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The Chromatin Accessibility Landscape in Cell Plasticity and Reprogramming: Understanding and Overcoming the Barriers. 细胞可塑性和重编程中的染色质可及性景观：理解和克服障碍。
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-04-10 DOI: 10.1002/bies.70005
Diyi Yang, Xingting Guo, Rongwen Xi
{"title":"The Chromatin Accessibility Landscape in Cell Plasticity and Reprogramming: Understanding and Overcoming the Barriers.","authors":"Diyi Yang, Xingting Guo, Rongwen Xi","doi":"10.1002/bies.70005","DOIUrl":"https://doi.org/10.1002/bies.70005","url":null,"abstract":"<p><p>Cell plasticity enables the dynamic changes in cell identities necessary for normal development and tissue repair. Induced cell reprogramming, which leverages this plasticity, holds great promise for regenerative medicine and personalized therapies. However, the success of cell reprogramming is often impeded by various molecular barriers, such as epigenetic marks, cell senescence, and the activation of alternative or refractory routes. In this review, we examine the cell reprogramming events that occur within or between germ layers and adult stem cell lineages and propose that the overall similarity in the pre-existing chromatin accessibility landscape is a major determinant of reprogramming efficiency from one cell type to another. A better understanding of the regulation and control of chromatin accessibility should facilitate the development of new methods and strategies to improve cell reprogramming efficiency and advance translational research.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e70005"},"PeriodicalIF":3.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanistic Insights Into the Assembly of Functional CRL3 Dimeric Complexes. 功能性CRL3二聚体复合物组装机制的研究。
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-04-10 DOI: 10.1002/bies.202400175
Weize Wang, Zonglin Dai, Ling Liang, Youdong Mao, Yuxin Yin
{"title":"Mechanistic Insights Into the Assembly of Functional CRL3 Dimeric Complexes.","authors":"Weize Wang, Zonglin Dai, Ling Liang, Youdong Mao, Yuxin Yin","doi":"10.1002/bies.202400175","DOIUrl":"https://doi.org/10.1002/bies.202400175","url":null,"abstract":"<p><p>The assembly of Cullin3-based RING E3 ubiquitin ligase (CRL3) complexes is orchestrated in two consecutive steps: the formation of the dimeric BTB domain core and the recruitment of CUL3-RBX1 subunits. Each step is tightly regulated to ensure the formation of complete and functional dimeric CRL3s. The first assembly step is regulated by two mechanisms: \"co-co assembly\" and proteasome-dependent degradation of aberrant heterodimers. The second step is facilitated by a conserved CUL3 N-terminal assembly (NA) motif. The CUL3 NA motif contributes to the assembly of CRL3s in two aspects: interacting with both BTB domain-containing protein protomers to facilitate complete dimeric assembly, and enhancing the stability of CRL3s by overcoming the tensions generated by conformational entropy during ubiquitin transfer. Given that all Cullin proteins contain N-terminal extensions, we postulate that these extensions, similar to the CUL3 NA motif-contributed assembly, play an important role in the functional regulation of CRLs and thus warrant further investigation.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e202400175"},"PeriodicalIF":3.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is Enhancer Function Driven by Protein-Protein Interactions? From Bacteria to Leukemia. 增强子功能是由蛋白质-蛋白质相互作用驱动的吗？从细菌到白血病。
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-04-08 DOI: 10.1002/bies.70006
Nicholas T Crump, Thomas A Milne
{"title":"Is Enhancer Function Driven by Protein-Protein Interactions? From Bacteria to Leukemia.","authors":"Nicholas T Crump, Thomas A Milne","doi":"10.1002/bies.70006","DOIUrl":"https://doi.org/10.1002/bies.70006","url":null,"abstract":"<p><p>The precise regulation of the transcription of genes is essential for normal development and for the maintenance of life. Aberrant gene expression changes drive many human diseases. Despite this, we still do not completely understand how precise gene regulation is controlled in living systems. Enhancers are key regulatory elements that enable cells to specifically activate genes in response to environmental cues, or in a stage or tissue-specific manner. Any model of enhancer activity needs to answer two main questions: (1) how enhancers are able to identify and act on specific genes and (2) how enhancers influence transcription. To address these points, we first outline some of the basic principles that can be established from simpler prokaryotic systems, then discuss recent work on aberrant enhancer activity in leukemia. We argue that highly specific protein-protein interactions are a key driver of enhancer-promoter proximity, allowing enhancer-bound factors to directly act on RNA polymerase and activate transcription.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e70006"},"PeriodicalIF":3.2,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic Plasma Membrane Topography Linked With Arp2/3 Actin Network Induction During Cell Shape Change. 细胞形状变化过程中动态质膜形貌与Arp2/3肌动蛋白网络诱导相关。
