Analytical science advances最新文献

{"title":"Comparison Between a New PSA Assay With the Well-Established Beckman Coulter Immunoassay: A Preliminary Report","authors":"Evelina La Civita,&nbsp;Mariano Fiorenza,&nbsp;Giuseppe Jannuzzi,&nbsp;Carmela Polito,&nbsp;Rosa Sirica,&nbsp;Gianluigi Carbone,&nbsp;Domenica Sorvillo,&nbsp;Aniello Saviano,&nbsp;Matteo Ferro,&nbsp;Daniela Terracciano","doi":"10.1002/ansa.70017","DOIUrl":"10.1002/ansa.70017","url":null,"abstract":"<p>Prostate-specific antigen (PSA) is a critical biomarker for prostate cancer (PCa) patient clinical management. In this study, we sought to compare three different immunoassays (CLIA): Beckman Coulter Access Hybritech (PSA-B) (reference method), Immulite 2000 PSA (PSA-I) and the newly introduced Atellica IM PSA assay (PSA-A). We selected serum samples from our routine clinical testing at University Hospital Federico II between April and May 2024 from 104 men with a median age of 66 years (interquartile range = 57–74). Total PSA was determined using three different assays: PSA-B, PSA-A and PSA-I. A significant correlation between PSA-B and PSA-I assays was found for samples in the overall population (Spearman <i>r</i> (<i>ρ</i>) = 0.99, <i>p</i> &lt; 0.0001). PSA-I displayed a strong correlation with PSA-B for values below 2 ng/mL (<i>ρ</i> = 0.98, <i>p</i> &lt; 0.0001), for values between 2 and 10 ng/mL (<i>ρ</i> = 0.97, <i>p</i> &lt; 0.0001) and for values above 10 ng/mL (<i>ρ</i> = 0.77, <i>p</i> &lt; 0.0001). A significant positive correlation was found between PSA-B and PSA-A in the overall population (<i>ρ</i> = 0.97, <i>p</i> &lt; 0.0001) and in stratified analyses between PSA-A and PSA-B for values below 2 ng/mL (<i>ρ</i> = 0.86, <i>p</i> &lt; 0.0001), from 2 ng/mL to 10 ng/mL (<i>ρ</i> = 0.93, <i>p</i> &lt; 0.0001) and above 10 ng/mL (<i>ρ</i> = 0.77, <i>p</i> &lt; 0.0001). Although both PSA-I and PSA-A demonstrated a significant positive correlation with PSA-B, PSA-I displayed a significantly better correlation with PSA-B than PSA-A in samples with PSA below 2 ng/mL.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"6 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Release Monitoring and Detection of Formulated Solid Nanoparticle–Conjugated Nicotine in Blood and Urine Using Electrochemical Technique","authors":"Blessing Wisdom Ike,&nbsp;Joshua C. Nwabuife,&nbsp;John Alake,&nbsp;Darko Kwabena Adu,&nbsp;Lungelo Miya,&nbsp;Ruchika Chauhan,&nbsp;Zondi Nate,&nbsp;Rajshekhar Karpoormath,&nbsp;Mbuso Faya","doi":"10.1002/ansa.70018","DOIUrl":"10.1002/ansa.70018","url":null,"abstract":"<p>Tobacco (nicotine) has been reported as one of the worst global public health pandemics in history, claiming about 8 million lives annually. According to the World Health Organisation (WHO), nicotine accounts for about 7 million deaths of firsthand users and over 1.3 million morbidities of secondhand users. Furthermore, smokeless tobacco products have been linked to more than 300 million morbidities, including chronic kidney illnesses. On the basis of this trend, a possible increase of over 100% in mortality rate and a state of emergency have been predicted from now till 2050. However, electrochemical analysis has demonstrated cost-effective and easily synthesised sensors as a timely alternative for the rapid analysis and quantification of nicotine in diverse products. A carbon-based silver sensor was fabricated and characterised by energy-dispersive x-ray (EDX) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), direct light scattering (DLS), and x-ray diffraction (XRD). Herein, we report the first electrochemical detection, release monitoring and quantification of conjugated nicotine. The sensor showed a significant sensitivity, specificity and discriminating power with a detection and quantification limit of 2.283 × 10⁻⁹ and 0.761 × 10⁻⁸ M, respectively. An average recovery rate of 96.26% was recorded. The applicability of the modified electrode was examined in human urine and serum. The research showed the potential of this method for monitoring doping and nicotine release, as well as for diagnostic and quality control purposes.