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Mitochondrial Microproteins: Emerging Regulators in Neurodevelopment and Neurodegeneration 线粒体微蛋白：神经发育和神经退行性变中的新兴调节因子。
IF 2.7 3区 生物学
BioEssays Pub Date : 2025-08-22 DOI: 10.1002/bies.70058
Nada Borghol, Sozerko Yandiev, Julien Courchet
{"title":"Mitochondrial Microproteins: Emerging Regulators in Neurodevelopment and Neurodegeneration","authors":"Nada Borghol,&nbsp;Sozerko Yandiev,&nbsp;Julien Courchet","doi":"10.1002/bies.70058","DOIUrl":"10.1002/bies.70058","url":null,"abstract":"<p>Recent advances in genomics uncovered a large number of microproteins, which are peptides of less than 100 amino-acids encoded by small open reading frames. In contrast to their identification, the validation of the functions of microproteins remains challenging. Especially, what are their biological functions in the cell and how this relates to disease conditions are still largely unknown. Although microproteins ensure a plethora of cellular functions, recent evidence demonstrate that they may disproportionately affect cellular metabolism. In this review, we will address the roles of mitochondrial-targeted microproteins, and especially how this class of protein regulates neuronal metabolism in neurodevelopment and neurodegeneration, and may contribute to axonal and dendritic metabolic disorders.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.70058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Inner Nuclear Membrane Has a Unique Lipid Signature 内核膜具有独特的脂质特征。
IF 2.7 3区 生物学
BioEssays Pub Date : 2025-08-18 DOI: 10.1002/bies.70055
Yang Niu, Tamas Balla
{"title":"The Inner Nuclear Membrane Has a Unique Lipid Signature","authors":"Yang Niu,&nbsp;Tamas Balla","doi":"10.1002/bies.70055","DOIUrl":"10.1002/bies.70055","url":null,"abstract":"<p>Although the inner nuclear membrane (INM) is generally considered to be continuous with the outer nuclear membrane (ONM) and connected to the remaining endoplasmic reticulum (ER), it has been well recognized that it is functionally distinct, having a unique protein composition. It has increasingly been recognized, however, that the INM also differs from the ONM and the other ER domains in its lipid composition. It is an intriguing proposition that the unique lipid profile of the INM is intricately linked to its specialized functions related to the nuclear events. Despite rapid progress in recent years in our understanding of the unique lipid profile of the INM and its role in the control of nuclear functions, there is a lot that remains to be understood. This review summarizes recent advances in characterizing the INM lipid composition and lipid synthetic pathways including their possible roles in the control of nuclear functions. Additionally, it discusses current challenges and areas deserving further investigation.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.70055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Nuclear Envelope Budding: Getting Large Macromolecular Complexes Out of the Nucleus” 更正“核包膜萌芽：从核中获得大分子复合物”。
IF 2.7 3区 生物学
BioEssays Pub Date : 2025-08-17 DOI: 10.1002/bies.70057
{"title":"Correction to “Nuclear Envelope Budding: Getting Large Macromolecular Complexes Out of the Nucleus”","authors":"","doi":"10.1002/bies.70057","DOIUrl":"10.1002/bies.70057","url":null,"abstract":"<p>K. C. Sule, M. Nakamura, and S. M. Parkhurst, “Nuclear Envelope Budding: Getting Large Macromolecular Complexes Out of the Nucleus,” <i>BioEssays</i> 46 (2024): 2300182.</p><p>In this article, reference [85] was incorrect. The correct reference should be:</p><p>[85] J. W. Park, E. J. Lee, E. Moon, et al., “Orthodenticle Homeobox 2 is Transported to Lysosomes by Nuclear Budding Vesicles,” Nature Communications 14, no. 1 (2023): 1111, https://doi.org/10.1038/s41467-023-36697-5. Epub 20230227.</p><p>We apologize for this error.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.70057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Growth Cones Sense Extracellular Cues and Drive Neuronal Migration 生长锥如何感知细胞外信号并驱动神经元迁移：迁移神经元和轴突生长锥之间的共享机制。
IF 2.7 3区 生物学
BioEssays Pub Date : 2025-08-15 DOI: 10.1002/bies.70050
Takahiro Kanzawa, Chikako Nakajima, Masato Sawada, Kazunobu Sawamoto
{"title":"How Growth Cones Sense Extracellular Cues and Drive Neuronal Migration","authors":"Takahiro Kanzawa,&nbsp;Chikako Nakajima,&nbsp;Masato Sawada,&nbsp;Kazunobu Sawamoto","doi":"10.1002/bies.70050","DOIUrl":"10.1002/bies.70050","url":null,"abstract":"<p>Migrating neurons form a growth cone at the tip of their leading process. This specialized structure shares striking anatomical and functional similarities with axonal growth cones. We hypothesize that both cones respond to common extracellular cues and direct neuronal migration and axon extension, respectively, through analogous mechanisms. Guidance cues provide growth cones with attractive or repulsive signals to direct them towards their targets. By binding to specific receptors on growth cones, these cues trigger intracellular signaling pathways that reorganize the cytoskeleton and propel neurons or axons in precise directions. Notably, many of the receptors that mediate axon guidance are also present in the growth cones of migrating neurons, reinforcing the idea of a conserved molecular machinery. Elucidating the molecular mechanisms underlying growth cone dynamics in migrating neurons promises to deepen our understanding of neuronal development, and to pave the way for new regenerative therapies aimed at promoting neuronal migration.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.70050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
