{"title":"人类成年神经发生的减少是一种权衡,而不是直接的负选择。","authors":"David Morizet, Laure Bally-Cuif","doi":"10.1002/bies.70041","DOIUrl":null,"url":null,"abstract":"<p>The reduction of adult neurogenesis in the human brain, compared to other vertebrate species, has been proposed to result from an active counter-selection to permit the stability of circuits needed for long-term memorization and higher cognitive abilities. Here, bringing forward behavior studies and evolution-based observations, we discuss the benefits of adult neurogenesis and data suggesting that its loss is unlinked with cognitive levels. Considering cell lineages and functional assays, we further note that human-specific genomic features (such as novel gene variants or regulatory sequences) frequently hit pathways that may lead to the premature exhaustion of embryonic neural progenitors after the developmental phase of cortex formation. We propose that reduced adult neurogenesis in humans may be a tradeoff for these changes, themselves selected for to permit the enlargement and complexification of the cerebral cortex during development.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 9","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.70041","citationCount":"0","resultStr":"{\"title\":\"Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection\",\"authors\":\"David Morizet, Laure Bally-Cuif\",\"doi\":\"10.1002/bies.70041\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The reduction of adult neurogenesis in the human brain, compared to other vertebrate species, has been proposed to result from an active counter-selection to permit the stability of circuits needed for long-term memorization and higher cognitive abilities. Here, bringing forward behavior studies and evolution-based observations, we discuss the benefits of adult neurogenesis and data suggesting that its loss is unlinked with cognitive levels. Considering cell lineages and functional assays, we further note that human-specific genomic features (such as novel gene variants or regulatory sequences) frequently hit pathways that may lead to the premature exhaustion of embryonic neural progenitors after the developmental phase of cortex formation. We propose that reduced adult neurogenesis in humans may be a tradeoff for these changes, themselves selected for to permit the enlargement and complexification of the cerebral cortex during development.</p>\",\"PeriodicalId\":9264,\"journal\":{\"name\":\"BioEssays\",\"volume\":\"47 9\",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-07-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.70041\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BioEssays\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/bies.70041\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BioEssays","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bies.70041","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection
The reduction of adult neurogenesis in the human brain, compared to other vertebrate species, has been proposed to result from an active counter-selection to permit the stability of circuits needed for long-term memorization and higher cognitive abilities. Here, bringing forward behavior studies and evolution-based observations, we discuss the benefits of adult neurogenesis and data suggesting that its loss is unlinked with cognitive levels. Considering cell lineages and functional assays, we further note that human-specific genomic features (such as novel gene variants or regulatory sequences) frequently hit pathways that may lead to the premature exhaustion of embryonic neural progenitors after the developmental phase of cortex formation. We propose that reduced adult neurogenesis in humans may be a tradeoff for these changes, themselves selected for to permit the enlargement and complexification of the cerebral cortex during development.
期刊介绍:
molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged
BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.