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-03-31 DOI: 10.1002/bies.70004
Tony J C Harris
{"title":"Dynamic Plasma Membrane Topography Linked With Arp2/3 Actin Network Induction During Cell Shape Change.","authors":"Tony J C Harris","doi":"10.1002/bies.70004","DOIUrl":"https://doi.org/10.1002/bies.70004","url":null,"abstract":"<p><p>Recent studies show the importance of mesoscale changes to plasma membrane (PM) topography during cell shape change. Local folding and flattening of the cell surface is mechanosensitive, changing in response to both microenvironment structural elements and intracellular cytoskeletal activities. These topography changes elicit local mechanical signaling events that act in conjunction with molecular signal transduction pathways to remodel the cell cortex. Experimental manipulations of local PM curvature show its sufficiency for recruiting Arp2/3 actin network induction pathways. Additionally, studies of diverse cell shape changes-ranging from neutrophil migration to early Drosophila embryo cleavage to neural stem cell asymmetric division-show that local generation of PM folding is linked with local Arp2/3 actin network induction, which then remodels the PM topography during dynamic control of cell structure. These examples are reviewed in detail, together with known and potential causes of PM topography changes, downstream effects, and higher-order feedback.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e70004"},"PeriodicalIF":3.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fighting Antibiotic Resistance: Insights Into Human Barriers and New Opportunities: Antibiotic Resistance Constantly Rises With the Development of Human Activities. We discuss Barriers and Opportunities to Get It Under Control. 对抗抗生素耐药性：洞察人类的障碍和新的机遇：抗生素耐药性随着人类活动的发展而不断上升。我们讨论了控制它的障碍和机会。
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-03-27 DOI: 10.1002/bies.70001
Aubin Pitiot, Camille Rolin, Carole Seguin-Devaux, Jacques Zimmer
{"title":"Fighting Antibiotic Resistance: Insights Into Human Barriers and New Opportunities: Antibiotic Resistance Constantly Rises With the Development of Human Activities. We discuss Barriers and Opportunities to Get It Under Control.","authors":"Aubin Pitiot, Camille Rolin, Carole Seguin-Devaux, Jacques Zimmer","doi":"10.1002/bies.70001","DOIUrl":"https://doi.org/10.1002/bies.70001","url":null,"abstract":"<p><p>The public health issue of bacterial multi-resistance to antibiotics has gained awareness among the public, researchers, and the pharmaceutical sector. Nevertheless, the spread of antimicrobial resistance has been considerably aggravated by human activities, climate change, and the subsequent increased release of antibiotics, drug-resistant bacteria, and antibiotic resistance genes in the environment. The extensive use of antibiotics for medical and veterinary purposes has not only induced increasing resistance but also other health problems, including negative effects on the patient's microbiome. Preventive strategies, new treatment modalities, and increased surveillance are progressively set up. A comprehensive approach is, however, lacking for urgently tackling this adverse situation. To address this challenge, we discussed here the main causes driving antimicrobial resistance and pollution of the environment by factors favorable to the emergence of drug resistance. We next propose some key priorities for research, prevention, surveillance, and education to supervise an effective clinical and sustainable response.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e70001"},"PeriodicalIF":3.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Issue Information: BioEssays 4/2025 期刊信息：BioEssays 4/2025
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-03-24 DOI: 10.1002/bies.70000
{"title":"Issue Information: BioEssays 4/2025","authors":"","doi":"10.1002/bies.70000","DOIUrl":"https://doi.org/10.1002/bies.70000","url":null,"abstract":"","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Known and Unknown About Female Reproductive Tract Mucus Rheological Properties. 女性生殖道粘液流变学特性的已知与未知。
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-03-22 DOI: 10.1002/bies.70002
Luke Achinger, Derek F Kluczynski, Abigail Gladwell, Holly Heck, Faith Zhang, Ethan Good, Alexis Waggoner, Mykala Reinhart, Megan Good, Dawson Moore, Dennis Filatoff, Supriya Dhar, Elisa Nigro, Lucas Flanagan, Sunny Yadav, Trinity Williams, Aniruddha Ray, Tariq A Shah, Matthew W Liberatore, Tomer Avidor-Reiss