All Organisms Can Be Anesthetized, but There's No Point? 所有生物都可以被麻醉，但没有意义？
IF 2.7 3区 生物学
BioEssays Pub Date : 2025-08-14 DOI: 10.1002/bies.70056
Lucia Sylvain-Bonfanti, Delphine Arbelet-Bonnin, Christophe Lalanne, Olivier Dellis, Patrice Meimoun, Patrick Laurenti, Etienne Grésillon, François Bouteau
{"title":"All Organisms Can Be Anesthetized, but There's No Point?","authors":"Lucia Sylvain-Bonfanti,&nbsp;Delphine Arbelet-Bonnin,&nbsp;Christophe Lalanne,&nbsp;Olivier Dellis,&nbsp;Patrice Meimoun,&nbsp;Patrick Laurenti,&nbsp;Etienne Grésillon,&nbsp;François Bouteau","doi":"10.1002/bies.70056","DOIUrl":"10.1002/bies.70056","url":null,"abstract":"<p>Because of their interest in medicine, most studies on anesthesia have historically focused on the nervous systems of animals. This has often led to the neglect of the fact that all life forms have the potential to be anesthetized. Anesthetics target proteins, such as four-domain voltage-dependent Na<sup>+</sup>/Ca<sup>2</sup>⁺ channels (4D-NaV/CaV) and glutamate receptor channels (iGluR/GLR), which have homologs in a wide variety of species. These proteins originate from ancestral channels that predate eukaryotes in the evolutionary process. These channels are evidently so essential for living cells that they are under strong selective pressure. Consequently, the susceptibility of most living organisms to anesthesia has been interpreted as a result of natural selection. Here, we propose an alternative hypothesis that this susceptibility is attributable to an intrinsic weakness in living cells.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.70056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defective Ribosome Recycling: A Bridge Between Translation Fidelity, Organelle Dysfunction, and Diseases 缺陷核糖体回收：翻译保真度，细胞器功能障碍和疾病之间的桥梁：探索有缺陷的核糖体回收因子如何影响核糖体代谢和细胞器稳态，导致人类疾病。
IF 2.7 3区 生物学
BioEssays Pub Date : 2025-08-11 DOI: 10.1002/bies.70054
Foozhan Tahmasebinia, Zhihao Wu
{"title":"Defective Ribosome Recycling: A Bridge Between Translation Fidelity, Organelle Dysfunction, and Diseases","authors":"Foozhan Tahmasebinia,&nbsp;Zhihao Wu","doi":"10.1002/bies.70054","DOIUrl":"10.1002/bies.70054","url":null,"abstract":"<p>Ribosome recycling is a fundamental biological process crucial for cellular health. Defective recycling disrupts ribosome biogenesis and organelle function, particularly in mitochondria, contributing to ribosomopathies, neurodegenerative diseases, and cancer. While not directly linked to human diseases via known genetic mutations, emerging evidence suggests a critical interplay between ribosome recycling and organelle quality control. Impaired ribosome recycling leads to aberrant ribosome production, compromised translational quality control, protein misfolding, and subsequent organelle dysfunction and cellular stress. These cascading defects underscore the critical need for effective ribosome reutilization, especially under stress, as disruptions can cause translational arrest and heightened stress signaling, perturbing cellular homeostasis. Our analyses establish an indirect but significant link between ribosome recycling and human disease, offering new perspectives on how translational fidelity and organelle maintenance converge to support cellular well-being.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12453390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Genome to Geroscience: How DNA Damage Shapes Systemic Decline 从基因组到基因科学：DNA损伤如何塑造系统性衰退。
IF 2.7 3区 生物学
BioEssays Pub Date : 2025-08-10 DOI: 10.1002/bies.70051
Athanasios Siametis, George A. Garinis
{"title":"From Genome to Geroscience: How DNA Damage Shapes Systemic Decline","authors":"Athanasios Siametis,&nbsp;George A. Garinis","doi":"10.1002/bies.70051","DOIUrl":"10.1002/bies.70051","url":null,"abstract":"<p>Persistent genomic instability compromises cellular viability while also triggers non-cell-autonomous responses that drive dysfunction across tissues, contributing to aging. Recent evidence suggests that DNA damage activates secretory programs, including the release of inflammatory cytokines, damage-associated molecular patterns, and extracellular vesicles, that reshape immune homeostasis, stem cell function, and metabolic balance. Although these responses may initially support tissue integrity and organismal survival, their chronic activation has been associated with tissue degenerative changes and systemic decline. Here, we discuss how nuclear DNA damage responses trigger the activation of cytoplasmic sensing pathways, promote secretory phenotypes, and affect organismal physiology. Targeting DNA damage-driven mechanisms may help buffer harmful systemic responses while preserving regeneration and immune surveillance, offering new ways to delay aging-related decline.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Top-Down Coercive Mechanisms and the Major Transitions in Evolution 自上而下的强制机制和进化中的主要转变。
