From Genome to Geroscience: How DNA Damage Shapes Systemic Decline

IF 2.7 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
BioEssays Pub Date : 2025-08-10 DOI:10.1002/bies.70051
Athanasios Siametis, George A. Garinis
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引用次数: 0

Abstract

Persistent genomic instability compromises cellular viability while also triggers non-cell-autonomous responses that drive dysfunction across tissues, contributing to aging. Recent evidence suggests that DNA damage activates secretory programs, including the release of inflammatory cytokines, damage-associated molecular patterns, and extracellular vesicles, that reshape immune homeostasis, stem cell function, and metabolic balance. Although these responses may initially support tissue integrity and organismal survival, their chronic activation has been associated with tissue degenerative changes and systemic decline. Here, we discuss how nuclear DNA damage responses trigger the activation of cytoplasmic sensing pathways, promote secretory phenotypes, and affect organismal physiology. Targeting DNA damage-driven mechanisms may help buffer harmful systemic responses while preserving regeneration and immune surveillance, offering new ways to delay aging-related decline.

Abstract Image

Abstract Image

从基因组到基因科学:DNA损伤如何塑造系统性衰退。
持续的基因组不稳定会损害细胞活力,同时也会引发非细胞自主反应,导致组织功能障碍,从而导致衰老。最近的证据表明,DNA损伤激活了分泌程序,包括炎症细胞因子的释放,损伤相关的分子模式和细胞外囊泡,重塑免疫稳态,干细胞功能和代谢平衡。虽然这些反应最初可能支持组织完整性和有机体存活,但它们的慢性激活与组织退行性变化和全身性衰退有关。在这里,我们讨论核DNA损伤反应如何触发细胞质感应途径的激活,促进分泌表型,并影响生物体生理。靶向DNA损伤驱动机制可能有助于缓冲有害的系统反应,同时保持再生和免疫监视,提供新的方法来延缓衰老相关的衰退。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BioEssays
BioEssays 生物-生化与分子生物学
CiteScore
7.30
自引率
2.50%
发文量
167
审稿时长
4-8 weeks
期刊介绍: molecular – cellular – biomedical – physiology – translational research – systems - hypotheses encouraged BioEssays is a peer-reviewed, review-and-discussion journal. Our aims are to publish novel insights, forward-looking reviews and commentaries in contemporary biology with a molecular, genetic, cellular, or physiological dimension, and serve as a discussion forum for new ideas in these areas. An additional goal is to encourage transdisciplinarity and integrative biology in the context of organismal studies, systems approaches, through to ecosystems, where appropriate.
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