BioEssays最新文献_第2页

Can stable introns and noncoding RNAs be harnessed to improve health through activation of mitohormesis? 能否利用稳定的内含子和非编码 RNA，通过激活有丝分裂来改善健康？

IF 4 3区生物学

BioEssays Pub Date : 2024-09-20 DOI: 10.1002/bies.202400143

Seow Neng Chan, Jun Wei Pek

引用次数: 0

Linking secretion and cytoskeleton in immunity– a case for Arabidopsis TGNap1 将免疫中的分泌和细胞骨架联系起来--拟南芥 TGNap1 的一个案例

IF 4 3区生物学

BioEssays Pub Date : 2024-09-20 DOI: 10.1002/bies.202400150

Deepak D. Bhandari, Federica Brandizzi

引用次数: 0

Cytoskeletal mechanisms regulating attaching/effacing bacteria interactions with host cells: It takes a village to build the pedestal 调节附着/脱离细菌与宿主细胞相互作用的细胞骨架机制：建造基座需要一个村庄

IF 4 3区生物学

BioEssays Pub Date : 2024-09-20 DOI: 10.1002/bies.202400160

Nayden G. Naydenov, Armando Marino-Melendez, Kenneth G. Campellone, Andrei I. Ivanov

{"title":"Cytoskeletal mechanisms regulating attaching/effacing bacteria interactions with host cells: It takes a village to build the pedestal","authors":"Nayden G. Naydenov, Armando Marino-Melendez, Kenneth G. Campellone, Andrei I. Ivanov","doi":"10.1002/bies.202400160","DOIUrl":"https://doi.org/10.1002/bies.202400160","url":null,"abstract":"The actin cytoskeleton is a key cellular structure subverted by pathogens to infect and survive in or on host cells. Several pathogenic strains of Escherichia coli, such as enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC), developed a unique mechanism to remodel the actin cytoskeleton that involves the assembly of actin filament-rich pedestals beneath the bacterial attachment sites. Actin pedestal assembly is driven by bacterial effectors injected into the host cells, and this structure is important for EPEC and EHEC colonization. While the interplay between bacterial effectors and the actin polymerization machinery of host cells is well-understood, how other mechanisms of actin filament remodelling regulate pedestal assembly and bacterial attachment are poorly investigated. This review discusses the gaps in our understanding of the complexity of the actin cytoskeletal remodelling during EPEC and EHEC infection. We describe possible roles of actin depolymerizing, crosslinking and motor proteins in pedestal dynamics, and bacterial interactions with the host cells. We also discuss the biological significance of pedestal assembly for bacterial infection.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compartmentalized signaling in the soma: Coordination of electrical and protein kinase A signaling at neuronal ER‐plasma membrane junctions 体节中的区隔化信号传导：神经元ER-质膜连接处的电信号和蛋白激酶A信号的协调

IF 4 3区生物学

BioEssays Pub Date : 2024-09-13 DOI: 10.1002/bies.202400126

Nicholas C. Vierra

{"title":"Compartmentalized signaling in the soma: Coordination of electrical and protein kinase A signaling at neuronal ER‐plasma membrane junctions","authors":"Nicholas C. Vierra","doi":"10.1002/bies.202400126","DOIUrl":"https://doi.org/10.1002/bies.202400126","url":null,"abstract":"Neuronal information processing depends on converting membrane depolarizations into compartmentalized biochemical signals that can modify neuronal activity and structure. However, our understanding of how neurons translate electrical signals into specific biochemical responses remains limited, especially in the soma where gene expression and ion channel function are crucial for neuronal activity. Here, I emphasize the importance of physically compartmentalizing action potential‐triggered biochemical reactions within the soma. Emerging evidence suggests that somatic endoplasmic reticulum–plasma membrane (ER‐PM) junctions are specialized organelles that coordinate electrical and biochemical signaling. The juxtaposition of ion channels and signaling proteins at a prominent subset of these sites enables compartmentalized calcium and cAMP‐dependent protein kinase (PKA) signaling. I explore the hypothesis that these PKA‐containing ER‐PM junctions serve as critical sites for translating membrane depolarizations into PKA signals and identify key gaps in knowledge of the assembly, regulation, and neurobiological functions of this somatic signaling system.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health‐promoting worms? Prospects and pitfalls of helminth therapy 促进健康的蠕虫？蠕虫疗法的前景与陷阱

IF 4 3区生物学

BioEssays Pub Date : 2024-09-12 DOI: 10.1002/bies.202400080

Ingrid Lamminpää, Federico Boem, Amedeo Amedei

引用次数: 0

Tissue-resident memory T cells: Harnessing their properties against infection for cancer treatment 组织驻留记忆 T 细胞：利用其抗感染特性治疗癌症

IF 4 3区生物学

BioEssays Pub Date : 2024-09-11 DOI: 10.1002/bies.202400119

João Fernandes, Marc Veldhoen, Cristina Ferreira

引用次数: 0

The researcher's guide to selecting biomarkers in mental health studies 研究人员在心理健康研究中选择生物标记物指南

IF 3.2 3区生物学

BioEssays Pub Date : 2024-09-11 DOI: 10.1002/bies.202300246

Josine E. Verhoeven, Owen M. Wolkowitz, Isaac Barr Satz, Quinn Conklin, Femke Lamers, Catharina Lavebratt, Jue Lin, Daniel Lindqvist, Stefanie E. Mayer, Philippe A. Melas, Yuri Milaneschi, Martin Picard, Ryan Rampersaud, Natalie Rasgon, Kathryn Ridout, Gustav Söderberg Veibäck, Caroline Trumpff, Audrey R. Tyrka, Kathleen Watson, Gwyneth Winnie Y. Wu, Ruoting Yang, Anthony S. Zannas, Laura K. M. Han, Kristoffer N. T. Månsson