IF 2.7 3区 生物学
BioEssays Pub Date : 2025-08-08 DOI: 10.1002/bies.70047
Javier Suárez, Adrian Stencel, Isobel Ronai
{"title":"Top-Down Coercive Mechanisms and the Major Transitions in Evolution","authors":"Javier Suárez,&nbsp;Adrian Stencel,&nbsp;Isobel Ronai","doi":"10.1002/bies.70047","DOIUrl":"10.1002/bies.70047","url":null,"abstract":"<p>We propose that top-down coercive mechanisms have played a role in the origin and maintenance of the Major Transitions in Evolution (MTE). Top-down coercion has potentially been underappreciated due to the lack of a conceptual framework. Therefore, we provide a formalized top-down coercion framework for the MTE. Our conceptualization of top-down biological coercion is a loss of potential due to a constraint from the top-down. We also present three case studies of coercive top-down mechanisms in the evolution of eukaryotic cells, multicellularity and eusocial insect colonies. The MTE project studies the origin and maintenance of new levels of individuality in the biological hierarchy. Previously, the MTE has been conceived as a bottom-up process. Our coercion framework provides new empirical questions regarding the origin of transitions and helps reframe discussions of fitness in the MTE.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.70047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dinucleoside Polyphosphates in Cellular Signaling: Function and Evolution Across Life 二核苷多磷酸在细胞信号传导中的作用和进化。
IF 2.7 3区 生物学
BioEssays Pub Date : 2025-08-08 DOI: 10.1002/bies.70049
Gert Bange, Jennifer N. Andexer, Henning J. Jessen, Johannes Freitag, Sonja-Verena Albers, Jan Pané-Farré
{"title":"Dinucleoside Polyphosphates in Cellular Signaling: Function and Evolution Across Life","authors":"Gert Bange,&nbsp;Jennifer N. Andexer,&nbsp;Henning J. Jessen,&nbsp;Johannes Freitag,&nbsp;Sonja-Verena Albers,&nbsp;Jan Pané-Farré","doi":"10.1002/bies.70049","DOIUrl":"10.1002/bies.70049","url":null,"abstract":"<p>Once considered biochemical oddities, dinucleoside polyphosphates such as diadenosine tetraphosphate (Ap4A) are now recognized as conserved signaling molecules involved in essential cellular processes, including stress response, RNA stability, and proteostasis. To capture recent advances and reignite collaborative efforts in this re-emerging field, the one-day symposium “<i>Dinucleoside Polyphosphates in Cellular Signalling: Function and Evolution Across Life</i>” was held in Marburg on May 27, 2025. The meeting brought together researchers across disciplines and domains of life to share insights into Ap4A's diverse roles—from bacterial virulence and plant signaling to human disease—and showcased powerful new tools for studying its function, laying the groundwork for future discovery and innovation.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.70049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Hidden Architects: Nitric Oxide and Redox Dynamics in Plant Stem Cell Homeostasis 隐藏的建筑师：植物干细胞稳态中的一氧化氮和氧化还原动力学。
IF 2.7 3区 生物学
BioEssays Pub Date : 2025-08-01 DOI: 10.1002/bies.70048
Jian Zeng, Xin'Ai Zhao, Jan U. Lohmann
{"title":"The Hidden Architects: Nitric Oxide and Redox Dynamics in Plant Stem Cell Homeostasis","authors":"Jian Zeng,&nbsp;Xin'Ai Zhao,&nbsp;Jan U. Lohmann","doi":"10.1002/bies.70048","DOIUrl":"10.1002/bies.70048","url":null,"abstract":"<p>Plant stem cell homeostasis is a tightly controlled process governed by a complex network of transcription factors, hormones, signaling molecules, and various environmental factors. Among these, nitric oxide (NO) and redox signaling have emerged as critical regulators. This review examines the multifaceted role of NO in maintaining plant stem cell homeostasis, focusing on its influence through redox dynamics, DNA methylation, and hormonal regulation. We also explore the intricate cross-talk between NO signaling and other key pathways, including environmental stimuli and the target of rapamycin (TOR) pathway, in balancing stem cell maintenance and differentiation within both shoot and root meristems. Additionally, we discuss NO's involvement in post-translational modifications and transcriptional regulation, offering insights into its broader role in plant growth and development.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 10","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.70048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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