{"title":"The Known and Unknown About Female Reproductive Tract Mucus Rheological Properties.","authors":"Luke Achinger, Derek F Kluczynski, Abigail Gladwell, Holly Heck, Faith Zhang, Ethan Good, Alexis Waggoner, Mykala Reinhart, Megan Good, Dawson Moore, Dennis Filatoff, Supriya Dhar, Elisa Nigro, Lucas Flanagan, Sunny Yadav, Trinity Williams, Aniruddha Ray, Tariq A Shah, Matthew W Liberatore, Tomer Avidor-Reiss","doi":"10.1002/bies.70002","DOIUrl":"https://doi.org/10.1002/bies.70002","url":null,"abstract":"<p><p>Spermatozoa reach the fallopian tube during ovulation by traveling through the female reproductive tract mucus. This non-Newtonian viscoelastic medium facilitates spermatozoon movement to accomplish fertilization or, in some cases, blocks spermatozoon movement, leading to infertility. While rheological properties are known to affect spermatozoon motility with in vitro models using synthetic polymers, their precise effects in vivo are understudied. This paper reviews the rheological measurements of reproductive tract mucus during ovulation in humans and model animals, focusing on viscosity and its potential effect on spermatozoa. Mucus viscosity in the female reproductive tract's different compartments is poorly understood. While information on this subject is incomplete, most mammals appear to have a viscosity decrease along their female reproductive tracts. Based on this sparse information, we hypothesize that viscosity changes in female reproductive tracts may guide spermatozoa to eggs, a novel concept that could improve our understanding of reproductive biology.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":" ","pages":"e70002"},"PeriodicalIF":3.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distinct Stress Regulators in the CRL Family: Emerging Roles of F-Box Proteins CRL家族中不同的应激调节因子：F-Box蛋白的新角色：Cullin-RING连接酶和应激传感。
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-03-16 DOI: 10.1002/bies.202400249
Jiwon Hwang, Linda Lauinger, Peter Kaiser
{"title":"Distinct Stress Regulators in the CRL Family: Emerging Roles of F-Box Proteins","authors":"Jiwon Hwang,&nbsp;Linda Lauinger,&nbsp;Peter Kaiser","doi":"10.1002/bies.202400249","DOIUrl":"10.1002/bies.202400249","url":null,"abstract":"<div>\u0000 \u0000 <p>Cullin-RING ligases (CRLs) are central regulators of environmental and cellular stress responses, orchestrating diverse processes through the ubiquitination of substrate proteins. As modular complexes, CRLs employ substrate-specific adaptors to target proteins for degradation and other ubiquitin-mediated processes, enabling dynamic adaptation to environmental cues. Recent advances have highlighted the largest CRL subfamily SCF (Skp1-cullin-F-box) in environmental sensing, a role historically underappreciated for SCF ubiquitin ligases. Notably, emerging evidence suggests that the F-box domain, a 50-amino acid motif traditionally recognized for mediating protein-protein interactions, can act as a direct environmental sensor due to its ability to bind heavy metals. Despite these advances, the roles of many CRL components in environmental sensing remain poorly understood. This review provides an overview of CRLs in stress response regulation and emphasizes the emerging functions of F-box proteins in environmental adaptation.</p>\u0000 </div>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 5","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heavy Metal Meets Protein Homeostasis: Emerging Roles of F-Box Proteins? 重金属与蛋白质稳态：F-Box蛋白的新角色？
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-03-16 DOI: 10.1002/bies.202500035
Callie E. W. Crawford, George M. Burslem
{"title":"Heavy Metal Meets Protein Homeostasis: Emerging Roles of F-Box Proteins?","authors":"Callie E. W. Crawford,&nbsp;George M. Burslem","doi":"10.1002/bies.202500035","DOIUrl":"10.1002/bies.202500035","url":null,"abstract":"","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 5","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Signatures of Nonlinear Aging: Molecular Stages of Life 非线性衰老的特征：生命的分子阶段：衰老过程中的突然变化作为年龄分类系统的潜在生物标志物。
IF 3.2 3区 生物学
BioEssays Pub Date : 2025-03-16 DOI: 10.1002/bies.202400222
Maja Olecka, Helen Morrison, Steve Hoffmann
{"title":"Signatures of Nonlinear Aging: Molecular Stages of Life","authors":"Maja Olecka,&nbsp;Helen Morrison,&nbsp;Steve Hoffmann","doi":"10.1002/bies.202400222","DOIUrl":"10.1002/bies.202400222","url":null,"abstract":"<div>\u0000 \u0000 <p>The traditional view of aging as a gradual, progressive process is increasingly being challenged. A growing body of evidence suggests the existence of abrupt transitions in the aging process, marked by sudden molecular shifts. Interestingly, the data indicates that such transitions occur not only in late life but also throughout the entire lifespan. Further research on the nature of such events could enhance our understanding of aging and pave the way for novel therapeutic strategies, including personalized medicine. We propose that these abrupt molecular shifts could serve as biomarkers, dividing the lifespan into distinct stages and providing the foundation for a much-needed staging system for aging. Furthermore, we argue that the sudden changes may be the hallmarks of aging tipping points, that is, points in time where aging processes are quickly amplified after surpassing critical biological thresholds.</p>\u0000 </div>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 5","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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