Annales d'endocrinologie最新文献

{"title":"Lipodystrophy and severe insulin resistance syndrome: epidemiological data from a French national rare diseases registry.","authors":"Marie-Christine Vantyghem, Estelle Nobécourt, Camille Vatier, Elise Bismuth, Clémence Deshuille, Nabila Elarouci, Anne-Sophie Jannot, Brigitte Delemer, Corinne Vigouroux","doi":"10.1016/j.ando.2025.101730","DOIUrl":"https://doi.org/10.1016/j.ando.2025.101730","url":null,"abstract":"<p><strong>Context: </strong>Lipodystrophy and extreme insulin resistance syndrome are rare diseases with severe metabolic complications. Reported epidemiological data are conflicting.</p><p><strong>Objective: </strong>We aimed to evaluate nationwide and regional prevalences of lipodystrophy and insulin resistance syndrome in France, and to study diagnostic and care-pathways.</p><p><strong>Methods: </strong>We studied data from the French National Rare Disease Registry (BNDMR), which includes all patients attending rare disease reference centers in France. We analyzed demographic data and age at first signs and at diagnosis in patients with an ORPHA code of lipodystrophy or severe insulin resistance syndrome.</p><p><strong>Results: </strong>The number of patients registered with lipodystrophy/insulin resistance syndrome doubled from 2017 to 2023, with the deployment of nationwide epidemiological tools in specialized rare diseases centers. Currently, 567 of the 652 patients (58% female) had a diagnosis of genetically determined disease with generalized (GL) or partial lipodystrophy (PL), giving an estimated national prevalence of 1.6 and 6.4 per million, respectively. Wide regional differences in estimated prevalence may be partly due to founder pathogen variants, or local spread of clinical skills and knowledge. Median age at first signs and diagnosis were respectively 1 [IQR: 1-3] and 5 years [0-20] for GL, and 22 [14-35] and 40 years [25-52] for PL, with earlier first signs of PL in women than in men.</p><p><strong>Conclusion: </strong>The estimated prevalence of genetic lipodystrophy/extreme insulin resistance syndrome has increases with the use of dedicated epidemiological tools, suggesting persistent underdiagnosis. Knowledge of these diseases needs to be improved to decrease diagnostic delay and reduce regional and gender-associated diagnostic disparities.</p>","PeriodicalId":93871,"journal":{"name":"Annales d'endocrinologie","volume":" ","pages":"101730"},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between orbital immune cell subsets and clinical activity in thyroid eye disease.","authors":"Mingqiao Zhang, Liang Liang, Hong Hu, Chengyang Tang, Qian Huang, Jian Long","doi":"10.1016/j.ando.2025.101729","DOIUrl":"https://doi.org/10.1016/j.ando.2025.101729","url":null,"abstract":"<p><strong>Purpose: </strong>To assess correlations between orbital immune cell subsets and the clinical activity in thyroid eye disease (TED).</p><p><strong>Methods: </strong>The orbital samples from 12 healthy controls and 29 TED patients (active group, n=12; inactive group, n=17) were analyzed. Total lymphocytes, CD3+T cells, CD4+T cells, CD8+ T cells, CD3+CD4+CD8+ T cells (double-positive (DPT) T-cells), CD3+CD4-CD8-T cells (double negative (DNT) T-cells), B cells, natural killer (NK) cells and NKT cells were counted on flow cytometry. Correlations between the number of orbital immune cells and clinical activity score (CAS) were analyzed.</p><p><strong>Results: </strong>Age was greater in active than inactive TED patients, and in inactive TED patients than in controls (all p<0.05). TED duration was shorter in active than inactive patients (all p<0.05). FT3 and TSH levels were higher in controls than in active TED patients (p<0.05). There was no significant difference in TRAb level between active and inactive patients. There were no significant differences in smoking status, gender or FT4 level between the 3 groups (all p > 0.05). The numbers of orbital total lymphocytes, CD3+ T cells, CD4+ T cells, CD8+ T cells, DNT cells, NK cells, NKT cells and CD4+/CD8+ T cells in active TED patients were significantly higher than in inactive patients and controls (all p<0.05). After adjusting for age and TED duration, the number of CD3+ T cells, CD4+ T cells, CD8+ T cells, NK cells and NKT cells were independent predictors of TED activity (p=0.03, OR=1.19; p=0.04, OR=1.69; p=0.03, OR=1.48; p=0.04, OR=2.08; p=0.03, OR=2.89, respectively).