Analytical science advances最新文献

{"title":"Biomimetic chromatography—A novel application of the chromatographic principles","authors":"Klara L Valko","doi":"10.1002/ansa.202200004","DOIUrl":"10.1002/ansa.202200004","url":null,"abstract":"<p>Biomimetic chromatography is the name of the High Performance Liquid Chromatography (HPLC) methods that apply stationary phases containing proteins and phospholipids that can mimic the biological environment where drug molecules distribute. The applied mobile phases are aqueous organic with a pH of 7.4 to imitate physiological conditions that would be encountered in the human body. The calibrated retention of molecules on biomimetic stationary phases reveals a compound's affinity to proteins and phospholipids, which can be used to model the biological and environmental fate of molecules. This technology, when standardised, enables the prediction of in vivo partition and distribution behaviour of compounds and aids the selection of the best compounds for further studies to become a drug molecule. Applying biomimetic chromatographic measurements helps reduce the number of animal experiments during the drug discovery process. New biomimetic stationary phases, such as sphingomyelin and phosphatidylethanolamine, widen the application to the modelling of blood–brain barrier distribution and lung tissue binding. Recently, the measured properties have also been used to predict toxicity, such as phospholipidosis and cardiotoxicity. The aquatic toxicity of drugs and pesticides can be predicted using biomimetic chromatographic data. Biomimetic chromatographic separation methods may also be extended in the future to predict protein and receptor binding kinetics. The development of new biomimetic stationary phases and new prediction models will further accelerate the widespread application of this analytical method.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"3 3-4","pages":"146-153"},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.202200004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43949138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in the characterisation of oligonucleotides by high performance liquid chromatography-mass spectrometry in 2021: A short review","authors":"Fabien Hannauer,&nbsp;Rachelle Black,&nbsp;Andrew D. Ray,&nbsp;Eugen Stulz,&nbsp;G. John Langley,&nbsp;Stephen W. Holman","doi":"10.1002/ansa.202100066","DOIUrl":"10.1002/ansa.202100066","url":null,"abstract":"<p>The first oligonucleotide therapeutic was approved by the Food and Drug Administration in 1998, and since then, 12 nucleic acids have been commercialised as medicines. To be approved, the oligonucleotides need to be identified and characterised as well as its related impurities. Different methods exist, but the most commonly used is ion-pairing reversed-phase liquid chromatography with tandem mass spectrometry. The separation obtained depends on the mobile phase and column used. Other methods have been developed, notably by using hydrophilic interaction chromatography and two-dimensional high performance liquid chromatography. Furthermore, ion-pairing reversed-phase high performance liquid chromatography ultra-violet spectroscopy detection and mass spectrometry has been optimised for the analysis of methylated nucleobases due to the utilisation of this modification in the drugs. This review covers the recent advancements in the analysis and characterisation of oligonucleotides in 2021 by high performance liquid chromatography mass spectrometry, notably by hydrophilic interaction chromatography and two-dimensional liquid chromatography but also the different parameters that influence the analysis by ion-pairing reversed-phase high performance liquid chromatography, the characterisation of methylated nucleobases, and the recent software developed for oligonucleotides.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"3 3-4","pages":"90-102"},"PeriodicalIF":0.0,"publicationDate":"2022-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.202100066","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41893644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spotlight on mass spectrometric non-target screening analysis: Advanced data processing methods recently communicated for extracting, prioritizing and quantifying features","authors":"Susanne Minkus,&nbsp;Stefan Bieber,&nbsp;Thomas Letzel","doi":"10.1002/ansa.202200001","DOIUrl":"10.1002/ansa.202200001","url":null,"abstract":"<p>Non-target screening of trace organic compounds complements routine monitoring of water bodies. So-called features need to be extracted from the raw data that preferably represent a chemical compound. Relevant features need to be prioritized and further be interpreted, for instance by identifying them. Finally, quantitative data is required to assess the risks of a detected compound. This review presents recent and noteworthy contributions to the processing of non-target screening (NTS) data, prioritization of features as well as (semi-) quantitative methods that do not require analytical standards. The focus lies on environmental water samples measured by liquid chromatography, electrospray ionization and high-resolution mass spectrometry. Examples for fully-integrated data processing workflows are given with options for parameter optimization and choosing between different feature extraction algorithms to increase feature coverage. The regions of interest-multivariate curve resolution method is reviewed which combines a data compression alternative with chemometric feature extraction. Furthermore, prioritization strategies based on a confined chemical space for annotation, guidance by targeted analysis and signal intensity are presented. Exploiting the retention time (RT) as diagnostic evidence for NTS investigations is highlighted by discussing RT indexing and prediction using quantitative structure-retention relationship models. Finally, a seminal technology for quantitative NTS is discussed without the need for analytical standards based on predicting ionization efficiencies.