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"6 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.70018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Mixed Biased Estimator for Ill-Conditioning Challenges in Linear Regression Model With Chemometrics Applications","authors":"Muhammad Amin,&nbsp;Sadiah M. A. Aljeddani,&nbsp;Muhammad Nauman Akram,&nbsp;Sajida Yasmeen","doi":"10.1002/ansa.70020","DOIUrl":"10.1002/ansa.70020","url":null,"abstract":"<p>In linear regression models, the ordinary least squares (OLS) method is used to estimate the unknown regression coefficients. However, the OLS estimator may provide unreliable estimates in non-orthogonal models. This article introduces a novel mixed-biased estimator to address the challenges posed by the non-orthogonal model. The proposed estimator is derived through a combination of two estimators, namely, the Stein and ridge estimators. The theoretical properties of the proposed estimator are discussed. Moreover, we suggest estimation methods to estimate the value of the shrinkage parameters for the proposed estimator. We compare the performance of the proposed estimator with the Stein estimator, the ridge estimator with standard and two best ridge parameters and the ordinary least square estimator. This evaluation is based on the mean squared error performance criterion, using both a simulation study and two practical applications related to cement and crock datasets. The simulation study and applications results show that the proposed estimator performs better than the other considered estimators.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"6 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mini Review: Highlight of Recent Advances and Applications of MALDI Mass Spectrometry Imaging in 2024","authors":"Yuen Tung Ngai,&nbsp;Darren Lau,&nbsp;Parul Mittal,&nbsp;Peter Hoffmann","doi":"10.1002/ansa.70016","DOIUrl":"10.1002/ansa.70016","url":null,"abstract":"<p>Matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) is an emerging imaging tool that allows visualisation of hundreds of analytes unbiasedly in a single experiment. This paper highlights the adaptations of MALDI-MSI in different context in 2024, such as clinical diagnostic, pharmacology, forensics applications, plant metabolism and biology. Challenges and advancements were also discussed regarding sample preparation, instrumentations, data analysis, and integration of machine learning in the trend of single cell resolution and multi-omics. There are still rooms for improvements in sensitivity, spatial resolution, acquisition algorithm and data integration across multi-omics data to enable MALDI-MSI at subcellular level.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"6 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.70016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient Nonenzymatic Electrochemical Detection of Glucose Using CuO Nanoparticles@CNT-Wrapped Graphene Oxide Composite Electrode","authors":"Amina Khalid,&nbsp;Rizwan Shoukat,&nbsp;Abid Ali,&nbsp;Salih Akyürekli,&nbsp;Arfaa Sajid,&nbsp;Muhammad Adeel Asghar,&nbsp;Qaisar Manzoor,&nbsp;Arif Nazir,&nbsp;Norah Alsadun,&nbsp;Amel Y. Ahmed","doi":"10.1002/ansa.70019","DOIUrl":"10.1002/ansa.70019","url":null,"abstract":"<p>A highly sensitive and stable nonenzymatic glucose biosensor has been developed via composite materials composed of CuO and graphene oxide (GO)/carbon nanotube (CNT) nanohybrid (CuO/GO/CNTs). Copper oxide nanoparticle(NP)-modified CNTs were stacked via graphene sheets and synthesized through hydrothermal method, providing a larger surface area with boosted catalytic activity for efficient mass and electron passage, respectively. Scanning electron microscopy (SEM) and energy-dispersive x-ray (EDX) spectroscopy have been used to investigate the morphology and composition of as-prepared nanohybrids, whereas x-ray diffraction (XRD) patterns provide information about the crystal structure and lattice parameters. Fabricated nanohybrid was used as electrode material to develop the nonenzymatic glucose biosensor, which exhibited better performance with a linear dynamic range from 0.06 to 0.74 mM, a high sensitivity of 328 mA mM⁻¹ cm⁻² and a low detection limit of up to 0.033 mM with a fast response time of 2 s. Although the stability and reusability of the fabricated electrode have been tested. The limit of detection was determined by using the traditional formula LOD = (SNR × <i>σ</i>)/Slope. The outcomes recommend the synthesized novel structured nanohybrid as a promising material possessing significant impact for flexible and wearable biosensing applications.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"6 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.70019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Iron Oxide Magnetic Nanoparticles Modified by Superhydrophobic Cellulose as a Sorbent for Solid-Phase Extraction of Fat-Soluble Vitamins","authors":"Fariborz Momenbeik,&nbsp;Arezoo Khatam","doi":"10.1002/ansa.70015","DOIUrl":"10.1002/ansa.70015","url":null,"abstract":"<p>Superhydrophobic cellulose-coated magnetic nanoparticles (SCCMNPs) were synthesized and applied as an advanced solid-phase extraction (SPE) sorbent for the simultaneous extraction of fat-soluble vitamins (FSVs) (A, E and D₃). These modified nanoparticles (NPs) improve extraction efficiency and reduce process time through magnetic separation. The cellulose