters, aggressive clinicopathological features and risk of recurrence in differentiated thyroid cancer.","authors":"Lu Yu, Xiao Chen, Jiaqi Liu, Hanyu Wang, Hui Sun","doi":"10.1080/07853890.2025.2491153","DOIUrl":"https://doi.org/10.1080/07853890.2025.2491153","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed (1) to investigate the association between aggressive clinicopathological characteristics and the American Thyroid Association (ATA) recurrence risk classification in differentiated thyroid cancer (DTC) patients, and (2) to investigate the prognostic value of preoperative thyroid parameters.</p><p><strong>Methods: </strong>A total of 3833 patients histologically confirmed DTC were recruited. Preoperative clinical and postoperative pathologic data were retrospectively collected. Participants were stratified into low recurrence risk and intermediate-to-high recurrence risk groups based on the ATA risk stratification system.</p><p><strong>Results: </strong>The study cohort had a mean age of 48.87 ± 8.08 years, and 1,465 (76.82%) were female. Male (OR = 1.37, <i>p</i> = .024), aged 52 years and older (OR = 2.01, <i>p</i> < .001), larger tumor size (OR = 3.71, <i>p</i> = 0.011), nerve invasion (OR = 6.69, <i>p</i> = .004), margin involvement (OR = 5.46, <i>p</i> < .001), multifocality (OR = 3.71, <i>p</i> < .001), and bilaterality (OR = 3.95, <i>p</i> < .001) were identified as risk factors for a higher ATA recurrence risk classification, in addition to established factors such as lymph node metastasis and angioinvasion, after adjusting for potential confounding variables. Higher preoperative levels of free triiodothyronine (FT3), FT3 to free thyroxine (FT3/FT4), and lower thyroid feedback quantile-based index (TFQI) levels were associated with a higher ATA recurrence risk classification. The comprehensive predictive model incorporating these variables demonstrated excellent discrimination (AUC = 0.836). Furthermore, higher FT3/FT4 levels and lower TFQI levels were associated with higher risk of lymph node metastases and angioinvasion.</p><p><strong>Conclusions: </strong>Factors such as male sex, older age, multifocality, bilaterality, margin involvement, nerve invasion, larger tumor size, and preoperative thyroid parameters serve as complementary predictors for higher ATA recurrence risk in DTC, in addition to conventional risk factors. These insights contribute to a more nuanced understanding and optimization of current risk stratification methodologies.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2491153"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive circRNA expression profile and hub genes screening during human liver development.","authors":"Si Ying Li, Shu Ting Liu, Chen Yi Wang, Yu Zuo Bai, Zheng Wei Yuan, Xiao Bing Tang","doi":"10.1080/07853890.2025.2497111","DOIUrl":"https://doi.org/10.1080/07853890.2025.2497111","url":null,"abstract":"<p><strong>Background: </strong>Understanding the expression of non-coding RNA in the liver during embryonic development provides important insights into liver diseases. Therefore, we investigated circular RNA (circRNA) roles in human liver development, an unexplored research domain.</p><p><strong>Methods: </strong>Using high-throughput sequencing and bioinformatics, we analysed foetal liver samples across developmental stages (7-20 weeks post-conception). Differentially expressed (DE) genes were identified and subjected to enrichment analysis using Gene Ontology (GO), Kyoto Encyclopaedia of Genes and Genomes (KEGG), and Disease Ontology (DO). Modular analysis was performed using the Search Tool for Retrieval of Interacting Genes (STRING), followed by construction of a protein-protein interaction (PPI) network using Cytoscape software. The key genes were screened using Molecular Complex Detection (MCODE). The mRNA levels of hub genes were validated using quantitative reverse transcription polymerase chain reaction (qRT-PCR).</p><p><strong>Results: </strong>There were 645 DE circRNAs and 5,145 DE mRNAs between human livers at the three growth stages (HB, EH, and LH). It was found that the activity of circRNAs was boosted remarkably in the hepatoblastic stage. Enrichment analysis found they mainly involved in nervous system regulation of liver function, embryonic organ development and digestive system development. In addition, DE circRNAs were primarily involved in the PI3K-AKT, MAPK and calcium pathways, potentially contributing to adult liver diseases. Notably, only hsa_circ_001471 and novel_circ_017382 were simultaneously identified at all stages and were persistently downregulated. A co-expression regulatory network involving these circRNAs was established. Three hub genes (LGR5, FOXL1 and RSPO3) were identified from the PPI network of 167 genes and may play key roles in human liver development. The RT-qPCR validation results were in agreement with the sequencing data.</p><p><strong>Conclusions: </strong>Our findings provide the first insights into the roles and regulatory networks of circRNAs in human liver development, laying the groundwork for further investigations of molecular and signalling networks.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2497111"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}