Journal of chromatography open最新文献

{"title":"Current research on determination of medically valued stilbenes and stilbenoids from spruce and pine with chromatographic and spectrometric methods—A review","authors":"Heli Sirén","doi":"10.1016/j.jcoa.2024.100169","DOIUrl":"10.1016/j.jcoa.2024.100169","url":null,"abstract":"<div><p>The review compiles a selection of the recently published chemical research on stilbenes, stilbene glucuronides, and stilbenoids. The basic structure of stilbene group compounds is 1,2-diphenylethene. They can be isolated from spruce, pine, and other conifers, and specifically from wood bark, needles, heartwood, and roots.</p><p>Stilbenes and stilbenoids possess antioxidative, anti-inflammatory, and antimicrobial impacts what for they are used in pharmaceuticals. They decrease of glucose and triglyceride concentrations in plasma. Especially, they are used for treatment of cancer, liver injuries, and Alzheimer's disease.</p><p>Lately, extraction of stilbene group compounds from wood materials was done with alcohol, water, or nonpolar solvents. Moreover, they were extracted with supercritical fluid and hot water extraction methods. Rectified extracts were studied with liquid and/or gas chromatography. Mass spectrometry with negative electrospray ionization was the prevalent method for their identification. HPLC-MS methods were preferred over GC to identify dimeric stilbenes and oligomeric stilbenoids.</p></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"6 ","pages":"Article 100169"},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772391724000562/pdfft?md5=ee46d6d02ebfeb5a0c262823bcb77da6&pid=1-s2.0-S2772391724000562-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141998413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of nutritional and bioactive properties of selected edible flowers: Characterisation of phenolic compounds by reversed-phase high performance liquid chromatography","authors":"Indrani Chetia,&nbsp;Arup Jyoti Das,&nbsp;Laxmikant S. Badwaik","doi":"10.1016/j.jcoa.2024.100167","DOIUrl":"10.1016/j.jcoa.2024.100167","url":null,"abstract":"<div><p>Edible flowers have been consumed from ancient times and it was believed to deliver medicinal properties. This study explored some common edible flowers from Assam, India, such as Night Jasmine (<em>Nyctanthus arbortristis</em>), Drumstick (<em>Moringa oleifera</em>), Pumpkin (<em>Cucurbita spp</em>.), and Nongmangkha (<em>Phlogacanthus thyrsiflorus</em>), to assess their nutritional values, phytochemical characteristics, antioxidant potential, and mineral content. Additionally, the study aimed to analyze the presence of various phenolic compounds in these flowers using HPLC. Nongmangkha flowers exhibited the highest total phenolic content (TPC) of 118.12 mg GAE/g and total flavonoid content (TFC) of 75.36 mg QE/g. Drumstick flowers showed the highest ash content at 6.55 % and also the highest DPPH radical scavenging activity at 89.76 %. Potassium was found among all these flowers ranged from 11.95 to 4.412 mg/g, zinc 0.046 to 0.130 mg/g and iron 0.235 to 0.513 mg/g. HPLC screening showed that, Night jasmine flowers had gallic acid, resorcinol, caffeic acid, p-coumeric acid, ferulic acid. The findings of this study are valuable for understanding the nutritional composition of these edible flowers. Additionally, further scientific research is needed on their bioaccessibility and bioavailability, as well as on the application of these flowers in the development of food products</p></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"6 ","pages":"Article 100167"},"PeriodicalIF":0.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772391724000549/pdfft?md5=945e97f6bb60eb46ba39150719492565&pid=1-s2.0-S2772391724000549-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141964450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Untargeted metabolomics approaches for the characterization of cereals and their derived products by means of liquid chromatography coupled to high resolution mass spectrometry","authors":"Desiree Bozza ,&nbsp;Davide Barboni ,&nbsp;Natasha Damiana Spadafora ,&nbsp;Simona Felletti ,&nbsp;Chiara De Luca ,&nbsp;Chiara Nosengo ,&nbsp;Greta Compagnin ,&nbsp;Alberto Cavazzini ,&nbsp;Martina Catani","doi":"10.1016/j.jcoa.2024.100168","DOIUrl":"10.1016/j.jcoa.2024.100168","url":null,"abstract":"<div><p>This review is aimed at providing an overview of the application of liquid chromatography-high resolution mass spectrometry (LC-HRMS) in the metabolomic study of cereal grains, with special emphasis on wheat, maize, barley, and rice. The significant role of untargeted metabolomics in identifying and quantifying metabolites is highlighted, thereby elucidating biochemical pathways involved in flavour, disease detection, and the development of disease-resistant varieties. The use of stable isotope labelling for enhanced compound annotation and the exploration of metabolic pathways involved in plant defence mechanisms and stress resilience are also discussed. The integration of cutting-edge analytical techniques is becoming of fundamental importance to enhance the understanding of metabolic reconfigurations in response to various conditions, thereby contributing to the improvement of cereal quality and ensuring food safety. The potential health benefits of phytochemicals in human nutrition and the role of specific metabolites as biomarkers for crop resistance and susceptibility to diseases, pests, and abiotic stresses are discussed. Overall, valuable insights into the advancement of analytical chemistry and its applications in agricultural science are provided by this review.