Journal of chromatography open最新文献_第2页

Stability issue of amino acids and organic acids in exhaled breath condensate and the potential use for lung cancer diagnosis 呼出液中氨基酸和有机酸的稳定性问题及其在肺癌诊断中的潜在应用

IF 3.2

Journal of chromatography open Pub Date : 2026-05-01 Epub Date: 2026-04-21 DOI: 10.1016/j.jcoa.2026.100338

Korcan Korba , Ebru Calkan Yildirim , Su Ozgur , Tuncay Goksel , Fatma Nil Ertas , Levent Pelit

{"title":"Stability issue of amino acids and organic acids in exhaled breath condensate and the potential use for lung cancer diagnosis","authors":"Korcan Korba , Ebru Calkan Yildirim , Su Ozgur , Tuncay Goksel , Fatma Nil Ertas , Levent Pelit","doi":"10.1016/j.jcoa.2026.100338","DOIUrl":"10.1016/j.jcoa.2026.100338","url":null,"abstract":"<div><div>As a non-invasive biofluid, exhaled breath condensate (EBC), which contains various volatile and non-volatile metabolites, such as amino acids (AAs) and organic acids (OAs), offers immense potential for metabolic monitoring and disease diagnosis. Although the ubiquitous nature of AAs and OAs in overlapping biochemical networks often complicates their use as standalone biomarkers, profiling these central metabolites remains crucial for understanding disease-induced metabolic dysregulation. Despite their proposed biomarker properties in conventional matrices such as blood and urine, the investigation of these metabolites in EBC is remarkably sparse, highlighting a clear imperative for further research. The objective of this study is to evaluate the impact of storage stability conditions of selected AAs and OAs in EBC, optimize their analytical conditions, and investigate their potential as non-invasive biomarkers for lung cancer (LuC) diagnosis. After revealing the storage conditions, a study was conducted in which EBC samples were collected from 30 patients diagnosed with LuC and 19 healthy subjects. While five metabolites (pipecolic acid, aspartic acid, taurine, succinic acid, and trigonelline), have been detected in all samples, notable prevalence variations emerged: phenylalanine was elevated in LuC patients (83% vs. 53%), whereas tryptophan and threonine exhibited rare, group-exclusive distributions. Conversely, the AA tryptophan was found exclusively in two healthy individuals and was absent in all LuC patient samples. Although statistical evaluations, including the Mann-Whitney U test and AUC-ROC analysis, revealed that the dataset lacks absolute discriminative power, these foundational EBC profiles provide critical insights for advancing future non-invasive diagnostic studies.</div></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"9 ","pages":"Article 100338"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A critical review and analysis of thermodynamic and kinetic effects on extraction of medical devices by organic solvents as a sample preparation step in devices’ chemical characterization 综述和分析了有机溶剂萃取医疗器械作为样品制备步骤在器械化学表征中的热力学和动力学影响

IF 3.2

Journal of chromatography open Pub Date : 2026-05-01 Epub Date: 2026-01-18 DOI: 10.1016/j.jcoa.2026.100309

By Jianwei Li

{"title":"A critical review and analysis of thermodynamic and kinetic effects on extraction of medical devices by organic solvents as a sample preparation step in devices’ chemical characterization","authors":"By Jianwei Li","doi":"10.1016/j.jcoa.2026.100309","DOIUrl":"10.1016/j.jcoa.2026.100309","url":null,"abstract":"<div><div>The extraction of medical devices by organic solvents as a sample preparation step is perhaps the most critical process in chemical characterization of medical devices, as the decision of solvent choice determines not only the resulting extractables profiles (e.g., the number, molecular weight, and concentration of extractables), but also the degree of analytical challenges in identification and quantification, when performing instrumental analysis of extracts. Both concentration and chemical identities of all extractables are used in subsequent toxicological risk assessment, which is required to support regulatory submission and approval of medical devices. There is currently a considerable debate on which solvent(s) should be used to balance the desired extraction and clinical relevance to biological tissue exposure due to scientific and regulatory consequences. The purpose of this article is intended to streamline solvent selection in chemical characterization, particularly on the rational development of a semipolar solvent to stimulate or exaggerate biological (storage) fatty tissues. A comprehensive review and analysis of solvent extraction of polymer materials from thermodynamic and kinetic perspectives is provided first. The solvent-material interactions (swelling) and their consequences on kinetics and thermodynamics are subsequently elaborated. The conclusions of thermodynamic and kinetic properties, together with solvent-material interactions, are used to establish solvent similarity criteria between semipolar solvents and fatty tissues. Finally, solvent solubility, degree of material swelling by solvents, diffusion coefficients in device material, partition coefficient between material and solvent, and solvent compatibility with instrumental analysis are used as the criteria to establish representative solvents to fatty tissues in chemical characterization studies. Blood simulating solvents are well established and not discussed in the article.</div></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"9 ","pages":"Article 100309"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The challenges and prospects of capillary zone electrophoresis-mass spectrometry for characterization of monoclonal antibodies biotherapeutics 毛细管区带电泳-质谱技术用于单克隆抗体生物治疗药物鉴定的挑战与展望

