发布求助
文献互助 智能选刊 最新文献

BioEssays最新文献

筛选
英文 中文
In vitro gametogenesis: Towards competent oocytes 体外配子发生：获得合格卵母细胞：多能干细胞在培养过程中产生卵母细胞的局限性和未来改进。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-11-05 DOI: 10.1002/bies.202400106
Eishi Aizawa, Antoine H. F. M. Peters, Anton Wutz
{"title":"In vitro gametogenesis: Towards competent oocytes","authors":"Eishi Aizawa,&nbsp;Antoine H. F. M. Peters,&nbsp;Anton Wutz","doi":"10.1002/bies.202400106","DOIUrl":"10.1002/bies.202400106","url":null,"abstract":"<p>Production of oocytes from pluripotent cell cultures in a dish represents a new paradigm in stem cell and developmental biology and has implications for how we think about life. The spark of life for the next generation occurs at fertilization when sperm and oocyte fuse. In animals, gametes are the only cells that transmit their genomes to the next generation. Oocytes contain in addition a large cytoplasm with factors that direct embryonic development. Reconstitution of mouse oocyte and embryonic development in culture provides experimental opportunities and facilitates an unprecedented understanding of molecular mechanisms. However, the application of in vitro gametogenesis to reproductive medicine or infertility treatment remains challenging. One significant concern is the quality of in vitro-derived oocytes. Here, we review the current understanding and identify limitations in generating oocytes in vitro. From this basis, we explore opportunities for future improvements of the in vitro approach to generating high-quality oocytes.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do viruses age? 病毒会老化吗？
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-11-03 DOI: 10.1002/bies.202400241
Gustavo Caetano-Anollés
{"title":"Do viruses age?","authors":"Gustavo Caetano-Anollés","doi":"10.1002/bies.202400241","DOIUrl":"10.1002/bies.202400241","url":null,"abstract":"","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CHARM and EvoETR: Precision epigenetic tools for gene silencing CHARM 和 EvoETR：基因沉默的精准表观遗传工具。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-11-03 DOI: 10.1002/bies.202400186
Anirudh Pillai, Vasundhara Verma, Sanjeev Galande
{"title":"CHARM and EvoETR: Precision epigenetic tools for gene silencing","authors":"Anirudh Pillai,&nbsp;Vasundhara Verma,&nbsp;Sanjeev Galande","doi":"10.1002/bies.202400186","DOIUrl":"10.1002/bies.202400186","url":null,"abstract":"<p>With the advent of gene editing technologies like CRISPR/Cas9, it has become possible to edit genomic regions of interest for research and therapeutic purposes. These technologies have also been adapted to alter gene expression without changing their DNA sequence, allowing epigenetic edits. While genetic editors make edits by cutting the genome at specified regions, epigenetic editors leverage the same targeting mechanism but act based on the epigenetic modifier fused to them, such as a methyltransferase. Here, we discuss two recently employed epigenetic editors (epi-editors) that silenced target genes involved in disease to mitigate their effects. Neumann et al. reported the construction of an epigenetic editor called CHARM that could methylate and silence the prion gene in mouse brains and subsequently switch itself off. Additionally, Capelluti et al. developed an epi-editor called EvoETR that knocked down <i>Pcsk9</i> in the murine liver to reduce LDL levels. We aim to highlight the design principles underlying the design of these epi-editors to inform future editor designs.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orphan genes are not a distinct biological entity 孤岛基因不是一个独立的生物实体。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-11-03 DOI: 10.1002/bies.202400146
Andres Barboza Pereira, Matthew Marano, Ramya Bathala, Rigoberto Ayala Zaragoza, Andres Neira, Alex Samano, Adekola Owoyemi, Claudio Casola
