Analytical science advances最新文献

{"title":"Diacylated 1,10-diaza-18-crown-6 as an Alternative Template for Fluorescent Sensors of Calcium Ions","authors":"Oscar G. Smith,&nbsp;Jennifer C. Anene,&nbsp;Simon Wheeler","doi":"10.1002/ansa.202400034","DOIUrl":"10.1002/ansa.202400034","url":null,"abstract":"<p>The performance of many known fluorescent sensors for Ca²⁺ is pH-dependent. We set out to address this by preparing a novel calcium sensor based on diacylated 1,10-diaza-18-crown-6 and containing no basic centres. The sensor is sensitive to sub-millimolar levels of Ca²⁺ and partially tolerant of an aqueous environment. However, it suffers from a lack of selectivity over some other divalent cations, and retained pH sensitivity in the acidic range. The relations between these properties and the sensor's structure are discussed.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"5 11-12","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a Dried Blood Spot Assay for Testosterone Measurement Using Liquid Chromatography-Tandem Mass Spectrometry","authors":"Yehudah Gruenstein","doi":"10.1002/ansa.202400035","DOIUrl":"10.1002/ansa.202400035","url":null,"abstract":"<p>Testosterone is a critical hormone involved in regulating various physiological processes in both men and women. Accurate testosterone measurement is essential for diagnosing endocrine disorders such as hypogonadism and polycystic ovary syndrome and for routine testing. Traditionally, testosterone levels are measured using serum or plasma samples, which present challenges in sample collection, storage, and transport, particularly in resource-limited settings. Dried blood spot (DBS) sampling has emerged as an effective alternative for hormone analysis, offering significant advantages in terms of sample stability, ease of collection, and simplified logistics. This study aimed to validate a DBS-based testosterone assay using liquid chromatography-tandem mass spectrometry (LC-MS/MS) to ensure accuracy and precision comparable to conventional serum-based methods. Drops of whole blood samples were collected from adult volunteers using a single-use safety lancet for finger pricks, with blood applied onto DBS cards (PerkinElmer 226 Spot Saver RUO card) for further analysis. The testosterone was extracted from DBS using a liquid-liquid method and analyzed with LC-MS/MS. The assay demonstrated excellent linearity across a wide concentration range (0.1–100 ng/mL) with a correlation coefficient (r²) of 0.999 and achieved a lower limit of detection of 0.058 ng/mL and a lower limit of quantification of 0.086 ng/mL. The method showed high precision, with intra- and inter-day coefficients of variation below 10%, and satisfactory recovery rates. Hematocrit correction and matrix effect evaluations confirmed the robustness of the assay for clinical and research applications. Additionally, the assay displayed a strong clinical correlation between testosterone levels in DBS and venous serum samples, supporting its reliability for testosterone monitoring. This validation study supports that the DBS-based LC-MS/MS testosterone assay is a reliable tool for testosterone quantification for routine testing.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"5 11-12","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Scientists in Analytical Sciences: Zhuoheng Zhou","authors":"Zhuoheng Zhou","doi":"10.1002/ansa.202400057","DOIUrl":"https://doi.org/10.1002/ansa.202400057","url":null,"abstract":"&lt;p&gt;Through a collection of editorials titled “Emerging Scientists in Analytical Sciences,” we aim to spotlight promising individuals who are actively engaged in the realm of analytical sciences. For this editorial, we invited Zhuoheng Zhou who recently submitted his PhD thesis at the Vrije Universiteit Brussel.&lt;/p&gt;&lt;p&gt;During my junior high school years, I was very grateful to have attended a scientific event named “&lt;i&gt;knowing about colours&lt;/i&gt;”, where teachers demonstrated the light dispersion through a prism and the separation of chlorophyll green and carotenoid yellow by a piece of filter paper (until many years later that I realized it was the “&lt;i&gt;Eureka moment&lt;/i&gt;” of chromatography). I was fascinated by the hidden complexity of mother nature, as much as the fact that it tends to leave us a backdoor to have a glimpse of the core. There was no such thing as attractive to a teenager as solving riddles with obscure hints scattered here and there. I later read about the biography of Antoine Lavoisier and his illumination on the essence of combustion [&lt;span&gt;1&lt;/span&gt;]. The profound impact of his quantitative and analytical thinking on modern chemistry research made me realize that analytical science is &lt;i&gt;de facto&lt;/i&gt; pro-science, the philosophies, methodologies and techniques it comprises are primers for any scientific research activities. To understand something, you have to “see” or “feel” it first.