人类成年神经发生的减少是一种权衡,而不是直接的负选择。

IF 2.7 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
BioEssays Pub Date : 2025-07-14 DOI:10.1002/bies.70041
David Morizet, Laure Bally-Cuif
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引用次数: 0

摘要

与其他脊椎动物相比,人类大脑中成年神经发生的减少被认为是一种主动的反选择,以保证长期记忆和更高认知能力所需回路的稳定性。在这里,我们提出了行为研究和基于进化的观察,我们讨论了成人神经发生的好处和数据表明其损失与认知水平无关。考虑到细胞谱系和功能分析,我们进一步注意到,人类特有的基因组特征(如新的基因变异或调控序列)经常影响可能导致皮层形成发育阶段后胚胎神经祖细胞过早衰竭的途径。我们认为,人类成人神经发生的减少可能是这些变化的一种权衡,这些变化本身是为了允许大脑皮层在发育过程中扩大和复杂化而被选择的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection

Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection

The reduction of adult neurogenesis in the human brain, compared to other vertebrate species, has been proposed to result from an active counter-selection to permit the stability of circuits needed for long-term memorization and higher cognitive abilities. Here, bringing forward behavior studies and evolution-based observations, we discuss the benefits of adult neurogenesis and data suggesting that its loss is unlinked with cognitive levels. Considering cell lineages and functional assays, we further note that human-specific genomic features (such as novel gene variants or regulatory sequences) frequently hit pathways that may lead to the premature exhaustion of embryonic neural progenitors after the developmental phase of cortex formation. We propose that reduced adult neurogenesis in humans may be a tradeoff for these changes, themselves selected for to permit the enlargement and complexification of the cerebral cortex during development.

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来源期刊
BioEssays
BioEssays 生物-生化与分子生物学
CiteScore
7.30
自引率
2.50%
发文量
167
审稿时长
4-8 weeks
期刊介绍: molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.
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