</p><p><strong>Conclusions: </strong>Numerous immunoinflammatory cells were observed in the orbits of both active and inactive TED patients and in controls, but expression was highest in active TED patients. CD4+ T cell, CD8+ T cell, NK cell, and NKT cell counts were independent factors for the CAS in TED.</p>","PeriodicalId":93871,"journal":{"name":"Annales d'endocrinologie","volume":" ","pages":"101729"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of primary hyperparathyroidism in MEN1: from initial subtotal surgery to complex treatment of the remaining gland.","authors":"Louis Schubert, Martin Gaillard, Charlotte Melot, Thierry Delbot, Anne Ségolène Cottereau, Eugénie Koumakis, Fidéline Bonnet-Serrano, Lionel Groussin","doi":"10.1016/j.ando.2025.101721","DOIUrl":"https://doi.org/10.1016/j.ando.2025.101721","url":null,"abstract":"<p><p>Multiple endocrine neoplasia type-1 (MEN1) is a rare genetic disease with autosomal dominant transmission, which can cause various tumors, particularly endocrine, in a given patient. Primary hyperparathyroidism (PHPT) is the most common and earliest manifestation, leading to surgery before the age of 50 in most patients. Biological severity and renal and/or bone complications dictate the timing of parathyroid surgery. The objective is to correct hypercalcemia to prevent impact, while minimizing the risk of hypoparathyroidism. The most widely recommended procedure is subtotal parathyroidectomy (3 or 3.5 glands removed), with thymic horn resection via a cervical route. The development of imaging techniques, however, makes it possible to discuss partial surgery (resection of 1 or 2 glands) on a case-by-case basis depending on preoperative imaging and other elements such as patient age. Finally, hypercalcemia recurrence after initial surgery is a common feature of MEN1, and management of the remaining gland is challenging with various options: reoperation, calcimimetics and US-guided ablation or therapeutic abstention.</p>","PeriodicalId":93871,"journal":{"name":"Annales d'endocrinologie","volume":" ","pages":"101721"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pituitary dysfunction after cranial radiotherapy for brain tumor.","authors":"Julie Chapon, Julien Berthillier, Amna Klich, Ronan Tanguy, Nathalie Perreton, Pauline Drouin, Aude Brac-de-la-Perrière, Chantal Simonet, Helene Lasolle, Gerald Raverot, Fabien Subtil, Françoise Borson-Chazot","doi":"10.1016/j.ando.2025.101722","DOIUrl":"https://doi.org/10.1016/j.ando.2025.101722","url":null,"abstract":"<p><strong>Background: </strong>Cranial radiotherapy for extrapituitary brain tumor is a rare cause of acquired pituitary deficiency. The main objective of the present study was to evaluate the incidence and time onset of pituitary deficit and to investigate predictive factors.</p><p><strong>Material and methods: </strong>This retrospective cohort study included 246 patients referred to our endocrinology department between 2005 and 2021 for hormone testing after radiotherapy for extra-pituitary brain tumor. Incidence of pituitary deficit was reported with 95% confidence intervals [95% CI]. Deficit-free survival was estimated on the Kaplan Meier method.</p><p><strong>Results: </strong>Mean (SD) age at inclusion was 32.2 years (20.3). 141 patients were male (57.3%). 175 (71.1%) were irradiated after and 71 (28.9%) at or before the age of 15. Mean (SD) follow-up was 10 years (7). At the end of the study, 118 patients (48.0%) had ≥ 1 hormonal deficit: GH deficit in 88 patients (36.5%), TSH deficit in 61 (24.8%), LH/FSH deficit in 47 (19.5%); ACTH deficit was identified in 12 patients (4.9%), and was never isolated. The overall incidence of pituitary deficits was 10.3 per 100 person-years (95% CI [30.8; 65.3]) and did not differ according to age at irradiation. Pituitary deficits occurred within a mean (SD) 2.6 years (2.5), 4.9 years (3.3), 4.0 years (2.4) and 4.8 years (3.1) for ACTH, TSH, GH and LH/FSH, respectively. The only factor associated with deficit-free survival was pituitary gland D50 (maximum dose received by at least 50% of gland volume): D50 37-44 Gy compared to 1-24 Gy; HR: 2.51; 95% CI [1.09; 5.80]; p = 0.031.