BioEssays最新文献_第2页

Issue Information: BioEssays 4/2026 期刊信息：BioEssays 4/2026

IF 2.7 3区生物学

BioEssays Pub Date : 2026-03-31 DOI: 10.1002/bies.70134

引用次数: 0

BioEssays 3/2026 BioEssays 3/2026

IF 2.7 3区生物学

BioEssays Pub Date : 2026-03-25 DOI: 10.1002/bies.70132

引用次数: 0

Beyond Short Microhomologies: Mismatch-Compatible Pol θ-Mediated DNA Damage Repair 超越短微同源性：错配兼容Pol θ介导的DNA损伤修复。

IF 2.7 3区生物学

BioEssays Pub Date : 2026-03-25 DOI: 10.1002/bies.70129

Yuzhen Li, Richard D. Wood

引用次数: 0

Host Genetic Regulation of Stem Cell–Virus Interactions in Human Health 人类健康中干细胞-病毒相互作用的宿主遗传调控。

IF 2.7 3区生物学

BioEssays Pub Date : 2026-03-25 DOI: 10.1002/bies.70123

Alexios-Fotios A. Mentis, Athanasios Kossyvakis, Dimitrios Chatzidimitriou

{"title":"Host Genetic Regulation of Stem Cell–Virus Interactions in Human Health","authors":"Alexios-Fotios A. Mentis, Athanasios Kossyvakis, Dimitrios Chatzidimitriou","doi":"10.1002/bies.70123","DOIUrl":"10.1002/bies.70123","url":null,"abstract":"<div>\u0000 \u0000 <p>The interactions between human viruses and human stem cells may differ from those with differentiated cells. These differences may arise through heterogeneous intercellular mechanisms and responses to specific infectious agents, resulting in different phenotypes that affect human pathophysiology. Understanding and exploiting such differences could have clinical and translational potential. Here, we discuss the various mechanistic interactions between stem cells and viruses related to entry mechanisms, replication dynamics, and immunomodulation. In doing so, we critically assess proposed models and hypotheses about how viruses manipulate stem cell biology, while also providing new paradigms for stem cell biology and therapeutic interventions. We highlight recent discoveries on the dual role of viruses in oncogenesis and oncolysis. In parallel, we explore similarities between stem cells and complex viruses—such as giant viruses and jumbo phages—to propose novel perspectives on viral adaptability and pathogenesis. We examine both established mechanisms and emerging viral phenomena to encourage further research and debate on the clinical implications of viral interactions with stem cells.</p>\u0000 </div>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"48 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic Allostery in T Cell Receptor Specificity: A Role for Peptides and MHC Polymorphisms in Allosterically Tuning Immune Recognition T细胞受体特异性的动态变构：多肽和MHC多态性在变构调节免疫识别中的作用。

IF 2.7 3区生物学

BioEssays Pub Date : 2026-03-25 DOI: 10.1002/bies.70126

Bassant Eldaly, Brian M. Baker

{"title":"Dynamic Allostery in T Cell Receptor Specificity: A Role for Peptides and MHC Polymorphisms in Allosterically Tuning Immune Recognition","authors":"Bassant Eldaly, Brian M. Baker","doi":"10.1002/bies.70126","DOIUrl":"10.1002/bies.70126","url":null,"abstract":"<p>T cell receptor (TCR) recognition of peptide/MHC complexes is fundamental for adaptive immunity. Many studies have described the importance of peptide/MHC motion or dynamics in TCR recognition. A role for dynamics in recognition intersects with the concept of dynamic allostery, which describes how alterations to a protein's energy landscape and thus motions influence function, often in the absence of conformational changes. Tuning of MHC protein energy landscapes by different peptides has clearly been shown. Evidence is mounting, however, that MHC polymorphisms also alter the protein's energy landscape. Here, we address this concept, summarizing findings that suggest that, in addition to dictating peptide binding and selection, naturally occurring variations within MHC proteins promote differential peptide and protein dynamics, altering TCR recognition in an MHC allele-dependent manner. We hypothesize that MHC polymorphisms have been selected evolutionarily in part to tune the protein's dynamic response, altering immune specificity and further diversifying immune responses across populations.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"48 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13015781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motor-Assisted Co-Migration of Intracellular Organelles and Microtubules as a Mechanism for Directed Cargo Transport 运动辅助胞内细胞器和微管的共同迁移作为定向货物运输的机制。