</p></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"6 ","pages":"Article 100168"},"PeriodicalIF":0.0,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772391724000550/pdfft?md5=4a51831e82a1c85408dfd397fa88b08f&pid=1-s2.0-S2772391724000550-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical properties, antioxidant activity and phytochemical profiling of Australian Tetragonula carbonaria cerumen","authors":"Nicola Deyerling ,&nbsp;Juliane Achenbach ,&nbsp;Mariana Mello dos Santos,&nbsp;Cornelia Locher","doi":"10.1016/j.jcoa.2024.100164","DOIUrl":"10.1016/j.jcoa.2024.100164","url":null,"abstract":"<div><p>This study investigated the physicochemical and antioxidant properties of stingless bee (<em>Tetragonula carbonaria</em>) cerumen from Australia, while also identifying some phenolic constituents using High-Performance Thin-Layer Chromatography (HPTLC). The antioxidant activity of the ethanolic <em>T. carbonaria</em> cerumen extracts was determined using a Ferric Reducing Antioxidant Power (FRAP) assay and a HPTLC-DPPH approach was used to identify the constituents that contribute to the antioxidant activity of the cerumen samples. For the determination of the total phenolic content (TPC), a modified Folin-Ciocalteu assay was carried out. The FRAP values ranged from 5.19 ± 0.40 to 16.2 ± 0.70 mmol Fe²⁺/kg of raw cerumen and the TPC values from 3.77 ± 0.12 to 81.3 ± 2.04 mg GAE/g of raw cerumen. The HPTLC analysis revealed the presence of gallic acid and kaempferol in the ethanolic <em>T. carbonaria</em> cerumen extracts which contribute to the antioxidant activity of the samples. The findings of the study demonstrate the antioxidant activity of Australian <em>T. carbonaria</em> cerumen and highlight the importance of more research into its chemical composition, bioactivity and potential therapeutical use.</p></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"6 ","pages":"Article 100164"},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772391724000513/pdfft?md5=cdadd057529d9d25293307b1730e765f&pid=1-s2.0-S2772391724000513-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141962129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phthalylglycyl chloride as a derivatization reagent for determination of urinary amino acids using ultra high-performance liquid chromatography coupled with high resolution mass spectrometry","authors":"Azamat Temerdashev ,&nbsp;Pavel N. Nesterenko ,&nbsp;Sanka N. Atapattu ,&nbsp;Yu-Qi Feng ,&nbsp;Maria Zorina ,&nbsp;Kseniya Zhurkina ,&nbsp;Elina Gashimova ,&nbsp;Maxim O. Steshin ,&nbsp;Victor V. Dotsenko","doi":"10.1016/j.jcoa.2024.100162","DOIUrl":"10.1016/j.jcoa.2024.100162","url":null,"abstract":"<div><p>A new derivatization reagent, phthalylglycyl chloride (<strong>PG-Cl</strong>), for the analysis of urinary amino acids was demonstrated using reversed-phase ultra-high performance liquid chromatography coupled to electrospray ionization-quadrupole-time-of-flight mass spectrometer. The study compares the limits of detection and quantification for different sample preparation techniques with the commonly used and effective method of derivatization using dansyl chloride. The stability of the derivatives was investigated, and the study includes an example of urinary amino acid analysis using PG-Cl derivatization. The optimal values for pH, temperature, and concentration of the derivatization reagent were established. Limits of quantification in the range of 0.5–500 µg/mL were obtained for different amino acids. The possibility of phthalylglycyl chloride usage for non-target screening applications and targeted analysis of amino acids in urine was discussed. An advantages and issues of PG-Cl in comparison with commonly used acyl-chlorides (FMOC-Cl and DNS-Cl) provided and discussed.</p></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"6 ","pages":"Article 100162"},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772391724000495/pdfft?md5=6691640ed40d6a22a0605c3ed55bb40a&pid=1-s2.0-S2772391724000495-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141840758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-attribute monitoring applications in biopharmaceutical analysis","authors":"Anurag S. Rathore,&nbsp;Deepika Sarin,&nbsp;Sanghati Bhattacharya,&nbsp;Sunil Kumar","doi":"10.1016/j.jcoa.2024.100166","DOIUrl":"10.1016/j.jcoa.2024.100166","url":null,"abstract":"<div><p>Since the introduction of Quality by Design for production of biopharmaceuticals, the global biopharma industry has been advancing towards developing highly efficient and sensitive platforms for monitoring product quality