{"title":"Orphan genes are not a distinct biological entity","authors":"Andres Barboza Pereira,&nbsp;Matthew Marano,&nbsp;Ramya Bathala,&nbsp;Rigoberto Ayala Zaragoza,&nbsp;Andres Neira,&nbsp;Alex Samano,&nbsp;Adekola Owoyemi,&nbsp;Claudio Casola","doi":"10.1002/bies.202400146","DOIUrl":"10.1002/bies.202400146","url":null,"abstract":"<p>The genome sequencing revolution has revealed that all species possess a large number of unique genes critical for trait variation, adaptation, and evolutionary innovation. One widely used approach to identify such genes consists of detecting protein-coding sequences with no homology in other genomes, termed orphan genes. These genes have been extensively studied, under the assumption that they represent valid proxies for species-specific genes. Here, we critically evaluate taxonomic, phylogenetic, and sequence evolution evidence showing that orphan genes belong to a range of evolutionary ages and thus cannot be assigned to a single lineage. Furthermore, we show that the processes generating orphan genes are substantially more diverse than generally thought and include horizontal gene transfer, transposable element domestication, and overprinting. Thus, orphan genes represent a heterogeneous collection of genes rather than a single biological entity, making them unsuitable as a subject for meaningful investigation of gene evolution and phenotypic innovation.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Why hematopoietic stem cells fail in Fanconi anemia: Mechanisms and models 造血干细胞为何在范可尼贫血症中失效？机制与模型。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-10-25 DOI: 10.1002/bies.202400191
Suying Liu, ES Vivona, Peter Kurre
{"title":"Why hematopoietic stem cells fail in Fanconi anemia: Mechanisms and models","authors":"Suying Liu,&nbsp;ES Vivona,&nbsp;Peter Kurre","doi":"10.1002/bies.202400191","DOIUrl":"10.1002/bies.202400191","url":null,"abstract":"<p>Fanconi anemia (FA) is generally classified as a DNA repair disorder, conferring a genetic predisposition to cancer and prominent bone marrow failure (BMF) in early childhood. Corroborative human and murine studies point to a fetal origin of hematopoietic stem cell (HSC) attrition under replicative stress. Along with intriguing recent insights into non-canonical roles and domain-specific functions of FA proteins, these studies have raised the possibility of a DNA repair-independent BMF etiology. However, deeper mechanistic insight is critical as current curative options of allogeneic stem cell transplantation and emerging gene therapy have limited eligibility, carry significant side effects, and involve complex procedures restricted to resource-rich environments. To develop rational and broadly accessible therapies for FA patients, the field will need more faithful disease models that overcome the scarcity of patient samples, leverage technological advances, and adopt investigational clinical trial designs tailored for rare diseases.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pervasive transcription and its regulation 无处不在的转录及其调控。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-10-25 DOI: 10.1002/bies.202400208
Hongjia Liu, Qiong Li, Amit Sharma, Kun Luo, Hongde Liu
{"title":"Pervasive transcription and its regulation","authors":"Hongjia Liu,&nbsp;Qiong Li,&nbsp;Amit Sharma,&nbsp;Kun Luo,&nbsp;Hongde Liu","doi":"10.1002/bies.202400208","DOIUrl":"10.1002/bies.202400208","url":null,"abstract":"","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142495523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Issue Information: BioEssays 11/2024 发行信息：生物论文 11/2024
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-10-23 DOI: 10.1002/bies.202470018
{"title":"Issue Information: BioEssays 11/2024","authors":"","doi":"10.1002/bies.202470018","DOIUrl":"https://doi.org/10.1002/bies.202470018","url":null,"abstract":"","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"46 11","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202470018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142524941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Taming of the microbial beasts: Plant immunity tethers potentially pathogenic microbiota members 驯服微生物野兽：植物免疫力束缚了潜在的致病微生物群成员。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-10-15 DOI: 10.1002/bies.202400171
Frederickson Entila, Kenichi Tsuda