&lt;/p&gt;&lt;p&gt;I also owe my special thanks to Professor Bo Zhang at Xiamen University for hosting me as a research trainee during the summer of my second bachelor's year. This was the first time I had a chance to step on the floor of a research lab and to have a flavour of modern analytical instruments (mainly chromatographs, electrophoresis apparatus and spectrometers). Despite my “greenness”, I was still assigned to a small project on developing a fast reverse-phase chromatographic method as the second-separation dimension in a two-dimensional liquid chromatography (2D-LC) set-up, following a first-dimension strong cation-exchange separation, for intact protein profiling in velvet antler (a constituent of traditional Chinese medicines). The trainee program had a very generous deadline which permitted me to start with extensive exploratory scouting runs (a nicer way to say “trial-and-error”) and to get myself familiarized with various column chemistries and separation conditions (although in a rather primitive and intuitive way). I remember vividly the goose bumps that I had when I saw my first chromatogram on the screen with five distinctive peaks, only five minutes after I manually injected some sort of colourless, transparent, and homogeneous liquid that a senior prepared for me. The joy of knowing the supposedly unknown (more like finishing the last chapter of a detective fiction book) sparked my deep interest in the world of analytical science and particularly separation science up to this day.&lt;/p&gt;&lt;p&gt;My PhD thesis comprised of two major parts. The first","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"5 9-10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.202400057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitive and Cost-Effective Tools in the Detection of Ovarian Cancer Biomarkers","authors":"Anis Elhami,&nbsp;Ahmad Mobed,&nbsp;Reza Soleimany,&nbsp;Yalda Yazdani,&nbsp;Esmat Sadat Kazemi,&nbsp;Mahya Mohammadi,&nbsp;Hossein Saffarfar","doi":"10.1002/ansa.202400029","DOIUrl":"https://doi.org/10.1002/ansa.202400029","url":null,"abstract":"<p>Women diagnosed with late-stage ovarian cancer suffer a very high rate of mortality. Accordingly, it is imperative to detect and diagnose the disease as early as possible in its development. Achievement of this aim implies relatively large-scale screening of women at an age of clinical significance through assay of biomarkers for disease present in blood or serum. Biosensor detection offers an attractive technology for the automated detection of such species. Among several biomarkers that have been identified that are present in patients with ovarian cancer, the only one that is commonly tested for in clinical use is cancer antigen 125, which is considered to be a poor biomarker for the disease. Here, we describe several biosensors that developed in the past decade for the detection of ovarian cancer biomarkers such as CA125, human epididymis protein 4 (HE4) and apolipoprotein A1. The challenges presented by the fabrication of biosensor devices for detecting ovarian cancer and the limited number of biosensors developed for this purpose are discussed.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"5 9-10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.202400029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cobalt-Based Ferrite Modified Carbon Nanotubes Fibers for Flexible and Disposable Microelectrode Toward Electrochemical Glucose Sensing","authors":"Abid Ali,&nbsp;Rizwan Shoukat,&nbsp;Ahmad Raza Ashraf,&nbsp;Zarqa Rasheed,&nbsp;Sheza Muqaddas,&nbsp;Munawar Iqbal,&nbsp;Munira Khalid,&nbsp;Wissem Mnif,&nbsp;Ismail ElKamil Suliman Mohamed","doi":"10.1002/ansa.202400032","DOIUrl":"10.1002/ansa.202400032","url":null,"abstract":"<p>Glucose detection is critical in clinical health and the food industry, particularly in the diagnosis of blood sugar levels. Carbon-based fiber materials have recently featured prominently as non-enzymatic electrochemical glucose detectors. Herein, cobalt-based ferrite (CoFe₂O₄) in the form of nanoparticles has been successfully fabricated over the carbon nanotubes (CNTs) fiber via a simple hydrothermal process. Fabricated microelectrode (CoFe₂O₄@CNTs) was investigated as an electrocatalyst toward the non-enzymatic electrochemical glucose sensors. The structure and morphology of the modified fiber were studied by scanning electron microscopy including energy-dispersive X-ray spectroscopy. The electrochemical capability of the microelectrode was analyzed by using different electrochemical techniques including cyclic voltammetry, chronoamperometry, and electrochemical impedance spectroscopy (EIS). The proposed sensors exhibited a superb sensitivity of 0.21 µAcm⁻² mM⁻¹, a good linear range from 1 to 9 mM, and a lower detection limit of 1.7 mM. Further investigation via EIS indicated the low charge transfer resistance as compared to the bare CNTs-based fiber. Outcomes revealed that the material can potentially prove promising for the disposable microelectrode toward electrochemical glucose sensing.