attributes. Incorporating mass-spectrometry-based multi-attribute monitoring (MAM) as a novel tool for identifying and characterizing post-translational modifications in biotherapeutics has gained increasing traction. The ability of MAM to monitor multiple critical quality attributes coupled with new peak detection functions in a single workflow is highly desirable to the biopharmaceutical industry. This review examines and discusses the evolution and adaptation of MAM for routine product quality assessment. MAM applications in biotherapeutic characterization, comparability, and chemometrics have also been discussed, along with the gaps and future perspectives of the MAM implementation in biopharmaceutical drug development. Primary focus has been kept on major developments in last 6 years (2018–2024).</p></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"6 ","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772391724000537/pdfft?md5=fec65ba833eddbc014d3341be8d9dd7f&pid=1-s2.0-S2772391724000537-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141847009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards a sustainable rice husk ash-derived solid-phase extraction: Perfluoroalkyl substances as probe contaminants of waters","authors":"Petra Bianchini ,&nbsp;Francesca Merlo ,&nbsp;Mirko Prato ,&nbsp;Silvia Dante ,&nbsp;Andrea Serra ,&nbsp;Guido Premoli ,&nbsp;Antonella Profumo ,&nbsp;Andrea Speltini","doi":"10.1016/j.jcoa.2024.100165","DOIUrl":"10.1016/j.jcoa.2024.100165","url":null,"abstract":"<div><p>Rice husk ash is an important waste of agricultural industry that, within the framework of the circular economy, has been easily converted into a sustainable sorbent material. This was tested in this work for the pre-concentration of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), representative perfluoroalkyl substances as probe environmental pollutants of waters, with HPLC-MS/MS quantification. The preparation involves a rapid microwave-assisted oxidation followed by a hydrothermal treatment, which was studied using a 2² design of experiments. The final material was thoroughly characterized and tested for its affinity to the target analytes by solid-phase extraction in environmental waters and wastewaters. Recoveries in the range 67–113 % (RSD &lt; 11 %, <em>n</em> <em>=</em> <em>3</em>) were achieved at environmentally relevant concentrations (10, 50, and 100 ng L^-1) and the sorbent was reusable for at least ten consecutive extractions. Good linearity (R² = 0.9997) was observed, with a method quantification limit in the water sample of 10 ng L^-1 that allows the analysis of PFOA and PFOS below the established limits. The method was evaluated for greenness using AGREEprep and SPMS metrics, and it was then applied to the analysis of actual water samples from Northern Italy.</p></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"6 ","pages":"Article 100165"},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772391724000525/pdfft?md5=410ba24bfc5f3a7c112e7c230973f963&pid=1-s2.0-S2772391724000525-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141850015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green extraction, chemical profile and biological activity of waste products from the olive oil industry: From waste to wealth","authors":"Miryam Perrucci ,&nbsp;Marco Dezio ,&nbsp;Hammad Saleem ,&nbsp;Fabrizio Ruggieri ,&nbsp;Marcello Locatelli","doi":"10.1016/j.jcoa.2024.100161","DOIUrl":"10.1016/j.jcoa.2024.100161","url":null,"abstract":"<div><p>Olive oil is the most used vegetable oil for human consumption and its production represents an important economic sector, especially in Mediterranean countries. Olive trees are grown in more than 40 countries around the world on over 10 million hectares. The milling industry generates large quantities of liquid and solid residues, the disposal of which requires sophisticated and rather expensive procedures, given the polluting characteristics of the processing products. Since a considerable measure of olive-derived biomass is generated each year, it could be used as a potential source of bioactive compounds. This work evaluates the possibility of recovering natural antioxidants from by-products of the olive oil mill, through the optimization of extraction processes with green approaches. In the present work, through HPLC-PDA analysis with a validated method, it was possible to characterize a chemical profile of the extracts obtained through an optimized (DoE) and green approach. The waste products of the olive oil companies represent the samples considered in this work, and are derived from the pomace and the washing water of 2-phases, 2.5-phases, and 3-phase extra virgin olive oil (EVO) production plants. The optimized extraction methodology, starting from the 2.5-phase olive pomace, proved to be satisfactory in terms of efficiency by evaluating the effect of parameters such as extraction time and process temperature. The application of this methodology to other types of pomace and agro-industrial by-products has highlighted excellent results in terms of extraction yield, demonstrating the validity of this procedure as also suitable for other solid residues coming from the olive oil mill. Regarding the treatment in vegetation water, the developed protocol allowed the chromatographic profile of the analytes extracted from this matrix to be evaluated, leading to satisfactory results in terms of quantitative yields. Samples of these extracts are also subjected to biological tests in order to evaluate their antioxidant and enzyme inhibition activities.