IF 3.2

Journal of chromatography open Pub Date : 2026-05-01 Epub Date: 2025-11-25 DOI: 10.1016/j.jcoa.2025.100293

Claudia Desiderio , Alexandra Muntiu

{"title":"The challenges and prospects of capillary zone electrophoresis-mass spectrometry for characterization of monoclonal antibodies biotherapeutics","authors":"Claudia Desiderio , Alexandra Muntiu","doi":"10.1016/j.jcoa.2025.100293","DOIUrl":"10.1016/j.jcoa.2025.100293","url":null,"abstract":"<div><div>The application of Capillary Zone Electrophoresis (CZE) in proteomic analysis has increased significantly since the technique was hyphenated with high resolution mass spectrometry (HR-MS). The coupling was successful in combining the analytical features of high separation efficiency and resolving power of CZE with the precision of molecular mass measurements and sequencing of HR-MS analyzers for characterization of proteins and peptides and of their proteoforms, even in pre-digested, intact and native form. In this regard, CZE has made a strong contribution in the field of analysis and characterization of monoclonal antibodies (mAb) biotherapeutics, due to its high resolution power and separation mechanism based on differential migration, demonstrating challenging features for discriminating variants with rapid and high-efficiency analyses and for assessment of manufacturing quality control and safety of the final product. This review aims to highlight the most recent applications of CZE-MS in separation and characterization of mAb biotherapeutics based on the most recent literature (2022-2025). The various analytical approaches used in proteins MS characterization will be illustrated, with particular emphasis on the top-down approach, widely applied in this field of analysis and offering comprehensive characterization of proteoforms and exploration of protein interactions under native conditions. CZE-MS demonstrated an effective analytical strategy for the detailed characterization of mAb proteoforms with high potential for application in the challenging task of monitoring mAb release in advanced drug delivery systems.</div></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"9 ","pages":"Article 100293"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145618376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modified bi-Gaussian models to describe chromatographic peaks as a function of peak-shape parameters 改进双高斯模型，将色谱峰描述为峰形参数的函数

IF 3.2

Journal of chromatography open Pub Date : 2026-05-01 Epub Date: 2026-02-21 DOI: 10.1016/j.jcoa.2026.100317

J.J. Baeza-Baeza, L.J. Baeza-Ballesteros, J.R. Torres-Lapasió, M.C. García-Alvarez-Coque