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"5 11-12","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preprocessing of spectroscopic data to highlight spectral features of materials","authors":"Francisco Javier Esquivel,&nbsp;José Luis Romero-Béjar,&nbsp;José Antonio Esquivel","doi":"10.1002/ansa.202400018","DOIUrl":"https://doi.org/10.1002/ansa.202400018","url":null,"abstract":"<p>The study of the extensive data sets generated by spectrometers, which are of the type commonly referred to as big data, plays a crucial role in extracting valuable information on mineral composition in various fields, such as chemistry, geology, archaeology, pharmacy and anthropology. The analysis of these spectroscopic data falls into the category of big data, which requires the application of advanced statistical methods such as principal component analysis and cluster analysis. However, the large amount of data (big data) recorded by spectrometers makes it very difficult to obtain reliable results from raw data. The usual method is to carry out different mathematical transformations of the raw data. Here, we propose to use the affine transformation for highlight the underlying features for each sample. Finally, an application to spectroscopic data collected from minerals or rocks recorded by NASA's Jet Propulsion Laboratory is performed. An illustrative example has been included by analysing three mineral samples, which have different diageneses and parageneses and belong to different mineralogical groups.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"5 9-10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.202400018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Potential of the Sulfated Exopolysaccharides From the Brown Microalga Halamphora sp.: Antioxidant, Antimicrobial, and Antiapoptotic Profiles","authors":"Fatma Ben Mansour,&nbsp;Wassim Guermazi,&nbsp;Mohamed Chamkha,&nbsp;Khaled Bellassoued,&nbsp;Hichem Ben Salah,&nbsp;Abdel Halim Harrath,&nbsp;Waleed Aldahmash,&nbsp;Md Ataur Rahman,&nbsp;Habib Ayadi","doi":"10.1002/ansa.202400030","DOIUrl":"https://doi.org/10.1002/ansa.202400030","url":null,"abstract":"<p>This study aims to investigate the physicochemical characteristics of the exopolysaccharides (EPS) extracted from the microalgae species <i>Halamphora</i> sp., as well as to evaluate their antioxidant, antibacterial, and anti-apoptotic activities. The crude extracellular polysaccharides from the halophilic diatom <i>Halamphora</i> sp. were found to be extracellular heterosulfated anionic polysaccharides containing carbohydrates (76.33 ± 1.80%), proteins (0.15 ± 0.02%), uronic acids (5.44 ± 0.08%) and sulfate (7.56 ± 0.86%). The lowest protein (0.24%) and lipid (0.15%) contents suggested that EPS was highly pure. Gas chromatography–mass spectrometry analysis revealed that the carbohydrate fraction consisted of xylose, <span>l</span>-galactose, <span>d</span>-galactose, glucose, ribitol, mannose, and inositol with corresponding mole percentages of 40.55, 13.25, 13.00, 9.95, 9.82, 2.90, and 2.28, respectively. In vitro, tests showed a high total antioxidant capacity probably related to <span>l</span>-galactose followed by <span>d</span>-galactose, uronic acid, and ribitol. In addition, extracellular polysaccharides (EPS) demonstrated effective antimicrobial Gram + properties with inhibition zones ranging from 10 to 12 mm. Molecular docking showed an antiapoptotic effect, as the best docking score was generated due to the interaction of xylose and caspase 3 (−6.9 kcal/mol) and <span>l</span>-galactose and caspase 3 (−5 kcal/mol). Overall, the findings of this study suggest the possibility of using the EPS extract of <i>Halamphora</i> sp. as an additive for nutraceutical and cosmetic purposes.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"5 9-10","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.202400030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of orange fruit peel extract concentration on the synthesis of zinc oxide nanoparticles","authors":"Emebet Wondmnew,&nbsp;Getachew Tizazu","doi":"10.1002/ansa.202400023","DOIUrl":"https://doi.org/10.1002/ansa.202400023","url":null,"abstract":"<p>In this investigation, the impact of reducing agent concentration on the synthesis of zinc oxide nanoparticles (ZnO NPs) was examined. During the synthesis, an assessment of ionic conductivity was carried out, revealing a significant increase in conductivity prior to the introduction of the reducing agent, followed by a sharp decrease upon its addition. Characterization of the ZnO NPs involved ultraviolet-visible spectroscopy, scanning electron microscopy, Fourier-transform infrared spectroscopy, and, X-ray diffraction analysis. The outcomes suggest that the characteristics of the ZnO NPs are influenced by the concentration of the reducing agent during the synthesis process. Notably, the ZnO NPs synthesized with a higher concentration of reducing agent exhibited a narrower optical band gap and increased surface energy. Furthermore, employing a concentration of 0.5 v/v resulted in the rapid production of NPs with relatively uniform sizes. Conversely, concentrations below 0.5 v/v lead to slow formation, while concentrations exceeding 0.5 v/v yielded non-uniform NPs.