</p><p><strong>Conclusion: </strong>Half of the patients presented pituitary deficits 10 years after irradiation for extrapituitary brain tumor. However, ACTH deficit was rare, and never isolated, suggesting that it is not necessary to carry out a dynamic test for ACTH if no other deficits are diagnosed.</p>","PeriodicalId":93871,"journal":{"name":"Annales d'endocrinologie","volume":" ","pages":"101722"},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of neuronal markers for pituitary dysfunction following traumatic brain injury: A preliminary study.","authors":"Aysa Hacioglu, Emre Urhan, Zuleyha Karaca, Ahmet Selcuklu, Halil Ulutabanca, Okkes Celil Gokcek, Bilal Yekeler, Kursad Unluhizarci, Kaj Blennow, Henrik Zetterberg, Fahrettin Kelestimur","doi":"10.1016/j.ando.2024.10.003","DOIUrl":"https://doi.org/10.1016/j.ando.2024.10.003","url":null,"abstract":"<p><strong>Purpose: </strong>Traumatic brain injury (TBI), a well-known risk factor for pituitary dysfunction, is associated with increased serum neurofilament light chain (NFL), glial fibrillary acidic protein (GFAP), and total tau (t-tau) levels. We aimed to assess the predictive value of these markers and pituitary dysfunction following TBI in a prospective manner.</p><p><strong>Methods: </strong>Adult patients following TBI were included. Serum levels of NFL, GFAP, t-tau and pituitary and target hormones were analyzed prospectively during first week and one year after TBI.</p><p><strong>Results: </strong>Twenty-two patients (17 males, 5 females; mean age 40±15 years) were included in the study. Basal NFL levels correlated positively with length of hospital stay and basal cortisol (r=0.643, p=0.001 and r=0.558, p=0.007, respectively) and negatively with Glasgow Coma Scale (GCS) score and basal IGF-1 levels (r=-0.429, p=0.046 and r=-0.481, p=0.023, respectively), while there was no significant correlation between GFAP, t-tau and hormone levels. NFL, GFAP, and t-tau levels significantly decreased, and none of the patients developed hormone deficiencies one year after TBI. No correlations were detected between basal markers and first year pituitary hormone levels.</p><p><strong>Conclusion: </strong>Serum NFL levels were correlated with hormonal changes during acute phase of TBI reflecting the physiological response to trauma. Larger studies are needed to analyze the associations during chronic phase.</p>","PeriodicalId":93871,"journal":{"name":"Annales d'endocrinologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"20-Hydroxyecdysone induces brown adipose tissue glycogen accumulation in obese gerbil model: Histochemical study","authors":"Z. Bellahreche, O. Sihali-Beloui, N. Semiane, A. Mallek, Y. Dahmani","doi":"10.1016/j.ando.2023.07.469","DOIUrl":"https://doi.org/10.1016/j.ando.2023.07.469","url":null,"abstract":"Obesity is a major public health problem. It is defined as an abnormal or excessive accumulation of fat harmful to health. Although the majority of obesity studies focus on changes in white adipose tissue, investigations into brown adipose tissue and its activation are becoming an increasingly popular area of interest. In this study, we attempted to examine the effects of 20-hydroxyecdysone (20E) on the glycogen amount stored in interscapular brown adipose tissue (IBAT). 15 gerbils were divided into: control group submitted to natural diet, two experimental groups submitted to high-calorie-diet supplemented or not with 20E. At the end of the experimental period, the animals were sacrificed and the IBAT was fixed in 10% formalin. Sections of 5 micrometers were made and stained with periodic acid-Schiff (PAS), to highlight the polysaccharides. Glycogen quantification in IBAT was performed using ImageJ software (NIH, Bethesda, MD, USA). PAS staining demonstrated that in the control gerbils, IBAT had strong cytoplasmic presence of glycogen. However, in the high-calorie diet group, the microscopy images had weaker PAS staining with lipid droplets infiltration compared to control group. We observed an important IBAT cytoplasm staining with PAS in group treated with 20E, indicating cells glycogen overload with reduction of lipid droplets accumulation. The quantification of glycogen had confirmed the qualitative study. Although the relationship between brown adipose tissue and glycogen storage remains underestimated and misunderstood, these preliminary results show that 20E could activate obese gerbil's brown adipocytes to store more