{"title":"Modified bi-Gaussian models to describe chromatographic peaks as a function of peak-shape parameters","authors":"J.J. Baeza-Baeza, L.J. Baeza-Ballesteros, J.R. Torres-Lapasió, M.C. García-Alvarez-Coque","doi":"10.1016/j.jcoa.2026.100317","DOIUrl":"10.1016/j.jcoa.2026.100317","url":null,"abstract":"<div><div>The modelling and prediction of chromatographic peak profiles have been extensively studied, with foundational contributions such as Grushka's bi-Gaussian model. In this work, this approach is extended to two modified Gaussian models: The Linear Modified Gaussian (LMG) and the Parabolic Variance Modified Gaussian (PVMG). These models enhance the traditional Gaussian framework by allowing the peak variance to change according to parabolic trends, thereby capturing deviations from ideal Gaussian peak shapes. This added flexibility enables a more accurate representation of a wide range of chromatographic peak shapes with varying degrees of asymmetry. The proposed modified bi-Gaussian models (BLMG and BVMG with six and seven parameters) use peak-shape parameters that can be expressed as functions of retention time. This makes them well suited for predicting peak shape and chromatographic resolution, which are key factors in optimising the separation of complex analyte mixtures. The BVMG model with seven parameters yields fitting errors below 1 % for most peaks and below 2 % for the peaks of all assayed probe compounds, comparable to the more sophisticated Parabolic Lorentzian Modified Gaussian (PLMG) model, while relying only on peak-shape parameters (retention time, peak height at the peak maximum, and half-widths measured at 60 and 10 % of peak height). The performance of the models is validated through the fitting and prediction of chromatographic peaks for compounds eluted using two columns with distinct retention mechanisms: Zorbax C18 and Hypercarb porous graphitic carbon columns.</div></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"9 ","pages":"Article 100317"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147384201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyphenolic profiling of Euphorbia cardiophylla, an endemic Turkish species, using Liquid chromatography-High resolution Orbitrap mass spectrometry and investigating its biological activity 用液相色谱-高分辨率轨道阱质谱法分析土耳其特有植物大鼠心叶的多酚类物质，并研究其生物活性

IF 3.2

Journal of chromatography open Pub Date : 2026-05-01 Epub Date: 2026-02-12 DOI: 10.1016/j.jcoa.2026.100312

Inan Dursun , Lütfi Behçet , Cemil Aydoğan

{"title":"Polyphenolic profiling of Euphorbia cardiophylla, an endemic Turkish species, using Liquid chromatography-High resolution Orbitrap mass spectrometry and investigating its biological activity","authors":"Inan Dursun , Lütfi Behçet , Cemil Aydoğan","doi":"10.1016/j.jcoa.2026.100312","DOIUrl":"10.1016/j.jcoa.2026.100312","url":null,"abstract":"<div><div>This study used<img> LC/High resolution Orbitrap-mass spectrometry (LC/HR Orbitrap-MS) to comprehensively investigate the phenolic compound profile and biological activities of <em>E. cardiophylla</em> a species endemic to Türkiye. The leaf and root methanol extracts of the plant were evaluated, and their total phenolic (TPC) and total flavonoid (TFC) contents were determined using various antioxidant tests (DPPH, ABTS and CUPRAC). The findings revealed that the leaf extract contained significantly higher levels of phenolic compounds than the root extract, with TPC and TFC values of 125.64 ± 6.25 mg GAE/g and 49.42 ± 1.89 mg QE/g, respectively. Antioxidant activity tests showed that the leaf extract had much higher capacities for DPPH (309.04 ± 2.64 mg TE/g), ABTS (481.11 ± 9.12 mg TE/g) and CUPRAC (787.86 ± 15.09 mg TE/g) than the root extract. Analysis using LC/HR Orbitrap-MS <img>has revealed the presence of compounds such as rutin hydrate (19,351.87 µg/g), quinic acid (31,473.66 µg/g), isoquercitrin (11,546.45 µg/g), astragalin (5472.01 µg/g) and gallic acid (1459.39 µg/g) at high levels in the <em>E. cardiophylla</em> plant. These results demonstrate that <em>E. cardiophylla</em> has a high phenolic content and strong antioxidant properties, suggesting that it could be a valuable source of natural bioactives for use in pharmaceuticals and nutraceuticals.</div></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"9 ","pages":"Article 100312"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147384701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in gels application for green analytical sample preparation 凝胶在绿色分析样品制备中的应用进展

IF 3.2

Journal of chromatography open Pub Date : 2026-05-01 Epub Date: 2026-02-07 DOI: 10.1016/j.jcoa.2026.100311

Maria Chiara Frondaroli, Edoardo Parisi, Vittoria Terrigno, Erica Cutè, Susanna Della Posta, Chiara Fanali

