BioEssays最新文献_第4页

Thermosensory Roles of G Protein-Coupled Receptors and Other Cellular Factors in Animals G蛋白偶联受体和其他细胞因子在动物热感觉中的作用。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-26 DOI: 10.1002/bies.202400233

Kohei Ohnishi, Takaaki Sokabe

引用次数: 0

Issue Information: BioEssays 1/2025 期刊信息：BioEssays 1/2025

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-20 DOI: 10.1002/bies.202570001

引用次数: 0

A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems 补偿时钟：昼夜节律系统的温度和营养补偿机制。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-18 DOI: 10.1002/bies.202400211

Elizabeth-Lauren Stevenson, Adrienne K. Mehalow, Jennifer J. Loros, Christina M. Kelliher, Jay C. Dunlap

{"title":"A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems","authors":"Elizabeth-Lauren Stevenson, Adrienne K. Mehalow, Jennifer J. Loros, Christina M. Kelliher, Jay C. Dunlap","doi":"10.1002/bies.202400211","DOIUrl":"10.1002/bies.202400211","url":null,"abstract":"<div>\u0000 \u0000 Circadian rhythms are ∼24-h biological oscillations that enable organisms to anticipate daily environmental cycles, so that they may designate appropriate day/night functions that align with these changes. The molecular clock in animals and fungi consists of a transcription-translation feedback loop, the plant clock is comprised of multiple interlocking feedback-loops, and the cyanobacterial clock is driven by a phosphorylation cycle involving three main proteins. Despite the divergent core clock mechanisms across these systems, all circadian clocks are able to buffer period length against changes in the ambient growth environment, such as temperature and nutrients. This defining capability, termed compensation, is critical to proper timekeeping, yet the underlying mechanism(s) remain elusive. Here we examine the known players in, and the current models for, compensation across five circadian systems. While compensation models across these systems are not yet unified, common themes exist across them, including regulation via temperature-dependent changes in post-translational modifications.\u0000 </div>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perspective on Death: A Gateway to a New Biology 死亡视角：通往新生物学的大门。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-17 DOI: 10.1002/bies.202400158

Peter A. Noble, Alexander Pozhitkov

引用次数: 0

Circadian Control of Protein Synthesis 蛋白质合成的昼夜节律控制。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-12 DOI: 10.1002/bies.202300158

Nathan R. James, John S. O'Neill

引用次数: 0

How Small Proteins Adjust the Metabolism of Cyanobacteria Under Stress 小蛋白如何调节应激下蓝藻的代谢：小蛋白在蓝藻应激反应中的作用。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-12 DOI: 10.1002/bies.202400245

Alexander Kraus, Wolfgang R. Hess

{"title":"How Small Proteins Adjust the Metabolism of Cyanobacteria Under Stress","authors":"Alexander Kraus, Wolfgang R. Hess","doi":"10.1002/bies.202400245","DOIUrl":"10.1002/bies.202400245","url":null,"abstract":"Several recently discovered small proteins of less than 100 amino acids control important, but sometimes surprising, steps in the metabolism of cyanobacteria. There is mounting evidence that a large number of small protein genes have also been overlooked in the genome annotation of many other microorganisms. Although too short for enzymatic activity, their functional characterization has frequently revealed the involvement in processes such as signaling and sensing, interspecies communication, stress responses, metabolism, regulation of transcription and translation, and in the formation of multisubunit protein complexes. Cyanobacteria are the only prokaryotes that perform oxygenic photosynthesis. They thrive under a wide variety of conditions as long as there is light and must cope with dynamic changes in the environment. To acclimate to these fluctuations, frequently small regulatory proteins become expressed that target key enzymes and metabolic processes. The consequences of their actions are profound and can even impact the surrounding microbiome. This review highlights the diverse functions of recently discovered small proteins that control cyanobacterial metabolism. It also addresses why many of these proteins have been overlooked so far and explores the potential for implementing metabolic engineering strategies to improve the use of cyanobacteria in biotechnological applications.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400245","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phagocytosis by the retinal pigment epithelium: New insights into polarized cell mechanics 视网膜色素上皮的吞噬作用：极化细胞力学的新见解。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-11 DOI: 10.1002/bies.202300197

