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Issue Information: BioEssays 4/2025
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-03-24 DOI: 10.1002/bies.70000
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引用次数: 0
The Known and Unknown About Female Reproductive Tract Mucus Rheological Properties.
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-03-22 DOI: 10.1002/bies.70002
Luke Achinger, Derek F Kluczynski, Abigail Gladwell, Holly Heck, Faith Zhang, Ethan Good, Alexis Waggoner, Mykala Reinhart, Megan Good, Dawson Moore, Dennis Filatoff, Supriya Dhar, Elisa Nigro, Lucas Flanagan, Sunny Yadav, Trinity Williams, Aniruddha Ray, Tariq A Shah, Matthew W Liberatore, Tomer Avidor-Reiss
{"title":"The Known and Unknown About Female Reproductive Tract Mucus Rheological Properties.","authors":"Luke Achinger, Derek F Kluczynski, Abigail Gladwell, Holly Heck, Faith Zhang, Ethan Good, Alexis Waggoner, Mykala Reinhart, Megan Good, Dawson Moore, Dennis Filatoff, Supriya Dhar, Elisa Nigro, Lucas Flanagan, Sunny Yadav, Trinity Williams, Aniruddha Ray, Tariq A Shah, Matthew W Liberatore, Tomer Avidor-Reiss","doi":"10.1002/bies.70002","DOIUrl":"https://doi.org/10.1002/bies.70002","url":null,"abstract":"<p><p>Spermatozoa reach the fallopian tube during ovulation by traveling through the female reproductive tract mucus. This non-Newtonian viscoelastic medium facilitates spermatozoon movement to accomplish fertilization or, in some cases, blocks spermatozoon movement, leading to infertility. While rheological properties are known to affect spermatozoon motility with in vitro models using synthetic polymers, their precise effects in vivo are understudied. This paper reviews the rheological measurements of reproductive tract mucus during ovulation in humans and model animals, focusing on viscosity and its potential effect on spermatozoa. Mucus viscosity in the female reproductive tract's different compartments is poorly understood. While information on this subject is incomplete, most mammals appear to have a viscosity decrease along their female reproductive tracts. Based on this sparse information, we hypothesize that viscosity changes in female reproductive tracts may guide spermatozoa to eggs, a novel concept that could improve our understanding of reproductive biology.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e70002"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distinct Stress Regulators in the CRL Family: Emerging Roles of F-Box Proteins: Cullin-RING Ligases and Stress-Sensing.
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-03-16 DOI: 10.1002/bies.202400249
Jiwon Hwang, Linda Lauinger, Peter Kaiser
{"title":"Distinct Stress Regulators in the CRL Family: Emerging Roles of F-Box Proteins: Cullin-RING Ligases and Stress-Sensing.","authors":"Jiwon Hwang, Linda Lauinger, Peter Kaiser","doi":"10.1002/bies.202400249","DOIUrl":"https://doi.org/10.1002/bies.202400249","url":null,"abstract":"<p><p>Cullin-RING ligases (CRLs) are central regulators of environmental and cellular stress responses, orchestrating diverse processes through the ubiquitination of substrate proteins. As modular complexes, CRLs employ substrate-specific adaptors to target proteins for degradation and other ubiquitin-mediated processes, enabling dynamic adaptation to environmental cues. Recent advances have highlighted the largest CRL subfamily SCF (Skp1-cullin-F-box) in environmental sensing, a role historically underappreciated for SCF ubiquitin ligases. Notably, emerging evidence suggests that the F-box domain, a 50-amino acid motif traditionally recognized for mediating protein-protein interactions, can act as a direct environmental sensor due to its ability to bind heavy metals. Despite these advances, the roles of many CRL components in environmental sensing remain poorly understood. This review provides an overview of CRLs in stress response regulation and emphasizes the emerging functions of F-box proteins in environmental adaptation.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e202400249"},"PeriodicalIF":3.2,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heavy Metal Meets Protein Homeostasis: Emerging Roles of F-Box Proteins?