glycogen.","PeriodicalId":93871,"journal":{"name":"Annales d'endocrinologie","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135274371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L’hémiballisme secondaire à l’hyperglycémie non cétosique : une situation rare","authors":"Z. Habbadi, I. Gam","doi":"10.1016/j.ando.2023.07.455","DOIUrl":"https://doi.org/10.1016/j.ando.2023.07.455","url":null,"abstract":"Le diabète déséquilibré peut entraîner des complications neurologiques comme des crises épileptiques et des troubles de conscience. L’hémiballisme est une manifestation plus rare. Le mécanisme expliquant la survenue de ces mouvements anormaux lors d’une hyperglycémie sans cétose reste mal élucidé. Patiente de 67 ans, hypertendue sous traitement, diabétique de type 2 depuis 4 ans sous association metformine et insuline. Admise aux urgences neurologiques pour des mouvements anormaux de l’hémicorps droit d’apparition brutale. Ces mouvements prédominent au niveau proximal, d’abord au niveau du membre supérieur droit, puis au membre inférieur homolatéral à type de flexion extension et de rotation. Ils sont brusques et irréguliers altérant sa qualité de vie. Le bilan étiologique révèle une hyperglycémie à 5 g/L sans hyperosmolarité ni cétonurie ni syndrome infectieux associé. La TDM cérébrale montre une atteinte du striatum gauche. L’évolution était marquée par la disparition de l’hémiballisme deux semaines après l’équilibre glycémique et la mise sous neuroleptique à faible dose. L’hémiballisme est un mouvement unilatéral rapide, brutal, non rythmique, non suppressible, dû à une atteinte du striatum controlatéral. Bien que rare, l’hyperglycémie non cétosique est l’une de ses causes. Dans ce cadre, plusieurs hypothèses sont avancées. En effet, l’épuisement de l’acide gamma-aminobutyrique et de l’acétate au cours de l’hyperglycémie sans cétose, avec le manque d’énergie et l’acidose métabolique, serait à l’origine de l’apparition des mouvements anormaux. Le diagnostic est radiologique et le traitement repose sur l’équilibre glycémique.","PeriodicalId":93871,"journal":{"name":"Annales d'endocrinologie","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135274381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiothyréose : à propos de neuf cas","authors":"W. Ben Hilel, I. Rojbi, S. Mekni, S. Essayeh, K. Khiari, I. Ben Nacef","doi":"10.1016/j.ando.2023.07.254","DOIUrl":"https://doi.org/10.1016/j.ando.2023.07.254","url":null,"abstract":"La cardiothyréose, complication majeure de l’hyperthyroïdie peut révéler ou survenir après le diagnostic la maladie. L’objectif de ce travail est de décrire le profil clinique, paraclinique et évolutif de la cardiothyréose. Il s’agissait d’une étude rétrospective descriptive réalisée à partir des patients hyperthyroïdiens hospitalisés dans notre service entre 2008 et 2022. Le diagnostic de cardiothyréose était retenu devant un trouble de rythme, une insuffisance cardiaque ou coronaire. Au total, 4 % des patients hyperthyroïdiens avaient une cardiothyréose (9/227). L’âge moyen était 55 ± 12 ans avec un sexe ratio = 2. La fréquence cardiaque moyenne était à 166 ± 32. L’amaigrissement et les palpitations étaient les signes prédominants retrouvés chez huit patients. L’hyperthyroïdie était fruste chez un patient. Le taux moyen de TSH était à 0,032 ± 0,02 U/ml et de FT4 à 3,5 ± 1,96 ng/dl [VN : 0,7–1,48]. Huit patients avaient une maladie de Basedow. L’arythmie cardiaque par fibrillation atriale (ACFA) était objectivée chez tous les patients et révélatrice de l’hyperthyroïdie dans trois cas. L’association ACFA et insuffisance cardiaque étaient présente chez deux patients. L’ETT montrait Une FEVG inférieure à 50 % et une HTAP dans deux cas. Le bisoprolol a été prescrit chez cinq patients. Parmi les six patients suivis après normalisation de la FT4, on obtenait la conversion de l’ACFA chez trois. La cardiothyréose est une complication sérieuse de l’hyperthyroïdie pouvant menacer le pronostic vital. L’ACFA est la forme clinique la plus fréquente et le retour au rythme sinusal n’est pas constant après contrôle de l’hyperthyroïdie, d’où l’intérêt du diagnostic et de prise en charge précoce de l’hyperthyroïdie.","PeriodicalId":93871,"journal":{"name":"Annales d'endocrinologie","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135274386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospitalisations