Taking Down the Primary Cilium: Pathways for Disassembly in Differentiating Cells.

IF 2.7 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
BioEssays Pub Date : 2025-09-01 DOI:10.1002/bies.70060
Carolyn M Ott, Saikat Mukhopadhyay
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引用次数: 0

Abstract

Primary cilia are customized subcellular signaling compartments leveraged to detect signals in diverse physiological contexts. Although prevalent throughout mammalian tissues, primary cilia are not universal. Many non-ciliated cells derive from developmental lineages that include ciliated progenitors; however, little is known about how primary cilia are lost as cells differentiate. Here, we examine how ciliated and non-ciliated states emerge during development and are actively maintained. We highlight several pathways for primary cilia loss, including cilia resorption in pre-mitotic cells, cilia deconstruction in post-mitotic cells, cilia shortening via remodeling, and cilia disassembly preceding multiciliogenesis. Lack of ciliogenesis is known to decrease primary cilia frequency and cause ciliopathies. Failure to maintain cilia can also cause primary cilia to be absent. Conversely, defects in primary cilia suppression or disassembly can lead to the presence of primary cilia in non-ciliated cells. We examine how changes in ciliation states could contribute to tumorigenesis and neurodegeneration.

初级纤毛的脱落:分化细胞的拆卸途径。
初级纤毛是定制的亚细胞信号室,用于检测不同生理环境下的信号。虽然在哺乳动物组织中普遍存在,但初级纤毛并非普遍存在。许多非纤毛细胞来自包括纤毛祖细胞在内的发育谱系;然而,对于细胞分化过程中初级纤毛是如何丢失的,我们知之甚少。在这里,我们研究了文明国家和非文明国家是如何在发展过程中出现并得到积极维护的。我们强调了原发性纤毛损失的几种途径,包括有丝分裂前细胞的纤毛吸收,有丝分裂后细胞的纤毛解构,通过重塑的纤毛缩短,以及多纤毛发生前的纤毛拆卸。已知缺乏纤毛发生会减少原发纤毛的频率并引起纤毛病。纤毛保养失败也会导致原发纤毛缺失。相反,原发纤毛抑制或拆卸的缺陷可导致原发纤毛出现在非纤毛细胞中。我们研究调解状态的变化如何有助于肿瘤发生和神经退行性变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BioEssays
BioEssays 生物-生化与分子生物学
CiteScore
7.30
自引率
2.50%
发文量
167
审稿时长
4-8 weeks
期刊介绍: molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.
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