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"3 3-4","pages":"103-112"},"PeriodicalIF":0.0,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.202200001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49226869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TiO2/CdS composite photocathode improves the performance and degradation of wastewater in microbial fuel cells","authors":"Jingying Ma,&nbsp;Zhihao An,&nbsp;Wenwen Zhang,&nbsp;Jia Shen,&nbsp;Yulin Qi,&nbsp;Donghui Chen","doi":"10.1002/ansa.202100062","DOIUrl":"10.1002/ansa.202100062","url":null,"abstract":"<p>Optimization of dye decolourization for wastewater and power production are explored in dual-chamber microbial fuel cells (MFCs) with TiO₂/CdS photocathodes. The rapid reduction of azo dye methylene blue (MB) and power production were enhanced with TiO₂/CdS photocathode under illumination. The analysis of electrochemical impedance spectra indicated that the photocatalysis of TiO₂/CdS accelerated the electron transfer process of photoelectrode reduction. Moreover, the UV-visible light spectrophotometer showed that the maximum degradation of the MFCs was 98.25%, which illustrated that MB may be cleaved by photoelectrons generated by light irradiation on the illuminated TiO₂/CdS photocathode. Finally, the power production of MFCs in this work promoted reductive decolourization of the dye MB solution.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"3 5-6","pages":"188-197"},"PeriodicalIF":0.0,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.202100062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47603521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of surface-enhanced Raman spectroscopy in environmental detection","authors":"Lynn R. Terry,&nbsp;Sage Sanders,&nbsp;Rebecca H. Potoff,&nbsp;Jacob W. Kruel,&nbsp;Manan Jain,&nbsp;Huiyuan Guo","doi":"10.1002/ansa.202200003","DOIUrl":"https://doi.org/10.1002/ansa.202200003","url":null,"abstract":"<p>As the human population grows, the anthropogenic impacts from various agricultural and industrial processes produce unwanted contaminants in the environment. The accurate, sensitive and rapid detection of such contaminants is vital for human health and safety. Surface-enhanced Raman spectroscopy (SERS) is a valuable analytical tool with wide applications in environmental contaminant monitoring. The aim of this review is to summarize recent advancements within SERS research as it applies to environmental detection, with a focus on research published or accessible from January 2021 through December 2021 including early-access publications. Our goal is to provide a wide breadth of information that can be used to provide background knowledge of the field, as well as inform and encourage further development of SERS techniques in protecting environmental quality and safety. Specifically, we highlight the characteristics of effective SERS nanosubstrates, and explore methods for the SERS detection of inorganic, organic, and biological contaminants including heavy metals, pharmaceuticals, plastic particles, synthetic dyes, pesticides, viruses, bacteria and mycotoxins. We also discuss the current limitations of SERS technologies in environmental detection and propose several avenues for future investigation. We encourage researchers to fill in the identified gaps so that SERS can be implemented in a real-world environment more effectively and efficiently, ultimately providing reliable and timely data to help and make science-based strategies and policies to protect environmental safety and public health.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"3 3-4","pages":"113-145"},"PeriodicalIF":0.0,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.202200003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92308204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of ambient ionization mass spectrometry in 2021: An annual review","authors":"Stephanie Rankin-Turner,&nbsp;James C. Reynolds,&nbsp;Matthew A. Turner,&nbsp;Liam M. Heaney","doi":"10.1002/ansa.202100067","DOIUrl":"https://doi.org/10.1002/ansa.202100067","url":null,"abstract":"<p>Ambient ionization mass spectrometry (AIMS) has revolutionized the field of analytical chemistry, enabling the rapid, direct analysis of samples in their native state. Since the inception of AIMS almost 20 years ago, the analytical community has driven the further development of this suite of techniques, motivated by the plentiful advantages offered in addition to traditional mass spectrometry. Workflows can be simplified through the elimination of sample preparation, analysis times can be significantly reduced and analysis remote from the traditional laboratory space has become a real possibility. As such, the interest in AIMS has rapidly spread through analytical communities worldwide, and AIMS techniques are increasingly being integrated with standard laboratory operations. This annual review covers applications of AIMS techniques throughout 2021, with a specific focus on AIMS applications in a number of key fields of research including disease diagnostics, forensics and security, food safety testing and environmental sciences. While some new techniques are introduced, the focus in AIMS research is increasingly shifting from the development of novel techniques toward efforts to improve existing AIMS techniques, particularly in terms of reproducibility, quantification and ease-of-use.