coating, further modified with stearoyl chloride, enhances sorbent stability and specificity, providing strong hydrophobic interactions while preventing NP aggregation. Extracted vitamins were quantified by high-performance liquid chromatography. Optimization of coating materials revealed that 1.0000 g cellulose and 1.00 mL stearoyl chloride per 1.0000 g magnetic NPs (MNPs) were optimal. The NPs were characterized using Fourier-transform infrared spectroscopy, alternating gradient force magnetometry, dynamic light scattering and zeta potential measurements. Optimized extraction conditions included 50.0 mg sorbent, 10.00 mL sample solution (pH = 5.0), 250 µL tetrahydrofuran as the desorption solvent and 1.5-min sorption/desorption times. Calibration curves exhibited excellent linearity (<i>R</i>² ≥ 0.999), with a dynamic linear range of 2.4 × 10¹–1.0 × 10³ µg/L, limits of detection ≤8.6 µg/L, repeatability (%relative standard deviation [RSD] ≤ 4.6) and accuracy (recovery ≥79.60%). This is the first report demonstrating the application of stearoyl-modified cellulose in SPE, enabling rapid, solvent-efficient and highly selective vitamin extraction. The method provides a sustainable, cost-effective and high-performance alternative to conventional SPE, achieving efficient recovery with minimal sorbent amount, attributed to its optimized hydrophobicity from the affordable cellulose support. The application of this method in extracting FSVs from pharmaceutical formulations highlights these NPs as a promising next-generation SPE sorbent, offering an efficient, selective and environmentally benign solution.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"6 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.70015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143909096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Rubiae Radix et Rhizoma and Its Adulterants Based on “Mass Spectrometry Matrix”","authors":"Xianrui Wang,&nbsp;Minghua Li,&nbsp;Yu Zhang,&nbsp;Jiating Zhang,&nbsp;Wenguang Jing,&nbsp;Xiaohan Guo,&nbsp;Xianlong Cheng,&nbsp;Feng Wei","doi":"10.1002/ansa.70014","DOIUrl":"10.1002/ansa.70014","url":null,"abstract":"<p><i>Galium elegans</i> Wall. in Roxb. (GWR) and <i>Rubia tibetica</i> Hook. f. (RTH) are common adulterants of rubiae radix et rhizoma (RRR). To strengthen RRR adulteration regulation, this paper conducted the adulteration analysis of RRR according to the “mass spectrometry (MS) matrix”. Ultra-high-performance liquid chromatography-quadrupole time-of-flight-full information tandem MS expression analyzed the GWR, RTH, and RRR to obtain quantized data. The ionic intersections were extracted from different batches of the same herbs as their “ionic representation”, respectively. Then, the ionic matrix of each herb relative to each other was screened out, and the top-<i>n</i> ions were regarded as the “MS matrix” of the three herbs. The “MS matrix” was used for matching test samples to obtain a credibility index. On the other hand, chemometrics was used to validate. RRR adulteration can be realized according to the “MS matrix”. Note that, 3% adulterants can still be identified and three market samples were identified as adulterants. Further research proved that the adulteration identification based on the “MS matrix” of RRR, RTH and GWR is reasonable and reliable. The RRR adulteration analysis can be realized according to the “MS matrix”. The “MS matrix” has certain proprietary and has an important reference for RRR adulteration regulation.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"6 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Analytical and Chemometric Strategies for Forensic Classification of Homemade Explosives","authors":"Abdulrahman Aljanaahi,&nbsp;Muhammad K. Hakeem,&nbsp;Abdulla Aljanaahi,&nbsp;Iltaf Shah","doi":"10.1002/ansa.70010","DOIUrl":"10.1002/ansa.70010","url":null,"abstract":"<p>Homemade explosives (HMEs), commonly used in improvised explosive devices (IEDs), present a significant forensic challenge due to their chemical variability, accessibility and adaptability. Traditional forensic methodologies often struggle with environmental contamination, complex sample matrices and the non-specificity of precursor residues. Recent advances in analytical techniques and chemometric methods have enhanced the detection, classification and interpretation of explosive residues. Infrared (IR) spectroscopy and gas chromatography–mass spectrometry (GC–MS) have seen improvements in spectral resolution and real-time detection capabilities, allowing for more accurate differentiation of explosive precursors. Thermal analysis techniques, such as thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), now provide refined kinetic modelling to assess the decomposition pathways of