BioEssays最新文献_第2页

Issue Information: BioEssays 10/2026 期刊信息：BioEssays 10/2026

IF 3.3 3区生物学

BioEssays Pub Date : 2026-09-29 DOI: 10.1002/bies.70191

引用次数: 0

Catecholamine Chemistry Dictated the Divergence of Melanization and Signaling Processes During Animal Evolution 儿茶酚胺化学决定了动物进化过程中黑色素化和信号传导过程的分化

IF 3.3 3区生物学

BioEssays Pub Date : 2026-09-29 DOI: 10.1002/bies.70189

David Njus, Markus Friedrich

引用次数: 0

Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease 靶向小胶质细胞转录重编程作为阿尔茨海默病的治疗策略

IF 3.3 3区生物学

BioEssays Pub Date : 2026-09-29 DOI: 10.1002/bies.70186

Byungwook Kim, Selena S. Wang, Justin R. Kim, Jungsu Kim

{"title":"Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease","authors":"Byungwook Kim, Selena S. Wang, Justin R. Kim, Jungsu Kim","doi":"10.1002/bies.70186","DOIUrl":"https://doi.org/10.1002/bies.70186","url":null,"abstract":"Recent human genetic studies revealed that Alzheimer's disease risk loci are enriched in genes expressed in myeloid cells, including microglia, the brain's resident immune cells. Notably, several risk-associated genes, such as SPI1 and MEF2C, encode transcription factors (TFs) that control critical microglial functions, including phagocytosis, inflammatory responses, and neurotrophic support.The objective of this article is to review the recent progress in understanding these TFs and evaluate them as therapeutic targets rather than as markers of microglial state. We examine the genetic evidence implicating PU.1, MEF2C, IRF8, and BHLHE40/41, the in vivo evidence from animal models, the transcriptional network these factors regulate, and the barriers to clinical translation.Because these TFs orchestrate broad gene expression networks by regulating multiple disease-relevant downstream partners, targeting their expression level or activity could achieve greater therapeutic efficacy than targeting single genes, provided that the dose and disease stage of modulation are carefully considered.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"48 10","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.70186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149072506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When Does Stress Build Strength? Linking Stress Physiology to Resilience in the Age of Rapid Environmental Change 什么时候压力会增强力量？在环境快速变化的时代，将压力生理学与恢复力联系起来。

IF 3.3 3区生物学

BioEssays Pub Date : 2026-09-28 DOI: 10.1002/bies.70184

Frederic Angelier, David Costantini, Cecilia Houdelier, Valeria Marasco

{"title":"When Does Stress Build Strength? Linking Stress Physiology to Resilience in the Age of Rapid Environmental Change","authors":"Frederic Angelier, David Costantini, Cecilia Houdelier, Valeria Marasco","doi":"10.1002/bies.70184","DOIUrl":"10.1002/bies.70184","url":null,"abstract":"The rapid, unprecedented rate of worldwide pressures organisms are currently exposed to, from climate instability to pollution, urges to expand research focus toward stress resilience. Here, our main goal is to call for an integrative effort to understand conserved processes underlying whole-organism stress resilience with a specific focus on the following questions: (i) How can stress resilience be defined? (ii) What are its main underlying metrics at the whole-organism level (focus on glucocorticoid hormones, oxidative stress, neural and behavioral metrics)? (iii) What is the role of stress inoculation- and hormetic-like effects to build resilience throughout an organism´s lifespan? By building up on emerging knowledge spanning from behavioral biology and ecophysiology to biomedicine, we explore conserved mechanisms of stress resilience that are relevant for both environmental and human health. Finally, we encourage for more research on wildlife study systems, which experience natural and cumulative stressors across ecologically relevant settings, and can thus help uncover functional mechanisms of stress resilience across vertebrates, including humans.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"48 9","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149069200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcription and Three-Dimensional Genome Organization: Cause, Consequence, or Coordination? 转录和三维基因组组织：原因，结果，还是协调？

IF 3.3 3区生物学

BioEssays Pub Date : 2026-09-18 DOI: 10.1002/bies.70182

Dagyeong Yang, Elissa P. Lei

{"title":"Transcription and Three-Dimensional Genome Organization: Cause, Consequence, or Coordination?","authors":"Dagyeong Yang, Elissa P. Lei","doi":"10.1002/bies.70182","DOIUrl":"10.1002/bies.70182","url":null,"abstract":"Transcription and three-dimensional (3D) genome organization are closely coupled, but their precise relationship remains unresolved. Evidence from perturbation, imaging, and modeling studies suggests that transcription is not strictly required for the establishment of large-scale genome features such as compartments and topologically associating domains (TADs). Instead, transcription seems to exert more prominent effects at finer spatial scales, where it influences enhancer–promoter interactions, local chromatin loops, and microcompartments. RNA molecules, polymerase-driven supercoiling, and R-loop formation may further modulate chromatin organization at the gene level. At the same time, many architectural proteins and transcriptional regulators operate with functional overlap, complicating efforts to disentangle cause and consequence. Together, these observations suggest that genome architecture provides a relatively stable framework for regulated gene expression, while transcription and associated factors refine chromatin organization in a context-dependent manner. Understanding how these processes are integrated will require systematic, multi-scale perturbations across different biological and biochemical systems.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"48 9","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.70182","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolution, Mechanisms, and Therapeutic Implications of Mobile Tetracycline Destructases 移动四环素破坏酶的进化、机制和治疗意义。