{"title":"Taming of the microbial beasts: Plant immunity tethers potentially pathogenic microbiota members","authors":"Frederickson Entila,&nbsp;Kenichi Tsuda","doi":"10.1002/bies.202400171","DOIUrl":"10.1002/bies.202400171","url":null,"abstract":"<p>Plants are in intimate association with taxonomically structured microbial communities called the plant microbiota. There is growing evidence that the plant microbiota contributes to the holistic performance and general health of plants, especially under unfavorable situations. Despite the attached benefits, surprisingly, the plant microbiota in nature also includes potentially pathogenic strains, signifying that the plant hosts have tight control over these microbes. Despite the conceivable role of plant immunity in regulating its microbiota, we lack a complete understanding of its role in governing the assembly, maintenance, and function of the plant microbiota. Here, we highlight the recent progress on the mechanistic relevance of host immunity in orchestrating plant-microbiota dialogues and discuss the pluses and perils of these microbial assemblies.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How the technologies behind self-driving cars, social networks, ChatGPT, and DALL-E2 are changing structural biology 自动驾驶汽车、社交网络、ChatGPT 和 DALL-E2 背后的技术如何改变生物结构。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-10-15 DOI: 10.1002/bies.202400155
Matthias Bochtler
{"title":"How the technologies behind self-driving cars, social networks, ChatGPT, and DALL-E2 are changing structural biology","authors":"Matthias Bochtler","doi":"10.1002/bies.202400155","DOIUrl":"10.1002/bies.202400155","url":null,"abstract":"<p>The performance of deep Neural Networks (NNs) in the text (ChatGPT) and image (DALL-E2) domains has attracted worldwide attention. Convolutional NNs (CNNs), Large Language Models (LLMs), Denoising Diffusion Probabilistic Models (DDPMs)/Noise Conditional Score Networks (NCSNs), and Graph NNs (GNNs) have impacted computer vision, language editing and translation, automated conversation, image generation, and social network management. Proteins can be viewed as texts written with the alphabet of amino acids, as images, or as graphs of interacting residues. Each of these perspectives suggests the use of tools from a different area of deep learning for protein structural biology. Here, I review how CNNs, LLMs, DDPMs/NCSNs, and GNNs have led to major advances in protein structure prediction, inverse folding, protein design, and small molecule design. This review is primarily intended as a deep learning primer for practicing experimental structural biologists. However, extensive references to the deep learning literature should also make it relevant to readers who have a background in machine learning, physics or statistics, and an interest in protein structural biology.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ageing virus hypothesis: Epigenetic ageing beyond the Tree of Life 老化病毒假说：超越生命之树的表观遗传衰老。
IF 3.2 3区 生物学
BioEssays Pub Date : 2024-10-14 DOI: 10.1002/bies.202400099
Éric Bapteste
{"title":"The ageing virus hypothesis: Epigenetic ageing beyond the Tree of Life","authors":"Éric Bapteste","doi":"10.1002/bies.202400099","DOIUrl":"10.1002/bies.202400099","url":null,"abstract":"<p>A recent thought-provoking theory argues that complex organisms using epigenetic information for their normal development and functioning must irreversibly age as a result of epigenetic signal loss. Importantly, the scope of this theory could be considerably expanded, with scientific benefits, by analyzing epigenetic ageing beyond the borders of the Tree of Life. Viruses that use epigenetic signals for their normal functioning may also age, that is, present an increasing risk of failing to complete their individual life cycle and to disappear with time. As viruses are ancient, abundant, and infect a considerable diversity of hosts, the ageing virus hypothesis, if verified, would have important consequences for many fields of the Life sciences. Uncovering ageing viruses would integrate the most abundant and biologically central entities on Earth into theories of ageing, enhance virology, gerontology, evolutionary biology, molecular ecology, genomics, and possibly medicine through the development of new therapies manipulating viral ageing.</p>","PeriodicalId":9264,"journal":{"name":"BioEssays","volume":"47 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bies.202400099","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信