BioEssays最新文献_第2页

Current and Future Landscape of SERCAs' Functions in Non-Excitatory Cells and Diseases. SERCAs在非兴奋性细胞和疾病中功能的现状和未来前景。

IF 3.2 3区生物学

BioEssays Pub Date : 2025-06-06 DOI: 10.1002/bies.70029

Jingyan Yu, Hongyu Wang, Mengqian Ding, Xiuling Zhao, Xiaoning Zhang

{"title":"Current and Future Landscape of SERCAs' Functions in Non-Excitatory Cells and Diseases.","authors":"Jingyan Yu, Hongyu Wang, Mengqian Ding, Xiuling Zhao, Xiaoning Zhang","doi":"10.1002/bies.70029","DOIUrl":"https://doi.org/10.1002/bies.70029","url":null,"abstract":"Calcium (Ca2+) signaling as the primary intracellular second messenger orchestrates a myriad of physiological processes. Maintaining Ca2+ homeostasis relies on Ca2+ channels, pumps, exchangers, and buffers. Sarco/endoplasmic reticulum Ca2+-ATPases (SERCAs or ATP2A) encoded by ATP2A1, ATP2A2, or ATP2A3 are primary Ca2+ pumps localized on the endoplasmic reticulum (ER)/sarcoplasmic reticulum (SR) that actively sequester Ca2+ from the cytoplasm back to the ER/SR, thereby preventing the detrimental overload of cytoplasmic Ca2+ concentration. Recent studies have highlighted the significant roles and the underlying mechanisms of SERCAs in non-excitatory cells such as those within epithelial, adipose, immune, and reproductive systems or tissues. This article aims to provide a comprehensive summary of the functional characteristics and regulatory mechanisms of the SERCA family, with a particular focus on the latest research concerning their roles and mechanisms in various non-excitatory cells and related cancers. This work will provide insight into understanding the Ca2+ signaling regulatory networks mediated by SERCAs and their implications for the diagnosis and treatment of Ca2+ dyshomeostasis-related diseases and propose potentially constructive suggestions for the direction of research around Ca2+ signaling transductions, as well as guiding strategies for disease diagnosis, treatment, and drug development by targeting SERCAs.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e70029"},"PeriodicalIF":3.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NF-Y Transcription Factors: Key Players in Biotic and Abiotic Stress Tolerance in Plants. NF-Y转录因子：植物生物和非生物胁迫耐受的关键因素。

IF 3.2 3区生物学

BioEssays Pub Date : 2025-06-06 DOI: 10.1002/bies.70023

Yosra Chouaibi, Walid Ben Romdhane, Alina Wiszniewska, Narjes Baazaoui, Nawres Gamas, Mohamed Taieb Bouteraa, Bouthaina Ben Akacha, Miroslava Kačániová, Anis Ben Hsouna, Stefania Garzoli, Rania Ben Saad

{"title":"NF-Y Transcription Factors: Key Players in Biotic and Abiotic Stress Tolerance in Plants.","authors":"Yosra Chouaibi, Walid Ben Romdhane, Alina Wiszniewska, Narjes Baazaoui, Nawres Gamas, Mohamed Taieb Bouteraa, Bouthaina Ben Akacha, Miroslava Kačániová, Anis Ben Hsouna, Stefania Garzoli, Rania Ben Saad","doi":"10.1002/bies.70023","DOIUrl":"https://doi.org/10.1002/bies.70023","url":null,"abstract":"Research on biologically active compounds has significantly expanded, driven by the goal of enhancing plant protection against diverse environmental stresses. Plants serve as invaluable resources for studying these compounds, as their immune system relies on a complex network of peptides, proteins, and hormones. Among the key transcription factor (TF) families involved in plant stress responses; the nuclear factor-Y (NF-Y) family plays a pivotal role in modulating gene expression under environmental stresses. TFs NF-Y build three subunits forming heterotrimeric complexes, which collectively bind to CCAAT-box promoter regions, modulating genes essential for stress adaptation and survival. Compared with animals and fungi, higher plants possess a significantly expanded repertoire of NF-Y subunits, allowing for greater functional diversity. These proteins are involved in complex regulatory networks that integrate environmental signals with developmental processes. The expression of NF-Y encoding genes is often tissue-specific and dynamically regulated in response to stress conditions, highlighting their role in fine-tuning plant resilience. Furthermore, NF-Ys interact with key signaling pathways governing abiotic stress responses, contributing to enhanced tolerance against drought, salinity, and temperature fluctuations. This review explores the structural characteristics of NF-Y TFs, their functions in the development and growth of plants, their involvement in reactions to various stresses, and the molecular aspects underlying their regulatory functions. Additionally, we discuss their potential applications in crop improvement strategies, emphasizing their significance in developing stress-resilient plant varieties.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e70023"},"PeriodicalIF":3.2,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MYC Walks the Tightrope: Driving Cancer Proliferation While Mitigating Cellular Stress and Enabling Immune Escape MYC走钢丝：驱动癌症增殖，同时减轻细胞压力和使免疫逃逸。