IF 3.3 3区生物学

BioEssays Pub Date : 2026-09-17 DOI: 10.1002/bies.70183

Yao-Peng Xue, Ruihao Li, Vincent J. Gillespie, Zhewen Yang, Wai Kwan Tang, Niraj H. Tolia, Timothy A. Wencewicz, Gautam Dantas

{"title":"Evolution, Mechanisms, and Therapeutic Implications of Mobile Tetracycline Destructases","authors":"Yao-Peng Xue, Ruihao Li, Vincent J. Gillespie, Zhewen Yang, Wai Kwan Tang, Niraj H. Tolia, Timothy A. Wencewicz, Gautam Dantas","doi":"10.1002/bies.70183","DOIUrl":"10.1002/bies.70183","url":null,"abstract":"<div>\u0000 \u0000 Tetracycline destructases (TDases) pose an emerging global threat by enzymatically inactivating all generations of tetracycline (Tet) antibiotics, including last-resort agents such as tigecycline. Despite their recent identification, TDases have rapidly disseminated worldwide, largely driven by mobile genetic elements and environmental reservoirs. This review synthesizes current knowledge on TDase genomics, structural and catalytic mechanisms, ecological niches, and clinical impacts. We detail the mechanistic distinctions between type 1 and type 2 TDases, emphasizing their divergent structural configurations and substrate specificity profiles. Additionally, we examine strategies for therapeutic intervention, highlighting progress in structure-guided inhibitor development. Key gaps remain in understanding ancestral reservoirs, evolutionary trajectories, and effective surveillance strategies. Addressing these areas through integrative evolutionary, biochemical, and ecological studies is critical for mitigating the clinical spread and therapeutic impact of TDases globally.\u0000 </div>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"48 9","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ATRX Condensates as Candidate Organizers of Enhancer-Centered Nuclear Microenvironments in Neural Progenitors ATRX凝聚物作为神经祖细胞增强子中心核微环境的候选组织者

IF 3.3 3区生物学

BioEssays Pub Date : 2026-09-11 DOI: 10.1002/bies.70178

Ryo Tomooka, Jun Kohyama

{"title":"ATRX Condensates as Candidate Organizers of Enhancer-Centered Nuclear Microenvironments in Neural Progenitors","authors":"Ryo Tomooka, Jun Kohyama","doi":"10.1002/bies.70178","DOIUrl":"https://doi.org/10.1002/bies.70178","url":null,"abstract":"<div>\u0000 \u0000 Neural progenitor cells (NPCs) must preserve lineage identity while remaining responsive to developmental cues. Here, we discuss the hypothesis that ATRX condensates help organize enhancer-centered nuclear microenvironments in NPCs. ATRX has long been studied in heterochromatin maintenance, histone variant deposition, and chromatin remodeling; earlier work has also shown that ATRX can occupy euchromatic and active regulatory regions and contribute to transcriptional regulation. Recent evidence in human NPCs indicates that ATRX forms nuclear puncta with condensate-like properties, associates with neurogenic enhancer-rich regions, and incorporates regulatory factors such as CHD7 and p300. Perturbation of ATRX condensate formation is associated with changes in enhancer-associated ATRX occupancy, neural gene-expression programs, and neuroepithelial organization, suggesting a regulatory mode that may complement canonical heterochromatin-associated functions. We propose a dual-mode model in which folded domains contribute to chromatin anchoring at repressive regions, whereas intrinsically disordered regions support condensate-associated organization at active developmental enhancers. We emphasize that whether ATRX condensates activate enhancers de novo, stabilize pre-existing enhancer states, buffer transcriptional variability, or primarily organize cofactor localization remains unresolved. We also discuss limitations of the current evidence and outline acute, locus-specific experiments needed to test the model.\u0000 </div>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"48 9","pages":""},"PeriodicalIF":3.3,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148943191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lactate Metabolism: Separating Correlation From Causation 乳酸代谢：从因果关系中分离相关性。

IF 3.3 3区生物学

BioEssays Pub Date : 2026-09-09 DOI: 10.1002/bies.70181

Bhavya Blaze, Ahmad A. Cluntun

引用次数: 0

The Small but Versatile Cyclin-Dependent Kinase Subunit CKS 小而多功能的周期蛋白依赖性激酶亚基CKS：秀丽隐杆线虫的CKS-1调节卵母细胞减数分裂的后期开始和后期B所需。

IF 3.3 3区生物学

BioEssays Pub Date : 2026-09-09 DOI: 10.1002/bies.70180

Jie Yang, Bruce Bowerman

引用次数: 0

Issue Information: BioEssays 9/2026 期刊信息：BioEssays 9/2026