IF 3.2 3区生物学

BioEssays Pub Date : 2025-01-15 DOI: 10.1002/bies.202400299

Rana Fetit

引用次数: 0

Epithelial Polarity Loss and Multilayer Formation: Insights Into Tumor Growth and Regulatory Mechanisms.

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-31 DOI: 10.1002/bies.202400189

Jie Sun, Md Biplob Hosen, Wu-Min Deng, Aiguo Tian

{"title":"Epithelial Polarity Loss and Multilayer Formation: Insights Into Tumor Growth and Regulatory Mechanisms.","authors":"Jie Sun, Md Biplob Hosen, Wu-Min Deng, Aiguo Tian","doi":"10.1002/bies.202400189","DOIUrl":"https://doi.org/10.1002/bies.202400189","url":null,"abstract":"Epithelial tissues serve as critical barriers in metazoan organisms, maintaining structural integrity and facilitating essential physiological functions. Epithelial cell polarity regulates mechanical properties, signaling, and transport, ensuring tissue organization and homeostasis. However, the barrier function is challenged by cell turnover during development and maintenance. To preserve tissue integrity while removing dying or unwanted cells, epithelial tissues employ cell extrusion. This process removes both dead and live cells from the epithelial layer, typically causing detached cells to undergo apoptosis. Transformed cells, however, often resist apoptosis, leading to multilayered structures and early carcinogenesis. Malignant cells may invade neighboring tissues. Loss of cell polarity can lead to multilayer formation, cell extrusion, and invasion. Recent studies indicate that multilayer formation in epithelial cells with polarity loss involves a mixture of wild-type and mutant cells, leading to apical or basal accumulation. The directionality of accumulation is regulated by mutations in polarity complex genes. This phenomenon, distinct from traditional apical or basal extrusion, exhibits similarities to the endophytic or exophytic growth observed in human tumors. This review explores the regulation and implications of these phenomena for tissue biology and disease pathology.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e202400189"},"PeriodicalIF":3.2,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Horizons in Myotonic Dystrophy Type 1: Cellular Senescence as a Therapeutic Target.

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-26 DOI: 10.1002/bies.202400216

Cécilia Légaré, J Andrew Berglund, Elise Duchesne, Nicolas A Dumont

{"title":"New Horizons in Myotonic Dystrophy Type 1: Cellular Senescence as a Therapeutic Target.","authors":"Cécilia Légaré, J Andrew Berglund, Elise Duchesne, Nicolas A Dumont","doi":"10.1002/bies.202400216","DOIUrl":"https://doi.org/10.1002/bies.202400216","url":null,"abstract":"Myotonic dystrophy type 1 (DM1) is considered a progeroid disease (i.e., causing premature aging). This hypervariable disease affects multiple systems, such as the musculoskeletal, central nervous, gastrointestinal, and others. Despite advances in understanding the underlying pathogenic mechanism of DM1, numerous gaps persist in our understanding, hindering elucidation of the heterogeneity and severity of its symptoms. Accumulating evidence indicates that the toxic intracellular RNA accumulation associated with DM1 triggers cellular senescence. These cells are in a state of irreversible cell cycle arrest and secrete a cocktail of cytokines, referred to as a senescence-associated secretory phenotype (SASP), that can have harmful effects on neighboring cells and more broadly. We hypothesize that cellular senescence contributes to the pathophysiology of DM1, and clearance of senescent cells is a promising therapeutic approach for DM1. We will discuss the therapeutic potential of different senotherapeutic drugs, especially senolytics that eliminate senescent cells, and senomorphics that reduce SASP expression.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e202400216"},"PeriodicalIF":3.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuropeptides: The Evergreen Jack-of-All-Trades in Neuronal Circuit Development and Regulation.

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-26 DOI: 10.1002/bies.202400238

Zsofia Hevesi, Tomas Hökfelt, Tibor Harkany

引用次数: 0

Thermosensory Roles of G Protein-Coupled Receptors and Other Cellular Factors in Animals.

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-26 DOI: 10.1002/bies.202400233

Kohei Ohnishi, Takaaki Sokabe

引用次数: 0

Issue Information: BioEssays 1/2025

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-20 DOI: 10.1002/bies.202570001

引用次数: 0

A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems.

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-18 DOI: 10.1002/bies.202400211

Elizabeth-Lauren Stevenson, Adrienne K Mehalow, Jennifer J Loros, Christina M Kelliher, Jay C Dunlap

{"title":"A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems.","authors":"Elizabeth-Lauren Stevenson, Adrienne K Mehalow, Jennifer J Loros, Christina M Kelliher, Jay C Dunlap","doi":"10.1002/bies.202400211","DOIUrl":"10.1002/bies.202400211","url":null,"abstract":"Circadian rhythms are ∼24-h biological oscillations that enable organisms to anticipate daily environmental cycles, so that they may designate appropriate day/night functions that align with these changes. The molecular clock in animals and fungi consists of a transcription-translation feedback loop, the plant clock is comprised of multiple interlocking feedback-loops, and the cyanobacterial clock is driven by a phosphorylation cycle involving three main proteins. Despite the divergent core clock mechanisms across these systems, all circadian clocks are able to buffer period length against changes in the ambient growth environment, such as temperature and nutrients. This defining capability, termed compensation, is critical to proper timekeeping, yet the underlying mechanism(s) remain elusive. Here we examine the known players in, and the current models for, compensation across five circadian systems. While compensation models across these systems are not yet unified, common themes exist across them, including regulation via temperature-dependent changes in post-translational modifications.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e202400211"},"PeriodicalIF":3.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perspective on Death: A Gateway to a New Biology.

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-17 DOI: 10.1002/bies.202400158

Peter A Noble, Alexander Pozhitkov

引用次数: 0

Circadian Control of Protein Synthesis.

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-12 DOI: 10.1002/bies.202300158

Nathan R James, John S O'Neill

引用次数: 0

How Small Proteins Adjust the Metabolism of Cyanobacteria Under Stress: The Role of Small Proteins in Cyanobacterial Stress Responses.

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-12 DOI: 10.1002/bies.202400245

Alexander Kraus, Wolfgang R Hess

{"title":"How Small Proteins Adjust the Metabolism of Cyanobacteria Under Stress: The Role of Small Proteins in Cyanobacterial Stress Responses.","authors":"Alexander Kraus, Wolfgang R Hess","doi":"10.1002/bies.202400245","DOIUrl":"https://doi.org/10.1002/bies.202400245","url":null,"abstract":"Several recently discovered small proteins of less than 100 amino acids control important, but sometimes surprising, steps in the metabolism of cyanobacteria. There is mounting evidence that a large number of small protein genes have also been overlooked in the genome annotation of many other microorganisms. Although too short for enzymatic activity, their functional characterization has frequently revealed the involvement in processes such as signaling and sensing, interspecies communication, stress responses, metabolism, regulation of transcription and translation, and in the formation of multisubunit protein complexes. Cyanobacteria are the only prokaryotes that perform oxygenic photosynthesis. They thrive under a wide variety of conditions as long as there is light and must cope with dynamic changes in the environment. To acclimate to these fluctuations, frequently small regulatory proteins become expressed that target key enzymes and metabolic processes. The consequences of their actions are profound and can even impact the surrounding microbiome. This review highlights the diverse functions of recently discovered small proteins that control cyanobacterial metabolism. It also addresses why many of these proteins have been overlooked so far and explores the potential for implementing metabolic engineering strategies to improve the use of cyanobacteria in biotechnological applications.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e202400245"},"PeriodicalIF":3.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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