Dinucleoside Polyphosphates in Cellular Signaling: Function and Evolution Across Life

IF 2.7 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
BioEssays Pub Date : 2025-08-08 DOI:10.1002/bies.70049
Gert Bange, Jennifer N. Andexer, Henning J. Jessen, Johannes Freitag, Sonja-Verena Albers, Jan Pané-Farré
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引用次数: 0

Abstract

Once considered biochemical oddities, dinucleoside polyphosphates such as diadenosine tetraphosphate (Ap4A) are now recognized as conserved signaling molecules involved in essential cellular processes, including stress response, RNA stability, and proteostasis. To capture recent advances and reignite collaborative efforts in this re-emerging field, the one-day symposium “Dinucleoside Polyphosphates in Cellular Signalling: Function and Evolution Across Life” was held in Marburg on May 27, 2025. The meeting brought together researchers across disciplines and domains of life to share insights into Ap4A's diverse roles—from bacterial virulence and plant signaling to human disease—and showcased powerful new tools for studying its function, laying the groundwork for future discovery and innovation.

Abstract Image

Abstract Image

二核苷多磷酸在细胞信号传导中的作用和进化。
二核苷多磷酸,如四磷酸二腺苷(Ap4A),曾经被认为是生化上的异类,现在被认为是一种保守的信号分子,参与必要的细胞过程,包括应激反应、RNA稳定性和蛋白质稳态。为了了解这一新兴领域的最新进展并重新点燃合作努力,2025年5月27日在马尔堡举行了为期一天的研讨会“细胞信号传导中的二核苷多磷酸盐:生命中的功能和进化”。会议汇集了来自不同学科和生命领域的研究人员,分享了对Ap4A的不同作用的见解——从细菌毒力和植物信号到人类疾病——并展示了研究其功能的强大新工具,为未来的发现和创新奠定了基础。
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来源期刊
BioEssays
BioEssays 生物-生化与分子生物学
CiteScore
7.30
自引率
2.50%
发文量
167
审稿时长
4-8 weeks
期刊介绍: molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.
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