</p></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"6 ","pages":"Article 100161"},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772391724000483/pdfft?md5=324b87718d3f41c9fa2dc82ba239699d&pid=1-s2.0-S2772391724000483-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141839873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent trends in capillary electrokinetic chromatography with liposomes, lipid aggregates, and lipid emulsions","authors":"Valeriia Lishchuk,&nbsp;Susanne K. Wiedmer","doi":"10.1016/j.jcoa.2024.100163","DOIUrl":"10.1016/j.jcoa.2024.100163","url":null,"abstract":"<div><p>The main trends in the use of liposomes or lipid aggregates as pseudostationary phases in capillary electrokinetic chromatography (EKC) over the past 15 years are reviewed. Due to the ability of liposomes to mimic cell membranes, they have found wide applications in analytical chemistry and especially in the field of biomedical sciences. Various liposomes, lipid aggregates, and liposomal formulations have been adopted as background electrolytes in EKC and ultraviolet detection is by far the most commonly used detection mode. The possibility to vary the type of lipids and their content in the lipid aggregates has increasingly expanded the usage of liposome EKC for solving specific tasks. The presented data shows that there is great potential of liposome EKC in investigations of interactions between lipid membranes and compounds and the applications are typically related to biomedical and pharmaceutical issues, but not limited to these.</p></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"6 ","pages":"Article 100163"},"PeriodicalIF":0.0,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772391724000501/pdfft?md5=34646143cfcf78d0ac82080194e68a6c&pid=1-s2.0-S2772391724000501-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141960286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted ultra-high performance liquid chromatography-tandem mass spectrometry assay for the quantification of medium-chain phosphatidylcholines in platelets of coronary artery disease patients","authors":"Tamara Janker ,&nbsp;Adrian Brun ,&nbsp;Adrian Sievers-Engler ,&nbsp;Kristina Dittrich ,&nbsp;Meinrad Gawaz ,&nbsp;Michael Lämmerhofer","doi":"10.1016/j.jcoa.2024.100160","DOIUrl":"10.1016/j.jcoa.2024.100160","url":null,"abstract":"<div><p>In a recent untargeted clinical lipidomics study of platelets of coronary artery disease (CAD) patients, medium-chain phosphatidylcholines (MCPCs) with C8 and C10 fatty acyl residues were found significantly upregulated in the patient group with acute coronary syndrome (ACS) as compared to chronic coronary syndrome (CCS) and healthy controls. To support this finding, this work presents the development and optimization of a targeted UHPLC-QTrap-MS/MS method with multiple reaction monitoring acquisition for the quantitative analysis of MCPCs (PC 10:0/8:0, PC 16:0/8:0, PC 10:0/20:4 and PC 10:0/10:0) in platelets for biomarker validation. A systematic optimization of chromatographic and mass spectrometric parameters was performed. A charged surface hybrid CSH C18 (1.7 µm, 130 Å) column and fine-tuned gradient elution with 2-propanol/acetonitrile and ammonium acetate as additive to the mobile phase was employed in the final method in ESI negative mode. Four selected PC standards (PC 6:0/6:0, PC 8:0/8:0, PC 10:0/10:0 and PC 12:0/12:0), which cover well the carbon and retention rime range of the target analytes, were used for the optimization process and calibration. Quantification was based on matrix-matched calibration with these four selected commercially available MCPC standards as surrogate calibrants and PC 6:0/6:0(d22) as internal standard. Furthermore, an organic solvent and fatty acyl carbon number-corrected response factor approach gave also accuracies within acceptance limits of bioanalytical validation guidelines and has more generic applicability. Compared to the previous untargeted RPLC-ESI-QTOF-MS/MS method, the optimized targeted UHPLC-QTrap-MS/MS assay showed increased sensitivity and selectivity for the detection of medium-chain PCs in platelet samples of CAD (LOQs in the range of 0.5–5 nmol/L). The method performance parameters indicated its suitability for a future biomarker validation study of MCPCs in platelets.</p></div>","PeriodicalId":93576,"journal":{"name":"Journal of chromatography open","volume":"6 ","pages":"Article 100160"},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772391724000471/pdfft?md5=94f223a6354a83dd19ff692036fde84d&pid=1-s2.0-S2772391724000471-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141960487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}