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-03-16 DOI: 10.1002/bies.202500035
Callie E W Crawford, George M Burslem
{"title":"Heavy Metal Meets Protein Homeostasis: Emerging Roles of F-Box Proteins?","authors":"Callie E W Crawford, George M Burslem","doi":"10.1002/bies.202500035","DOIUrl":"https://doi.org/10.1002/bies.202500035","url":null,"abstract":"","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e202500035"},"PeriodicalIF":3.2,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Signatures of Nonlinear Aging: Molecular Stages of Life: Sudden Changes During Aging as Potential Biomarkers for an Age Classification System.
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-03-16 DOI: 10.1002/bies.202400222
Maja Olecka, Helen Morrison, Steve Hoffmann
{"title":"Signatures of Nonlinear Aging: Molecular Stages of Life: Sudden Changes During Aging as Potential Biomarkers for an Age Classification System.","authors":"Maja Olecka, Helen Morrison, Steve Hoffmann","doi":"10.1002/bies.202400222","DOIUrl":"https://doi.org/10.1002/bies.202400222","url":null,"abstract":"<p><p>The traditional view of aging as a gradual, progressive process is increasingly being challenged. A growing body of evidence suggests the existence of abrupt transitions in the aging process, marked by sudden molecular shifts. Interestingly, the data indicates that such transitions occur not only in late life but also throughout the entire lifespan. Further research on the nature of such events could enhance our understanding of aging and pave the way for novel therapeutic strategies, including personalized medicine. We propose that these abrupt molecular shifts could serve as biomarkers, dividing the lifespan into distinct stages and providing the foundation for a much-needed staging system for aging. Furthermore, we argue that the sudden changes may be the hallmarks of aging tipping points, that is, points in time where aging processes are quickly amplified after surpassing critical biological thresholds.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e202400222"},"PeriodicalIF":3.2,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental Approaches to Visualize Effector Protein Translocation During Host-Pathogen Interactions
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-03-13 DOI: 10.1002/bies.202400188
Verena Nadin Fritsch, Michael Hensel
{"title":"Experimental Approaches to Visualize Effector Protein Translocation During Host-Pathogen Interactions","authors":"Verena Nadin Fritsch,&nbsp;Michael Hensel","doi":"10.1002/bies.202400188","DOIUrl":"10.1002/bies.202400188","url":null,"abstract":"<p>Bacterial pathogens deliver effector proteins into host cells by deploying sophisticated secretion systems. This effector translocation during host-pathogen interactions is a prerequisite for the manipulation of host cells and organisms and is important for pathogenesis. Analyses of dynamics and kinetics of translocation, subcellular localization, and cellular targets of effector proteins lead to understanding the mode of action and function of effector proteins in host-pathogen interplay. This review provides an overview of biochemical and genetic tools that have been developed to study protein effector translocation qualitatively or quantitatively. After introducing the challenges of analyses of effector translocation during host-pathogen interaction, we describe various methods ranging from static visualization in fixed cells to dynamic live-cell imaging of effector protein translocation. We show the main findings enabled by the approaches, emphasize the advantages and limitations of the methods, describe recent approaches that allow real-time tracking of effector proteins in living cells on a single molecule level, and highlight open questions in the field to be addressed by application of new methods.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400188","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AAV Genome Topology Decides ITR Secondary Structure. AAV 基因组拓扑决定 ITR 二级结构
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-03-05 DOI: 10.1002/bies.202400266
Patrick Wilmott, Leszek Lisowski
{"title":"AAV Genome Topology Decides ITR Secondary Structure.","authors":"Patrick Wilmott, Leszek Lisowski","doi":"10.1002/bies.202400266","DOIUrl":"https://doi.org/10.1002/bies.202400266","url":null,"abstract":"<p><p>Intra-strand base pairing is possible when double-stranded DNA contains inverted repeats, but vanishingly improbable without so-called negative superhelicity. This superhelicity itself is conditional upon whether the molecule can retain torsional stress-a question of \"topology.\" This principle has been uncontroversial to biophysicists since the 1980s but has proven challenging for outsiders to grasp and retain. For those in AAV research, this constitutes a decades-long missed connection. AAV is one of a multitude of viruses bearing secondary-structure-forming elements on their termini. Its \"inverted terminal repeats\" (ITRs) can self-anneal into relatively large hammerhead structures on both ends of the dynamically structured genome and are central to numerous host interactions that drive the viral lifecycle. A standalone article such as this is therefore warranted to promote an understanding of these ideas in the AAV research community and highlight their significance in the basic biology of the virus and its vector gene delivery system.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e202400266"},"PeriodicalIF":3.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phosphoregulation of Microtubule Assembly and Disassembly for Phragmoplast Expansion During Plant Cytokinesis.