IF 2.7 3区生物学

BioEssays Pub Date : 2026-03-25 DOI: 10.1002/bies.70127

Chuying Zhou, Mineko Kengaku

{"title":"Motor-Assisted Co-Migration of Intracellular Organelles and Microtubules as a Mechanism for Directed Cargo Transport","authors":"Chuying Zhou, Mineko Kengaku","doi":"10.1002/bies.70127","DOIUrl":"10.1002/bies.70127","url":null,"abstract":"<p>Intracellular cargo transport relies on a microtubule (MT) network and its molecular motors, dynein and kinesin. While conventional models emphasize motor-driven cargo movement along stationary MT tracks, emerging evidence suggests that dynamic movements of MTs also contribute to directional transport. We propose a model of cargo co-migration with moving MTs, exemplified by nuclear migration in developing neurons. This transport mode may operate across cell types, provided that cargo-MT tethering and directional MT movements are present. We hypothesize multiple complementary mechanisms, including motor catch-bond formation and clustering, as well as MT-associated protein-mediated anchorage. We further discuss how directional MT movements can be generated through motor-driven sliding, cortical gliding, actin-MT crosslinking, and dynamic MT instability. This coupled transport mechanism provides an additional layer of directional control that supplements motor-stepping-dependent transport. Potential experimental approaches to validate this hypothesis are discussed. Understanding MT-mediated cargo delivery could refine our current models of intracellular transport and reveal new insights into neurodevelopmental and neurodegenerative disorders.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"48 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13015778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diverse Scaffolds Facilitate NLRP3 Clustering and Inflammasome Formation in Response to Perturbations in Cell Homeostasis 不同支架促进NLRP3聚集和炎性小体形成，以响应细胞稳态的扰动。

IF 2.7 3区生物学

BioEssays Pub Date : 2026-03-25 DOI: 10.1002/bies.70130

Elvira Boršić-Mlinarič, Iva Hafner-Bratkovič

引用次数: 0

Morphogen Gradients as Drivers of Mosaicism During Early Human Development 形态发生梯度：早期人类发育中嵌合现象的驱动因素。

IF 2.7 3区生物学

BioEssays Pub Date : 2026-03-25 DOI: 10.1002/bies.70128

Sergio P. Acebrón, Janina Hattemer, Tobias Rausch, Anchel De Jaime-Soguero

引用次数: 0

Vimentin Intermediate Filaments: A Paradigm Shift From Static Structure to Dynamic Cytoplasmic Network 维门蛋白中间丝：从静态结构到动态细胞质网络的范式转变。

IF 2.7 3区生物学

BioEssays Pub Date : 2026-03-15 DOI: 10.1002/bies.70125

Bhuvanasundar Renganathan, Stephen A. Adam, Vladimir I. Gelfand

引用次数: 0

Transposon Ecology and the Octopus Genome 转座子生态学和章鱼基因组。

IF 2.7 3区生物学

BioEssays Pub Date : 2026-03-14 DOI: 10.1002/bies.70124

Stefan Linquist, Tyler A. Elliott, Stefan C. Kremer, T. Ryan Gregory, Brent Saylor, Karl Cottenie

{"title":"Transposon Ecology and the Octopus Genome","authors":"Stefan Linquist, Tyler A. Elliott, Stefan C. Kremer, T. Ryan Gregory, Brent Saylor, Karl Cottenie","doi":"10.1002/bies.70124","DOIUrl":"10.1002/bies.70124","url":null,"abstract":"<p>Recent discoveries of transposable element (TE) activity in the octopus genome suggest, to some, that these “jumping genes” facilitated the evolution of cephalopod brains and possibly contribute to cognitive flexibility in these animals. In contrast, TEs are often regarded as genomic parasites with net deleterious effects on host fitness. The octopus genome provides an opportunity to compare these proposals to a genome-ecological alternative. We review evidence of TE accumulation and somatic activity, showing compatibility with both organism-beneficial and selfish-DNA interpretations. To resolve this, we apply ecological thinking within the genome to generate novel predictions. If TEs are adapted to a “requirement niche” typically found in germline cells, then TE-population growth rates (replication rates) should be nonnegative under similar “environmental” conditions (e.g., similar gene expression patterns to testes). This invites a comparison of expression levels across tissues. It is reasonable to infer some organism-beneficial function only when TE expression levels deviate from those predicted by the degree of niche-overlap with germline cells.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"48 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12988792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147455599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0