{"title":"The researcher's guide to selecting biomarkers in mental health studies","authors":"Josine E. Verhoeven, Owen M. Wolkowitz, Isaac Barr Satz, Quinn Conklin, Femke Lamers, Catharina Lavebratt, Jue Lin, Daniel Lindqvist, Stefanie E. Mayer, Philippe A. Melas, Yuri Milaneschi, Martin Picard, Ryan Rampersaud, Natalie Rasgon, Kathryn Ridout, Gustav Söderberg Veibäck, Caroline Trumpff, Audrey R. Tyrka, Kathleen Watson, Gwyneth Winnie Y. Wu, Ruoting Yang, Anthony S. Zannas, Laura K. M. Han, Kristoffer N. T. Månsson","doi":"10.1002/bies.202300246","DOIUrl":"10.1002/bies.202300246","url":null,"abstract":"Clinical mental health researchers may understandably struggle with how to incorporate biological assessments in clinical research. The options are numerous and are described in a vast and complex body of literature. Here we provide guidelines to assist mental health researchers seeking to include biological measures in their studies. Apart from a focus on behavioral outcomes as measured via interviews or questionnaires, we advocate for a focus on biological pathways in clinical trials and epidemiological studies that may help clarify pathophysiology and mechanisms of action, delineate biological subgroups of participants, mediate treatment effects, and inform personalized treatment strategies. With this paper we aim to bridge the gap between clinical and biological mental health research by (1) discussing the clinical relevance, measurement reliability, and feasibility of relevant peripheral biomarkers; (2) addressing five types of biological tissues, namely blood, saliva, urine, stool and hair; and (3) providing information on how to control sources of measurement variability.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202300246","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142208411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond RNAi: How the Dicer protein modulates the antiviral innate immune response in mammalian cells: Mammalian Dicer could regulate the innate immune response in an RNAi-independent manner as a result of losing long dsRNA processive activity. 超越 RNAi：Dicer 蛋白如何调节哺乳动物细胞的抗病毒先天免疫反应：哺乳动物的 Dicer 由于失去了长 dsRNA 的加工活性，因此可以不依赖 RNAi 的方式调节先天性免疫反应。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-09-09 DOI: 10.1002/bies.202400173

Léa Gaucherand, Morgane Baldaccini, Sébastien Pfeffer

引用次数: 0

Research progress on plant stress-associated protein (SAP) family: Master regulators to deal with environmental stresses. 植物胁迫相关蛋白（SAP）家族的研究进展：应对环境胁迫的主调节因子

IF 3.2 3区生物学

BioEssays Pub Date : 2024-09-09 DOI: 10.1002/bies.202400097

Rania Ben Saad, Walid Ben Romdhane, Natália Čmiková, Narjes Baazaoui, Mohamed Taieb Bouteraa, Bouthaina Ben Akacha, Yosra Chouaibi, Maria Maisto, Anis Ben Hsouna, Stefania Garzoli, Alina Wiszniewska, Miroslava Kačániová

{"title":"Research progress on plant stress-associated protein (SAP) family: Master regulators to deal with environmental stresses.","authors":"Rania Ben Saad, Walid Ben Romdhane, Natália Čmiková, Narjes Baazaoui, Mohamed Taieb Bouteraa, Bouthaina Ben Akacha, Yosra Chouaibi, Maria Maisto, Anis Ben Hsouna, Stefania Garzoli, Alina Wiszniewska, Miroslava Kačániová","doi":"10.1002/bies.202400097","DOIUrl":"https://doi.org/10.1002/bies.202400097","url":null,"abstract":"Every year, unfavorable environmental factors significantly affect crop productivity and threaten food security. Plants are sessile; they cannot move to escape unfavorable environmental conditions, and therefore, they activate a variety of defense pathways. Among them are processes regulated by stress-associated proteins (SAPs). SAPs have a specific zinc finger domain (A20) at the N-terminus and either AN1 or C2H2 at the C-terminus. SAP proteins are involved in many biological processes and in response to various abiotic or biotic constraints. Most SAPs play a role in conferring transgenic stress resistance and are stress-inducible. The emerging field of SAPs in abiotic or biotic stress response regulation has attracted the attention of researchers. Although SAPs interact with various proteins to perform their functions, the exact mechanisms of these interactions remain incompletely understood. This review aims to provide a comprehensive understanding of SAPs, covering their diversity, structure, expression, and subcellular localization. SAPs play a pivotal role in enabling crosstalk between abiotic and biotic stress signaling pathways, making them essential for developing stress-tolerant crops without yield penalties. Collectively, understanding the complex regulation of SAPs in stress responses can contribute to enhancing tolerance against various environmental stresses through several techniques such as transgenesis, classical breeding, or gene editing.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142153159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dangerous liaisons: Loss of keratinocyte control over melanocytes in melanomagenesis. 危险的联系黑色素瘤形成过程中角质细胞失去对黑色素细胞的控制。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-09-04 DOI: 10.1002/bies.202400135

Kathleen J Green, Jenny Pokorny, Brieanna Jarrell

引用次数: 0