{"title":"Recent advances in gels application for green analytical sample preparation","authors":"Maria Chiara Frondaroli, Edoardo Parisi, Vittoria Terrigno, Erica Cutè, Susanna Della Posta, Chiara Fanali","doi":"10.1016/j.jcoa.2026.100311","DOIUrl":"10.1016/j.jcoa.2026.100311","url":null,"abstract":"<div><div>The ongoing quest for more environmentally sustainable analytical methodologies has led to the development of gels as highly versatile and promising materials for sample preparation. Their high surface area, adjustable porosity, mechanical stability, and the capacity to accommodate a diverse array of functional chemical groups, render them remarkably well-suited for the selective capture, retention, and regulated release of a broad spectrum of analytes. Recent studies have demonstrated significant advancements in the field of gel research and innovation, including hydrogels, ionogels, eutectogels, xerogels, aerogels, and cryogels. It has been demonstrated that the properties of gels can be modulated for a variety of sample preparation techniques, including solid-phase extraction, dispersive SPE, magnetic SPE, solid-phase microextraction, and matrix solid-phase dispersion. The synergy between gels and nanostructured materials, such as metal–organic frameworks, carbon nanotubes, graphene oxide, and magnetic nanoparticles, and many others, leads to a pronounced increase in extraction capacity and selectivity. Thus, gel-based materials are gaining attention over a wide range of analytical purposes, including environmental monitoring, food safety testing, and biological analysis.</div></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"9 ","pages":"Article 100311"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging the potential of capsule phase microextraction for simultaneous determination of anaesthetic and opioid drugs in postmortem samples of its fatal intoxication 利用胶囊相微萃取法同时测定死后致死性中毒样品中麻醉剂和阿片类药物的潜力

IF 3.2

Journal of chromatography open Pub Date : 2026-05-01 Epub Date: 2025-11-22 DOI: 10.1016/j.jcoa.2025.100291

Bharti Jain , Rajeev Jain , Abuzar Kabir , Torki Zughaibi , Shweta Sharma

{"title":"Leveraging the potential of capsule phase microextraction for simultaneous determination of anaesthetic and opioid drugs in postmortem samples of its fatal intoxication","authors":"Bharti Jain , Rajeev Jain , Abuzar Kabir , Torki Zughaibi , Shweta Sharma","doi":"10.1016/j.jcoa.2025.100291","DOIUrl":"10.1016/j.jcoa.2025.100291","url":null,"abstract":"<div><div>The reliable identification of anaesthetic and opioid drugs in biological matrices is of critical importance in forensic toxicology, particularly in cases of drug misuse and suspected medical malpractice. Given the typically low concentrations of these analytes in postmortem samples, an efficient extraction and preconcentration strategy is indispensable. Capsule phase microextraction (CPME), a recently developed sol-gel–based sample preparation technology that encapsulates sorbents within a porous tubular polymeric membrane, was employed for the selective isolation of anaesthetics (bupivacaine, lidocaine, ropivacaine, and prilocaine) and the opioid (tramadol) from postmortem blood and tissue samples (liver, kidney, stomach, and spleen). Subsequent analysis was performed using gas chromatography–mass spectrometry (GC–MS). The optimized CPME-GC–MS method exhibited excellent analytical performance, achieving linear calibration ranges of 0.01–1.0 μg mL⁻¹ in blood and 0.01–1.0 μg g⁻¹ in tissue samples, with limits of quantification as low as 0.0060–0.0079 μg mL⁻¹ (blood) and 0.0080–0.0099 μg g⁻¹ (tissues). Precision studies confirmed strong method reliability, with intra-day repeatability below 5% and inter-day reproducibility below 10%. The method was successfully applied to authentic postmortem specimens from a suspected fatal intoxication case attributed to medical negligence involving anaesthetic and opioid drugs. Beyond its forensic applicability, the environmental and operational sustainability of the protocol was critically evaluated using ComplexMoGAPI, AGREE and CACI assessment tools, confirming the method’s greenness and practicality. Overall, the CPME-GC- MS workflow offers a robust, sensitive, and eco-friendly analytical platform, representing a significant advancement for drug monitoring in medico-legal investigations.</div></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"9 ","pages":"Article 100291"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145618377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Water and organic content tuning of mobile phase for Enantioseparation of fungicides by capillary electrochromatography using cellulose Tris(3‑chloro-4-methylphenylcarbamate) based stationary phase 以3 -氯-4-甲基苯基氨基甲酸酯纤维素为固定相，毛细管电色谱法分离杀菌剂对映体的水和有机物含量调整