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"3 3-4","pages":"67-89"},"PeriodicalIF":0.0,"publicationDate":"2022-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.202100067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92372162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current trends in the development of polymer-based monolithic stationary phases","authors":"Martina Nechvátalová,&nbsp;Jiří Urban","doi":"10.1002/ansa.202100065","DOIUrl":"10.1002/ansa.202100065","url":null,"abstract":"<p>This review focuses on the development and applications of organic polymer monoliths, with special attention to the literature published in 2021. The latest protocols in the preparation of polymer monoliths are discussed. In particular, tailored surface modification using nanomaterials, the development of chiral stationary phases and development of stationary phases for capillary electrochromatography are reviewed. Furthermore, the optimization of pore forming solvents composition is also discussed. Finally, the use of monolithic stationary phases in sample treatment using solid-phase extraction and enrichment methods, molecularly imprinted polymers and enzymatic reactors is mentioned.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"3 3-4","pages":"154-164"},"PeriodicalIF":0.0,"publicationDate":"2022-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.202100065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48447200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resonance Raman analysis of intracellular vitamin B12 analogs in methanogenic archaea","authors":"Nanako Kanno,&nbsp;Shingo Kato,&nbsp;Takashi Itoh,&nbsp;Moriya Ohkuma,&nbsp;Shinsuke Shigeto","doi":"10.1002/ansa.202100042","DOIUrl":"10.1002/ansa.202100042","url":null,"abstract":"<p>Methanogenic archaea (methanogens) are microorganisms that can synthesize methane. They are found in diverse environments ranging from paddy fields to animal digestive tracts to deep-sea hydrothermal vents. Investigating their distribution and physiological activity is crucial for the detailed analysis of the dynamics of greenhouse gas generation and the search for the environmental limits of life. In methanogens, cobamide cofactors (vitamin B₁₂ analogs) play a key role in methane synthesis and carbon fixation, thus serving as a marker compound that metabolically characterizes them. Here, we report on resonance Raman detection of cobamides in methanogenic cells without destroying cells and provide structural insights into those cobamides. We succeeded in detecting cobamides in four representative methanogens <i>Methanosarcina mazei</i>, <i>Methanosarcina barkeri</i>, <i>Methanopyrus kandleri</i>, and <i>Methanocaldococcus jannaschii</i>. The former two are mesophilic, cytochrome-containing methanogens, whereas the latter two are hyperthermophilic, non-cytochrome-containing methanogens. The 532 nm-excited Raman spectra of single or multiple cells of the four species all showed resonance Raman bands of cobamides arising mainly from the corrin ring, with the most intense one at ∼1500 cm⁻¹. We envision that resonance Raman microspectroscopy could be useful for in situ, nondestructive identification of methanogenic cells that produce high levels of cobamides.</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"3 5-6","pages":"165-173"},"PeriodicalIF":0.0,"publicationDate":"2022-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.202100042","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46756634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analytical Science Advances announces its new Associate Editorial Board","authors":"Paul Trevorrow,&nbsp;Daniel Petras,&nbsp;Lissa C. Anderson,&nbsp;Tal Luzzatto Knaan,&nbsp;Anthony J. Saviola,&nbsp;Ignacy Rzagalinski,&nbsp;Mohammad Sharif Khan,&nbsp;Danuta Dudzik,&nbsp;Debbie Dewaele,&nbsp;Laure-Elie Carloni,&nbsp;Qin Tu,&nbsp;Yaxi Hu,&nbsp;Benjamin-Florian Hempel","doi":"10.1002/ansa.202100901","DOIUrl":"https://doi.org/10.1002/ansa.202100901","url":null,"abstract":"<p><i>Analytical Science Advances</i> is proud to announce its new Associate Editorial Board comprised of Early Career Researchers (ECRs) representing a range of sub-disciplines across the analytical sciences. Chaired by <b>Benjamin-Florian Hempel</b>, the group—including <b>Daniel Petras</b>, University of Tübingen; <b>Lissa Anderson</b>, National High Magnetic Field Laboratory; <b>Tal Luzzatto Knaan</b>, University of Haifa; <b>Anthony Saviola</b>, University of Colorado Anschutz Medical Campus; <b>Ignacy Rzagalinski</b>, Max Planck Institute of Molecular Cell Biology and Genetics; <b>Mohammad Sharif Khan</b>, Wake Forest Baptist Health; <b>Danuta Dudzik</b>, Medical University of Gdańsk; <b>Debbie Dewaele</b>, Janssen R&amp;D; <b>Laure-Elie Carloni</b>, Janssen R&amp;D; <b>Qin Tu,</b> Northwest A&amp;F University; and <b>Yaxi Hu</b>, Carleton University—aims to bring fresh perspectives to journal policy and editorial management.