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"5 7-8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.202400023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future worldwide coronavirus disease 2019 epidemic predictions by Gaidai multivariate risk evaluation method","authors":"Oleg Gaidai,&nbsp;Yu Cao,&nbsp;Yan Zhu,&nbsp;Alia Ashraf,&nbsp;Zirui Liu,&nbsp;Hongchen Li","doi":"10.1002/ansa.202400027","DOIUrl":"https://doi.org/10.1002/ansa.202400027","url":null,"abstract":"<p>Accurate estimation of pandemic likelihood in every US state of interest and at any time. Coronavirus disease 2019 (COVID-19) is an infectious illness with a high potential for global dissemination and low rates of fatality and morbidity, placing some strains on national public health systems. This research intends to benchmark a novel technique, that enables hazard assessment, based on available clinical data, and dynamically observed patient numbers while taking into account pertinent territorial and temporal mapping. Multicentre, population-based, and biostatistical strategies have been utilized to process raw/unfiltered medical survey data. The expansion of extreme value statistics from the univariate to the bivariate situation meets with numerous challenges. First, the univariate extreme value types theorem cannot be directly extended to the bivariate (2D) case,—not to mention challenges with system dimensionality higher than 2D. Assessing outbreak risks of future outbreaks in any nation/region of interest. Existing bio-statistical approaches do not always have the benefits of effectively handling large regional dimensionality and cross-correlation between various regional observations. These methods deal with temporal observations of multi-regional phenomena. Apply contemporary, novel statistical/reliability techniques directly to raw/unfiltered clinical data. The current study outlines a novel bio-system hazard assessment technique that is particularly suited for multi-regional environmental, bio, and public health systems, observed over a representative period. With the use of the Gaidai multivariate hazard assessment approach, epidemic outbreak spatiotemporal risks may be properly assessed. Based on raw/unfiltered clinical survey data, the Gaidai multivariate hazard assessment approach may be applied to a variety of public health applications. The study's primary finding was an assessment of the risks of epidemic outbreaks, along with a matching confidence range. Future global COVID-19/severe acute respiratory syndrome coronavirus 2 (SARS-COV2) epidemic risks have been examined in the current study; however, COVID-19/SARS-COV2 infection transmission mechanisms have not been discussed.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"5 7-8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.202400027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of a kosmotrope (Na2CO3) and chaotrope (NaCl) in chemometric optimization of aqueous two-phase extraction of bioactive compounds in Hypoxis iridifolia","authors":"Rangani Tracy Lukheli,&nbsp;Nikita Tawanda Tavengwa,&nbsp;Tebogo Mphatlalala Mokgehle","doi":"10.1002/ansa.202400006","DOIUrl":"https://doi.org/10.1002/ansa.202400006","url":null,"abstract":"<p>Enterolactone, coumaric acid and vitexin are polyphenolic compounds present in a variety of fruits, vegetables, cereals and plants. These bioactive compounds are in high demand due to their antioxidant property in various tissues and organs. The purpose of this study was to develop a simultaneous extraction method, an aqueous two-phase extraction (ATPE) method, that would enable the extraction of these compounds from <i>Hypoxis iridifolia</i>. This environmentally friendly extraction method only applied water and ethanol as extraction solvents for these analytes from the plant matrix. After phase separation, the analytes were salted-out from the aqueous phase into the organic phase with the aid of a chaotrope (NaCl) or kosmotrope (Na₂CO₃). Thereafter, the analytes were withdrawn by a micro-pipette for analysis on the high-performance liquid chromatography–photodiode array detector. Optimization was conducted using a central composite design, where three parameters were examined which involved percentage ethanol, centrifugation time and salt type. Generally, the optimized conditions for extraction were an ethanol percentage of 100% and a centrifugation time of 10 min, which yielded concentrations of 2942, 23,823 and 8881 mg kg⁻¹ for enterolactone, vitexin and coumaric acid, respectively, in the presence of a kosmotrope. The optimized conditions of extraction in the presence of chaotrope were an ethanol percentage of 66% and a centrifugation time of 10 min with concentrations of 6727, 20,833 and 8618 mg kg⁻¹ for enterolactone, vitexin and coumaric acid, respectively. The ATPE method involving Na₂CO₃ was a better extractant of all the compounds studied relative to that of NaCl. The superior extraction capability of Na₂CO₃ in ATPE could serve as a prototype for the development of efficient extraction methods to meet the high demand for medicinal compounds derived from natural products.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"5 7-8","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.202400006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}