IF 3.2

Journal of chromatography open Pub Date : 2026-05-01 Epub Date: 2025-11-19 DOI: 10.1016/j.jcoa.2025.100289

Giovanni D’Orazio , Salvatore Fanali

{"title":"Water and organic content tuning of mobile phase for Enantioseparation of fungicides by capillary electrochromatography using cellulose Tris(3‑chloro-4-methylphenylcarbamate) based stationary phase","authors":"Giovanni D’Orazio , Salvatore Fanali","doi":"10.1016/j.jcoa.2025.100289","DOIUrl":"10.1016/j.jcoa.2025.100289","url":null,"abstract":"<div><div>This study investigated the effect of mobile phase composition, especially water content in a mixture of protic and non-protic organic solvents, on chiral recognition and separation efficiency using a cellulose tris(3‑chloro-4-methylphenylcarbamate)-based stationary phase in the enantioseparation of selected fungicide compounds. The chiral stationary phase, coated on porous native silica particles, was packed into fused silica capillaries (250 mm x 100 µm I.D.) via the \"slurry\" packing method. The capillary column was utilized for the enantiomeric separation of five azole compounds through capillary electrochromatography. The primary objective was to thoroughly investigate how the composition of the mobile phase affects enantioresolution. This was achieved by systematically varying the ratios of methanol, acetonitrile, and water while keeping the buffer concentration, type, and pH constant. The role of water content was studied in relation to chiral interactions by evaluating its effect on key chromatographic parameters such as retention factor, resolution, and efficiency.</div><div>By selecting an appropriate acetonitrile to methanol ratio at a fixed water content, chiral resolutions (<em>Rs</em>) ranging from approximately 2.0 to 3.5 were achieved for the tested analytes.</div></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"9 ","pages":"Article 100289"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145618379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preliminary characterization of wind turbine blade waste by solvolysis, microwave-assisted extraction, and comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry 通过溶剂溶解、微波辅助萃取和综合二维气相色谱-飞行时间质谱法对风力涡轮机叶片废弃物进行初步表征

IF 3.2

Journal of chromatography open Pub Date : 2026-05-01 Epub Date: 2025-12-09 DOI: 10.1016/j.jcoa.2025.100301

Giulia Giacoppo , Charlotte Mase , Marco Piparo , Pierre Giusti , Caroline Mangote , Callum Branfoot , Luisa Pasti , Flavio Antonio Franchina , Marco Beccaria

{"title":"Preliminary characterization of wind turbine blade waste by solvolysis, microwave-assisted extraction, and comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry","authors":"Giulia Giacoppo , Charlotte Mase , Marco Piparo , Pierre Giusti , Caroline Mangote , Callum Branfoot , Luisa Pasti , Flavio Antonio Franchina , Marco Beccaria","doi":"10.1016/j.jcoa.2025.100301","DOIUrl":"10.1016/j.jcoa.2025.100301","url":null,"abstract":"<div><div>The growth of renewable energy infrastructure highlights the urgent need for sustainable solutions to manage its end-of-life materials, including wind turbine blades (WTBs). These composite materials present significant challenges in recycling due to their complex heterogeneous structure and varied chemical composition. To depolymerize WTB composite materials, a solvolysis process was applied. The resulting chemical products underwent microwave-assisted extraction (MAE), using a mixture of <em>n-</em>hexane and methanol (10:3, v:v). The non-polar organic phase was subjected to analysis using comprehensive two-dimensional gas chromatography–time-of-flight mass spectrometry (GC×GC-ToFMS). On the basis of electron impact ionization mass spectral matching at 70 eV, linear retention index data, and molecular distribution on the two-dimensional space, >110 compounds were putatively identified, mainly composed by aromatic and heteroatom-containing species. To the best of our knowledge, this is the first time that the molecular composition of WTBs has been investigated by MAE-GC×GC–MS.</div></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"9 ","pages":"Article 100301"},"PeriodicalIF":3.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surrogate chromatographic models and the solvation parameter model 替代色谱模型和溶剂化参数模型

IF 3.2

Journal of chromatography open Pub Date : 2026-05-01 Epub Date: 2025-11-21 DOI: 10.1016/j.jcoa.2025.100292

Sanka N. Atapattu , Colin F. Poole

引用次数: 0