IF 3.2 3区生物学

BioEssays Pub Date : 2025-06-05 DOI: 10.1002/bies.70022

Sharon Prince, Carly Burmeister, Lucy Macharia

引用次数: 0

Liquid Guardians: Biomolecular Condensates Shield Heterochromatin Against Cellular Senescence. 液体守护者：生物分子凝聚物保护异染色质免受细胞衰老。

IF 3.2 3区生物学

BioEssays Pub Date : 2025-06-05 DOI: 10.1002/bies.70026

Jia Xie, Ze-Guang Han

{"title":"Liquid Guardians: Biomolecular Condensates Shield Heterochromatin Against Cellular Senescence.","authors":"Jia Xie, Ze-Guang Han","doi":"10.1002/bies.70026","DOIUrl":"https://doi.org/10.1002/bies.70026","url":null,"abstract":"Heterochromatin, a crucial constituent of the eukaryotic nucleus with highly conserved and transcriptionally silenced characteristics, plays a pivotal role in safeguarding genome stability, regulating nuclear morphology, and mediating cell fate. Recent convincing evidence indicates that the formation and maintenance of heterochromatin are implicated in cellular senescence and age-associated disorders. Interestingly, an attractive mechanism involving liquid-liquid phase separation (LLPS) may exert a central role in regulating heterochromatin formation and maintenance. In this review, we provide an overview of recent research to illustrate the role and regulatory mechanism of the biomolecular condensates in the regulation of heterochromatin stabilization. In addition, we elucidate how heterochromatin loss contributes to cellular senescence by triggering genome instability, and explore the potential therapeutic strategies to counteract cellular senescence and age-related pathologies by restoring heterochromatin stability. Finally, we outline current research challenges and future directions aimed at achieving a more comprehensive understanding of the link among heterochromatin regulation, phase separation, and cellular senescence, for ameliorating the effects of ageing in the future.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e70026"},"PeriodicalIF":3.2,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intergenerational Enlargement of Human Organs as a Driver of Increased Cancer Risk? 人体器官代际增大是癌症风险增加的驱动因素？

IF 3.2 3区生物学

BioEssays Pub Date : 2025-06-04 DOI: 10.1002/bies.70024

Costas Koufaris, Vicky Nicolaidou

引用次数: 0

BioEssays 1/2025 BioEssays 1/2025

IF 3.2 3区生物学

BioEssays Pub Date : 2025-05-30 DOI: 10.1002/bies.70008

引用次数: 0

Issue Information: BioEssays 6/2025 期刊信息：BioEssays 6/2025

IF 3.2 3区生物学

BioEssays Pub Date : 2025-05-23 DOI: 10.1002/bies.70017

引用次数: 0

Human Cervix Chip: A Preclinical Model for Studying the Role of the Cervical Mucosa and Microbiome in Female Reproductive Health 人类宫颈芯片：研究宫颈黏膜和微生物组在女性生殖健康中的作用的临床前模型。

IF 3.2 3区生物学

BioEssays Pub Date : 2025-05-22 DOI: 10.1002/bies.70014

Zohreh Izadifar, Anna Stejskalova, Aakanksha Gulati, Ola Gutzeit, Donald E. Ingber

{"title":"Human Cervix Chip: A Preclinical Model for Studying the Role of the Cervical Mucosa and Microbiome in Female Reproductive Health","authors":"Zohreh Izadifar, Anna Stejskalova, Aakanksha Gulati, Ola Gutzeit, Donald E. Ingber","doi":"10.1002/bies.70014","DOIUrl":"10.1002/bies.70014","url":null,"abstract":"Advancements in women's reproductive health have been hindered by insufficient knowledge and the underrepresentation of women in research, leading to symptom-focused care with poor outcomes. Modeling female reproductive biology and disease pathophysiology has been challenging due to the complexity and dynamic nature of the female organs. Here, we briefly review recent advancements made with a new in vitro microfluidic organ-on-a-chip model of the human cervix (Cervix Chip) that faithfully mimics key features of the cervix, including mucus production and physiological responses to hormonal, environmental, and microbial stimuli. We also discuss how this preclinical platform can provide a way to obtain unique insights into the role of mucosal immunity, genetic and risk factors, as well as microbiome and pathogen interactions in human cervix health and disease, while bridging knowledge gaps in fertility and pregnancy-related conditions. By enabling preclinical drug screening and accelerating translational research, the Cervix Chip holds the potential to improve the development of therapeutics, diagnostics, and ultimately, the sexual and reproductive health of millions of women globally.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 7","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compact Origins and Where to Find Them: ORC's Guide to Genome-Wide Licensing 紧凑的起源和在哪里找到它们：ORC的全基因组许可指南。

IF 3.2 3区生物学

BioEssays Pub Date : 2025-05-19 DOI: 10.1002/bies.70018

Christian Speck, Luitpold Maximilian Reuter

引用次数: 0

When G Protein-Coupled Receptor Signaling Meets the Primary Cilium: Implications for Sonic Hedgehog Signaling 当G蛋白偶联受体信号与初级纤毛相遇：对Sonic Hedgehog信号的影响。

IF 3.2 3区生物学

BioEssays Pub Date : 2025-05-19 DOI: 10.1002/bies.70021

Sung-Eun Kim

引用次数: 0