</p><p>Each Associate Editorial Board member, selected through a nomination process, is expected to serve a 2-year term at which time the appointment may be extended to an additional 2 years contingent on desire to continue and review of contributions by other Associate Editorial Board members. Associate Editorial Board members will meet regularly for social think tanks with the Managing Editor, the Editors-in-Chief and other members of the Editorial Board to share views of the publishing process, develop tools and services that better support ECRs and evaluate selectivity criteria to address biases. All members will also interact through a quarterly meeting to ensure a continuous and dynamic dialogue aimed at determining how to better serve our authors and readers.</p><p>No doubt that the new Associate Editorial Board will do its best to join the Editors and the Advisory Board in serving the broad and diverse community of analytical scientists.<span>¹</span></p><p>***</p><p>As Chair of this talented and outstanding Associate Editorial team, I feel deeply honored and already looking forward to the next meetings, hopefully in-person again, to exchange many more ideas.</p><p>***</p><p>***</p><p>***</p>","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"3 1-2","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.202100901","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137639281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial for special issue: Metabolomics in India","authors":"Biswapriya B. Misra,&nbsp;Dietrich A. Volmer","doi":"10.1002/ansa.202100064","DOIUrl":"10.1002/ansa.202100064","url":null,"abstract":"&lt;p&gt;The explosive growth of metabolomics has greatly reinvigorated interest in metabolism from a systems biology perspective. With a growing knowledge-based economy in India, the field of metabolomics has seen impressive growth in the past decade, thanks to the well-educated and skilled scientists of this country.&lt;/p&gt;&lt;p&gt;In order to capture the progress and advances in metabolomics, we decided on a special issue in early 2020 for this new journal, Analytical Science Advances (ASA), and we could think of no better topic than “Metabolomics in India,” to provide the Indian metabolomics community with a platform to showcase its exciting new developments. We invited authors to submit articles that focused on topics from analytical mass spectrometry to omics technologies and received many exciting articles. After rigorous peer-review over the past 12 months during the COVID-19 pandemic, the process resulted in the eventual acceptance of 12 articles. The original research articles used either nuclear magnetic resonance (NMR), LC-MS/MS, or GC-MS as tools for generating metabolomics scale data.&lt;/p&gt;&lt;p&gt;Mishra et al&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; demonstrated the use of UHPLC-ESI-MS/MS in bioprospection of stem bark materials of &lt;i&gt;Betula utilis&lt;/i&gt; collected from various geographical regions in India, leading to identification of 10 bioactive triterpenoids, phenolics, and flavonoids using a targeted multiple reaction monitoring (MRM) approach. Such validated methods with respect to linearity, intra- and interday precision, and accuracy will help the field move forward in areas of confident quantification of bioactive substances from phytochemical resources.&lt;/p&gt;&lt;p&gt;Rendedula et al&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; demonstrated the resolving power and sensitivity of solid-phase extraction (SPE) ultra-high performance liquid chromatograph (UHPLC) hyphenated to quadrupole hybrid Orbitrap mass spectrometry (Q-Orbitrap-MS) in capturing 26 phthalates, pharmaceuticals, and personal care products (PPPCPs) in river water samples from an Indian river, the Ganges.&lt;/p&gt;&lt;p&gt;Colvin et al&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; adopted a proteomics and metabolomics guided approach to demonstrate their utility in mosquito larvicidal toxicity in Bacillus sp. Isolated from the mid-gut of &lt;i&gt;Culex quinquefasciatus&lt;/i&gt; larvae. They reported differential toxicities of the four identified bacterial strains to specific metabolites and proteins occurring in the pathogens, indicating the importance of microbial ID and profiling efforts in infectious disease research.&lt;/p&gt;&lt;p&gt;Guleria et al&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; used an NMR-based untargeted metabolomics effort in serum and muscle tissues for diagnosis and activity assessment of idiopathic inflammatory myopathies. Metabolic profiles of sera (N = 99) and muscle (N = 21) from patients with idiopathic inflammatory myopathies were compared with healthy control (HC) samples (N = 75 for serum and N = 12 for muscle tissues) employing 800 MHz NMR spectroscopy. The patient sera","PeriodicalId":93411,"journal":{"name":"Analytical science advances","volume":"2 11-12","pages":"495-496"},"PeriodicalIF":0.0,"publicationDate":"2021-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/ansa.202100064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50821529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}