Ceniz Zihni

引用次数: 0

Decoding Angiocrine Signaling: Endothelial Cells as Drivers of Organ Regeneration and Homeostasis 解码血管分泌信号：内皮细胞作为器官再生和体内平衡的驱动因素。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-09 DOI: 10.1002/bies.202400278

Riikka Kivelä

引用次数: 0

Evidence of Epigenetic Oncogenesis: A Turning Point in Cancer Research 表观遗传肿瘤发生的证据：癌症研究的转折点。

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-09 DOI: 10.1002/bies.202400183

Jean-Pascal Capp, Benoît Aliaga, Vera Pancaldi

{"title":"Evidence of Epigenetic Oncogenesis: A Turning Point in Cancer Research","authors":"Jean-Pascal Capp, Benoît Aliaga, Vera Pancaldi","doi":"10.1002/bies.202400183","DOIUrl":"10.1002/bies.202400183","url":null,"abstract":"In cancer research, the term epigenetics was used in the 1970s in its modern sense encompassing non-genetic events modifying the chromatin state, mainly to oppose the emerging oncogene paradigm. However, starting from the establishment of this prominent concept, the importance of these epigenetic phenomena in cancer rarely led to questioning the causal role of genetic alterations. Only in the last 10 years, the accumulation of problematic data, better experimental technologies, and some ambitious models pushed the idea that epigenetics could be at least as important as genetics in early oncogenesis. Until this year, a direct demonstration of epigenetic oncogenesis was still lacking. Now, Parreno, Cavalli and colleagues, using a refined experimental model in the fruit fly Drosophila melanogaster, enforced the initiation of tumors solely by imposing a transient loss of Polycomb repression, leading to a purely epigenetic oncogenesis phenomenon. Despite a few caveats that we discuss, this pioneering work represents a major breakpoint in cancer research. We are led to consider the theoretical and conceptual implications on oncogenesis and to search for links between this artificial experimental model and naturally occurring processes, while revisiting cancer theories that were previously proposed as alternatives to the oncogene-centered paradigm.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Ion Channel Magnetic Pharmacology: Are Magnetic Cues a Viable Alternative to Ion Channel Drugs? 探索离子通道磁药理学：磁线索是离子通道药物的可行替代品吗？

IF 3.2 3区生物学

BioEssays Pub Date : 2024-12-09 DOI: 10.1002/bies.202400200

Vitalii Zablotskii, Tatyana Polyakova, Alexandr Dejneka

{"title":"Exploring Ion Channel Magnetic Pharmacology: Are Magnetic Cues a Viable Alternative to Ion Channel Drugs?","authors":"Vitalii Zablotskii, Tatyana Polyakova, Alexandr Dejneka","doi":"10.1002/bies.202400200","DOIUrl":"10.1002/bies.202400200","url":null,"abstract":"We explore the potential of using magnetic cues as a novel approach to modulating ion channel expression, which could provide an alternative to traditional pharmacological interventions. Ion channels are crucial targets for pharmacological therapies, and ongoing research in this field continues to introduce new methods for treating various diseases. However, the efficacy of ion channel drugs is often compromised by issues such as target selectivity, leading to side effects, toxicity, and complex drug interactions. These challenges, along with problems like drug resistance and difficulties in crossing biological barriers, highlight the need for innovative strategies. In this context, the proposed use of magnetic cues to modulate ion channel expression may offer a promising solution to address these limitations, potentially improving the safety and effectiveness of treatments, particularly for long-term use. Key developments in this area are reviewed, the relationships between changes in ion channel expression and magnetic fields are summarized, knowledge gaps are identified, and central issues relevant to future research are discussed.","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 3","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400200","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0