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-03-03 DOI: 10.1002/bies.202500004
Yuh-Ru Julie Lee, Bo Liu
{"title":"Phosphoregulation of Microtubule Assembly and Disassembly for Phragmoplast Expansion During Plant Cytokinesis.","authors":"Yuh-Ru Julie Lee, Bo Liu","doi":"10.1002/bies.202500004","DOIUrl":"https://doi.org/10.1002/bies.202500004","url":null,"abstract":"<p><p>Plant cytokinesis results in the formation of the cell plate by the phragmoplast which contains dynamic microtubules serving as the track for the delivery of cell wall builders included in Golgi vesicles. During the centrifugal process of cell plate assembly, new microtubules are assembled and bundled at the leading edge to prepare for vesicle transport while older microtubules are disassembled at the lagging edge upon the completion of vesicle delivery. The turnover of phragmoplast microtubules in this process is thought to be regulated by phosphorylation of the key microtubule bundling factor MAP65. A recent study revealed a surprising role of the α-Aurora kinase, which is typically known for its role in governing the formation of the bipolar spindle apparatus, in phosphorylating the primary microtubule bundler MAP65-3 in Arabidopsis. This phosphorylation positively contributes to the expansion of the phragmoplast. The phragmoplast midzone is also the hub for other cytokinesis-important kinases. It is intriguing how these kinases are targeted and how they may crosstalk with each other to orchestrate the expansion of the phragmoplast.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e202500004"},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Environmental and Their Disruption of Integrin Signaling in Lipid Rafts.
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-02-26 DOI: 10.1002/bies.202400276
Tina Izard
{"title":"Environmental and Their Disruption of Integrin Signaling in Lipid Rafts.","authors":"Tina Izard","doi":"10.1002/bies.202400276","DOIUrl":"10.1002/bies.202400276","url":null,"abstract":"<p><p>Talin, a key integrin activator, is essential for cellular adhesion, signal transduction, and mechanical stability. Its transition between autoinhibited and active conformations allows dynamic regulation of adhesion in response to environmental cues. Cholesterol-rich membrane microdomains, such as lipid rafts, organize and stabilize signaling platforms, influencing talin and integrin conformational states. Cholesterol is a switch modulating talin activation, integrin binding, and adhesion. Environmental pollutants, including heavy metals and air toxins, disrupt cholesterol homeostasis, destabilize lipid rafts, and interfere with talin-integrin interactions. These disruptions impair adhesion, tissue repair, and signaling fidelity, contributing to atherosclerosis and cancer metastasis. Understanding talin's interaction with cholesterol-rich domains offers critical insights into adhesion regulation and reveals the broader impact of environmental toxicants on cellular function. This framework emphasizes the importance of membrane composition, particularly cholesterol, in mediating the effects of environmental stressors and suggests potential therapeutic interventions.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e202400276"},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The LAM Is Not Enough–An Idea to Watch Regarding Adipose Tissue Macrophages and Their Disease Relevance
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-02-26 DOI: 10.1002/bies.202500020
Lorenz Adlung
{"title":"The LAM Is Not Enough–An Idea to Watch Regarding Adipose Tissue Macrophages and Their Disease Relevance","authors":"Lorenz Adlung","doi":"10.1002/bies.202500020","DOIUrl":"10.1002/bies.202500020","url":null,"abstract":"","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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