unstable energetic materials, improving forensic risk assessments. Additionally, x-ray diffraction (XRD) has contributed to forensic material sourcing by distinguishing between industrial-grade and improvised explosive formulations. Chemometric approaches, including principal component analysis (PCA), linear discriminant analysis (LDA) and partial least squares discriminant analysis (PLS-DA), have revolutionized forensic data analysis by improving classification accuracy and enabling automated identification of explosive components. Advanced machine learning models are being integrated with spectral datasets to enhance real-time decision-making in forensic laboratories and portable field devices. Despite these advancements, challenges remain in adapting laboratory-based techniques for field deployment, particularly in enhancing the sensitivity and robustness of portable analytical instruments. This review critically evaluates the latest developments in forensic analytical chemistry, highlighting strengths, limitations and emerging strategies to improve real-world HME detection and classification.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"6 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.70010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presumptive Tests for Xylazine—A Computer Vision Approach","authors":"Hui Yun Chang,&nbsp;Kristin Donnachie,&nbsp;Timothy J. D. McCabe,&nbsp;Henry Barrington,&nbsp;Felicity Carlysle-Davies,&nbsp;Kristin Ceniccola-Campos,&nbsp;Marc Reid","doi":"10.1002/ansa.70008","DOIUrl":"10.1002/ansa.70008","url":null,"abstract":"<p>Abuse of xylazine is an immediate global public health concern. We report the distinct and measurable colour changes when xylazine is exposed to the Mandelin, Marquis and Mecke presumptive test reagents. The colour changes observed with xylazine are distinct from those of drugs that give colour changes from the same presumptive tests. To overcome the subjective limitations of determining spot test results by-eye, we applied image and video analyses to quantify the distinctive features of presumptive tests with xylazine and thus differentiate it from other illicit substances tested under the same conditions, including morphine, fentanyl, heroin and methamphetamine. Herein, experimental protocols utilising <i>Kineticolor</i>, a computer vision software, were developed to qualitatively and quantitatively study presumptive tests for xylazine detection. To the best of our knowledge, these findings represent the first presumptive test strategy towards specific, quantifiable and potentially field-ready detection of xylazine.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"6 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.70008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Troponin I Biosensors: Innovations in Real-Time Diagnosis of Cardiovascular Diseases","authors":"Sara Ebrahimi,&nbsp;Vahid Alivirdiloo,&nbsp;Mobasher Hajiabbasi,&nbsp;Shahab Masoumi,&nbsp;Mahya Mohammadi,&nbsp;Somayye Hosseini,&nbsp;Sogand Omidi Gargari,&nbsp;Ahmad Mobed","doi":"10.1002/ansa.70009","DOIUrl":"10.1002/ansa.70009","url":null,"abstract":"<p>Cardiac troponin I (cTnI) is a crucial biological macromolecule found in the contractile apparatus of cardiac myocytes, exclusively expressed in cardiomyocytes. It is released into the bloodstream upon cardiac tissue injury, serving as a vital biomarker for the early detection of various heart diseases. Despite advancements in cTnI diagnostics and cardiovascular disease (CVD) detection, there is an ongoing need for more effective early diagnostic methods and innovative approaches. Current CVD diagnosis often relies on clinical signs and symptoms, supplemented by molecular imaging (MI) or biomarkers associated with CVD. However, challenges remain regarding the reliability, specificity and accuracy of analyses for myocardial infarction, particularly in its early stages. Emerging nanomaterial systems present promising solutions for enhancing diagnostic tools due to their unique physical and chemical properties. Various nanomaterials, such as gold nanoparticles, carbon nanotubes, quantum dots, lipids and polymer nanoparticles, are paving new pathways for cardiac disease detection. The advancements in nanomaterial science offer exciting opportunities for cardiac screening. This article provides a comprehensive overview of these advancements, categorizing research efforts focused on both optical and electrochemical platforms, thereby contributing to the evolution of cardiac screening methodologies and addressing the critical need for reliable early diagnostic solutions.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"6 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.70009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}