pour maladies hypophysaires : profil épidémiologique et évolutif sur 13 ans","authors":"M. Baklouti, H. Ben Ayed, N. Hentati, O. Laajili, M. Trigui, F. Hadj Kacem, G. Nasri, R. Karray, J. Jdidi, S. Yaich, J. Dammak","doi":"10.1016/j.ando.2023.07.178","DOIUrl":"https://doi.org/10.1016/j.ando.2023.07.178","url":null,"abstract":"Les maladies hypophysaires (MH) constituent un des motifs les plus répondus en endocrinologie, dont la prise en charge pourrait parfois nécessiter l’hospitalisation. L’objectif de cette étude était de dresser le profil épidémiologique et évolutif des hospitalisations pour MH sur une période de 13 ans. Il s’agissait d’une étude rétrospective ayant inclus les patients hospitalisés pour MH dans le CHU Hedi Chaker Sfax, Tunisie, durant la période 2006–2018. Sur un total de 148 596 admissions, 240 patients (0,16 %) étaient hospitalisés pour MH. Le sexe ratio était de 0,55. L’âge médian était de 43 ans (Intervalle interquartile (IIQ) = [30,7–53] ans). Ils y avaient 39 patients (16,3 %) âgés de plus de 60 ans. 158 patients (65,8 %) étaient hospitalisés pour une insuffisance hypophysaire et 82 cas (34,2 %) étaient admis pour un hyperaldostéronisme. La durée médiane du séjour était de 7 jours (IIQ = [5–10]). Une durée > 7 jours était notée chez 119 patients (49,6 %). Au total, 14 patients (5,8 %) présentaient des comorbidités associés, dont 5 (2 %) étaient endocriniennes. Le taux de létalité était de 0,4 %. L’étude des tendances chronologiques a montré une allure globale significativement à la baisse (Rho = (–0,83) ; p < 0,001)), de même que pour insuffisance hypophysaire (Rho = (–0,8) ; p = 0,001) et pour hyperaldostéronisme (Rho = (–0,73) ; p = 0,003). Malgré leurs tendances chronologiques à la baisse, les MH continuent à être une source de morbidité en milieu de soins, notamment chez les adultes jeunes. Une prise en charge adéquate et continue de ces maladies est primordiale pour prévenir les formes graves.","PeriodicalId":93871,"journal":{"name":"Annales d'endocrinologie","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135274403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ampleur, facteurs de risque et répercussion de l’obésité sur le bienêtre des professionnels de la santé","authors":"M. Baklouti, H. Ben Ayed, N. Hentati, O. Laajili, M. Trigui, G. Nasri, N. Ketata, J. Jdidi, M. Kassis, S. Yaich, J. Dammak","doi":"10.1016/j.ando.2023.07.501","DOIUrl":"https://doi.org/10.1016/j.ando.2023.07.501","url":null,"abstract":"La prévalence de l’obésité ne cesse d’augmenter au cours de ces dernières décennies en touchant toutes les catégories d’âges et de professions. L’objectif de cette étude était de déterminer la prévalence et les facteurs associés à l’obésité chez les PDS. Il s’agissait d’une étude transversale portant sur un échantillon représentatif de 300 PDS du CHU Hédi Chaker Sfax, Tunisie, durant les mois d’août–septembre 2021. L’évaluation de l’obésité a été faite selon une mesure standardisée de l’indice de masse corporelle (IMC). Un PDS était classé obèse si son IMC ≥ 30. Au total, 218 sujets étaient des femmes (72,7 %). L’âge moyen était de 25,6 ± 3,5 ans. Les principaux antécédents étaient le diabète et l’hypertension artérielle chez 23 sujets (97,6 %) et 17 sujets (5,7 %) respectivement. Le surpoids et l’obésité étaient présents chez 136 PDS (45,3 %) et la prévalence de l’obésité était de 6,7 %. L’analyse multivariée par régression logistique binaire a montré que l’âge ≥ 45 ans (odds ratio ajusté [ORA] = 5,13 ; p = 0,02), être marié (ORA = 4,26 ; p = 0,001) et travailler dans un service chirurgical (ORA = 3 ; p = 0,035) étaient des facteurs indépendants de l’obésité. Des répercussions de l’obésité sur l’état de santé étaient significativement plus notées chez les PDS diabétiques (OR = 6,63 ; p = 0,002) et hypertendus (OR = 10,48 ; p < 0,001) en milieu de travail en portant les équipements de protection individuelle. La prévalence de l’obésité était considérable chez les PDS. De multiples facteurs y étaient associés. L’éducation sanitaire, le dépistage et la prise en charge adéquate des PDS est primordiale afin de transmettre les bonnes habitudes aux patients.","PeriodicalId":93871,"journal":{"name":"Annales d'endocrinologie","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135274422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}